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Volumn 4, Issue 1, 2019, Pages

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Author keywords

[No Author keywords available]

Indexed keywords

CANCER IMMUNOTHERAPY; GASTROINTESTINAL TRACT; IMMUNE RESPONSE; MASS SPECTROMETRY; METABOLISM; MICROBIOME; NONHUMAN; REVIEW; HUMAN;

EID: 85075002014     PISSN: 20959907     EISSN: 20593635     Source Type: Journal    
DOI: 10.1038/s41392-019-0074-5     Document Type: Review
Times cited : (183)

References (539)
  • 1
    • 85058417389 scopus 로고    scopus 로고
    • Microbiome as a therapeutic target in alcohol-related liver disease
    • Sarin, S. K., Pande, A. & Schnabl, B. Microbiome as a therapeutic target in alcohol-related liver disease. J. Hepatol. 70, 260–272 (2019).
    • (2019) J. Hepatol. , vol.70 , pp. 260-272
    • Sarin, S.K.1    Pande, A.2    Schnabl, B.3
  • 2
    • 84961288867 scopus 로고    scopus 로고
    • Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
    • Sender, R., Fuchs, S. & Milo, R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164, 337–340 (2016).
    • (2016) Cell , vol.164 , pp. 337-340
    • Sender, R.1    Fuchs, S.2    Milo, R.3
  • 3
    • 85047735448 scopus 로고    scopus 로고
    • Gut dysbiosis: A potential link between increased cancer risk in ageing and inflammaging
    • Biragyn, A. & Ferrucci, L. Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging. Lancet Oncol. 19, e295–e304 (2018).
    • (2018) Lancet Oncol , vol.19 , pp. e295-e304
    • Biragyn, A.1    Ferrucci, L.2
  • 4
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010).
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1
  • 5
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchro-matic sequence of the human genome
    • International Human Genome Sequencing Consortium. Finishing the euchro-matic sequence of the human genome. Nature 431, 931–945 (2004).
    • (2004) Nature , vol.431 , pp. 931-945
  • 6
    • 85063615414 scopus 로고    scopus 로고
    • New insights from uncultivated genomes of the global human gut microbiome
    • Nayfach, S., Shi, Z. J., Seshadri, R., Pollard, K. S. & Kyrpides, N. C. New insights from uncultivated genomes of the global human gut microbiome. Nature 568, 505–510 (2019).
    • (2019) Nature , vol.568 , pp. 505-510
    • Nayfach, S.1    Shi, Z.J.2    Seshadri, R.3    Pollard, K.S.4    Kyrpides, N.C.5
  • 7
    • 85062538500 scopus 로고    scopus 로고
    • A new genomic blueprint of the human gut microbiota
    • Almeida, A. et al. A new genomic blueprint of the human gut microbiota. Nature 568, 499–504 (2019).
    • (2019) Nature , vol.568 , pp. 499-504
    • Almeida, A.1
  • 8
    • 85063619329 scopus 로고    scopus 로고
    • Structural variation in the gut microbiome associates with host health
    • Zeevi, D. et al. Structural variation in the gut microbiome associates with host health. Nature 568, 43–48 (2019).
    • (2019) Nature , vol.568 , pp. 43-48
    • Zeevi, D.1
  • 9
    • 85061150464 scopus 로고    scopus 로고
    • Microbiosis in pathogenesis and intervention of atopic dermatitis
    • Dou, J. et al. Microbiosis in pathogenesis and intervention of atopic dermatitis. Int. Immunopharmacol. 69, 263–269 (2019).
    • (2019) Int. Immunopharmacol , vol.69 , pp. 263-269
    • Dou, J.1
  • 10
    • 85061322186 scopus 로고    scopus 로고
    • Regulation of microRNA machinery and development by interspecies S-nitrosylation
    • Seth, P. et al. Regulation of microRNA machinery and development by interspecies S-nitrosylation. Cell 176, 1014–1025.e1012 (2019).
    • (2019) Cell , vol.176 , pp. 1014-1025
    • Seth, P.1
  • 11
    • 85048755356 scopus 로고    scopus 로고
    • Critical role for the microbiota in CX3CR1(+) intestinal mononuclear phagocyte regulation of intestinal T cell responses
    • Kim, M. et al. Critical role for the microbiota in CX3CR1(+) intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immunity 49, 151–163.e155 (2018).
    • (2018) Immunity , vol.49 , pp. 151-163
    • Kim, M.1
  • 12
    • 85046537041 scopus 로고    scopus 로고
    • Roseburia intestinalis inhibits interleukin17 excretion and promotes regulatory T cells differentiation in colitis
    • Zhu, C. et al. Roseburia intestinalis inhibits interleukin17 excretion and promotes regulatory T cells differentiation in colitis. Mol. Med. Rep. 17, 7567–7574 (2018).
    • (2018) Mol. Med. Rep , vol.17 , pp. 7567-7574
    • Zhu, C.1
  • 13
    • 85036500288 scopus 로고    scopus 로고
    • A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
    • Dodd, D. et al. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551, 648–652 (2017).
    • (2017) Nature , vol.551 , pp. 648-652
    • Dodd, D.1
  • 14
    • 84971519476 scopus 로고    scopus 로고
    • From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites
    • Koh, A., De Vadder, F., Kovatcheva-Datchary, P. & Backhed, F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165, 1332–1345 (2016).
    • (2016) Cell , vol.165 , pp. 1332-1345
    • Koh, A.1    de Vadder, F.2    Kovatcheva-Datchary, P.3    Backhed, F.4
  • 15
    • 85005965070 scopus 로고    scopus 로고
    • The human intestinal microbiome in health and disease
    • Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 2369-2379
    • Lynch, S.V.1    Pedersen, O.2
  • 16
    • 85065864469 scopus 로고    scopus 로고
    • Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice
    • Sharon, G. et al. Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice. Cell 177, 1600–1618.e1617 (2019).
    • (2019) Cell 177 , vol.e1617 , pp. 1600-1618
    • Sharon, G.1
  • 17
    • 85059328605 scopus 로고    scopus 로고
    • Association of gut microbiota composition and function with a senescence-accelerated mouse model of Alzheimer's disease using 16S rRNA gene and metagenomic sequencing analysis
    • Peng, W. et al. Association of gut microbiota composition and function with a senescence-accelerated mouse model of Alzheimer's disease using 16S rRNA gene and metagenomic sequencing analysis. Aging (Albany, NY) 10, 4054–4065 (2018).
    • (2018) Aging (Albany, NY) , vol.10 , pp. 4054-4065
    • Peng, W.1
  • 19
    • 85058361062 scopus 로고    scopus 로고
    • The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression
    • Tyagi, A. M. et al. The microbial metabolite butyrate stimulates bone formation via T regulatory cell-mediated regulation of WNT10B expression. Immunity 49, 1116–1131.e1117 (2018).
    • (2018) Immunity 49 , vol.e1117 , pp. 1116-1131
    • Tyagi, A.M.1
  • 20
    • 85067609952 scopus 로고    scopus 로고
    • Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
    • New York, NY
    • Maini Rekdal, V., Bess, E. N., Bisanz, J. E., Turnbaugh, P. J. & Balskus, E. P. Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science (New York, NY) 364, https://doi.org/10.1126/science. aau6323 (2019).
    • (2019) Science , pp. 364
    • Maini Rekdal, V.1    Bess, E.N.2    Bisanz, J.E.3    Turnbaugh, P.J.4    Balskus, E.P.5
  • 21
    • 85067882185 scopus 로고    scopus 로고
    • Mapping human microbiome drug metabolism by gut bacteria and their genes
    • Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R. & Goodman, A. L. Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature 570, 462–467 (2019).
    • (2019) Nature , vol.570 , pp. 462-467
    • Zimmermann, M.1    Zimmermann-Kogadeeva, M.2    Wegmann, R.3    Goodman, A.L.4
  • 22
    • 85059329854 scopus 로고    scopus 로고
    • Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORgammat(+) regulatory T cells and exacerbate colitis in mice
    • Britton, G. J. et al. Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORgammat(+) regulatory T cells and exacerbate colitis in mice. Immunity 50, 212–224.e214 (2019).
    • (2019) Immunity , vol.50 , pp. 212-224
    • Britton, G.J.1
  • 23
    • 85068192534 scopus 로고    scopus 로고
    • The gut microbiota and colon cancer
    • New York, NY
    • Garrett, W. S. The gut microbiota and colon cancer. Science (New York, NY) 364, 1133–1135 (2019).
    • (2019) Science , vol.364 , pp. 1133-1135
    • Garrett, W.S.1
  • 24
    • 85061191066 scopus 로고    scopus 로고
    • The neuroactive potential of the human gut microbiota in quality of life and depression
    • Valles-Colomer, M. et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat. Microbiol. 4, 623–632 (2019).
    • (2019) Nat. Microbiol. , vol.4 , pp. 623-632
    • Valles-Colomer, M.1
  • 25
    • 85060921451 scopus 로고    scopus 로고
    • Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children
    • Paun, A. et al. Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children. Sci. Immunol. 4, https://doi.org/10.1126/sciimmunol.aau8125 (2019).
    • (2019) Sci. Immunol , pp. 4
    • Paun, A.1
  • 26
    • 85061918601 scopus 로고    scopus 로고
    • Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal
    • Azzouz, D. et al. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann. Rheum. Dis. 78, 947–956 (2019).
    • (2019) Ann. Rheum. Dis. , vol.78 , pp. 947-956
    • Azzouz, D.1
  • 27
    • 85068081172 scopus 로고    scopus 로고
    • Microbiota therapy acts via a regulatory T cell MyD88/ RORgammat pathway to suppress food allergy
    • Abdel-Gadir, A. et al. Microbiota therapy acts via a regulatory T cell MyD88/ RORgammat pathway to suppress food allergy. Nat. Med. 25, 1164–1174 (2019).
    • (2019) Nat. Med. , vol.25 , pp. 1164-1174
    • Abdel-Gadir, A.1
  • 28
    • 85068458610 scopus 로고    scopus 로고
    • Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study
    • Depommier, C. et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat. Med. 25, 1096–1103 (2019).
    • (2019) Nat. Med. , vol.25 , pp. 1096-1103
    • Depommier, C.1
  • 29
    • 85062433308 scopus 로고    scopus 로고
    • Distinct genetic and functional traits of human intestinal prevotella copri strains are associated with different habitual diets
    • De Filippis, F. et al. Distinct genetic and functional traits of human intestinal prevotella copri strains are associated with different habitual diets. Cell Host Microbe 25, 444–453.e443 (2019).
    • (2019) Cell Host Microbe , vol.25 , pp. 444-453
    • de Filippis, F.1
  • 30
    • 85066626601 scopus 로고    scopus 로고
    • TMAO and heart disease: The new red meat risk?
    • Abbasi, J. TMAO and heart disease: the new red meat risk? JAMA https://doi.org/10.1001/jama.2019.3910 (2019).
    • (2019) JAMA
    • Abbasi, J.1
  • 31
    • 85049753953 scopus 로고    scopus 로고
    • Microbiome metabolomics reveals new drivers of human liver steatosis
    • Delzenne, N. M. & Bindels, L. B. Microbiome metabolomics reveals new drivers of human liver steatosis. Nat. Med. 24, 906–907 (2018).
