γ-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4383-4392

  Chyung, Jay H ^a   Raper, Daniel M ^a   Selkoe, Dennis J ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CELLS; CYTOLOGY; DISEASES; ENZYMES;

Β-AMYLOID PRECURSOR PROTEINS (APP); ALZHEIMER'S DISEASE; PLASMA MEMBRANES; PROTEOLYTIC MECHANISMS;

ENZYME KINETICS;

AMYLOID BETA PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC PROTEINASE; CELL ADHESION MOLECULE; GAMMA SECRETASE; JAGGED1; NICASTRIN; NOTCH RECEPTOR; PEN 2 PROTEIN; PRESENILIN; PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ALZHEIMER DISEASE; ARTICLE; CELL INTERACTION; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BIOTINYLATION; BLOTTING, WESTERN; CADHERINS; CELL COMMUNICATION; CELL LINE; CELL MEMBRANE; CRICETINAE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOCYTOSIS; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PRESENILIN-1; PRESENILIN-2; PROTEIN BINDING; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 14244268498     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409272200     Document Type: Article

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