Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (β-secretase)

Biochemistry

Volumn 44, Issue 1, 2005, Pages 105-112

  Turner III, Robert T ^a,b   Hong, Lin ^a,b   Koelsch, Gerald ^a,b   Ghosh, Arun K ^c   Tang, Jordan ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b Zapaq Inc   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CRYSTAL STRUCTURE; DISEASE CONTROL; HYDROPHOBICITY; MEMBRANES; PATHOLOGY;

AMYLOID PRECURSOR PROTEIN (APP); HYDROPHOBIC RESIDUES; STRUCTURAL LOCATIONS; TRANSITION-STATE BINDING;

SULFUR;

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; HYDROLASE; PROTEINASE; STATIN; TRYPTOPHAN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; HYDROPHOBICITY; KINETICS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; ENDOPEPTIDASES; KINETICS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 11844297294     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048106k     Document Type: Article

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