Effects of γ-secretase cleavage-region mutations on APP processing and Aβ formation: Interpretation with sequential cleavage and α-helical model

Journal of Neurochemistry

Volumn 107, Issue 3, 2008, Pages 722-733

  Tan, Jianxin ^a   Mao, Guozhang ^a   Cui, Mei Zhen ^a   Kang, Shin Chung ^b   Lamb, Bruce ^c   Wong, Boon Seng ^b,d   Sy, Man Sun ^b   Xu, Xuemin ^a,e  

^a UNIVERSITY OF TENNESSEE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e C247 Veterinary Teaching Hospital   (United States)

Author keywords

Alzheimer's disease; Amyloid; Amyloid precursor protein processing

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; GENE MUTATION; IMMUNOBLOTTING; IN VITRO STUDY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; MUTATION; NEURONS; PROTEIN STRUCTURE, SECONDARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 53749094951     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05643.x     Document Type: Article

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