메뉴 건너뛰기




Volumn 4, Issue 3, 2005, Pages 134-146

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation

Author keywords

Secretase; Alzheimer's disease; APP; Cadherins; Notch; Presenilins

Indexed keywords

AMYLOID BETA PROTEIN; CADHERIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

EID: 17644419726     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2005.00086.x     Document Type: Review
Times cited : (62)

References (178)
  • 1
    • 0028210761 scopus 로고
    • Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: Association with pathology
    • Anderson, A.J., Cummings, B.J. & Cotman, C.W. (1994) Increased immunoreactivity for Jun - and Fos-related proteins in Alzheimer's disease: association with pathology. Exp Neurol 125, 286-295.
    • (1994) Exp Neurol , vol.125 , pp. 286-295
    • Anderson, A.J.1    Cummings, B.J.2    Cotman, C.W.3
  • 6
    • 0031108103 scopus 로고    scopus 로고
    • Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
    • Baumeister, R., Leimer, U., Zweckbronner, I., Jakubek, C., Grunberg, J. & Haass, C. (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct 1, 149-159.
    • (1997) Genes Funct , vol.1 , pp. 149-159
    • Baumeister, R.1    Leimer, U.2    Zweckbronner, I.3    Jakubek, C.4    Grunberg, J.5    Haass, C.6
  • 7
    • 0031718204 scopus 로고    scopus 로고
    • Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer
    • Ben-Ze'ev, A. & Geiger, B. (1998) Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer. Curr Opin Cell Biol 10, 629-639.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 629-639
    • Ben-Ze'ev, A.1    Geiger, B.2
  • 8
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H. & Braak, E. (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82, 239-259.
    • (1991) Acta Neuropathol (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 14444272986 scopus 로고    scopus 로고
    • Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
    • Buxbaum, J.D., Liu, K.N., Luo, Y., Slack, J.L., Stocking, K.L., Peschon, J.J., Johnson, R.S., Castner, B.J., Cerretti, D.P. & Black, R.A. (1998) Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273, 27765-27767.
    • (1998) J Biol Chem , vol.273 , pp. 27765-27767
    • Buxbaum, J.D.1    Liu, K.N.2    Luo, Y.3    Slack, J.L.4    Stocking, K.L.5    Peschon, J.J.6    Johnson, R.S.7    Castner, B.J.8    Cerretti, D.P.9    Black, R.A.10
  • 10
    • 0037795653 scopus 로고    scopus 로고
    • Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase
    • Campbell, W.A., Reed, M.L., Strahle, J., Wolfe, M.S. & Xia, W. (2003) Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem 85, 1563-1574.
    • (2003) J Neurochem , vol.85 , pp. 1563-1574
    • Campbell, W.A.1    Reed, M.L.2    Strahle, J.3    Wolfe, M.S.4    Xia, W.5
  • 11
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    • Cao, X. & Sudhof, T.C. (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120.
    • (2001) Science , vol.293 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 12
    • 0032488995 scopus 로고    scopus 로고
    • The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
    • Capell, A., Grunberg, J., Pesold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D.J. & Haass, C. (1998) The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 273, 3205-3211.
    • (1998) J Biol Chem , vol.273 , pp. 3205-3211
    • Capell, A.1    Grunberg, J.2    Pesold, B.3    Diehlmann, A.4    Citron, M.5    Nixon, R.6    Beyreuther, K.7    Selkoe, D.J.8    Haass, C.9
  • 13
    • 0029379605 scopus 로고
    • Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease
    • Checler, F. (1995) Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem 65, 1431-1444.
    • (1995) J Neurochem , vol.65 , pp. 1431-1444
    • Checler, F.1
  • 14
    • 0035103358 scopus 로고    scopus 로고
    • The multiple paradoxes of presenilins
    • Checler, F. (2001) The multiple paradoxes of presenilins. J Neurochem 76, 1621-1627.
    • (2001) J Neurochem , vol.76 , pp. 1621-1627
    • Checler, F.1
  • 15
    • 0037184062 scopus 로고    scopus 로고
    • Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch
    • Chen, F., Gu, Y., Hasegawa, H., Ruan, X., Arawaka, S., Fraser, P., Westaway, D., Mount, H. & St George-Hyslop, P. (2002) Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch. J Biol Chem 277, 36521-36526.
    • (2002) J Biol Chem , vol.277 , pp. 36521-36526
    • Chen, F.1    Gu, Y.2    Hasegawa, H.3    Ruan, X.4    Arawaka, S.5    Fraser, P.6    Westaway, D.7    Mount, H.8    St. George-Hyslop, P.9
  • 16
    • 1542438695 scopus 로고    scopus 로고
    • Presenilin-interacting proteins
    • Chen, Q. & Schubert, D. (2002) Presenilin-interacting proteins. Expert Rev Mol Med 4, 1-18.
    • (2002) Expert Rev Mol Med , vol.4 , pp. 1-18
    • Chen, Q.1    Schubert, D.2
  • 18
    • 0033899857 scopus 로고    scopus 로고
    • A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog
    • Cox, R.T., McEwen, D.G., Myster, D.L., Duronio, R.J., Loureiro, J. & Peifer, M. (2000) A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog. Genetics 155, 1725-1740.
    • (2000) Genetics , vol.155 , pp. 1725-1740
    • Cox, R.T.1    McEwen, D.G.2    Myster, D.L.3    Duronio, R.J.4    Loureiro, J.5    Peifer, M.6
  • 22
    • 0034839287 scopus 로고    scopus 로고
    • The amyloid precursor protein (APP) -cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
    • Cupers, P., Orlans, I., Craessaerts, K., Annaert, W. & De Strooper, B. (2001b) The amyloid precursor protein (APP) -cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem 78, 1168-1178.
