Extracellular signal-regulated kinase phosphorylates tumor necrosis factor α-converting enzyme at threonine 735: A potential role in regulated shedding

Molecular Biology of the Cell

Volumn 13, Issue 6, 2002, Pages 2031-2044

  Díaz Rodríguez, Elena ^a   Montero, Juan Carlos ^a   Esparís Ogando, Azucena ^a   Yuste, Laura ^a   Pandiella, Atanasio ^a  

^a Centro de Investigacion del Cancer   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; THREONINE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ADAM PROTEIN; CARRIER PROTEIN; METALLOPROTEINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN TYROSINE KINASE A; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; AMINO ACID SEQUENCE; BINDING SITE; GENETIC TRANSFECTION; HELA CELL; METABOLISM; PHOSPHORYLATION; RESTRICTION MAPPING; RETROVIRUS;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; HELA CELLS; HUMAN; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; RESTRICTION MAPPING; RETROVIRIDAE; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; THREONINE; TRANSFECTION; ADAM PROTEINS; HUMANS; RECEPTOR, TRKA;

EID: 0035985185     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.01-11-0561     Document Type: Article

References (41)

1. A metalloproteinase disintegrin that releases tumor-necrosis factor-alpha from cells
2. ADAMs: Focus on the protease domain
3. Metalloprotease-disintegrins: Links to cell adhesion and cleavage of TNF alpha and Notch
4. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
5. TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment
6. The search for physiological substrates of MAP and SAP kinases in mammalian cells
7. Detection and quantification of phosphotyrosine in proteins
8. Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signaling-competent truncated forms
9. Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme
10. Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms
11. A synthetic inhibitor of the mitogen-activated protein kinase cascade
12. Membrane proteins with soluble counterparts: Role of proteolysis in the release of transmembrane proteins
13. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
14. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
15. Organization and regulation of mitogen-activated protein kinase signaling pathways
16. Processing of tumor necrosis factor-alpha precursor by metalloproteinases
17. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading
18. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
19. Membrane protein secretases
20. Signal transduction by the c-Jun N-terminal kinase (JNK): From inflammation to development
21. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
22. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors
23. Membrane-anchored growth factors
24. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
25. Regulation of tumor necrosis factor-α by a metalloproteinase inhibitor
26. Protection against a lethal dose of endotoxin by an inhibitor of tumor necrosis factor processing
27. Cloning of a disintegrin metalloproteinase that processes precursor tumor necrosis factor-α
28. p38 MAP kinases: Beyond the stress response
29. An essential role for ectodomain shedding in mammalian development
30. Shedding of tumor necrosis factor receptors by activated human neutrophils
31. C-terminal truncated forms of Met, the hepatocyte growth factor receptor
32. Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme
33. Cell volume-dependent regulation of L-selectin shedding in neutrophils: A role for p38 mitogen-activated protein kinase
34. Mitogen-activated protein kinase pathways
35. Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice
36. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
37. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease
38. A conserved docking motif in MAP kinases common to substrates, activators and regulators
39. Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation
40. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
41. Mechanism of down regulation of c-kit receptor