Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 20, 2003, Pages 11735-11740

  Cordy, Joanna M ^a   Hussain, Ishrut ^b   Dingwall, Colin ^b   Hooper, Nigel M ^a   Turner, Anthony J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; CHOLESTEROL; DETERGENT; GLYCOSYLPHOSPHATIDYLINOSITOL; TRITON X 100;

AGING; ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CHOLESTEROL; ENDOPEPTIDASES; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; HYDROLYSIS; LIPID METABOLISM; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUMOR CELLS, CULTURED;

EID: 0141482022     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1635130100     Document Type: Article

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