    • (2001) J Neurochem , vol.78 , pp. 1168-1178
    • Cupers, P.1    Orlans, I.2    Craessaerts, K.3    Annaert, W.4    De Strooper, B.5
  • 23
    • 0034509448 scopus 로고    scopus 로고
    • A very incomplete comprehensive theory of Alzheimer's disease
    • Davies, P. (2000) A very incomplete comprehensive theory of Alzheimer's disease. Ann N Y Acad Sci 924, 8-16.
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 8-16
    • Davies, P.1
  • 24
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
    • De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38, 9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 28
    • 0030924177 scopus 로고    scopus 로고
    • Cell surface expression of the Alzheimer disease-related presenilin proteins
    • Dewji, N.N. & Singer, S.J. (1997) Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc Natl Acad Sci U S A 94, 9926-9931.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9926-9931
    • Dewji, N.N.1    Singer, S.J.2
  • 29
    • 0029078972 scopus 로고
    • Correlations of synaptic and pathological markers with cognition of the elderly
    • discussion 298-304
    • Dickson, D.W., Crystal, H.A., Bevona, C., Honer, W., Vincent, I. & Davies, P. (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16, 285-298; discussion 298-304.
    • (1995) Neurobiol Aging , vol.16 , pp. 285-298
    • Dickson, D.W.1    Crystal, H.A.2    Bevona, C.3    Honer, W.4    Vincent, I.5    Davies, P.6
  • 32
    • 0037118248 scopus 로고    scopus 로고
    • A RIP tide in neuronal signal transduction
    • Ebinu, J.O. & Yankner, B.A. (2002) A RIP tide in neuronal signal transduction. Neuron 34, 499-502.
    • (2002) Neuron , vol.34 , pp. 499-502
    • Ebinu, J.O.1    Yankner, B.A.2
  • 34
    • 2442592973 scopus 로고    scopus 로고
    • The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: Modulation of APLP-1 processing by n-glycosylation
    • Eggert, S., Paliga, K., Soba, P., Evin, G., Masters, C.L., Weidemann, A. & Beyreuther, K. The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha -, beta -, gamma -, and epsilon -like cleavages: modulation of APLP-1 processing by n-glycosylation. J Biol Chem 279, 18146-18156.
    • J Biol Chem , vol.279 , pp. 18146-18156
    • Eggert, S.1    Paliga, K.2    Soba, P.3    Evin, G.4    Masters, C.L.5    Weidemann, A.6    Beyreuther, K.7
  • 38
    • 0036727125 scopus 로고    scopus 로고
    • Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling
    • Fortini, M.E. (2002) Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 3, 673-684.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 673-684
    • Fortini, M.E.1
  • 39
    • 0142197053 scopus 로고    scopus 로고
    • Neurobiology: Double trouble for neurons
    • Fortini, M.E. (2003) Neurobiology: double trouble for neurons. Nature 425, 565-566.
    • (2003) Nature , vol.425 , pp. 565-566
    • Fortini, M.E.1
  • 41
    • 0035909901 scopus 로고    scopus 로고
    • The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
    • Gao, Y. & Pimplikar, S.W. (2001) The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A 98, 14979-14984.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14979-14984
    • Gao, Y.1    Pimplikar, S.W.2
  • 43
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner, G.G. & Wong, C.W. (1984a) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122, 1131-1135.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 44
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner, G.G. & Wong, C.W. (1984b) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120, 885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 45
    • 0035798093 scopus 로고    scopus 로고
    • The neurobiology of slow synaptic transmission
    • Greengard, P. (2001) The neurobiology of slow synaptic transmission. Science 294, 1024-1030.
    • (2001) Science , vol.294 , pp. 1024-1030
    • Greengard, P.1
  • 46
    • 0038785079 scopus 로고    scopus 로고
    • Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family
    • Grunberg, J., Walter, J., Loetscher, H., Deuschle, U., Jacobsen, H. & Haass, C. (1998) Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry 37, 2263-2270.
    • (1998) Biochemistry , vol.37 , pp. 2263-2270
    • Grunberg, J.1    Walter, J.2    Loetscher, H.3    Deuschle, U.4    Jacobsen, H.5    Haass, C.6
  • 47
    • 0035929554 scopus 로고    scopus 로고
    • Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
    • Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K. & Ihara, Y. (2001) Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J Biol Chem 276, 35 235-35 238.
    • (2001) J Biol Chem , vol.276
    • Gu, Y.1    Misonou, H.2    Sato, T.3    Dohmae, N.4    Takio, K.5    Ihara, Y.6
  • 48
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    • Gumbiner, B.M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357.
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 49
    • 1442264828 scopus 로고    scopus 로고
    • Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
    • Haass, C. (2004) Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. Embo J 23, 483-488.
    • (2004) Embo J , vol.23 , pp. 483-488
    • Haass, C.1
  • 50
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy, J. (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20, 154-159.
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 51
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J. & Selkoe, D.J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 53
    • 0038360879 scopus 로고    scopus 로고
    • Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex
    • Hu, Y. & Fortini, M.E. (2003) Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol 161, 685-690.
    • (2003) J Cell Biol , vol.161 , pp. 685-690
    • Hu, Y.1    Fortini, M.E.2
  • 54
    • 0037059616 scopus 로고    scopus 로고
    • Structural remodeling of the synapse in response to physiological activity
    • Huntley, G.W., Benson, D.L. & Colman, D.R. (2002) Structural remodeling of the synapse in response to physiological activity. Cell 108, 1-4.