    • (2018) Nat. Med. , vol.24 , pp. 906-907
    • Delzenne, N.M.1    Bindels, L.B.2
  • 32
    • 85054466951 scopus 로고    scopus 로고
    • Dysregulated microbial fermentation of soluble fiber induces cholestatic liver
    • Singh, V. et al. Dysregulated microbial fermentation of soluble fiber induces cholestatic liver. Cancer Cell 175, 679–694.e622 (2018).
    • (2018) Cancer Cell , vol.175 , pp. 679-694
    • Singh, V.1
  • 33
    • 85030850973 scopus 로고    scopus 로고
    • Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells
    • Luu, T. H. et al. Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells. Cell Oncol. (Dordr.) 41, 13–24 (2018).
    • (2018) Cell Oncol. (Dordr.) , vol.41 , pp. 13-24
    • Luu, T.H.1
  • 34
    • 85047865846 scopus 로고    scopus 로고
    • Immunotherapy for pancreatic cancer: More than just a gut feeling
    • Riquelme, E., Maitra, A. & McAllister, F. Immunotherapy for pancreatic cancer: more than just a gut feeling. Cancer Discov. 8, 386–388 (2018).
    • (2018) Cancer Discov , vol.8 , pp. 386-388
    • Riquelme, E.1    Maitra, A.2    McAllister, F.3
  • 35
    • 85063737545 scopus 로고    scopus 로고
    • Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(−/−) mice
    • Li, Y. et al. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(−/−) mice. Nat. Commun. 10, 1492 (2019).
    • (2019) Nat. Commun , vol.10 , pp. 1492
    • Li, Y.1
  • 36
    • 85049834251 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus GG-derived soluble mediators modulate adaptive immune cells
    • Ludwig, I. S. et al. Lactobacillus rhamnosus GG-derived soluble mediators modulate adaptive immune cells. Front. Immunol. 9, 1546 (2018).
    • (2018) Front. Immunol. , vol.9 , pp. 1546
    • Ludwig, I.S.1
  • 37
    • 85068175354 scopus 로고    scopus 로고
    • Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis
    • New York, NY
    • Ansaldo, E. et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science (New York, NY) 364, 1179–1184 (2019).
    • (2019) Science , vol.364 , pp. 1179-1184
    • Ansaldo, E.1
  • 38
    • 85046246911 scopus 로고    scopus 로고
    • Activation of AhR with nuclear IKKalpha regulates cancer stem-like properties in the occurrence of radioresistance
    • Yan, B. et al. Activation of AhR with nuclear IKKalpha regulates cancer stem-like properties in the occurrence of radioresistance. Cell Death Dis. 9, 490 (2018).
    • (2018) Cell Death Dis , vol.9
    • Yan, B.1
  • 39
    • 85031998982 scopus 로고    scopus 로고
    • Distinct microbial communities trigger colitis development upon intestinal barrier damage via innate or adaptive immune cells
    • Roy, U. et al. Distinct microbial communities trigger colitis development upon intestinal barrier damage via innate or adaptive immune cells. Cell Rep. 21, 994–1008 (2017).
    • (2017) Cell Rep , vol.21 , pp. 994-1008
    • Roy, U.1
  • 40
    • 84958910139 scopus 로고    scopus 로고
    • Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine
    • Kim, K. S. et al. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science (New York, NY) 351, 858–863 (2016).
    • (2016) Science (New York, NY) , vol.351 , pp. 858-863
    • Kim, K.S.1
  • 41
    • 85041733102 scopus 로고    scopus 로고
    • Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
    • Mao, K. et al. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature 554, 255–259 (2018).
    • (2018) Nature , vol.554 , pp. 255-259
    • Mao, K.1
  • 42
    • 85039954221 scopus 로고    scopus 로고
    • Shaping of intestinal microbiota in Nlrp6-and Rag2-deficient mice depends on community structure
    • Galvez, E. J. C., Iljazovic, A., Gronow, A., Flavell, R. & Strowig, T. Shaping of intestinal microbiota in Nlrp6-and Rag2-deficient mice depends on community structure. Cell Rep. 21, 3914–3926 (2017).
    • (2017) Cell Rep , vol.21 , pp. 3914-3926
    • Galvez, E.J.C.1    Iljazovic, A.2    Gronow, A.3    Flavell, R.4    Strowig, T.5
  • 43
    • 85060753155 scopus 로고    scopus 로고
    • A defined commensal consortium elicits CD8 T cells and anticancer immunity
    • Tanoue, T. et al. A defined commensal consortium elicits CD8 T cells and anticancer immunity. Nature 565, 600–605 (2019).
    • (2019) Nature , vol.565 , pp. 600-605
    • Tanoue, T.1
  • 44
    • 85021740602 scopus 로고    scopus 로고
    • Functional characterization of novel Faecalibacterium prausnitzii strains isolated from healthy volunteers: A step forward in the use of F. prausnitzii as a next-generation probiotic
    • Martin, R. et al. Functional characterization of novel Faecalibacterium prausnitzii strains isolated from healthy volunteers: a step forward in the use of F. prausnitzii as a next-generation probiotic. Front. Microbiol. 8, 1226 (2017).
    • (2017) Front. Microbiol. , vol.8 , Issue.1226
    • Martin, R.1
  • 45
    • 77952718348 scopus 로고    scopus 로고
    • Anaerostipes butyraticus sp. Nov., an anaerobic, butyrate-producing bacterium from Clostridium cluster XIVa isolated from broiler chicken caecal content, and emended description of the genus Anaerostipes
    • Eeckhaut, V. et al. Anaerostipes butyraticus sp. nov., an anaerobic, butyrate-producing bacterium from Clostridium cluster XIVa isolated from broiler chicken caecal content, and emended description of the genus Anaerostipes. Int. J. Syst. Evolut. Microbiol. 60, 1108–1112 (2010).
    • (2010) Int. J. Syst. Evolut. Microbiol. , vol.60 , pp. 1108-1112
    • Eeckhaut, V.1
  • 46
    • 85072628724 scopus 로고    scopus 로고
    • A new colitis therapy strategy via the target colonization of magnetic nanoparticle-internalized Roseburia intestinalis
    • Xiao, M. et al. A new colitis therapy strategy via the target colonization of magnetic nanoparticle-internalized Roseburia intestinalis. Biomater. Sci. https://doi.org/10.1039/c9bm00980a (2019).
    • (2019) Biomater. Sci
    • Xiao, M.1
  • 47
    • 85043228831 scopus 로고    scopus 로고
    • Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
    • Zhao, L. et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science (New York, NY) 359, 1151–1156 (2018).
    • (2018) Science (New York, NY) , vol.359 , pp. 1151-1156
    • Zhao, L.1
  • 48
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P. & Macfarlane, G. T. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 1221–1227 (1987).
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 49
    • 85064937503 scopus 로고    scopus 로고
    • A weaning reaction to microbiota is required for resistance to immunopathologies in the adult
    • Al Nabhani, Z. et al. A weaning reaction to microbiota is required for resistance to immunopathologies in the adult. Immunity 50, 1276–1288.e1275 (2019).
    • (2019) Immunity 50 , vol.e1275 , pp. 1276-1288
    • Al Nabhani, Z.1
  • 50
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • Maslowski, K. M. et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461, 1282–1286 (2009).
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1
  • 52
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • Macia, L. et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015).
    • (2015) Nat. Commun. , vol.6
    • Macia, L.1
  • 53
    • 84949309790 scopus 로고    scopus 로고
    • Epithelial IL-18 equilibrium controls barrier function in colitis
    • Nowarski, R. et al. Epithelial IL-18 equilibrium controls barrier function in colitis. Cell 163, 1444–1456 (2015).
    • (2015) Cell , vol.163 , pp. 1444-1456
    • Nowarski, R.1
  • 54
    • 85053208491 scopus 로고    scopus 로고
    • Microbial metabolite sensor GPR43 controls severity of experimental GVHD
    • Fujiwara, H. et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat. Commun. 9, 3674 (2018).
    • (2018) Nat. Commun , vol.9 , pp. 3674
    • Fujiwara, H.1
  • 55
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh, N. et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 40, 128–139 (2014).
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1
  • 56
    • 85047608074 scopus 로고    scopus 로고
    • A common mechanism links activities of butyrate in the colon
    • Verma, M. S. et al. A common mechanism links activities of butyrate in the colon. ACS Chem. Biol. 13, 1291–1298 (2018).
    • (2018) ACS Chem. Biol , vol.13 , pp. 1291-1298
    • Verma, M.S.1
  • 57
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia, N. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451–455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 58
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa, Y. et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504, 446–450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 59
    • 85049121297 scopus 로고    scopus 로고
    • Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells
    • Martin-Gallausiaux, C. et al. Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. Sci. Rep. 8, 9742 (2018).
    • (2018) Sci. Rep. , vol.8
    • Martin-Gallausiaux, C.1
  • 60
    • 85042602029 scopus 로고    scopus 로고
    • To respond or not to respond—a personal perspective of intestinal tolerance
    • Mowat, A. M. To respond or not to respond—a personal perspective of intestinal tolerance. Nat. Rev. Immunol. 18, 405–415 (2018).
    • (2018) Nat. Rev. Immunol. , vol.18 , pp. 405-415
    • Mowat, A.M.1
  • 61
    • 85062881986 scopus 로고    scopus 로고
    • Mining the microbiota for microbial and metabolite-based immunotherapies
    • Skelly, A. N., Sato, Y., Kearney, S. & Honda, K. Mining the microbiota for microbial and metabolite-based immunotherapies. Nat. Rev. Immunol. 19, 305–323 (2019).
    • (2019) Nat. Rev. Immunol. , vol.19 , pp. 305-323
    • Skelly, A.N.1    Sato, Y.2    Kearney, S.3    Honda, K.4
  • 62
    • 84877954998 scopus 로고    scopus 로고
    • Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms
    • Konieczna, P. et al. Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms. PLoS ONE 8, e62617 (2013).
    • (2013) Plos ONE , vol.8
    • Konieczna, P.1
  • 63
    • 84922163095 scopus 로고    scopus 로고
    • Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
    • Park, J. et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 8, 80–93 (2015).
    • (2015) Mucosal Immunol , vol.8 , pp. 80-93
    • Park, J.1
  • 64
    • 85052632504 scopus 로고    scopus 로고
    • Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
    • Sun, M. et al. Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Nat. Commun. 9, 3555 (2018).
    • (2018) Nat. Commun. , vol.9
    • Sun, M.1
  • 65
    • 85068142395 scopus 로고    scopus 로고
    • Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells’ differentiation and function in induction of colitis
    • Chen, L. et al. Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells’ differentiation and function in induction of colitis. Inflamm. Bowel Dis. 25, 1450–1461 (2019).
    • (2019) Inflamm. Bowel Dis. , vol.25 , pp. 1450-1461
    • Chen, L.1
  • 66
    • 85070719138 scopus 로고    scopus 로고
    • Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8(+) T cells
    • Bachem, A. et al. Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8(+) T cells. Immunity https://doi.org/10.1016/j.immuni.2019.06.002 (2019).
