Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: Implications for β-amyloid peptide over-production and localization in Alzheimer's disease

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 12, 2004, Pages 2531-2540

  Yu, W H ^a,b   Kumar, A ^a   Peterhoff, C ^a   Shapiro Kulnane, L ^c   Uchiyama, Y ^d   Lamb, B T ^c   Cuervo, A M ^e   Nixon, R A ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Autophagy; Beta secretase; Gamma secretase; Lysosomes

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTIBODY; BETA SECRETASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; METRIZAMIDE; NICASTRIN; PEPTIDE; PRESENILIN 1; PROTEINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CELL VACUOLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD LABELING; INHIBITION KINETICS; LIVER; MEASUREMENT; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PURIFICATION; SEQUENCE ANALYSIS; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; AUTOPHAGY; ENDOPEPTIDASES; HUMANS; LIVER; MICE; MICE, TRANSGENIC; NEURONS; VACUOLES;

EID: 4344689871     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.05.010     Document Type: Article

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