    • (2002) Cell , vol.108 , pp. 1-4
    • Huntley, G.W.1    Benson, D.L.2    Colman, D.R.3
  • 56
    • 0030984042 scopus 로고    scopus 로고
    • Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains
    • Huynh, D.P., Vinters, H.V., Ho, D.H., Ho, V.V. & Pulst, S.M. (1997) Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J Neuropathol Exp Neurol 56, 1009-1017.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 1009-1017
    • Huynh, D.P.1    Vinters, H.V.2    Ho, D.H.3    Ho, V.V.4    Pulst, S.M.5
  • 57
    • 0036358698 scopus 로고    scopus 로고
    • Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: Evidence for distinct intramembranous 'gamma-secretase' activities
    • Ikeuchi, T. & Sisodia, S.S. (2002) Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous 'gamma-secretase' activities. Neuromolecular Med 1, 43-54.
    • (2002) Neuromolecular Med , vol.1 , pp. 43-54
    • Ikeuchi, T.1    Sisodia, S.S.2
  • 58
    • 0037424348 scopus 로고    scopus 로고
    • The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage
    • Ikeuchi, T. & Sisodia, S.S. (2003) The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent 'gamma-secretase' cleavage. J Biol Chem 278, 7751-7754.
    • (2003) J Biol Chem , vol.278 , pp. 7751-7754
    • Ikeuchi, T.1    Sisodia, S.S.2
  • 59
    • 0035874373 scopus 로고    scopus 로고
    • CREB signaling - Timing is everything
    • Impey, S. & Goodman, R.H. (2001) CREB signaling - timing is everything. Sci STKE 2001, PE1.
    • (2001) Sci STKE , vol.2001
    • Impey, S.1    Goodman, R.H.2
  • 61
    • 0036327098 scopus 로고    scopus 로고
    • Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
    • Kaether, C., Lammich, S., Edbauer, D., Ertl, M., Rietdorf, J., Capell, A., Steiner, H. & Haass, C. (2002) Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 158, 551-561.
    • (2002) J Cell Biol , vol.158 , pp. 551-561
    • Kaether, C.1    Lammich, S.2    Edbauer, D.3    Ertl, M.4    Rietdorf, J.5    Capell, A.6    Steiner, H.7    Haass, C.8
  • 63
    • 0035798238 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialogue between genes and synapses
    • Kandel, E.R. (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030-1038.
    • (2001) Science , vol.294 , pp. 1030-1038
    • Kandel, E.R.1
  • 65
    • 0037145062 scopus 로고    scopus 로고
    • Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis
    • Kang, D.E., Soriano, S., Xia, X., Eberhart, G.G., De Strooper, B., Zheng, H. & Koo, E.H. (2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 110, 751-762.
    • (2002) Cell , vol.110 , pp. 751-762
    • Kang, D.E.1    Soriano, S.2    Xia, X.3    Eberhart, G.G.4    De Strooper, B.5    Zheng, H.6    Koo, E.H.7
  • 66
    • 0037146553 scopus 로고    scopus 로고
    • Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage
    • Kim, D.Y., Ingano, L.A. & Kovacs, D.M. (2002) Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. J Biol Chem 277, 49 976-49 981.
    • (2002) J Biol Chem , vol.277
    • Kim, D.Y.1    Ingano, L.A.2    Kovacs, D.M.3
  • 67
    • 0030890399 scopus 로고    scopus 로고
    • Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
    • Kim, T.W., Pettingell, W.H., Hallmark, O.G., Moir, R.D., Wasco, W. & Tanzi, R.E. (1997a) Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J Biol Chem 272, 11 006-11 010.
    • (1997) J Biol Chem , vol.272
    • Kim, T.W.1    Pettingell, W.H.2    Hallmark, O.G.3    Moir, R.D.4    Wasco, W.5    Tanzi, R.E.6
  • 68
    • 0030868903 scopus 로고    scopus 로고
    • Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    • Kim, T.W., Pettingell, W.H., Jung, Y.K., Kovacs, D.M. & Tanzi, R.E. (1997b) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
    • (1997) Science , vol.277 , pp. 373-376
    • Kim, T.W.1    Pettingell, W.H.2    Jung, Y.K.3    Kovacs, D.M.4    Tanzi, R.E.5
  • 69
    • 0742270972 scopus 로고    scopus 로고
    • The ins and outs of presenilin 1 membrane topology
    • Kim, J. & Schekman, R. (2004) The ins and outs of presenilin 1 membrane topology. Proc Natl Acad Sci USA 101, 905-906.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 905-906
    • Kim, J.1    Schekman, R.2
  • 70
    • 0242361783 scopus 로고    scopus 로고
    • Identity and function of gamma-secretase
    • Kimberly, W.T. & Wolfe, M.S. (2003) Identity and function of gamma-secretase. J Neurosci Res 74, 353-360.
    • (2003) J Neurosci Res , vol.74 , pp. 353-360
    • Kimberly, W.T.1    Wolfe, M.S.2
  • 71
    • 0000792598 scopus 로고    scopus 로고
    • The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
    • Kimberly, W.T., Xia, W., Rahmati, T., Wolfe, M.S. & Selkoe, D.J. (2000) The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem 275, 3173-3178.
    • (2000) J Biol Chem , vol.275 , pp. 3173-3178
    • Kimberly, W.T.1    Xia, W.2    Rahmati, T.3    Wolfe, M.S.4    Selkoe, D.J.5
  • 72
    • 0035955693 scopus 로고    scopus 로고
    • The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
    • Kimberly, W.T., Zheng, J.B., Guenette, S.Y. & Selkoe, D.J. (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276, 40 288-40 292.
