BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: Implications for Alzheimer's disease therapeutics

Human Molecular Genetics

Volumn 10, Issue 12, 2001, Pages 1317-1324

  Roberds, Steven L ^a   Anderson, John ^b   Basi, Guriqbal ^b   Bienkowski, Michael J ^a   Branstetter, Daniel G ^a   Chen, Karen S ^b   Freedman, Stephen B ^b   Frigon, Normand L ^b   Games, Dora ^b   Hu, Kang ^b   Johnson Wood, Kelly ^b   Kappenman, Karl E ^a   Kawabe, Thomas T ^a   Kola, Ismail ^a   Kuehn, Ralf ^c   Lee, Michael ^b   Liu, Weiqun ^b   Motter, Ruth ^b   Nichols, Nanette F ^a   Power, Michael ^b   Robertson, David W ^a   Schenk, Dale ^b   Schoor, Michael ^c   Shopp, George M ^b   Shuck, Mary E ^a   Sinha, Sukanto ^b   Svensson, Kjell A ^a   Tatsuno, Gwen ^b   Tintrup, Hartmut ^c   Wijsman, John ^a   Wright, Sarah ^b   McConlogue, Lisa ^b   more..

^a PFIZER INC   (United States)

^b ELAN PHARMACEUTICALS   (United States)

^c Artemis Pharmaceuticals GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; BETA SECRETASE; GAMMA SECRETASE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BLOOD CHEMISTRY; BRAIN; BRAIN CORTEX; CELL COMPOSITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEVELOPMENT; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; GENETIC CODE; HISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MAMMAL; MORPHOLOGY; MOUSE; NEUROFIBRILLARY TANGLE; NEUROMUSCULAR DISEASE; NONHUMAN; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TISSUE CULTURE; URINALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELL LINE; CELLS, CULTURED; CULTURE TECHNIQUES; ENDOPEPTIDASES; ENZYME INHIBITORS; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT;

EID: 17344388652     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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