    • (2019) Immunity
    • Bachem, A.1
  • 67
    • 84979735744 scopus 로고    scopus 로고
    • Gut microbial metabolites fuel host antibody responses
    • Kim, M., Qie, Y., Park, J. & Kim, C. H. Gut microbial metabolites fuel host antibody responses. Cell Host Microbe 20, 202–214 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 202-214
    • Kim, M.1    Qie, Y.2    Park, J.3    Kim, C.H.4
  • 68
    • 85054317501 scopus 로고    scopus 로고
    • B cell-helping functions of gut microbial metabolites
    • Kim, C. H. B cell-helping functions of gut microbial metabolites. Microbial Cell 3, 529–531 (2016).
    • (2016) Microbial Cell , vol.3 , pp. 529-531
    • Kim, C.H.1
  • 69
    • 85068428572 scopus 로고    scopus 로고
    • Microbiota metabolite short-chain fatty acids facilitate mucosal adjuvant activity of cholera toxin through GPR43
    • Yang, W. et al. Microbiota metabolite short-chain fatty acids facilitate mucosal adjuvant activity of cholera toxin through GPR43. J. Immunol. https://doi.org/10.4049/jimmunol.1801068 (2019).
    • (2019) J. Immunol
    • Yang, W.1
  • 71
    • 85046534759 scopus 로고    scopus 로고
    • Gut microbiota utilize immunoglobulin A for mucosal colonization
    • Donaldson, G. P. et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science (New York, NY) 360, 795–800 (2018).
    • (2018) Science (New York, NY) , vol.360 , pp. 795-800
    • Donaldson, G.P.1
  • 72
    • 85020848232 scopus 로고    scopus 로고
    • Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43
    • Wu, W. et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol. 10, 946–956 (2017).
    • (2017) Mucosal Immunol , vol.10 , pp. 946-956
    • Wu, W.1
  • 73
    • 85060327779 scopus 로고    scopus 로고
    • The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
    • Schulthess, J. et al. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity 50, 432–445.e437 (2019).
    • (2019) Immunity 50 , vol.e437 , pp. 432-445
    • Schulthess, J.1
  • 74
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang, P. V., Hao, L., Offermanns, S. & Medzhitov, R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl. Acad. Sci. USA 111, 2247–2252 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 75
    • 85055538084 scopus 로고    scopus 로고
    • Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Sci. Transl. Med. 10
    • Scott, N. A. et al. Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Sci. Transl. Med. 10, eaao4775 (2018).
    • (2018) Eaao4775
    • Scott, N.A.1
  • 76
    • 84964577698 scopus 로고    scopus 로고
    • Microbial metabolite butyrate facilitates M2 macrophage polarization and function
    • Ji, J. et al. Microbial metabolite butyrate facilitates M2 macrophage polarization and function. Sci. Rep. 6, 24838 (2016).
    • (2016) Sci. Rep , vol.6
    • Ji, J.1
  • 77
    • 85060235134 scopus 로고    scopus 로고
    • Microbiome control of innate reactivity
    • Chen, F. & Stappenbeck, T. S. Microbiome control of innate reactivity. Curr. Opin. Immunol. 56, 107–113 (2019).
    • (2019) Curr. Opin. Immunol. , vol.56 , pp. 107-113
    • Chen, F.1    Stappenbeck, T.S.2
  • 78
    • 85027175538 scopus 로고    scopus 로고
    • Microbiota-activated PPAR-gamma signaling inhibits dys-biotic Enterobacteriaceae expansion
    • Byndloss, M. X. et al. Microbiota-activated PPAR-gamma signaling inhibits dys-biotic Enterobacteriaceae expansion. Science (New York, NY) 357, 570–575 (2017).
    • (2017) Science (New York, NY) , vol.357 , pp. 570-575
    • Byndloss, M.X.1
  • 79
    • 85057537429 scopus 로고    scopus 로고
    • Colonocyte metabolism shapes the gut microbiota. Science (New York, NY) 362
    • Litvak, Y., Byndloss, M. X. & Baumler, A. J. Colonocyte metabolism shapes the gut microbiota. Science (New York, NY) 362, eaat9076 (2018).
    • (2018) Eaat9076
    • Litvak, Y.1    Byndloss, M.X.2    Baumler, A.J.3
  • 81
    • 85052282474 scopus 로고    scopus 로고
    • A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection
    • Jacobson, A. et al. A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection. Cell Host Microbe 24, 296–307.e297 (2018).
    • (2018) Cell Host Microbe 24 , vol.e297 , pp. 296-307
    • Jacobson, A.1
  • 82
    • 85059927753 scopus 로고    scopus 로고
    • Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification
    • Sorbara, M. T. et al. Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification. J. Exp. Med. 216, 84–98 (2019).
    • (2019) J. Exp. Med , vol.216 , pp. 84-98
    • Sorbara, M.T.1
  • 83
    • 85038815699 scopus 로고    scopus 로고
    • Dysbiosis-associated change in host metabolism generates lactate to support Salmonella growth
    • Gillis, C. C. et al. Dysbiosis-associated change in host metabolism generates lactate to support Salmonella growth. Cell host microbe 23, 54–64.e56 (2018).
    • (2018) Cell Host Microbe 23 , vol.e56 , pp. 54-64
    • Gillis, C.C.1
  • 84
    • 85063896373 scopus 로고    scopus 로고
    • Roseburia intestinalis inhibits oncostatin M and maintains tight junction integrity in a murine model of acute experimental colitis
    • Tan, B. et al. Roseburia intestinalis inhibits oncostatin M and maintains tight junction integrity in a murine model of acute experimental colitis. Scand. J. Gastroenterol. 54, 432–440 (2019).
    • (2019) Scand. J. Gastroenterol. , vol.54 , pp. 432-440
    • Tan, B.1
  • 85
    • 84976310851 scopus 로고    scopus 로고
    • Hansson, G. C. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
    • Birchenough, G. M., Nystrom, E. E., Johansson, M. E. & Hansson, G. C. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science (New York, NY) 352, 1535–1542 (2016).
    • (2016) Science (New York, NY) , vol.352 , pp. 1535-1542
    • Birchenough, G.M.1    Nystrom, E.E.2    Johansson, M.E.3
  • 86
    • 85046876462 scopus 로고    scopus 로고
    • Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn’s disease and differentially expressed in goblet cells. Cell Mol. Gastroenterol
    • Ranson, N. et al. Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn’s disease and differentially expressed in goblet cells. Cell Mol. Gastroenterol. Hepatol. 6, 110–112.e118 (2018).
    • (2018) Hepatol. 6 , vol.e118 , pp. 110-112
    • Ranson, N.1
  • 87
    • 84896691062 scopus 로고    scopus 로고
    • NLRP6 inflammasome orchestrates the colonic host–microbial interface by regulating goblet cell mucus secretion
    • Wlodarska, M. et al. NLRP6 inflammasome orchestrates the colonic host–microbial interface by regulating goblet cell mucus secretion. Cell 156, 1045–1059 (2014).
    • (2014) Cell , vol.156 , pp. 1045-1059
    • Wlodarska, M.1
  • 88
    • 84961392222 scopus 로고    scopus 로고
    • Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
    • Mathewson, N. D. et al. Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat. Immunol. 17, 505–513 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 505-513
    • Mathewson, N.D.1
  • 89
    • 85060410773 scopus 로고    scopus 로고
    • Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression. Nephrol. Dial
    • Gonzalez, A. et al. Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression. Nephrol. Dial. Transpl. 34, 783–794 (2019).
    • (2019) Transpl , vol.34 , pp. 783-794
    • Gonzalez, A.1
  • 90
    • 85031497192 scopus 로고    scopus 로고
    • Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2
    • Zheng, L. et al. Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2. J. Immunol. 199, 2976–2984 (2017).
    • (2017) J. Immunol. , vol.199 , pp. 2976-2984
    • Zheng, L.1
  • 91
    • 85048026863 scopus 로고    scopus 로고
    • GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
    • Zhao, Y. et al. GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3. Mucosal Immunol. 11, 752–762 (2018).
    • (2018) Mucosal Immunol , vol.11 , pp. 752-762
    • Zhao, Y.1
  • 92
    • 85014126048 scopus 로고    scopus 로고
    • 2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathe-licidin in response to Entamoeba histolytica-and dextran sodium sulfate-induced colitis
    • Cobo, E. R., Kissoon-Singh, V., Moreau, F., Holani, R. & Chadee, K. MUC2 mucin and butyrate contribute to the synthesis of the antimicrobial peptide cathe-licidin in response to Entamoeba histolytica-and dextran sodium sulfate-induced colitis. Infect. Immun. 85, e00905-16 (2017).
    • (2017) Infect. Immun , vol.85 , pp. e00905-e00916
    • Cobo, E.R.1    Kissoon-Singh, V.2    Moreau, F.3    Holani, R.4    Chadee, K.M.U.C.5
  • 93
    • 85063984209 scopus 로고    scopus 로고
    • Butyrate protects mice from Clostridium difficile-induced colitis through an HIF-1-dependent mechanism. Cell Rep
    • Fachi, J. L. et al. Butyrate protects mice from Clostridium difficile-induced colitis through an HIF-1-dependent mechanism. Cell Rep. 27, 750–761.e757 (2019).
    • (2019) 27 , vol.e757 , pp. 750-761
    • Fachi, J.L.1
  • 94
    • 84995739780 scopus 로고    scopus 로고
    • A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility
    • Desai, M. S. et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167, 1339–1353.e1321 (2016).
    • (2016) Cell 167 , vol.e1321 , pp. 1339-1353
    • Desai, M.S.1
  • 95
    • 85038814668 scopus 로고    scopus 로고
    • Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration
    • Schroeder, B. O. et al. Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host Microbe 23, 27–40. e27 (2018).
    • (2018) Cell Host Microbe 23 , vol.e27 , pp. 27-40
    • Schroeder, B.O.1
  • 96
    • 85038876729 scopus 로고    scopus 로고
    • Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health
    • Zou, J. et al. Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health. Cell Host Microbe 23, 41–53.e44 (2018).
    • (2018) Cell Host Microbe 23 , vol.e44 , pp. 41-53
    • Zou, J.1
  • 97
    • 85061906892 scopus 로고    scopus 로고
    • Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: A 6-month randomised controlled-feeding trial
    • Wan, Y. et al. Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. Gut https://doi.org/10.1136/gutjnl-2018-317609 (2019).
    • (2019) Gut
    • Wan, Y.1
  • 98
    • 84973666361 scopus 로고    scopus 로고
    • The colonic crypt protects stem cells from microbiota-derived metabolites
    • Kaiko, G. E. et al. The colonic crypt protects stem cells from microbiota-derived metabolites. Cell 165, 1708–1720 (2016).
    • (2016) Cell , vol.165 , pp. 1708-1720
    • Kaiko, G.E.1
  • 99
    • 85060618269 scopus 로고    scopus 로고
    • Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation
    • Singh, V. et al. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. Gut https://doi.org/10.1136/gutjnl-2018-316250 (2019).
