Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17294-17300

  Demuro, Angelo ^a   Mina, Erene ^b   Kayed, Rakez ^b   Milton, Saskia C ^b   Parker, Ian ^a   Glabe, Charles G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; DISEASES; MECHANICAL PERMEABILITY; MOLECULAR BIOLOGY; MONOMERS;

CALCIUM DYSREGULATION; FIBRILS; NEUROTOXICITY; OLIGOMERIC STATES;

CALCIUM;

AMYLIN; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; COBALT; FLUORESCENT DYE; LYSOZYME; OLIGOMER; POLYGLUTAMINE; PRION PROTEIN; SOLUBLE AMYLOID OLIGOMER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CALCEIN; CARRIER PROTEIN; FLUORESCEIN DERIVATIVE; ION; PEPTIDE; PEPTIDE FRAGMENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM DYSREGULATION; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL DEATH; CELL DISRUPTION; CELL DYSFUNCTION; CELL STRAIN; CELL STRAIN SH SY5Y; CONCENTRATION RESPONSE; CYTOTOXICITY; DEGENERATIVE DISEASE; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; NEUROTOXICITY; PRIORITY JOURNAL; CELL MEMBRANE; CHEMISTRY; CYTOSOL; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; METABOLISM; NERVE CELL; PERMEABILITY; PHYSIOLOGY; TIME; TUMOR CELL LINE;

AMYLOID; AMYLOID BETA-PROTEIN; CALCIUM; CALCIUM CHANNELS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MEMBRANE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCEINS; FLUORESCENT DYES; HUMANS; IONS; MICROSCOPY, FLUORESCENCE; NEURONS; PEPTIDE FRAGMENTS; PEPTIDES; PERMEABILITY; TIME FACTORS;

EID: 20444496481     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500997200     Document Type: Article

References (47)

