The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective

Journal of Alzheimer's Disease

Volumn 6, Issue 1, 2004, Pages 53-65

  Pasternak, Stephen Howard ^b,c   Callahan, John William ^a   Mahuran, Don Joseph ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Amyloid plaques; Endosome; ER Quality Control System; Lysosome; Nicastrin; Presenilin; Proteasome; Spatial paradox; Subcellular fractionation

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; PROTEASOME;

ALZHEIMER DISEASE; CELL FRACTIONATION; ENDOPLASMIC RETICULUM; ENDOSOME; GOLGI COMPLEX; HUMAN; LYSOSOME; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW;

EID: 1842532328     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2004-6107     Document Type: Review

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