    • (2019) Gut
    • Singh, V.1
  • 100
    • 85052735485 scopus 로고    scopus 로고
    • The inhibitory innate immune sensor NLRP12 maintains a threshold against obesity by regulating gut microbiota homeostasis
    • Truax, A. D. et al. The inhibitory innate immune sensor NLRP12 maintains a threshold against obesity by regulating gut microbiota homeostasis. Cell Host Microbe 24, 364–378.e366 (2018).
    • (2018) Cell Host Microbe 24 , vol.e366 , pp. 364-378
    • Truax, A.D.1
  • 101
    • 85056653495 scopus 로고    scopus 로고
    • Commensal bacteria contribute to insulin resistance in aging by activating innate B1acells
    • Bodogai, M. et al. Commensal bacteria contribute to insulin resistance in aging by activating innate B1acells. Sci. Transl. Med. 10, https://doi.org/10.1126/scitranslmed.aat4271 (2018).
    • (2018) Sci. Transl. Med , vol.10
    • Bodogai, M.1
  • 102
    • 85061738433 scopus 로고    scopus 로고
    • Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
    • Sanna, S. et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat. Genet. 51, 600–605 (2019).
    • (2019) Nat. Genet. , vol.51 , pp. 600-605
    • Sanna, S.1
  • 103
    • 84945202481 scopus 로고    scopus 로고
    • Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
    • Chambers, E. S. et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 64, 1744–1754 (2015).
    • (2015) Gut , vol.64 , pp. 1744-1754
    • Chambers, E.S.1
  • 104
    • 85019847333 scopus 로고    scopus 로고
    • Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: A randomized crossover trial
    • Canfora, E. E. et al. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Sci. Rep. 7, 2360 (2017).
    • (2017) Sci. Rep. , vol.7
    • Canfora, E.E.1
  • 105
    • 85008657161 scopus 로고    scopus 로고
    • Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Mol
    • Brooks, L. et al. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Mol. Metab. 6, 48–60 (2017).
    • (2017) Metab , vol.6 , pp. 48-60
    • Brooks, L.1
  • 106
    • 85049923863 scopus 로고    scopus 로고
    • Potential of butyrate to influence food intake in mice and men
    • Fluitman, K. S., Wijdeveld, M., Nieuwdorp, M. & RG, I. J. Potential of butyrate to influence food intake in mice and men. Gut 67, 1203–1204 (2018).
    • (2018) Gut , vol.67 , pp. 1203-1204
    • Fluitman, K.S.1    Wijdeveld, M.2    Nieuwdorp, M.3    Rg, I.J.4
  • 107
    • 85050239208 scopus 로고    scopus 로고
    • Butyrate reduces appetite and activates brown adipose tissue via the gut–brain neural circuit
    • Li, Z. et al. Butyrate reduces appetite and activates brown adipose tissue via the gut–brain neural circuit. Gut 67, 1269–1279 (2018).
    • (2018) Gut , vol.67 , pp. 1269-1279
    • Li, Z.1
  • 108
    • 84899892790 scopus 로고    scopus 로고
    • The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
    • Frost, G. et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat. Commun. 5, 3611 (2014).
    • (2014) Nat. Commun. , vol.5
    • Frost, G.1
  • 110
    • 84973667684 scopus 로고    scopus 로고
    • Acetate mediates a microbiome–brain-beta-cell axis to promote metabolic syndrome
    • Perry, R. J. et al. Acetate mediates a microbiome–brain-beta-cell axis to promote metabolic syndrome. Nature 534, 213–217 (2016).
    • (2016) Nature , vol.534 , pp. 213-217
    • Perry, R.J.1
  • 111
    • 84951733419 scopus 로고    scopus 로고
    • Microbiota-dependent hepatic lipogenesis mediated by stearoyl CoA desaturase 1 (SCD1) promotes metabolic syndrome in TLR5-deficient mice
    • Singh, V. et al. Microbiota-dependent hepatic lipogenesis mediated by stearoyl CoA desaturase 1 (SCD1) promotes metabolic syndrome in TLR5-deficient mice. Cell Metab. 22, 983–996 (2015).
    • (2015) Cell Metab , vol.22 , pp. 983-996
    • Singh, V.1
  • 112
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
    • De Vadder, F. et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156, 84–96 (2014).
    • (2014) Cell , vol.156 , pp. 84-96
    • de Vadder, F.1
  • 113
    • 85050469860 scopus 로고    scopus 로고
    • Disruption of epithelial HDAC3 in intestine prevents diet-induced obesity in mice
    • Whitt, J. et al. Disruption of epithelial HDAC3 in intestine prevents diet-induced obesity in mice. Gastroenterology 155, 501–513 (2018).
    • (2018) Gastroenterology , vol.155 , pp. 501-513
    • Whitt, J.1
  • 114
    • 85055972770 scopus 로고    scopus 로고
    • Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
    • Kasahara, K. et al. Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model. Nat. Microbiol 3, 1461–1471 (2018).
    • (2018) Nat. Microbiol , vol.3 , pp. 1461-1471
    • Kasahara, K.1
  • 115
    • 85048539275 scopus 로고    scopus 로고
    • The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism. Cell Metab
    • Kamareddine, L., Robins, W. P., Berkey, C. D., Mekalanos, J. J. & Watnick, P. I. The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism. Cell Metab. 28, 449–462.e445 (2018).
    • (2018) 28 , vol.e445 , pp. 449-462
    • Kamareddine, L.1    Robins, W.P.2    Berkey, C.D.3    Mekalanos, J.J.4    Watnick, P.I.5
  • 116
    • 85061958692 scopus 로고    scopus 로고
    • Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue. Cell Rep
    • Li, B. et al. Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue. Cell Rep. 26, 2720–2737.e2725 (2019).
    • (2019) 26 , vol.e2725 , pp. 2720-2737
    • Li, B.1
  • 117
    • 85068219526 scopus 로고    scopus 로고
    • Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism
    • Scheiman, J. et al. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nat. Med. https://doi. org/10.1038/s41591-019-0485-4 (2019).
    • (2019) Nat. Med
    • Scheiman, J.1
  • 118
    • 84933043202 scopus 로고    scopus 로고
    • Host microbiota constantly control maturation and function of microglia in the CNS
    • Erny, D. et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18, 965–977 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 965-977
    • Erny, D.1
  • 120
    • 85071571087 scopus 로고    scopus 로고
    • Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota
    • Chen, R. et al. Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota. Pharmacol. Res. https://doi.org/10.1016/j.phrs.2019.104403 (2019).
    • (2019) Pharmacol. Res
    • Chen, R.1
  • 121
    • 84911884131 scopus 로고    scopus 로고
    • The gut microbiota influences blood–brain barrier permeability in mice
    • Braniste, V. et al. The gut microbiota influences blood–brain barrier permeability in mice. Sci. Transl. Med. 6, 263ra158 (2014).
    • (2014) Sci. Transl. Med. , vol.6
    • Braniste, V.1
  • 122
    • 85051628777 scopus 로고    scopus 로고
    • Microbiome–host systems interactions: Protective effects of propionate upon the blood-brain barrier
    • Hoyles, L. et al. Microbiome–host systems interactions: protective effects of propionate upon the blood-brain barrier. Microbiome 6, 55 (2018).
    • (2018) Microbiome , vol.6 , pp. 55
    • Hoyles, L.1
  • 123
    • 85068471081 scopus 로고    scopus 로고
    • Dietary fructose-induced gut dysbiosis promotes mouse hippo-campal neuroinflammation: A benefit of short-chain fatty acids
    • Li, J. M. et al. Dietary fructose-induced gut dysbiosis promotes mouse hippo-campal neuroinflammation: a benefit of short-chain fatty acids. Microbiome 7,98 (2019).
    • (2019) Microbiome , vol.7
    • Li, J.M.1
  • 124
    • 85067900645 scopus 로고    scopus 로고
    • Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells
    • Zhang, Q. et al. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells. Cell Res. 29, 516–532 (2019).
    • (2019) Cell Res , vol.29 , pp. 516-532
    • Zhang, Q.1
  • 125
    • 85069716044 scopus 로고    scopus 로고
    • Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes
    • Sorini, C. et al. Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes. Proc. Natl. Acad. Sci. USA https://doi.org/10.1073/pnas.1814558116 (2019).
    • (2019) Proc. Natl. Acad. Sci. USA
    • Sorini, C.1
  • 126
    • 85055415843 scopus 로고    scopus 로고
    • The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
    • Vatanen, T. et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature 562, 589–594 (2018).
    • (2018) Nature , vol.562 , pp. 589-594
    • Vatanen, T.1
  • 127
    • 85016122461 scopus 로고    scopus 로고
    • Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
    • Marino, E. et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat. Immunol. 18, 552–562 (2017).
    • (2017) Nat. Immunol , vol.18 , pp. 552-562
    • Marino, E.1
  • 128
    • 85049342446 scopus 로고    scopus 로고
    • Gut microbiota-stimulated innate lymphoid cells support beta-defensin 14 expression in pancreatic endocrine cells, preventing autoimmune diabetes
    • Miani, M. et al. Gut microbiota-stimulated innate lymphoid cells support beta-defensin 14 expression in pancreatic endocrine cells, preventing autoimmune diabetes. Cell Metab. 28, 557–572.e556 (2018).
    • (2018) Cell Metab , vol.28 , pp. 557-572
    • Miani, M.1
  • 129
    • 85059368920 scopus 로고    scopus 로고
    • A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity
    • Zegarra-Ruiz, D. F. et al. A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity. Cell Host Microbe 25, 113–127. e116 (2019).
    • (2019) Cell Host Microbe 25 , vol.e116 , pp. 113-127
    • Zegarra-Ruiz, D.F.1
  • 130
    • 85049131429 scopus 로고    scopus 로고
    • Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT
    • Haak, B. W. et al. Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood 131, 2978–2986 (2018).
    • (2018) Blood , vol.131 , pp. 2978-2986
    • Haak, B.W.1
  • 131
    • 85070328736 scopus 로고    scopus 로고
    • Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat
    • Antunes, K. H. et al. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response. Nat. Commun. 10, 3273 (2019).
    • (2019) Commun , vol.10 , pp. 3273
    • Antunes, K.H.1
  • 132
    • 85046816552 scopus 로고    scopus 로고
    • Dietary fiber confers protection against flu by shaping Ly6c (−) patrolling monocyte hematopoiesis and CD8(+) T cell metabolism
    • Trompette, A. et al. Dietary fiber confers protection against flu by shaping Ly6c (−) patrolling monocyte hematopoiesis and CD8(+) T cell metabolism. Immunity 48, 992–1005.e1008 (2018).
    • (2018) Immunity 48 , vol.e1008 , pp. 992-1005
    • Trompette, A.1
  • 133
    • 85040220188 scopus 로고    scopus 로고
    • Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
    • Lucas, S. et al. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat. Commun. 9, 55 (2018).
    • (2018) Nat. Commun. , vol.9
    • Lucas, S.1
  • 134
    • 85051746264 scopus 로고    scopus 로고
    • Microbial tryptophan catabolites in health and disease
    • Roager, H. M. & Licht, T. R. Microbial tryptophan catabolites in health and disease. Nat. Commun. 9, 3294 (2018).
