Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

Journal of Cell Science

Volumn 117, Issue 22, 2004, Pages 5437-5445

  von Arnim, Christine A F ^a   Tangredi, Michelle M ^a   Peltan, Ithan D ^a   Lee, Bonny M ^a   Irizarry, Michael C ^a   Kinoshita, Ayae ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; BACE; GGA; Phosphorylation

Indexed keywords

BETA SECRETASE; BINDING PROTEIN; MUTANT PROTEIN; PROTEIN GGA1; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CONTROLLED STUDY; DATA ANALYSIS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL DETECTION; WILD TYPE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADP-RIBOSYLATION FACTORS; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELL LINE; CELL LINE, TUMOR; ENDOPEPTIDASES; ENDOSOMES; FLUORESCENCE RESONANCE ENERGY TRANSFER; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

ANIMALIA;

EID: 9444282652     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01422     Document Type: Article

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