Assembly of the γ-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37213-37222

  LaVoie, Matthew J ^b   Fraering, Patrick C ^b   Ostaszewski, Beth L ^b   Ye, Wenjuan ^b   Kimberly, W Taylor ^b   Wolfe, Michael S ^b   Selkoe, Dennis J ^a  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; COMPLEXATION; DATA REDUCTION;

PROTEASE;

ENZYMES;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; DIMER; GAMMA SECRETASE; GENE PRODUCT; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PEN 2 PROTEIN; PRESENILIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; GENETICS; GLYCOSYLATION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CHOLIC ACIDS; CRICETINAE; ENDOPEPTIDASES; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PRESENILIN-1;

ANIMALIA;

EID: 0141733241     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303941200     Document Type: Article

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