    • (2018) Nat. Commun. , vol.9
    • Roager, H.M.1    Licht, T.R.2
  • 135
    • 84966526506 scopus 로고    scopus 로고
    • CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
    • Lamas, B. et al. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat. Med. 22, 598–605 (2016).
    • (2016) Nat. Med , vol.22 , pp. 598-605
    • Lamas, B.1
  • 136
    • 85035117631 scopus 로고    scopus 로고
    • Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases
    • Nikolaus, S. et al. Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases. Gastroenterology 153, 1504–1516.e1502 (2017).
    • (2017) Gastroenterology 153 , vol.e1502 , pp. 1504-1516
    • Nikolaus, S.1
  • 137
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • Zelante, T. et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39, 372–385 (2013).
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1
  • 138
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • Yano, J. M. et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161, 264–276 (2015).
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1
  • 139
    • 85047213592 scopus 로고    scopus 로고
    • Gut microbiota regulation of tryptophan metabolism in health and disease
    • Agus, A., Planchais, J. & Sokol, H. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23, 716–724 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 716-724
    • Agus, A.1    Planchais, J.2    Sokol, H.3
  • 140
    • 85052696566 scopus 로고    scopus 로고
    • Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation
    • Lv, Q. et al. Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation. Cell Death Dis. 9, 890 (2018).
    • (2018) Cell Death Dis , vol.9
    • Lv, Q.1
  • 141
    • 85053900152 scopus 로고    scopus 로고
    • The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity
    • Metidji, A. et al. The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity. Immunity 49, 353–362.e355 (2018).
    • (2018) Immunity 49 , vol.e355 , pp. 353-362
    • Metidji, A.1
  • 142
    • 85012142802 scopus 로고    scopus 로고
    • Feedback control of AHR signalling regulates intestinal immunity
    • Schiering, C. et al. Feedback control of AHR signalling regulates intestinal immunity. Nature 542, 242–245 (2017).
    • (2017) Nature , vol.542 , pp. 242-245
    • Schiering, C.1
  • 143
    • 85027063083 scopus 로고    scopus 로고
    • Lactobacillus reuteri induces gut intraepithelial CD4 (+)CD8alphaalpha(+) T cells
    • Cervantes-Barragan, L. et al. Lactobacillus reuteri induces gut intraepithelial CD4 (+)CD8alphaalpha(+) T cells. Science (New York, NY) 357, 806–810 (2017).
    • (2017) Science (New York, NY) , vol.357 , pp. 806-810
    • Cervantes-Barragan, L.1
  • 144
    • 85057717871 scopus 로고    scopus 로고
    • Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease
    • Swimm, A. et al. Indoles derived from intestinal microbiota act via type I interferon signaling to limit graft-versus-host disease. Blood 132, 2506–2519 (2018).
    • (2018) Blood , vol.132 , pp. 2506-2519
    • Swimm, A.1
  • 145
    • 85056573910 scopus 로고    scopus 로고
    • Plant-derived exosomal microRNAs shape the gut microbiota
    • Teng, Y. et al. Plant-derived exosomal microRNAs shape the gut microbiota. Cell Host Microbe 24, 637–652.e638 (2018).
    • (2018) Cell Host Microbe 24 , vol.e638 , pp. 637-652
    • Teng, Y.1
  • 146
    • 85067509865 scopus 로고    scopus 로고
    • Indole signaling at the host–microbiota–pathogen interface
    • Kumar, A. & Sperandio, V. Indole signaling at the host–microbiota–pathogen interface. mBio 10, https://doi.org/10.1128/mBio.01031-19 (2019).
    • (2019) Mbio , vol.10
    • Kumar, A.1    Sperandio, V.2
  • 147
    • 85040713985 scopus 로고    scopus 로고
    • The microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system
    • Kohli, N. et al. The microbiota metabolite indole inhibits Salmonella virulence: involvement of the PhoPQ two-component system. PLoS ONE 13, e0190613 (2018).
    • (2018) Plos ONE , vol.13
    • Kohli, N.1
  • 148
    • 85021811792 scopus 로고    scopus 로고
    • Indoleacrylic acid produced by commensal Peptos-treptococcus species suppresses inflammation
    • Wlodarska, M. et al. Indoleacrylic acid produced by commensal Peptos-treptococcus species suppresses inflammation. Cell Host Microbe 22, 25–37.e26 (2017).
    • (2017) Cell Host Microbe 22 , vol.e26 , pp. 25-37
    • Wlodarska, M.1
  • 149
    • 85021792667 scopus 로고    scopus 로고
    • Bacteria tell us how to protect our intestine
    • Birchenough, G. & Hansson, G. C. Bacteria tell us how to protect our intestine. Cell Host Microbe 22, 3–4 (2017).
    • (2017) Cell Host Microbe , vol.22 , pp. 3-4
    • Birchenough, G.1    Hansson, G.C.2
  • 150
    • 85027129808 scopus 로고    scopus 로고
    • Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo
    • Jennis, M. et al. Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo. Neuro-gastroenterol. Motil. 30, https://doi.org/10.1111/nmo.13178 (2018).
    • (2018) Neuro-Gastroenterol. Motil , vol.30
    • Jennis, M.1
  • 151
    • 84907597269 scopus 로고    scopus 로고
    • Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
    • Venkatesh, M. et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41, 296–310 (2014).
    • (2014) Immunity , vol.41 , pp. 296-310
    • Venkatesh, M.1
  • 152
    • 85063962184 scopus 로고    scopus 로고
    • Gut microbiota metabolite indole propionic acid targets tryptophan biosynthesis in Mycobacterium tuberculosis
    • Negatu, D. A. et al. Gut microbiota metabolite indole propionic acid targets tryptophan biosynthesis in Mycobacterium tuberculosis. mBio 10, https://doi.org/10.1128/mBio.02781-18 (2019).
    • (2019) Mbio , pp. 10
    • Negatu, D.A.1
  • 153
    • 85047110060 scopus 로고    scopus 로고
    • Dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses
    • Iyer, S. S. et al. Dietary and microbial oxazoles induce intestinal inflammation by modulating aryl hydrocarbon receptor responses. Cell 173, 1123–1134.e1111 (2018).
    • (2018) Cell 173 , vol.e1111 , pp. 1123-1134
    • Iyer, S.S.1
  • 154
    • 85048952408 scopus 로고    scopus 로고
    • Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health
    • Laurans, L. et al. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat. Med. 24, 1113–1120 (2018).
    • (2018) Nat. Med , vol.24 , pp. 1113-1120
    • Laurans, L.1
  • 155
    • 85061192204 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor: An environmental sensor integrating immune responses in health and disease
    • Rothhammer, V. & Quintana, F. J. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat. Rev. Immunol. 19, 184–197 (2019).
    • (2019) Nat. Rev. Immunol. , vol.19 , pp. 184-197
    • Rothhammer, V.1    Quintana, F.J.2
  • 156
    • 85053902640 scopus 로고    scopus 로고
    • Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course
    • Nourbakhsh, B. et al. Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course. Ann. Clin. Transl. Neurol. 5, 1211–1221 (2018).
    • (2018) Ann. Clin. Transl. Neurol. , vol.5 , pp. 1211-1221
    • Nourbakhsh, B.1
  • 157
    • 85047764155 scopus 로고    scopus 로고
    • Microglial control of astrocytes in response to microbial metabolites
    • Rothhammer, V. et al. Microglial control of astrocytes in response to microbial metabolites. Nature 557, 724–728 (2018).
    • (2018) Nature , vol.557 , pp. 724-728
    • Rothhammer, V.1
  • 158
    • 84966658995 scopus 로고    scopus 로고
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
    • Rothhammer, V. et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat. Med. 22, 586–597 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 586-597
    • Rothhammer, V.1
  • 159
    • 85047778733 scopus 로고    scopus 로고
    • Brain inflammatory cascade controlled by gut-derived molecules
    • Wekerle, H. Brain inflammatory cascade controlled by gut-derived molecules. Nature 557, 642–643 (2018).
    • (2018) Nature , vol.557 , pp. 642-643
    • Wekerle, H.1
  • 160
    • 84976434510 scopus 로고    scopus 로고
    • Regulating inflammation with microbial metabolites
    • Marsland, B. J. Regulating inflammation with microbial metabolites. Nat. Med. 22, 581–583 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 581-583
    • Marsland, B.J.1
  • 161
    • 85055470325 scopus 로고    scopus 로고
    • The gut microbiota metabolite indole alleviates liver inflammation in mice
    • Beaumont, M. et al. The gut microbiota metabolite indole alleviates liver inflammation in mice. Faseb J. https://doi.org/10.1096/fj.201800544 (2018).
    • (2018) Faseb J
    • Beaumont, M.1
  • 162
    • 85045954399 scopus 로고    scopus 로고
    • Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages
    • Krishnan, S. et al. Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages. Cell Rep. 23, 1099–1111 (2018).
    • (2018) Cell Rep , vol.23 , pp. 1099-1111
    • Krishnan, S.1
  • 163
    • 85056910175 scopus 로고    scopus 로고
    • Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice
    • Hendrikx, T. et al. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut 68, 1504–1515 (2018).
    • (2018) Gut , vol.68 , pp. 1504-1515
    • Hendrikx, T.1
  • 164
    • 85056004239 scopus 로고    scopus 로고
    • Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome
    • Natividad, J. M. et al. Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome. Cell Metab. 28, 737–749.e734 (2018).
    • (2018) Cell Metab , vol.28 , pp. 737-749
    • Natividad, J.M.1
  • 165
    • 85068174104 scopus 로고    scopus 로고
    • The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
    • Virtue, A. T. et al. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Sci. Transl. Med. 11, https://doi. org/10.1126/scitranslmed.aav1892 (2019).
    • (2019) Sci. Transl. Med , pp. 11
    • Virtue, A.T.1
  • 166
    • 84912137874 scopus 로고    scopus 로고
    • Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells
    • Chimerel, C. et al. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Rep. 9, 1202–1208 (2014).
    • (2014) Cell Rep , vol.9 , pp. 1202-1208
    • Chimerel, C.1
  • 167
    • 84908072394 scopus 로고    scopus 로고
    • Discovery and characterization of gut microbiota dec-arboxylases that can produce the neurotransmitter tryptamine
    • Williams, B. B. et al. Discovery and characterization of gut microbiota dec-arboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 16, 495–503 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 495-503
    • Williams, B.B.1
  • 168
    • 85048206165 scopus 로고    scopus 로고
    • Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion
    • Bhattarai, Y. et al. Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion. Cell Host Microbe 23, 775–785.e775 (2018).
    • (2018) Cell Host Microbe 23 , vol.e775 , pp. 775-785
    • Bhattarai, Y.1
  • 170
    • 85029128985 scopus 로고    scopus 로고
    • Commensal bacteria make GPCR ligands that mimic human signalling molecules
    • Cohen, L. J. et al. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549, 48–53 (2017).
    • (2017) Nature , vol.549 , pp. 48-53
    • Cohen, L.J.1
  • 171
    • 85065520847 scopus 로고    scopus 로고
    • A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology
    • Chen, H. et al. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. Cell 177, 1217–1231.e1218 (2019).
