γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

Journal of Cell Science

Volumn 116, Issue 6, 2003, Pages 1127-1136

  Herreman, An ^a   Van Gassen, Geert ^a   Bentahir, Mustapha ^a   Nyabi, Omar ^a   Craessaerts, Katleen ^a   Mueller, Ulrike ^b   Annaert, Wim ^a   De Strooper, Bart ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Secretase; Alzheimer's disease; Glycosylation; Nicastrin; Presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GLYCOSIDASE; GLYCOSYLATED PROTEIN; MANNOSIDASE INHIBITOR; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEIN PRECURSOR;

ANIMAL CELL; CELL CULTURE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; FIBROBLAST; GOLGI COMPLEX; HALF LIFE TIME; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; SIALYLATION; TRANS GOLGI NETWORK;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; ENDOPEPTIDASES; FIBROBLASTS; GENE EXPRESSION; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; KIDNEY; MANNOSE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; NEURONS; OLIGOSACCHARIDES; PRESENILIN-1; PRESENILIN-2;

ANIMALIA;

EID: 0037444574     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00292     Document Type: Review

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