    • (2001) J Biol Chem , vol.276
    • Kimberly, W.T.1    Zheng, J.B.2    Guenette, S.Y.3    Selkoe, D.J.4
  • 73
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small Abeta oligomers: The solution to an Alzheimer's disease conundrum?
    • Klein, W.L., Krafft, G.A. & Finch, C.E. (2001) Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci 24, 219-224.
    • (2001) Trends Neurosci , vol.24 , pp. 219-224
    • Klein, W.L.1    Krafft, G.A.2    Finch, C.E.3
  • 76
    • 0347785491 scopus 로고    scopus 로고
    • Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide
    • Lammich, S., Okochi, M., Takeda, M., Kaether, C., Capell, A., Zimmer, A.K., Edbauer, D., Walter, J., Steiner, H. & Haass, C. (2002) Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 277, 44 754-44 759.
    • (2002) J Biol Chem , vol.277
    • Lammich, S.1    Okochi, M.2    Takeda, M.3    Kaether, C.4    Capell, A.5    Zimmer, A.K.6    Edbauer, D.7    Walter, J.8    Steiner, H.9    Haass, C.10
  • 77
    • 0141733241 scopus 로고    scopus 로고
    • Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
    • LaVoie, M.J., Fraering, P.C., Ostaszewski, B.L. Ye W., Kimberly, W.T., Wolfe, M.S. & Selkoe, D.J. (2003) Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem 278, 37 213-37 222.
    • (2003) J Biol Chem , vol.278
    • LaVoie, M.J.1    Fraering, P.C.2    Ostaszewski, B.L.3    Ye, W.4    Kimberly, W.T.5    Wolfe, M.S.6    Selkoe, D.J.7
  • 78
    • 0141817915 scopus 로고    scopus 로고
    • The Notch Ligands, Jagged and Delta, are sequentially processed by alpha -secretase and presenilin/gamma-secretase and release signaling fragments
    • LaVoie, M.J. & Selkoe, D.J. (2003) The Notch Ligands, Jagged and Delta, are sequentially processed by alpha -secretase and presenilin/gamma- secretase and release signaling fragments. J Biol Chem 278, 34427-34437.
    • (2003) J Biol Chem , vol.278 , pp. 34427-34437
    • LaVoie, M.J.1    Selkoe, D.J.2
  • 79
    • 0037155219 scopus 로고    scopus 로고
    • Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4
    • Lee, H.J., Jung, K.M., Huang, Y.Z., Bennett, L.B., Lee, J.S., Mei, L. & Kim, T.W. (2002) Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277, 6318-6323.
    • (2002) J Biol Chem , vol.277 , pp. 6318-6323
    • Lee, H.J.1    Jung, K.M.2    Huang, Y.Z.3    Bennett, L.B.4    Lee, J.S.5    Mei, L.6    Kim, T.W.7
  • 81
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    • Levitan, D. & Greenwald, I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.
    • (1995) Nature , vol.377 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 82
  • 83
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad, E., Wasco, W., Poorkaj, P. et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 84
    • 0030293894 scopus 로고    scopus 로고
    • Membrane topology of the C. elegans SEL-12 presenilin
    • Li, X. & Greenwald, I. (1996) Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17, 1015-1021.
    • (1996) Neuron , vol.17 , pp. 1015-1021
    • Li, X.1    Greenwald, I.2
  • 87
    • 0034652309 scopus 로고    scopus 로고
    • Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
    • Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A. & Tang, J. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A 97, 1456-1460.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1456-1460
    • Lin, X.1    Koelsch, G.2    Wu, S.3    Downs, D.4    Dashti, A.5    Tang, J.6
  • 89
    • 0035089318 scopus 로고    scopus 로고
    • Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
    • Lopez-Perez, E., Zhang, Y., Frank, S.J., Creemers, J., Seidah, N. & Checler, F. (2001) Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10. J Neurochem 76, 1532-1539.
    • (2001) J Neurochem , vol.76 , pp. 1532-1539
    • Lopez-Perez, E.1    Zhang, Y.2    Frank, S.J.3    Creemers, J.4    Seidah, N.5    Checler, F.6
  • 90
    • 0032501149 scopus 로고    scopus 로고
    • Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: Control by the proteasome
    • Marambaud, P., Alves da Costa, C., Ancolio, K. & Checler, F. (1998a) Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome. Biochem Biophys Res Commun 252, 134-138.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 134-138
    • Marambaud, P.1    Alves Da Costa, C.2    Ancolio, K.3    Checler, F.4
  • 91
    • 0031950118 scopus 로고    scopus 로고
    • Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells
    • Marambaud, P., Ancolio, K., Lopez-Perez, E. & Checler, F. (1998b) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells. Mol Med 4, 147-157.
    • (1998) Mol Med , vol.4 , pp. 147-157
    • Marambaud, P.1    Ancolio, K.2    Lopez-Perez, E.3    Checler, F.4
  • 93
    • 0141429160 scopus 로고    scopus 로고
    • A CBP binding transcriptional represser produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
    • Marambaud, P., Wen, P.H., Dutt, A., Shioi, J., Takashima, A., Siman, R. & Robakis, N.K. (2003) A CBP binding transcriptional represser produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114, 635-645.
    • (2003) Cell , vol.114 , pp. 635-645
    • Marambaud, P.1    Wen, P.H.2    Dutt, A.3    Shioi, J.4    Takashima, A.5    Siman, R.6    Robakis, N.K.7
  • 95
    • 0141994826 scopus 로고    scopus 로고
    • Intramembrane-cleaving aspartic proteases and disease: Presenilins, signal peptide peptidase and their homologs
    • Martoglio, B. & Golde, T.E. (2003) Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Hum Mol Genet, 12 Spec 2, R201-R206.