    • (2019) Cell 177 , vol.e1218 , pp. 1217-1231
    • Chen, H.1
  • 172
    • 85044279631 scopus 로고    scopus 로고
    • Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
    • Jia, W., Xie, G. & Jia, W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat. Rev. Gastroenterol. Hepatol. 15, 111–128 (2018).
    • (2018) Nat. Rev. Gastroenterol. Hepatol. , vol.15 , pp. 111-128
    • Jia, W.1    Xie, G.2    Jia, W.3
  • 173
    • 85052980329 scopus 로고    scopus 로고
    • Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration
    • Jain, U. et al. Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration. Cell Host Microbe 24, 353–363.e355 (2018).
    • (2018) Cell Host Microbe 24 , vol.e355 , pp. 353-363
    • Jain, U.1
  • 174
    • 85058694912 scopus 로고    scopus 로고
    • Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Rep
    • Wang, K. et al. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Rep. 26, 222–235.e225 (2019).
    • (2019) 26 , vol.e225 , pp. 222-235
    • Wang, K.1
  • 175
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie, C. G. et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205–208 (2015).
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 176
    • 84920570015 scopus 로고    scopus 로고
    • Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile
    • Greathouse, K. L., Harris, C. C. & Bultman, S. J. Dysfunctional families: Clostridium scindens and secondary bile acids inhibit the growth of Clostridium difficile. Cell Metab. 21, 9–10 (2015).
    • (2015) Cell Metab , vol.21 , pp. 9-10
    • Greathouse, K.L.1    Harris, C.C.2    Bultman, S.J.3
  • 177
    • 85046401953 scopus 로고    scopus 로고
    • Microbiota-derived metabolic factors reduce Campylobacteriosis in mice
    • Sun, X. et al. Microbiota-derived metabolic factors reduce Campylobacteriosis in mice. Gastroenterology 154, 1751–1763.e1752 (2018).
    • (2018) Gastroenterology 154 , vol.e1752 , pp. 1751-1763
    • Sun, X.1
  • 178
    • 85059667892 scopus 로고    scopus 로고
    • Bile Acid 7alpha-dehydroxylating gut bacteria secrete antibiotics that inhibit clostridium difficile: Role of secondary bile acids. Cell
    • Kang, J. D. et al. Bile Acid 7alpha-dehydroxylating gut bacteria secrete antibiotics that inhibit clostridium difficile: role of secondary bile acids. Cell Chem. Biol. 26, 27–34.e24 (2019).
    • (2019) Chem. Biol. 26 , vol.e24 , pp. 27-34
    • Kang, J.D.1
  • 179
    • 85064969153 scopus 로고    scopus 로고
    • Intestinal bile acids induce a morphotype switch in vancomycin-resistant Enterococcus that facilitates intestinal colonization
    • McKenney, P. T. et al. Intestinal bile acids induce a morphotype switch in vancomycin-resistant Enterococcus that facilitates intestinal colonization. Cell Host Microbe 25, 695–705.e695 (2019).
    • (2019) Cell Host Microbe 25 , vol.e695 , pp. 695-705
    • McKenney, P.T.1
  • 180
    • 84944754899 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pou-chitis associated with the infection
    • Weingarden, A. R. et al. Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pou-chitis associated with the infection. J. Clin. Gastroenterol. 50, 624–630 (2016).
    • (2016) J. Clin. Gastroenterol. , vol.50 , pp. 624-630
    • Weingarden, A.R.1
  • 181
    • 85063786613 scopus 로고    scopus 로고
    • Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat
    • Wirbel, J. et al. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat. Med. 25, 679–689 (2019).
    • (2019) Med , vol.25 , pp. 679-689
    • Wirbel, J.1
  • 182
    • 85067007334 scopus 로고    scopus 로고
    • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer
    • Yachida, S. et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat. Med. 25, 968–976 (2019).
    • (2019) Nat. Med. , vol.25 , pp. 968-976
    • Yachida, S.1
  • 183
    • 85061095007 scopus 로고    scopus 로고
    • FXR regulates intestinal cancer stem cell proliferation
    • Fu, T. et al. FXR regulates intestinal cancer stem cell proliferation. Cell 176, 1098–1112.e1018 (2019).
    • (2019) Cell 176 , vol.e1018 , pp. 1098-1112
    • Fu, T.1
  • 184
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto, S. et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499, 97–101 (2013).
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1
  • 185
    • 84922336333 scopus 로고    scopus 로고
    • Microbiome: The bacterial tightrope
    • Bourzac, K. Microbiome: the bacterial tightrope. Nature 516, S14–S16 (2014).
    • (2014) Nature , vol.516 , pp. S14-S16
    • Bourzac, K.1
  • 186
    • 85047415625 scopus 로고    scopus 로고
    • Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
    • Ma, C. et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science (New York, NY) 360, https://doi.org/10.1126/science. aan5931 (2018).
    • (2018) Science (New York, NY) , vol.360
    • Ma, C.1
  • 187
    • 85047447962 scopus 로고    scopus 로고
    • Cancer immunity thwarted by the microbiome
    • Hartmann, N. & Kronenberg, M. Cancer immunity thwarted by the microbiome. Science (New York, NY) 360, 858–859 (2018).
    • (2018) Science (New York, NY) , vol.360 , pp. 858-859
    • Hartmann, N.1    Kronenberg, M.2
  • 188
    • 85064327066 scopus 로고    scopus 로고
    • CXCR6 inhibits hepatocarcinogenesis by promoting natural killer T-and CD4(+) T-cell-dependent control of senescence
    • Mossanen, J. C. et al. CXCR6 inhibits hepatocarcinogenesis by promoting natural killer T-and CD4(+) T-cell-dependent control of senescence. Gastroenterology 156, 1877–1889.e1874 (2019).
    • (2019) Gastroenterology , vol.156 , pp. 1877-1889
    • Mossanen, J.C.1
  • 189
    • 85063282512 scopus 로고    scopus 로고
    • Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis
    • Liao, X. et al. Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis. EbioMedicine https://doi.org/10.1016/j.ebiom.2019.03.057 (2019).
    • (2019) Ebiomedicine
    • Liao, X.1
  • 190
    • 84992327147 scopus 로고    scopus 로고
    • Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis
    • De Vadder, F. et al. Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. Cell Metab. 24, 151–157 (2016).
    • (2016) Cell Metab , vol.24 , pp. 151-157
    • de Vadder, F.1
  • 191
    • 85050992801 scopus 로고    scopus 로고
    • Accumulation of succinate controls activation of adipose tissue thermogenesis
    • Mills, E. L. et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature 560, 102–106 (2018).
    • (2018) Nature , vol.560 , pp. 102-106
    • Mills, E.L.1
  • 192
    • 85056322995 scopus 로고    scopus 로고
    • An unexpected trigger for calorie burning in brown fat
    • Hui, S. & Rabinowitz, J. D. An unexpected trigger for calorie burning in brown fat. Nature 560, 38–39 (2018).
    • (2018) Nature , vol.560 , pp. 38-39
    • Hui, S.1    Rabinowitz, J.D.2
  • 193
    • 85041920895 scopus 로고    scopus 로고
    • Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
    • Serena, C. et al. Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ISME J. 12, 1642–1657 (2018).
    • (2018) ISME J , vol.12 , pp. 1642-1657
    • Serena, C.1
  • 194
    • 85032683130 scopus 로고    scopus 로고
    • Intestinal microbiota are involved in the immunomodulatory activities of longan polysaccharide
    • Zhang, J. et al. Intestinal microbiota are involved in the immunomodulatory activities of longan polysaccharide. Mol. Nutr. Food Res. 61, 1700466 (2017).
    • (2017) Mol. Nutr. Food Res. , vol.61
    • Zhang, J.1
  • 195
    • 84902664217 scopus 로고    scopus 로고
    • Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis
    • Haraguchi, T. et al. Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis. J. Agric. Food Chem. 62, 5589–5594 (2014).
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 5589-5594
    • Haraguchi, T.1
  • 196
    • 85047291496 scopus 로고    scopus 로고
    • A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling
    • Schneider, C. et al. A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell 174, 271–284.e214 (2018).
    • (2018) Cell 174 , vol.e214 , pp. 271-284
    • Schneider, C.1
  • 197
    • 85049510740 scopus 로고    scopus 로고
    • Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit
    • Nadjsombati, M. S. et al. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49, 33–41.e37 (2018).
    • (2018) Immunity , vol.49 , pp. 33-41
    • Nadjsombati, M.S.1
  • 198
    • 85047302258 scopus 로고    scopus 로고
    • Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine
    • Lei, W. et al. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc. Natl. Acad. Sci. USA 115, 5552–5557 (2018).
    • (2018) Proc. Natl. Acad. Sci. USA , vol.115 , pp. 5552-5557
    • Lei, W.1
  • 199
    • 85049027697 scopus 로고    scopus 로고
    • The tuft cell-ILC2 circuit integrates intestinal defense and homeostasis
    • Hayakawa, Y. & Wang, T. C. The tuft cell-ILC2 circuit integrates intestinal defense and homeostasis. Cell 174, 251–253 (2018).
    • (2018) Cell , vol.174 , pp. 251-253
    • Hayakawa, Y.1    Wang, T.C.2
  • 200
    • 85049465185 scopus 로고    scopus 로고
    • Getting a taste for parasites in the gut
    • Loke, P. & Cadwell, K. Getting a taste for parasites in the gut. Immunity 49,16–18 (2018).
    • (2018) Immunity , vol.49 , pp. 16-18
    • Loke, P.1    Cadwell, K.2
  • 201
    • 85054385171 scopus 로고    scopus 로고
    • Succinate receptor mediates intestinal inflammation and fibrosis
    • Macias-Ceja, D. C. et al. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 12, 178–187 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 178-187
    • Macias-Ceja, D.C.1
  • 202
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha
    • Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature 496, 238–242 (2013).
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1
  • 203
    • 84990845578 scopus 로고    scopus 로고
    • Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
    • Mills, E. L. et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167, 457–470.e413 (2016).
    • (2016) Cell , vol.167 , pp. 457-470
    • Mills, E.L.1
  • 204
    • 85061132591 scopus 로고    scopus 로고
    • GPR31-dependent dendrite protrusion of intestinal CX3CR1(+) cells by bacterial metabolites
    • Morita, N. et al. GPR31-dependent dendrite protrusion of intestinal CX3CR1(+) cells by bacterial metabolites. Nature 566, 110–114 (2019).
    • (2019) Nature , vol.566 , pp. 110-114
    • Morita, N.1
  • 206
    • 85057565842 scopus 로고    scopus 로고
    • Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development
    • Lee, Y. S. et al. Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development. Cell Host Microbe 24, 833–846.e836 (2018).
    • (2018) Cell Host Microbe 24 , vol.e836 , pp. 833-846
    • Lee, Y.S.1
  • 207
    • 85056956630 scopus 로고    scopus 로고
    • Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens drosophila lifespan
    • Iatsenko, I., Boquete, J. P. & Lemaitre, B. Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens drosophila lifespan. Immunity 49, 929–942.e925 (2018).
