Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 6, 2006, Pages 1936-1940

  Cai, Dongming ^a   Zhong, Minghao ^b   Wang, Runsheng ^c   Netzer, William J ^a   Shields, Dennis ^d   Zheng, Hui ^c   Sisodia, Sangram S ^e   Foster, David A ^b   Gorelick, Fred S ^a,f   Xu, Huaxi ^a,g   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g BURNHAM INSTITUTE   (United States)

Author keywords

amyloid precursor protein; Axonal growth; Intracellular trafficking; Neurite branching; Trans Golgi network

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PHOSPHOLIPASE D1; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; GENE OVEREXPRESSION; GOLGI COMPLEX; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CATALYSIS; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; NEURITES; PHOSPHOLIPASE D; PRESENILIN-1; PROTEIN TRANSPORT;

ANIMALIA;

EID: 32444439640     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510710103     Document Type: Article

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