    • (2003) Hum Mol Genet 12 Spec , vol.2
    • Martoglio, B.1    Golde, T.E.2
  • 96
    • 0037166319 scopus 로고    scopus 로고
    • Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain
    • May, P., Reddy, Y.K. & Herz, J. (2002) Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem 277, 18 736-18 743.
    • (2002) J Biol Chem , vol.277
    • May, P.1    Reddy, Y.K.2    Herz, J.3
  • 98
    • 0037592332 scopus 로고    scopus 로고
    • Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase
    • Meyer, E.L., Strutz, N., Gahring, L.C. & Rogers, S.W. (2003) Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase. J Biol Chem 278, 23 786-23 796.
    • (2003) J Biol Chem , vol.278
    • Meyer, E.L.1    Strutz, N.2    Gahring, L.C.3    Rogers, S.W.4
  • 99
    • 18444391830 scopus 로고    scopus 로고
    • Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
    • Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C. & Steiner, H. (2002) Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci USA 99, 8025-8030.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8025-8030
    • Moehlmann, T.1    Winkler, E.2    Xia, X.3    Edbauer, D.4    Murrell, J.5    Capell, A.6    Kaether, C.7    Zheng, H.8    Ghetti, B.9    Haass, C.10    Steiner, H.11
  • 100
    • 0242321985 scopus 로고    scopus 로고
    • The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
    • Morais, V.A., Crystal, A.S., Pijak, D.S., Carlin, D., Costa, J., Lee, V.M. & Doms, R.W. (2003) The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. J Biol Chem 278, 43 284-43 291.
    • (2003) J Biol Chem , vol.278
    • Morais, V.A.1    Crystal, A.S.2    Pijak, D.S.3    Carlin, D.4    Costa, J.5    Lee, V.M.6    Doms, R.W.7
  • 102
    • 0032859043 scopus 로고    scopus 로고
    • The role of cell adhesion molecules in synaptic plasticity and memory
    • Murase, S. & Schuman, E.M. (1999) The role of cell adhesion molecules in synaptic plasticity and memory. Curr Opin Cell Biol 11, 549-553.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 549-553
    • Murase, S.1    Schuman, E.M.2
  • 103
    • 0034667650 scopus 로고    scopus 로고
    • Notch-1 activation by familial Alzheimer's disease (FAD) -linked mutant forms of presenilin-1
    • Nakajima, M., Shimizu, T. & Shirasawa, T. (2000) Notch-1 activation by familial Alzheimer's disease (FAD) -linked mutant forms of presenilin-1. J Neurosci Res 62, 311-317.
    • (2000) J Neurosci Res , vol.62 , pp. 311-317
    • Nakajima, M.1    Shimizu, T.2    Shirasawa, T.3
  • 105
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson, W.J. & Nusse, R. (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303, 1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 106
    • 0006325405 scopus 로고    scopus 로고
    • Alzheimer's disease: A reexamination of the amyloid hypothesis
    • Neve, R.L. & Robakis, N.K. (1998) Alzheimer's disease: a reexamination of the amyloid hypothesis. Trends Neurosci 21, 15-19.
    • (1998) Trends Neurosci , vol.21 , pp. 15-19
    • Neve, R.L.1    Robakis, N.K.2
  • 107
    • 0035824391 scopus 로고    scopus 로고
    • Gamma -secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
    • Ni, C.Y., Murphy, M.P., Golde, T.E. & Carpenter, G. (2001) Gamma -secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294, 2179-2181.
    • (2001) Science , vol.294 , pp. 2179-2181
    • Ni, C.Y.1    Murphy, M.P.2    Golde, T.E.3    Carpenter, G.4
  • 108
    • 0034669203 scopus 로고    scopus 로고
    • Presenilin affects arm/beta-catenin localization and function in Drosophila
    • Noll, E., Medina, M., Hartley, D., Zhou, J., Perrimon, N. & Kosik, K.S. (2000) Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol 227, 450-464.
    • (2000) Dev Biol , vol.227 , pp. 450-464
    • Noll, E.1    Medina, M.2    Hartley, D.3    Zhou, J.4    Perrimon, N.5    Kosik, K.S.6
  • 109
    • 0742287915 scopus 로고    scopus 로고
    • CRE-mediated transcription is increased in Huntington's disease transgenic mice
    • Obrietan, K. & Hoyt, K.R. (2004) CRE-mediated transcription is increased in Huntington's disease transgenic mice. J Neurosci 24, 791-796.
    • (2004) J Neurosci , vol.24 , pp. 791-796
    • Obrietan, K.1    Hoyt, K.R.2
  • 110
    • 0035956428 scopus 로고    scopus 로고
    • Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
    • Okamoto, I., Kawano, Y., Murakami, D., Sasayama, T., Araki, N., Miki, T., Wong, A.J. & Saya, H. (2001) Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol 155, 755-762.
    • (2001) J Cell Biol , vol.155 , pp. 755-762
    • Okamoto, I.1    Kawano, Y.2    Murakami, D.3    Sasayama, T.4    Araki, N.5    Miki, T.6    Wong, A.J.7    Saya, H.8
  • 111
    • 0032945724 scopus 로고    scopus 로고
    • Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1
    • Parent, A., Linden, D.J., Sisodia, S.S. & Borchelt, D.R. (1999) Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol Dis 6, 56-62.
