Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 14, 2003, Pages 3141-3152

  Bihel, Frédéric ^a   Quéléver, Gilles ^a   Lelouard, Hugues ^d   Petit, Agnès ^b   Da Costa, Cristine Alvès ^b   Pourquié, Olivier ^a   Checler, Frédéric ^b   Thellend, Annie ^c   Pierre, Philippe ^d   Kraus, Jean Louis ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CNRS   (France)

^c Centre National de la Recherche Scientifique   (France)

^d CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 CHLORO 7 NITRO 1 OXO 1H ISOCHROMEN 3 YLOXY)PROPIONITRILE; 4 CHLORO 3 (2 METHOXYETHOXY) 7 NITROISOCOUMARIN; 4 CHLORO 3 METHOXY 7 NITROISOCOUMARIN; 7 AMINO 4 CHLORO 3 (2 METHOXYETHOXY)ISOCOUMARIN; 7 AMINO 4 CHLORO 3 METHOXYISOCOUMARIN; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; CASPASE 3; CHYMOTRYPSIN A; CYSTEINE PROTEINASE; ISOCOUMARIN DERIVATIVE; PROTEASOME; PROTEIN SYNTHESIS INHIBITOR; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; [4 CHLORO 3 (2 METHOXYETHOXY) 1 OXO 1H ISOCHROMEN 7 YL]CARBAMIC ACID ADAMANTAN 1 YL ESTER;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; FEMALE; HUMAN; HUMAN CELL; PROTEIN SYNTHESIS INHIBITION; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

EID: 10744221565     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00235-9     Document Type: Article

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