Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid β42 production by direct modulation of γ-secretase activity

Journal of Biological Chemistry

Volumn 278, Issue 34, 2003, Pages 31831-31837

  Weggen, Sascha ^a   Eriksen, Jason L ^b   Sagi, Sarah A ^a   Pietrzik, Claus U ^a,c   Ozols, Victor ^b   Fauq, Abdul ^b   Golde, Todd E ^b   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYO CLINIC   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DISEASE CONTROL; DRUG THERAPY; MOLECULAR BIOLOGY;

ANTI-INFLAMMATORY DRUGS;

BIOCHEMICAL ENGINEERING;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; IBUPROFEN; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN 1; SULINDAC SULFIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; DRUG TARGETING; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; EXONS; HYDROLYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SULINDAC;

ANIMALIA;

EID: 0041876229     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303592200     Document Type: Article

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