    • (1999) Neurobiol Dis , vol.6 , pp. 56-62
    • Parent, A.1    Linden, D.J.2    Sisodia, S.S.3    Borchelt, D.R.4
  • 112
    • 0035808416 scopus 로고    scopus 로고
    • A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor
    • Pinnix, I., Musunuru, U., Tun, H., Sridharan, A., Golde, T., Eckman, C., Ziani-Cherif, C., Onstead, L. & Sambamurti, K. (2001) A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem 276, 481-487.
    • (2001) J Biol Chem , vol.276 , pp. 481-487
    • Pinnix, I.1    Musunuru, U.2    Tun, H.3    Sridharan, A.4    Golde, T.5    Eckman, C.6    Ziani-Cherif, C.7    Onstead, L.8    Sambamurti, K.9
  • 113
    • 0034674485 scopus 로고    scopus 로고
    • Molecular mechanisms associated with long-term consolidation of the NMDA signals
    • Platenik, J., Kuramoto, N. & Yoneda, Y. (2000) Molecular mechanisms associated with long-term consolidation of the NMDA signals. Life Sci 67, 335-364.
    • (2000) Life Sci , vol.67 , pp. 335-364
    • Platenik, J.1    Kuramoto, N.2    Yoneda, Y.3
  • 115
    • 0032919039 scopus 로고    scopus 로고
    • Mapping the APP/presenilin (PS) binding domains: The hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction
    • Pradier, L., Carpentier, N., Delalonde, L., Clavel, N., Bock, M.D., Buee, L., Mercken, L., Tocque, B. & Czech, C. (1999) Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction. Neurobiol Dis 6, 43-55.
    • (1999) Neurobiol Dis , vol.6 , pp. 43-55
    • Pradier, L.1    Carpentier, N.2    Delalonde, L.3    Clavel, N.4    Bock, M.D.5    Buee, L.6    Mercken, L.7    Tocque, B.8    Czech, C.9
  • 117
    • 0141540849 scopus 로고    scopus 로고
    • Secrets of a secretase: N-cadherin proteolysis regulates CBP function
    • Rao, V.R. & Finkbeiner, S. (2003) Secrets of a secretase: N-cadherin proteolysis regulates CBP function. Cell 114, 533-535.
    • (2003) Cell , vol.114 , pp. 533-535
    • Rao, V.R.1    Finkbeiner, S.2
  • 121
    • 0041701913 scopus 로고    scopus 로고
    • An Alzheimer's disease hypothesis based on transcriptional dysregulation
    • Robakis, N.K. (2003) An Alzheimer's disease hypothesis based on transcriptional dysregulation. Amyloid 10, 80-85.
    • (2003) Amyloid , vol.10 , pp. 80-85
    • Robakis, N.K.1
  • 122
    • 2142777413 scopus 로고
    • Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
    • Robakis, N.K., Ramakrishna, N., Wolfe, G. & Wisniewski, H.M. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc Natl Acad Sci USA 84, 4190-4194.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 4190-4194
    • Robakis, N.K.1    Ramakrishna, N.2    Wolfe, G.3    Wisniewski, H.M.4
  • 123
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev, E.I., Sherrington, R., Rogaeva, E.A. et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 125
    • 0032830931 scopus 로고    scopus 로고
    • TCF transcription factors: Molecular switches in carcinogenesis
    • Roose, J. & Clevers, H. (1999) TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424, M23-M37.
    • (1999) Biochim Biophys Acta , vol.1424
    • Roose, J.1    Clevers, H.2
  • 126
    • 0027936838 scopus 로고
    • Apolipoprotein E affects the rate of Alzheimer disease expression: Beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease
    • Roses, A.D. (1994) Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J Neuropathol Exp Neurol 53, 429-437.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 429-437
    • Roses, A.D.1
  • 127
    • 0037194897 scopus 로고    scopus 로고
    • Polyglutamine pathogenesis: Emergence of unifying mechanisms for Huntington's disease and related disorders
    • Ross, C.A. (2002) Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron 35, 819-822.
    • (2002) Neuron , vol.35 , pp. 819-822
    • Ross, C.A.1
  • 128
    • 0026665014 scopus 로고
    • Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells
    • Sambamurti, K., Shioi, J., Anderson, J.P., Pappolla, M.A. & Robakis, N.K. (1992) Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J Neurosci Res 33, 319-329.
    • (1992) J Neurosci Res , vol.33 , pp. 319-329
    • Sambamurti, K.1    Shioi, J.2    Anderson, J.P.3    Pappolla, M.A.4    Robakis, N.K.5
  • 129
    • 0034774969 scopus 로고    scopus 로고
    • Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
    • Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M.M., Teplow, D.B. & Haass, C. (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2, 835-841.
    • (2001) EMBO Rep , vol.2 , pp. 835-841
    • Sastre, M.1    Steiner, H.2    Fuchs, K.3    Capell, A.4    Multhaup, G.5    Condron, M.M.6    Teplow, D.B.7    Haass, C.8
  • 131
    • 0034595640 scopus 로고    scopus 로고
    • The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants
    • Saura, C.A., Tomita, T., Soriano, S., Takahashi, M., Leem, J.Y., Honda, T., Koo, E.H., Iwatsubo, T. & Thinakaran, G. (2000) The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. J Biol Chem 275, 17 136-17 142.
    • (2000) J Biol Chem , vol.275
    • Saura, C.A.1    Tomita, T.2    Soriano, S.3    Takahashi, M.4    Leem, J.Y.5    Honda, T.6    Koo, E.H.7    Iwatsubo, T.8    Thinakaran, G.9
  • 132
    • 0035955604 scopus 로고    scopus 로고
    • Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
    • Saxena, M.T., Schroeter, E.H., Mumm, J.S. & Kopan, R. (2001) Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem 276, 40 268-40 273.
