A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

Cell

Volumn 99, Issue 7, 1999, Pages 691-702

  Niwa, Maho ^a   Sidrauski, Carmela ^a   Kaufman, Randal J ^b   Walter, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEASE; PHOSPHOTRANSFERASE; PRESENILIN 1;

ANIMAL CELL; ARTICLE; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; RNA SPLICING; SIGNAL TRANSDUCTION;

EID: 0033598996     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81667-0     Document Type: Article

References (42)

1. Brown, M.S., and Goldstein, J.L. (1997). The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340.
2. Chan, Y.M., and Jan, Y.N. (1998). Roles for proteolysis and trafficking in notch maturation and signal transduction. Cell 94, 423-426.
3. Chapman, R.E., and Walter, P. (1997). Translational attenuation mediated by an mRNA intron. Curr. Biol. 7, 850-859.
4. Chapman, R., Sidrauski, C., and Walter, P. (1998). Intracellular signaling from the endoplasmic reticulum to the nucleus. Annu. Rev. Cell Dev. Biol. 14, 459-485.
5. Clark, M.W., and Abelson, J. (1987). The subnuclear localization of tRNA ligase in yeast. J. Cell Biol. 105, 1515-1526.
6. Cox, J.S., and Walter, P. (1996). A novel mechanism for regulating activity of a trancription factor that controls the unfolded protein response. Cell 87, 391-404.
7. Cox, J.S., Shamu, C.E., and Walter, P. (1993). Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206.
8. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998). Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
9. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J.S., Schroeter, E.H., Schrijvers, V., Wolfe, M.S., Ray, W.J., et al. (1999). A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518-522.
10. Erickson, A.H., and Blobel, G. (1979). Early events in the biosynthesis of the lysosomal enzyme Cathepsin D. J. Biol. Chem. 254, 11771-11774.
11. Foti, D.M., Welihinda, A., Kaufman, R.J., and Lee, A.S. (1999). Conservation and divergence of the yeast and mammalian unfolded protein response. J. Biol. Chem. 274, 30402-30409.
12. Gonzalez, T.N., Sidrauski, C., Dorfler, S., and Walter, P. (1999). Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 18, 3119-3132.
13. Hasan, M.T., Chang, C.C., and Chang, T.Y. (1994). Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression. Somat. Cell Mol. Genet. 20, 183-194.
14. Haze, K., Yoshida, H., Yanagi, H., Yura, T., and Mori, K. (1999). Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell, in press.
15. Katayama, T., Imaizumi, K., Sato, N., Miyoshi, K., Kudo, T., Hitomi, J., Morihara, T., Yoneda, T., Gomi, F., Mori, Y., et al. (1999). Presenilin-1 mutations downregulate the signaling pathway of the unfolded protein response. Nat. Cell Biol. 1, 479-485.
16. Kawahara, T., Yanagi, H., Yura, T., and Mori, K. (1997). Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol. Biol. Cell 8, 1845-1862.
17. Mori, K., Ma, W., Gething, M.-J., and Sambrook, J. (1993). A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743-756.
18. Mori, K., Kawahara, T., Yoshida, H., Yanagi, H., and Yura, T. (1996). Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1, 803-817.
19. Nikawa, J., Akiyoshi, M., Hirata, S., and Fukuda, T. (1996). Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression. Nucleic Acids Res. 24, 4222-4226.
20. Rawson, R.B., Zelenski, N.G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M.T., Chang, T.Y., Brown, M.S., and Goldstein, J.L. (1997). Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol. Cell 1, 47-57.
21. Rogaev, E.I., Sherrington, R., Rogaeva, E.A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995). Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
22. Sakai, J., Duncan, E.A., Rawson, R.B., Hua, X., Brown, M.S., and Goldstein, J.L. (1996). Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85, 1037-1046.
23. Sakai, J., Rawson, R.B., Espenshade, P.J., Cheng, D., Seegmiller, A.C., Goldstein, J.L., and Brown, M.S. (1998). Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell 2, 505-514.
24. Selkoe, D.J. (1998). The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447-453.
25. Shamu, C.E. (1998). Splicing: HACking into the unfolded-protein response. Curr. Biol. 8, R121-R123.
26. Shamu, C.E., and Walter, P. (1996). Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028-3039.
27. Shamu, C.E., Cox, J.S., and Walter, P. (1994). The unfolded-protein-response pathway in yeast. Trends Cell Biol. 4, 56-60.
28. Shen, J., Bronson, R.T., Chen, D.F., Xia, W., Selkoe, D.J., and Tonegawa, S. (1997). Skeletal and CNS defects in presenilin-1 deficient mice. Cell 89, 629-639.
29. Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
30. Sidrauski, C., and Walter, P. (1997). The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031-1039.
31. Sidrauski, C., Cox, J.S., and Walter, P. (1996). tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87, 405-413.
32. Sidrauski, C., Chapman, R., and Walter, P. (1998). The unfolded protein response: an intracellular signaling pathway with many surprising features. Trends Cell Biol. 8, 245-249.
33. Struhl, G., and Greenwald, I. (1999). Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525.
34. Tajima, S., Lauffer, L., Rath, V.L., and Walter, P. (1986). The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. J. Cell Biol. 103, 1167-1178.
35. Tirasophon, W., Welihinda, A.A., and Kaufman, R.J. (1998). A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12, 1812-1824.
36. Wang, X.Z., Harding, H.P., Zhang, Y., Jolicoeur, E.M., Kuroda, M., and Ron, D. (1998). Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17, 5708-5717.
37. Welihinda, A.A., and Kaufman, R.J. (1996). The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-autophosphorylation of Ire1p (Ern1p) are required for kinase activation. J. Biol. Chem. 271, 18181-18187.
38. Welihinda, A.A., Tirasophon, W., Green, S.R., and Kaufman, R.J. (1997). Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcription coactivator complex containing Ada5p. Proc. Natl. Acad. Sci. USA 94, 4289-4294.
39. Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T., and Selkoe, D.J. (1999). Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513-517.
40. Xia, W., Zhang, J., Ostaszewski, B.L., Kimberly, W.T., Seubert, P., Koo, E.H., Shen, J., and Selkoe, D.J. (1998). Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry 37, 16465-16471.
41. Ye, Y., Lukinova, N., and Fortini, M.E. (1999). Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398, 525-529.
42. Yoshida, H., Haze, K., Yanagi, H., Yura, T., and Mori, K. (1998). Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional inducion of mammalian glucose-regulated proteins. J. Biol. Chem. 273, 33741-33749.