Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

Neuron

Volumn 42, Issue 1, 2004, Pages 23-36

  Saura, Carlos A ^a   Choi, Se Young ^b   Beglopoulos, Vassilios ^a   Malkani, Seema ^a   Zhang, Dawei ^a,b   Rao, B S Shankaranarayana ^c   Chattarji, Sumantra ^c   Kelleher III, Raymond J ^d   Kandel, Eric R ^e   Duff, Karen ^f   Kirkwood, Alfredo ^b   Shen, Jie ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIN DEPENDENT KINASE 5; ENZYME ACTIVATOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEIN C FOS; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN P25; TAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL SURVIVAL; CONTROLLED STUDY; FOREBRAIN; GENE TARGETING; HIPPOCAMPUS; KNOCKOUT MOUSE; LEARNING; MEMORY; MEMORY DISORDER; MOUSE; MUTANT; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL;

ACTIVATING TRANSCRIPTION FACTOR 1; AGE FACTORS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTIBODIES, MONOCLONAL; ASSOCIATION LEARNING; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EXCITATORY AMINO ACID AGONISTS; FEAR; GENE EXPRESSION REGULATION; GENE PRODUCTS, GAG; IMMUNOHISTOCHEMISTRY; LAMIN TYPE B; LONG-TERM POTENTIATION; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; N-METHYLASPARTATE; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; PATCH-CLAMP TECHNIQUES; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-FOS; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 11144354609     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(04)00182-5     Document Type: Article

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