    • (2001) J Biol Chem , vol.276
    • Saxena, M.T.1    Schroeter, E.H.2    Mumm, J.S.3    Kopan, R.4
  • 133
    • 0037114010 scopus 로고    scopus 로고
    • Processing of beta-amyloid precursor-like protein-1 and -2 by gamma -secretase regulates transcription
    • Scheinfeld, M.H., Ghersi, E., Laky, K., Fowlkes, B.J. & D'Adamio, L. (2002) Processing of beta-Amyloid Precursor-like Protein-1 and -2 by gamma -Secretase Regulates Transcription. J Biol Chem 277, 44 195-44 201.
    • (2002) J Biol Chem , vol.277
    • Scheinfeld, M.H.1    Ghersi, E.2    Laky, K.3    Fowlkes, B.J.4    D'Adamio, L.5
  • 135
    • 1542677095 scopus 로고    scopus 로고
    • Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase- dependent and modulates cytosolic signaling
    • Schulz, J.G., Annaert, W., Vandekerckhove, J., Zimmermann, P., De Strooper, B. & David, G. (2003) Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. J Biol Chem 278, 48 651-48 657.
    • (2003) J Biol Chem , vol.278
    • Schulz, J.G.1    Annaert, W.2    Vandekerckhove, J.3    Zimmermann, P.4    De Strooper, B.5    David, G.6
  • 137
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe, D.J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81, 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 139
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R., Rogaev, E.I., Liang, Y. et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 140
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • Sinha, S., Anderson, J.P., Barbour, R. et al. (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540.
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 142
    • 0033536072 scopus 로고    scopus 로고
    • Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
    • Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J. & Yankner, B.A. (1999) Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A 96, 6959-6963.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6959-6963
    • Song, W.1    Nadeau, P.2    Yuan, M.3    Yang, X.4    Shen, J.5    Yankner, B.A.6
  • 143
    • 0035911156 scopus 로고    scopus 로고
    • Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing
    • Soriano, S., Kang, D.E., Fu, M., Pestell, R., Chevallier, N., Zheng, H. & Koo, E.H. (2001) Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol 152, 785-794.
    • (2001) J Cell Biol , vol.152 , pp. 785-794
    • Soriano, S.1    Kang, D.E.2    Fu, M.3    Pestell, R.4    Chevallier, N.5    Zheng, H.6    Koo, E.H.7
  • 144
    • 0033968306 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease
    • St George-Hyslop, P.M. (2000) Molecular genetics of Alzheimer's disease. Biol Psychiatry 47, 183-199.
    • (2000) Biol Psychiatry , vol.47 , pp. 183-199
    • St. George-Hyslop, P.M.1
  • 145
    • 0033610863 scopus 로고    scopus 로고
    • Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
    • Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P.M., Selkoe, D.J., Romig, H., Mendla, K. & Haass, C. (1998) Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J Biol Chem 273, 32 322-32 331.
    • (1998) J Biol Chem , vol.273
    • Steiner, H.1    Capell, A.2    Pesold, B.3    Citron, M.4    Kloetzel, P.M.5    Selkoe, D.J.6    Romig, H.7    Mendla, K.8    Haass, C.9
  • 147
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl, G. & Greenwald, I. (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525.
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 150
    • 0032103412 scopus 로고    scopus 로고
    • A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation
    • Tang, L., Hung, C.P. & Schuman, E.M. (1998) A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Neuron 20, 1165-1175.
    • (1998) Neuron , vol.20 , pp. 1165-1175
    • Tang, L.1    Hung, C.P.2    Schuman, E.M.3
  • 151
    • 0043235625 scopus 로고    scopus 로고
    • Presenilin-dependent 'gamma-secretase' processing of deleted in colorectal cancer (DCC)
    • Taniguchi, Y., Kim, S.H. & Sisodia, S.S. (2003) Presenilin-dependent 'gamma-secretase' processing of deleted in colorectal cancer (DCC). J Biol Chem 278, 30 425-30 428.
    • (2003) J Biol Chem , vol.278
    • Taniguchi, Y.1    Kim, S.H.2    Sisodia, S.S.3
  • 152
    • 0035950188 scopus 로고    scopus 로고
    • New frontiers in Alzheimer's disease genetics
    • Tanzi, R.E. & Bertram, L. (2001) New frontiers in Alzheimer's disease genetics. Neuron 32, 181-184.
    • (2001) Neuron , vol.32 , pp. 181-184
    • Tanzi, R.E.1    Bertram, L.2
  • 155
    • 0019494341 scopus 로고
    • Some morphometric aspects of the brain in senile dementia of the Alzheimer type
    • Terry, R.D., Peck, A., DeTeresa, R., Schechter, R. & Horoupian, D.S. (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10, 184-192.
    • (1981) Ann Neurol , vol.10 , pp. 184-192
    • Terry, R.D.1    Peck, A.2    DeTeresa, R.3    Schechter, R.4    Horoupian, D.S.5
  • 156
    • 0032545273 scopus 로고    scopus 로고
    • Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation
    • Tesco, G., Kim, T.W., Diehlmann, A., Beyreuther, K. & Tanzi, R.E. (1998) Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem 273, 33909-33914.
    • (1998) J Biol Chem , vol.273 , pp. 33909-33914
    • Tesco, G.1    Kim, T.W.2    Diehlmann, A.3    Beyreuther, K.4    Tanzi, R.E.5
  • 158
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar, R., Bennett, B.D., Babu-Khan, S. et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 159
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J., Selkoe, D.J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 161
    • 0142243064 scopus 로고    scopus 로고
    • Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis
    • Wang, P., Pereira, F.A., Beasley, D. & Zheng, H. (2003) Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development 130, 5019-5029.
