Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor

Journal of Biological Chemistry

Volumn 279, Issue 15, 2004, Pages 15153-15160

  Nyborg, Andrew C ^a   Kornilova, Anna Y ^b   Jansen, Karen ^a   Ladd, Thomas B ^a   Wolfe, Michael S ^b   Golde, Todd E ^a  

^a MAYO CLINIC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPLEXATION; DIMERS; ENZYME KINETICS; METABOLISM;

HOMODIMERS; SIGNAL PEPTIDES;

BIOCHEMISTRY;

ASPARTIC PROTEINASE; GAMMA SECRETASE INHIBITOR; GLYCOPROTEIN; PEPTIDASE; PRESENILIN 1; PROTEINASE; SIGNAL PEPTIDE; SIGNAL PEPTIDE PEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL LINE; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; EXPRESSED SEQUENCE TAG; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LABELING INDEX; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PURIFICATION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BLOTTING, WESTERN; BRAIN; CELL LINE; CHO CELLS; CRICETINAE; DIMERIZATION; ENDOPEPTIDASES; ENZYME INHIBITORS; EPITOPES; GLYCEROL; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBCELLULAR FRACTIONS; TRANSFECTION; TRICHLOROACETIC ACID;

ANIMALIA;

EID: 2442446430     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309305200     Document Type: Article

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