    • (2018) Immunity 49 , vol.e925 , pp. 929-942
    • Iatsenko, I.1    Boquete, J.P.2    Lemaitre, B.3
  • 208
    • 85048539297 scopus 로고    scopus 로고
    • Accessing bioactive natural products from the human microbiome
    • Milshteyn, A., Colosimo, D. A. & Brady, S. F. Accessing bioactive natural products from the human microbiome. Cell Host Microbe 23, 725–736 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 725-736
    • Milshteyn, A.1    Colosimo, D.A.2    Brady, S.F.3
  • 209
    • 85026755340 scopus 로고    scopus 로고
    • The microbial metabolite ne protects from influenza through type I interferon
    • New York, NY
    • Steed, A. L. et al. The microbial metabolite ne protects from influenza through type I interferon. Science (New York, NY) 357, 498–502 (2017).
    • (2017) Science , vol.357 , pp. 498-502
    • Steed, A.L.1
  • 210
    • 80054091498 scopus 로고    scopus 로고
    • Intestinal microbiota promote enteric virus replication and systemic pathogenesis
    • Kuss, S. K. et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science (New York, NY) 334, 249–252 (2011).
    • (2011) Science (New York, NY) , vol.334 , pp. 249-252
    • Kuss, S.K.1
  • 211
    • 85031756832 scopus 로고    scopus 로고
    • Take DAT, flu!
    • Lobel, L. & Garrett, W. S. Take DAT, flu! Immunity 47, 400–402 (2017).
    • (2017) Immunity , vol.47 , pp. 400-402
    • Lobel, L.1    Garrett, W.S.2
  • 212
    • 85046035681 scopus 로고    scopus 로고
    • A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells
    • Chang, Y. L. et al. A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. Mucosal Immunol. 12, 457–467 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 457-467
    • Chang, Y.L.1
  • 213
    • 85060518406 scopus 로고    scopus 로고
    • A gut punch fights cancer and infection
    • Reticker-Flynn, N. E. & Engleman, E. G. A gut punch fights cancer and infection. Nature 565, 573–574 (2019).
    • (2019) Nature , vol.565 , pp. 573-574
    • Reticker-Flynn, N.E.1    Engleman, E.G.2
  • 214
    • 85059797421 scopus 로고    scopus 로고
    • Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat
    • Singh, R. et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat. Commun. 10, 89 (2019).
    • (2019) Commun , vol.10 , pp. 89
    • Singh, R.1
  • 215
    • 85069561571 scopus 로고    scopus 로고
    • The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
    • Andreux, P. A. et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat. Metab. 1, 595–603 (2019).
    • (2019) Nat. Metab. , vol.1 , pp. 595-603
    • Andreux, P.A.1
  • 216
    • 84949255269 scopus 로고    scopus 로고
    • Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
    • Levy, M. et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163, 1428–1443 (2015).
    • (2015) Cell , vol.163 , pp. 1428-1443
    • Levy, M.1
  • 217
    • 85054610326 scopus 로고    scopus 로고
    • Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion
    • Connolly, J. P. R. et al. Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion. Nat. Commun. 9, 4187 (2018).
    • (2018) Nat. Commun , vol.9 , pp. 4187
    • Connolly, J.P.R.1
  • 218
    • 85055083712 scopus 로고    scopus 로고
    • Microbially produced imidazole propionate impairs insulin signaling through mTORC1
    • Koh, A. et al. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell 175, 947–961.e917 (2018).
    • (2018) Cell 175 , vol.e917 , pp. 947-961
    • Koh, A.1
  • 219
    • 85064911992 scopus 로고    scopus 로고
    • Gut microbiome-derived phenyl sulfate contributes to albu-minuria in diabetic kidney disease
    • Kikuchi, K. et al. Gut microbiome-derived phenyl sulfate contributes to albu-minuria in diabetic kidney disease. Nat. Commun. 10, 1835 (2019).
    • (2019) Nat. Commun , vol.10 , pp. 1835
    • Kikuchi, K.1
  • 220
    • 85065235901 scopus 로고    scopus 로고
    • Deciphering the chemical lexicon of host–gut microbiota interactions
    • Nicolas, G. R. & Chang, P. V. Deciphering the chemical lexicon of host–gut microbiota interactions. Trends Pharm. Sci. 40, 430–445 (2019).
    • (2019) Trends Pharm. Sci. , vol.40 , pp. 430-445
    • Nicolas, G.R.1    Chang, P.V.2
  • 221
    • 85064541109 scopus 로고    scopus 로고
    • Compartmentalized gut lymph node drainage dictates adaptive immune responses
    • Esterhazy, D. et al. Compartmentalized gut lymph node drainage dictates adaptive immune responses. Nature 569, 126–130 (2019).
    • (2019) Nature , vol.569 , pp. 126-130
    • Esterhazy, D.1
  • 222
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov, Y. P. et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28, 546–558 (2008).
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1
  • 223
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3(–) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • Huber, S. et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3(–) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34, 554–565 (2011).
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1
  • 224
    • 78650209225 scopus 로고    scopus 로고
    • T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells
    • Park, S. G. et al. T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells. Immunity 33, 791–803 (2010).
    • (2010) Immunity , vol.33 , pp. 791-803
    • Park, S.G.1
  • 225
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science (New York, NY) 331, 337–341 (2011).
    • (2011) Science (New York, NY) , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 226
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round, J. L. & Mazmanian, S. K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl. Acad. Sci. USA 107, 12204–12209 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 227
    • 79956315886 scopus 로고    scopus 로고
    • Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    • Geuking, M. B. et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34, 794–806 (2011).
    • (2011) Immunity , vol.34 , pp. 794-806
    • Geuking, M.B.1
  • 228
    • 84940547063 scopus 로고    scopus 로고
    • MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells
    • Ohnmacht, C. et al. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells. Science (New York, NY) 349, 989–993 (2015).
    • (2015) Science (New York, NY) , vol.349 , pp. 989-993
    • Ohnmacht, C.1
  • 229
    • 84961833659 scopus 로고    scopus 로고
    • Foxp3(+) T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation
    • Yang, B. H. et al. Foxp3(+) T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 9, 444–457 (2016).
    • (2016) Mucosal Immunol , vol.9 , pp. 444-457
    • Yang, B.H.1
  • 230
    • 85065074049 scopus 로고    scopus 로고
    • Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice
    • Torres, J. et al. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice. Gut https://doi.org/10.1136/gutjnl-2018-317855 (2019).
    • (2019) Gut
    • Torres, J.1
  • 231
    • 85047295547 scopus 로고    scopus 로고
    • Extrathymically generated regulatory T cells establish a niche for intestinal border-dwelling bacteria and affect physiologic metabolite balance
    • Campbell, C. et al. Extrathymically generated regulatory T cells establish a niche for intestinal border-dwelling bacteria and affect physiologic metabolite balance. Immunity 48, 1245–1257.e1249 (2018).
    • (2018) Immunity 48 , vol.e1249 , pp. 1245-1257
    • Campbell, C.1
  • 232
    • 85042146013 scopus 로고    scopus 로고
    • C-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
    • Xu, M. et al. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature 554, 373–377 (2018).
    • (2018) Nature , vol.554 , pp. 373-377
    • Xu, M.1
  • 233
    • 85061712972 scopus 로고    scopus 로고
    • C-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis
    • Neumann, C. et al. c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis. Nat. Immunol. 20, 471–481 (2019).
    • (2019) Nat. Immunol , vol.20 , pp. 471-481
    • Neumann, C.1
  • 234
    • 85038580888 scopus 로고    scopus 로고
    • Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation. Sci. Immunol. 2
    • Chai, J. N. et al. Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation. Sci. Immunol. 2, eaal5068 (2017).
    • (2017) Eaal5068
    • Chai, J.N.1
  • 235
    • 84940077758 scopus 로고    scopus 로고
    • MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells
    • Sefik, E. et al. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORgamma(+) regulatory T cells. Science (New York, NY) 349, 993–997 (2015).
    • (2015) Science (New York, NY) , vol.349 , pp. 993-997
    • Sefik, E.1
  • 236
    • 85048335276 scopus 로고    scopus 로고
    • What came first: The microbiota or the Tr(egg) cells?
    • Gefen, T. & Geva-Zatorsky, N. What came first: the microbiota or the Tr(egg) cells? Immunity 48, 1072–1074 (2018).
    • (2018) Immunity , vol.48 , pp. 1072-1074
    • Gefen, T.1    Geva-Zatorsky, N.2
  • 237
    • 84901065053 scopus 로고    scopus 로고
    • The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
    • Obata, Y. et al. The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat. Immunol. 15, 571–579 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 571-579
    • Obata, Y.1
  • 238
    • 85055112475 scopus 로고    scopus 로고
    • Subcellular antigen localization in commensal E. Coli is critical for T cell activation and induction of specific tolerance
    • Bennek, E. et al. Subcellular antigen localization in commensal E. coli is critical for T cell activation and induction of specific tolerance. Mucosal Immunol. 12, 97–107 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 97-107
    • Bennek, E.1
  • 239
    • 84944445669 scopus 로고    scopus 로고
    • A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function
    • Telesford, K. M. et al. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function. Gut Microbes 6, 234–242 (2015).
    • (2015) Gut Microbes , vol.6 , pp. 234-242
    • Telesford, K.M.1
  • 240
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian, S. K., Round, J. L. & Kasper, D. L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453, 620–625 (2008).
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 241
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (New York
    • Round, J. L. et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (New York, NY) 332, 974–977 (2011).
    • (2011) NY) , vol.332 , pp. 974-977
    • Round, J.L.1
  • 242
    • 84966293351 scopus 로고    scopus 로고
    • Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
    • Chu, H. et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science (New York, NY) 352, 1116–1120 (2016).
    • (2016) Science (New York, NY) , vol.352 , pp. 1116-1120
    • Chu, H.1
  • 243
    • 85026463382 scopus 로고    scopus 로고
    • Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
    • Bel, S. et al. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine. Science (New York, NY) 357, 1047–1052 (2017).
    • (2017) Science (New York, NY) , vol.357 , pp. 1047-1052
    • Bel, S.1
  • 244
    • 84961262270 scopus 로고    scopus 로고
    • The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation
    • Kabat, A. M. et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife 5, e12444 (2016).
    • (2016) Elife , vol.5
    • Kabat, A.M.1
  • 245
    • 85040543602 scopus 로고    scopus 로고
    • Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice
    • Pott, J., Kabat, A. M. & Maloy, K. J. Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice. Cell Host Microbe 23, 191–202.e194 (2018).
    • (2018) Cell Host Microbe 23 , vol.e194 , pp. 191-202
    • Pott, J.1    Kabat, A.M.2    Maloy, K.J.3
  • 246
    • 85042638378 scopus 로고    scopus 로고
    • Autophagy: Suicide prevention hotline for the gut epithelium
    • Grizotte-Lake, M. & Vaishnava, S. Autophagy: suicide prevention hotline for the gut epithelium. Cell Host Microbe 23, 147–148 (2018).
