Nicastrin is critical for stability and trafficking but not association of other presenilin/γ-secretase components

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17020-17026

  Zhang, Yun Wu ^a   Luo, Wen Jie ^b   Wang, Hong ^b   Lin, Ping ^c   Vetrivel, Kulandaivelu S ^d   Liao, Fang ^a   Li, Feng ^a   Wong, Philip C ^e   Farquhar, Marilyn G ^c   Thinakaran, Gopal ^d   Xu, Huaxi ^a  

^a BURNHAM INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRECURSOR PROTEIN; PRESENILIN (PS); SECRETASE; SIGNALING RECEPTOR;

BIOCHEMISTRY; BIODEGRADATION; BIOLOGICAL MEMBRANES; DISEASES;

ENZYMES;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; CYCLOHEXIMIDE; GAMMA SECRETASE; IMIPRAMINE; LACTACYSTIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PROTEASOME; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NICASTRIN PROTEIN; PROTEINASE; PSEN1 PROTEIN, HUMAN; PSENEN PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE OVEREXPRESSION; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN TRANSPORT; SENILE PLAQUE; ANIMAL; BIOLOGICAL MODEL; BIOTINYLATION; CELL CULTURE; CHEMISTRY; FLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; KINETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PROTEIN BINDING; RNA INTERFERENCE; TRANS GOLGI NETWORK;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BIOTINYLATION; CELL MEMBRANE; CELLS, CULTURED; ENDOPEPTIDASES; FIBROBLASTS; IMMUNOPRECIPITATION; KINETICS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PRESENILIN-1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, NOTCH; RNA INTERFERENCE; TRANS-GOLGI NETWORK;

EID: 20444472743     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409467200     Document Type: Article

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