1. Mattson, M. P. (2004) Nature 430, 631-639
2. Kosik, K. S. (1992) Science 256, 780-783
3. Selkoe, D. J. (1991) Sci. Am. 265, 68-71, 74-76, 78
4. Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., and Neve, R. L. (1987) Science 235, 880-884
5. Haass, C., and Selkoe, D. J. (1993) Cell 75, 1039-1042
6. Lashuel, H. A., Hartley, D. M., Balakhaneh, D., Aggarwal, A., Teichberg, S., and Callaway, D. J. (2002) J. Biol. Chem. 277, 42881-42890
7. Stefani, M., and Dobson, C. M. (2003) J. Mol. Med. 81, 678-699
8. Dobson, C. M. (2004) Science 304, 1259-1262
9. Glabe, C. G. (2004) Trends Biochem. Sci. 29, 542-547
10. Hardy, J. A., and Higgins, G. A. (1992) Science 256, 184-185
11. Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., Wals, P., Zhang, C., Finch, C. E., Krafft, G. A., and Klein, W. L. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6448-6453
12. Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., and Rogers, J. (1999) Am. J. Pathol. 155, 853-862
13. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
14. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., and Stefani, M. (2002) Nature 416, 507-511
15. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Science 300, 486-489
16. Naslund, J., Haroutunian, V., Mohs, R., Davis, K. L., Davies, P., Greengard, P., and Buxbaum, J. D. (2000) J. Am. Med. Assoc. 283, 1571-1577
17. Dahlgren, K. N., Manelli, A. M., Stine, W. B., Jr., Baker, L. K., Krafft, G. A., and LaDu, M. J. (2002) J. Biol. Chem. 277, 32046-32053
18. Caughey, B., and Lansbury, P. T. (2003) Annu. Rev. Neurosci. 26, 267-298
19. Bucciantini, M., Calloni, G., Chiti, F., Formigli, L., Nosi, D., Dobson, C. M., and Stefani, M. (2004) J. Biol. Chem. 279, 31374-31382
20. Carrell, R. W., and Lomas, D. A. (1997) Lancet 350, 134-138
21. Kawahara, M., Kuroda, Y., Arispe, N., and Rojas, E. (2000) J. Biol. Chem. 275, 14077-14083
22. Blanchard, B. J., Chen, A., Rozeboom, L. M., Stafford, K. A., Weigele, P., and Ingram, V. M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 14326-14332
23. Berridge, M. J., Bootman, M. D., and Lipp, P. (1998) Nature 395, 645-648
24. Pierrot, N., Ghisdal, P., Caumont, A. S., and Octave, J. N. (2004) J. Neurochem. 88, 1140-1150
25. Tucker, H. M., Rydel, R. E., Wright, S., and Estus, S. (1998) J. Neurochem. 71, 506-516
26. Mattson, M. P., and Rydel, R. E. (1992) Neurobiol. Aging 13, 617-621
27. Li, Y. P., Bushnell, A. F., Lee, C. M., Perlmutter, L. S., and Wong, S. K. (1996) Brain Res. 738, 196-204
28. LaFerla, F. M. (2002) Nat. Rev. Neurosci. 3, 862-872
29. Schubert, D., Behl, C., Lesley, R., Brack, A., Dargusch, R., Sagara, Y., and Kimura, H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1989-1993
30. Quo, Q., Furukawa, K., Sopher, B. L., Pham, D. G., Xie, J., Robinson, N., Martin, G. M., and Mattson, M. P. (1996) Neuroreport 8, 379-383
31. Mattson, M. P., and Chan, S. L. (2003) Nat. Cell Biol. 5, 1041-1043
32. Stutzmann, G. E., Caccamo, A., LaFerla, F. M., and Parker, I. (2004) J. Neurosci. 24, 508-513
33. Kagan, B. L., Hirakura, Y., Azimov, R., Azimova, R., and Lin, M. C. (2002) Peptides 23, 1311-1315
34. Kayed, R., Sokolov, Y., Edmonds, B., MacIntire, T. M., Milton, S.C., Hall, J. E., and Glabe, C. G. (2004) J. Biol. Chem. 279, 46363-46366
35. Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., and Glabe, C. (1992) J. Biol. Chem. 267, 546-554
36. Muller, W. E., Koch, S., Eckert, A., Hartmann, H., and Scheuer, K. (1995) Brain Res. 674, 133-136
37. Avdulov, N. A., Chochina, S. V., Igbavboa, U., Warden, C. S., Vassiliev, A. V., and Wood, W. G. (1997) J. Neurochem. 69, 1746-1752
38. Mason, R. P., Trumbore, M. W., and Pettegrew, J. W. (1996) Ann. N. Y. Acad. Sd. 777, 368-373
39. Green, J. D., Kreplak, L., Goldsbury, C., Li Blatter, X., Stolz, M., Cooper, G. S., Seelig, A., Kistler, J., and Aebi, U. (2004) J. Mol. Biol. 342, 877-887
40. Arispe, N., Rojas, E., and Pollard, H. B. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 567-571
41. Arispe, N. (2004) J. Membr. Biol. 197, 33-48
42. Lin, M. A., and Kagan, B. L. (2002) Peptides 23, 1215-1228
43. Kawahara, M., Arispe, N., Kuroda, Y., and Rojas, E. (1997) Biophys J. 73, 67-75
44. Hirakura, Y., Lin, M. C., and Kagan, B. L. (1999) J. Neurosci. Res. 57, 458-466
45. Hille, B. (2001) Ion Channels of Excitable Membranes, Sinauer, Sunderland, MA
46. Anguiano, M., Nowak, R. J., and Lansbury, P. T., Jr. (2002) Biochemistry 41, 11338-11343
47. Relini, A., Torrassa, S., Rolandi, R., Gliozzi, A., Rosano, C., Canale, C., Bolognesi, M., Plakoutsi, G., Bucciantini, M., Chiti, P., and Stefani, M. (2004) J. Mol. Biol. 338, 943-957