Gleevec inhibits β-amyloid production but not Notch cleavage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12444-12449

  Netzer, William J ^a   Dou, Fei ^a   Cai, Dongming ^a   Veach, Darren ^b   Jean, Stephanie ^a   Li, Yueming ^b   Bornmann, William G ^b   Clarkson, Bayard ^b   Xu, Huaxi ^a,c   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; IMATINIB; NOTCH RECEPTOR;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; FEMALE; FIBROBLAST; GUINEA PIG; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELLS, CULTURED; ENDOPEPTIDASES; ENZYME INHIBITORS; FEMALE; GENES, ABL; GUINEA PIGS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; PIPERAZINES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; RATS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0142059785     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1534745100     Document Type: Article

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