    • (2003) Development , vol.130 , pp. 5019-5029
    • Wang, P.1    Pereira, F.A.2    Beasley, D.3    Zheng, H.4
  • 162
    • 0037176727 scopus 로고    scopus 로고
    • A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
    • Weidemann, A., Eggert, S., Reinhard, F.B., Vogel, M., Paliga, K., Baier, G., Masters, C.L., Beyreuther, K. & Evin, G. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41, 2825-2835.
    • (2002) Biochemistry , vol.41 , pp. 2825-2835
    • Weidemann, A.1    Eggert, S.2    Reinhard, F.B.3    Vogel, M.4    Paliga, K.5    Baier, G.6    Masters, C.L.7    Beyreuther, K.8    Evin, G.9
  • 163
    • 0031054505 scopus 로고    scopus 로고
    • Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and beta-amyloid precursor protein
    • Weidemann, A., Paliga, K., Durrwang, U., Czech, C., Evin, G., Masters, C.L. & Beyreuther, K. (1997) Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. Nat Med 3, 328-332.
    • (1997) Nat Med , vol.3 , pp. 328-332
    • Weidemann, A.1    Paliga, K.2    Durrwang, U.3    Czech, C.4    Evin, G.5    Masters, C.L.6    Beyreuther, K.7
  • 164
    • 0032800818 scopus 로고    scopus 로고
    • Intracellular APP processing and A beta production in Alzheimer disease
    • Wilson, C.A., Doms, R.W. & Lee, V.M. (1999) Intracellular APP processing and A beta production in Alzheimer disease. J Neuropathol Exp Neurol 58, 787-794.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 787-794
    • Wilson, C.A.1    Doms, R.W.2    Lee, V.M.3
  • 165
    • 0242298785 scopus 로고    scopus 로고
    • Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production
    • Wilson, C.A., Doms, R.W. & Lee, V.M. (2003) Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production. J Neurosci Res 74, 361-369.
    • (2003) J Neurosci Res , vol.74 , pp. 361-369
    • Wilson, C.A.1    Doms, R.W.2    Lee, V.M.3
  • 166
    • 0033551099 scopus 로고    scopus 로고
    • Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
    • Wolfe, M.S., Xia, W., Moore, C.L., Leatherwood, D.D., Ostaszewski, B., Rahmati, T., Donkor, I.O. & Selkoe, D.J. (1999a) Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38, 4720-4727.
    • (1999) Biochemistry , vol.38 , pp. 4720-4727
    • Wolfe, M.S.1    Xia, W.2    Moore, C.L.3    Leatherwood, D.D.4    Ostaszewski, B.5    Rahmati, T.6    Donkor, I.O.7    Selkoe, D.J.8
  • 167
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    • Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T. & Selkoe, D.J. (1999b) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 170
    • 16944365745 scopus 로고    scopus 로고
    • Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
    • Xia, W., Zhang, J., Kholodenko, D., Citron, M., Podlisny, M.B., Teplow, D.B., Haass, C., Seubert, P., Koo, E.H. & Selkoe, D.J. (1997) Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 272, 7977-7982.
    • (1997) J Biol Chem , vol.272 , pp. 7977-7982
    • Xia, W.1    Zhang, J.2    Kholodenko, D.3    Citron, M.4    Podlisny, M.B.5    Teplow, D.B.6    Haass, C.7    Seubert, P.8    Koo, E.H.9    Selkoe, D.J.10
  • 172
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    • Ye, Y., Lukinova, N. & Fortini, M.E. (1999) Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398, 525-529.
    • (1999) Nature , vol.398 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3
  • 174
    • 0035941278 scopus 로고    scopus 로고
    • Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains
    • Yu, C., Kim, S.H., Ikeuchi, T., Xu, H., Gasparini, L., Wang, R. & Sisodia, S.S. (2001) Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. J Biol Chem 276, 43 756-43 760.
    • (2001) J Biol Chem , vol.276
    • Yu, C.1    Kim, S.H.2    Ikeuchi, T.3    Xu, H.4    Gasparini, L.5    Wang, R.6    Sisodia, S.S.7
  • 175
    • 0034618715 scopus 로고    scopus 로고
    • Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
    • Yu, G., Nishimura, M., Arawaka, S. et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407, 48-54.
    • (2000) Nature , vol.407 , pp. 48-54
    • Yu, G.1    Nishimura, M.2    Arawaka, S.3
  • 176
    • 0026515393 scopus 로고
    • c-fos protein-like immunoreactivity: Distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease
    • Zhang, P., Hirsch, E.G., Damier, P., Duyckaerts, C. & Javoy-Agid, F. (1992) c-fos protein-like immunoreactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease. Neuroscience 46, 9-21.
    • (1992) Neuroscience , vol.46 , pp. 9-21
    • Zhang, P.1    Hirsch, E.G.2    Damier, P.3    Duyckaerts, C.4    Javoy-Agid, F.5
  • 177
  • 178
    • 0030788767 scopus 로고    scopus 로고
    • Presenilin 1 interaction in the brain with a novel member of the Armadillo family
    • Zhou, J., Liyanage, U., Medina, M., Ho, C., Simmons, A.D., Lovett, M. & Kosik, K.S. (1997) Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8, 2085-2090.
    • (1997) Neuroreport , vol.8 , pp. 2085-2090
    • Zhou, J.1    Liyanage, U.2    Medina, M.3    Ho, C.4    Simmons, A.D.5    Lovett, M.6    Kosik, K.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.