Nonsteroidal Anti-Inflammatpry Drugs Can Lower Amyloidogenic Aβ 42 by Inhibiting Rho

Science

Volumn 302, Issue 5648, 2003, Pages 1215-1217

  Zhou, Yan ^a   Su, Yuan ^a   Li, Baolin ^a   Liu, Feng ^a   Ryder, John W ^a   Wu, Xin ^a   Gonzalez DeWhitt, Patricia A ^a   Gelfanova, Valentina ^a   Hale, John E ^a   May, Patrick C ^a   Paul, Steven H ^a   Ni, Binhui ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; DRUG INTERACTIONS; PROTEINS;

KINASES;

DRUG PRODUCTS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; IBUPROFEN; ISOPRENOID; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN CDC42; RAC1 PROTEIN; RHO FACTOR; RHO KINASE; SULINDAC SULFIDE; UNCLASSIFIED DRUG; AMIDE; AMYLOID BETA PROTEIN (1 38); AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-38); AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOPRENOID PHOSPHATE; PEPTIDE FRAGMENT; PROTEIN SERINE THREONINE KINASE; PROTEINASE; PYRIDINE DERIVATIVE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO-ASSOCIATED KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SECRETASE; SIGNAL PEPTIDE; SULINDAC;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENIC MOUSE; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALIA; MUS MUSCULUS;

AMIDES; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ENDOPEPTIDASES; BRAIN; CELL LINE, TUMOR; ENDOPEPTIDASES; ENZYME INHIBITORS; GUANOSINE TRIPHOSPHATE; HUMANS; IBUPROFEN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; POLYISOPRENYL PHOSPHATES; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SULINDAC; TRANSFECTION;

EID: 0242414463     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090154     Document Type: Article

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