The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate

Journal of Biological Chemistry

Volumn 276, Issue 39, 2001, Pages 36788-36796

  Yan, Riqiang ^a   Han, Ping ^b   Miao, Huiyi ^a   Greengard, Paul ^b   Xu, Huaxi ^b  

^a PFIZER INC   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; FLUORESCENCE; FRACTIONATION; SUBSTRATES;

CELLULAR LOCALIZATION;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; GREEN FLUORESCENT PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; HYBRID PROTEIN; PHOTOPROTEIN; PROTEINASE; SECRETASE; SUCROSE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL MEMBRANE; CONFOCAL MICROSCOPY; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME ACTIVITY; ENZYME LOCALIZATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; ANIMAL; BIOLOGICAL MODEL; BIOTINYLATION; CELL LINE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FLUORESCENCE MICROSCOPY; METABOLISM; PLASMID; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BIOTINYLATION; CATALYTIC DOMAIN; CELL LINE; CELL MEMBRANE; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; SUCROSE;

EID: 0035965275     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104350200     Document Type: Article

References (40)

1. Selkoe, D. J. (1999) Nature 399, A23-A31
2. Youkin, S. G. (1998) J. Physiol. 92, 289-292
3. Greenfield, J. P., Gross, R. S., Gouras, G. K., and Xu, H. (2000) Front. Biosci. 5, D72-D83
4. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 122, 1131-1135
5. Hardy, J. (1997) Trends Neurosci. 20, 154-159
6. Sisodia, S. S., Koo, E. H., Beyreuther, K., Unterbeck, A., and Price, D. L. (1990) Science 248, 492-495
7. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
8. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D, L., Walsh, F. S., Dingwall, C., and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427
9. Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999) Nature 402, 533-537
10. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., Zhao, J., McConlog, L., and John, V. (1999) Nature 402, 537-540
11. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1456-1460
12. Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C, Citron, M., and Vassar, R. A. (2000) J. Biol. Chem. 275, 37712-37717
13. Creemers, J. W., Dominguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K., Annaert, W., and De Strooper, B. (2001) J. Biol. Chem. 276, 4211-4217
14. Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., and Haass, C. (2000) J. Biol. Chem. 275, 30849-30854
15. Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G., and Haass, C. (2001) J. Biol. Chem. 276, 14634-14641
16. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M., and Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737
17. Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, F., Chrietien, M and Siedah, N. G. (2001) J. Biol. Chem. 276, 10879-10887
18. Shi, X. P., Chen, E., Yin, K. C., Na, S., Garsky, V. M., Lai, M. T., Li, Y. M., Platchek, M., Register, R. B., Sardana, M. K., Tang, M. J., Thiebeau, J., Wood, T., Shafer, J. A., and Gardell, S. J. (2001) J. Biol. Chem. 276, 10366-10373
19. Cook, D. G., Forman, M. S., Sung, J. C., Leight, S., Kolson, D. L., Iwatsubo, T., Lee, V. M., and Doms, R. W. (1997) Nat. Med. 3, 1021-1023
20. Hartmann, T., Bieger, S. C., Bruhl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., and Beyreuther K. (1997) Nat. Med. 3, 1016-1020
21. Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y., and Haass, C. (1997) J. Biol. Chem. 272, 16085-16088
22. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H. (1997) Proc. Natl. Acad. Sci. U. S. A. 96, 742-747
23. Buxbaum, J. D., Gandy, S. E., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A. J., and Greengard, P. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6003-6006
24. Wong, D. H., and Brodsky, F. M. (1992) J. Cell Biol. 117, 1171-1179
25. Horn, M., and Banting, G. (1994) Biochem. J. 301, 69-73
26. Koo, E., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
27. Xu, H., and Shields, D. (1993) J. Cell Biol. 122, 169-1184
28. Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C., Sisodia, S. S., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3748-3752
29. Gasparini, L., Gouras, G. K., Wang, R., Gross, R. S., Beal, M. F., Greengard, P., and Xu, H. (2001) J. Neurosci. 21, 2561-2570
30. Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C. L., and Beyreuther, K. (1989) Cell 57, 115-126
31. Chen, W. J., Goldstein, J. L., and Brown, M. S. (1990) J. Biol. Chem. 265, 3116-3123
32. Petris, M. J., Camakaris, J., Greenough, M., LaFontaine, S., and Mercer, J. F. (1998) Hum. Mol. Genet. 7, 2063-2071
33. Cai, H., Wang, Y., McCarthy, D., Wen, H., Borchelt, D. R., Price, D. L., and Wong, P. C (2001) Nat. Neurosci. 4, 233-234
34. Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., Martin, L., Louis, J. C., Yan, Q., Richards, W. G., Citron, M., and Vassar, R. (2001) Nat. Neurosci. 4, 231-232
35. Bretscher, M. S., and Munro, S. (1993) Science 261, 1280-1281
36. Machamer, C. E. (1993) Curr. Opin. Cell Biol. 5, 606-612
37. Yan, R., Munzner, J. B., Shuck, M. E., and Bienkowski, M. J. (June 22, 2001) J. Biol. Chem. 10.1074/jbc.M105583200
38. Watson, R. T., and Pessin, J. E. (2000) J. Biol. Chem. 275, 1261-1266
39. Teuchert, M., Berghofer, S., Klenk, H. D., and Garten, W. (1999) J. Biol. Chem. 274, 36781-36789
40. Gruninger-Leitch, F., Berndt, P., Langen, H., Nelboeck, P., and Dobeli, H. (2000) Nat. Biotechnol. 18, 66-70