Flap Position of Free Memapsin 2 (β-Secretase), a Model for Flap Opening in Aspartic Protease Catalysis

Biochemistry

Volumn 43, Issue 16, 2004, Pages 4689-4695

  Hong, Lin ^a,b   Tang, Jordan ^a,c  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b Zapaq Inc   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; HYDROGEN BONDS; MODELS; MOLECULAR ORIENTATION; PROTEINS;

FLAP POSITION; FREE MEMAPSIN; INTRAFLAO HYDROGEN BONDS;

CATALYSIS;

ASPARTIC PROTEINASE; BETA SECRETASE; HYDROGEN; PEPSIN A;

ARTICLE; CATALYSIS; EUKARYOTE; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TYROSINE;

EUKARYOTA;

EID: 1942470549     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0498252     Document Type: Article

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