    • (2018) Cell Host Microbe , vol.23 , pp. 147-148
    • Grizotte-Lake, M.1    Vaishnava, S.2
  • 247
    • 85028552559 scopus 로고    scopus 로고
    • Host-microbiota interactions and adaptive immunity
    • McCoy, K. D., Ronchi, F. & Geuking, M. B. Host-microbiota interactions and adaptive immunity. Immunol. Rev. 279, 63–69 (2017).
    • (2017) Immunol. Rev. , vol.279 , pp. 63-69
    • McCoy, K.D.1    Ronchi, F.2    Geuking, M.B.3
  • 248
    • 84907000772 scopus 로고    scopus 로고
    • Commensal bacteria protect against food allergen sensitization
    • Stefka, A. T. et al. Commensal bacteria protect against food allergen sensitization. Proc. Natl. Acad. Sci. USA 111, 13145–13150 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 13145-13150
    • Stefka, A.T.1
  • 249
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
    • Atarashi, K. et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500, 232–236 (2013).
    • (2013) Nature , vol.500 , pp. 232-236
    • Atarashi, K.1
  • 250
    • 85047070106 scopus 로고    scopus 로고
    • Roseburia intestinalis-derived flagellin is a negative regulator of intestinal inflammation
    • Quan, Y. et al. Roseburia intestinalis-derived flagellin is a negative regulator of intestinal inflammation. Biochem. Biophys. Res. Commun. 501, 791–799 (2018).
    • (2018) Biochem. Biophys. Res. Commun. , vol.501 , pp. 791-799
    • Quan, Y.1
  • 251
    • 85068214495 scopus 로고    scopus 로고
    • Pathogenic autoreactive T and B cells cross-react with mimo-topes expressed by a common human gut commensal to trigger autoimmunity
    • Ruff, W. E. et al. Pathogenic autoreactive T and B cells cross-react with mimo-topes expressed by a common human gut commensal to trigger autoimmunity. Cell Host Microbe 26, 100–113.e8 (2019).
    • (2019) Cell Host Microbe , vol.26 , pp. 100-113
    • Ruff, W.E.1
  • 252
    • 84892774558 scopus 로고    scopus 로고
    • Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells
    • An, D. et al. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 156, 123–133 (2014).
    • (2014) Cell , vol.156 , pp. 123-133
    • An, D.1
  • 253
    • 85054406407 scopus 로고    scopus 로고
    • Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A
    • Chan, J. L. et al. Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A. Mucosal Immunol. 12, 164–177 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 164-177
    • Chan, J.L.1
  • 254
    • 85045739794 scopus 로고    scopus 로고
    • Role of Lactobacillus reuteri in human health and diseases
    • Mu, Q., Tavella, V. J. & Luo, X. M. Role of Lactobacillus reuteri in human health and diseases. Front. Microbiol. 9, 757 (2018).
    • (2018) Front. Microbiol. , vol.9 , Issue.757
    • Mu, Q.1    Tavella, V.J.2    Luo, X.M.3
  • 255
    • 85055076579 scopus 로고    scopus 로고
    • Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells
    • Verma, R. et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells. Sci. Immunol. 3, https://doi.org/10.1126/sciimmunol.aat6975 (2018).
    • (2018) Sci. Immunol , pp. 3
    • Verma, R.1
  • 256
    • 85072726673 scopus 로고    scopus 로고
    • Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
    • Zhai, R. et al. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice. Front. Cell Infect. Microbiol. 9, 239 (2019).
    • (2019) Front. Cell Infect. Microbiol. , vol.9 , Issue.239
    • Zhai, R.1
  • 257
    • 84978431877 scopus 로고    scopus 로고
    • The microbiota in adaptive immune homeostasis and disease
    • Honda, K. & Littman, D. R. The microbiota in adaptive immune homeostasis and disease. Nature 535, 75–84 (2016).
    • (2016) Nature , vol.535 , pp. 75-84
    • Honda, K.1    Littman, D.R.2
  • 259
    • 85068720390 scopus 로고    scopus 로고
    • The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells
    • Omenetti, S. et al. The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells. Immunity https://doi.org/10.1016/j. immuni.2019.05.004 (2019).
    • (2019) Immunity
    • Omenetti, S.1
  • 260
    • 85064841521 scopus 로고    scopus 로고
    • Colitis-induced Th17 cells increase the risk for severe subsequent Clostridium difficile infection
    • Saleh, M. M. et al. Colitis-induced Th17 cells increase the risk for severe subsequent Clostridium difficile infection. Cell Host Microbe 25, 756–765.e755 (2019).
    • (2019) Cell Host Microbe 25 , vol.e755 , pp. 756-765
    • Saleh, M.M.1
  • 261
    • 85030631674 scopus 로고    scopus 로고
    • Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
    • Kim, S. et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature 549, 528–532 (2017).
    • (2017) Nature , vol.549 , pp. 528-532
    • Kim, S.1
  • 262
    • 85057599323 scopus 로고    scopus 로고
    • Microbiota-driven interleukin-17-producing cells and eosi-nophils synergize to accelerate multiple myeloma progression
    • Calcinotto, A. et al. Microbiota-driven interleukin-17-producing cells and eosi-nophils synergize to accelerate multiple myeloma progression. Nat. Commun. 9, 4832 (2018).
    • (2018) Nat. Commun. , vol.9
    • Calcinotto, A.1
  • 263
    • 85062295351 scopus 로고    scopus 로고
    • Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans
    • Bacher, P. et al. Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176, 1340–1355.e1315 (2019).
    • (2019) Cell 176 , vol.e1315 , pp. 1340-1355
    • Bacher, P.1
  • 264
    • 85062192674 scopus 로고    scopus 로고
    • Commensal Candida albicans positively calibrates systemic Th17 immunological responses
    • Shao, T. Y. et al. Commensal Candida albicans positively calibrates systemic Th17 immunological responses. Cell Host Microbe 25, 404–417.e406 (2019).
    • (2019) Cell Host Microbe 25 , vol.e406 , pp. 404-417
    • Shao, T.Y.1
  • 265
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485–498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 266
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, I. I. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337–349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 267
    • 53649100675 scopus 로고    scopus 로고
    • ATP drives lamina propria T(H)17 cell differentiation
    • Atarashi, K. et al. ATP drives lamina propria T(H)17 cell differentiation. Nature 455, 808–812 (2008).
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1
  • 268
    • 84943638660 scopus 로고    scopus 로고
    • An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses
    • Sano, T. et al. An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell 163, 381–393 (2015).
    • (2015) Cell , vol.163 , pp. 381-393
    • Sano, T.1
  • 269
    • 84943639694 scopus 로고    scopus 로고
    • Th17 cell induction by adhesion of microbes to intestinal epithelial cells
    • Atarashi, K. et al. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 163, 367–380 (2015).
    • (2015) Cell , vol.163 , pp. 367-380
    • Atarashi, K.1
  • 270
    • 85062594747 scopus 로고    scopus 로고
    • Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis
    • Ladinsky, M. S. et al. Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. Science (New York, NY) 363 https://doi.org/10.1126/science.aat4042 (2019).
    • (2019) Science (New York, NY) , vol.363
    • Ladinsky, M.S.1
  • 271
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer, K. et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479, 538–541 (2011).
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1
  • 272
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalo-myelitis
    • Lee, Y. K., Menezes, J. S., Umesaki, Y. & Mazmanian, S. K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalo-myelitis. Proc. Natl. Acad. Sci. USA 108(Suppl. 1), 4615–4622 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 273
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu, H. J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815–827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1
  • 274
    • 84898685253 scopus 로고    scopus 로고
    • Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses
    • Lecuyer, E. et al. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 40, 608–620 (2014).
    • (2014) Immunity , vol.40 , pp. 608-620
    • Lecuyer, E.1
  • 275
    • 84960336674 scopus 로고    scopus 로고
    • Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation
    • Kumar, P. et al. Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation. Immunity 44, 659–671 (2016).
    • (2016) Immunity , vol.44 , pp. 659-671
    • Kumar, P.1
  • 276
    • 84901979873 scopus 로고    scopus 로고
    • Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
    • Yang, Y. et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature 510, 152–156 (2014).
    • (2014) Nature , vol.510 , pp. 152-156
    • Yang, Y.1
  • 277
    • 85003426944 scopus 로고    scopus 로고
    • Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
    • Tan, T. G. et al. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc. Natl. Acad. Sci. USA 113, E8141–E8150 (2016).
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. E8141-E8150
    • Tan, T.G.1
  • 278
    • 85032889925 scopus 로고    scopus 로고
    • Commensal propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation
    • Colliou, N. et al. Commensal propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation. J. Clin. Investig. 127, 3970–3986 (2017).
    • (2017) J. Clin. Investig. , vol.127 , pp. 3970-3986
    • Colliou, N.1
  • 279
    • 85036551713 scopus 로고    scopus 로고
    • Salt-responsive gut commensal modulates TH17 axis and disease
    • Wilck, N. et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551, 585–589 (2017).
    • (2017) Nature , vol.551 , pp. 585-589
    • Wilck, N.1
  • 280
    • 85062778782 scopus 로고    scopus 로고
    • Short-chain fatty acid propionate protects from hyper-tensive cardiovascular damage
    • Bartolomaeus, H. et al. Short-chain fatty acid propionate protects from hyper-tensive cardiovascular damage. Circulation 139, 1407–1421 (2019).
    • (2019) Circulation , vol.139 , pp. 1407-1421
    • Bartolomaeus, H.1
  • 281
    • 85040646955 scopus 로고    scopus 로고
    • Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response
    • Faraco, G. et al. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nat. Neurosci. 21, 240–249 (2018).
    • (2018) Nat. Neurosci. , vol.21 , pp. 240-249
    • Faraco, G.1
  • 282
    • 85032492045 scopus 로고    scopus 로고
    • Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
    • Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science (New York, NY) 358, 359–365 (2017).
    • (2017) Science (New York, NY) , vol.358 , pp. 359-365
    • Atarashi, K.1
  • 283
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice
    • Devkota, S. et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice. Nature 487, 104–108 (2012).
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1
  • 284
    • 42149162217 scopus 로고    scopus 로고
    • Notch regulates IL-10 production by T helper 1 cells
    • Rutz, S. et al. Notch regulates IL-10 production by T helper 1 cells. Proc. Natl. Acad. Sci. USA 105, 3497–3502 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3497-3502
    • Rutz, S.1
  • 285
    • 85028562926 scopus 로고    scopus 로고
    • Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
    • Pickard, J. M., Zeng, M. Y., Caruso, R. & Nunez, G. Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease. Immunol. Rev. 279, 70–89 (2017).
    • (2017) Immunol. Rev. , vol.279 , pp. 70-89
    • Pickard, J.M.1    Zeng, M.Y.2    Caruso, R.3    Nunez, G.4
  • 286
    • 85053790780 scopus 로고    scopus 로고
    • NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
    • Jie, Z. et al. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nat. Immunol. 19, 1224–1235 (2018).
    • (2018) Nat. Immunol. , vol.19 , pp. 1224-1235
    • Jie, Z.1
  • 288
    • 85041069011 scopus 로고    scopus 로고
    • Nutrients mediate intestinal bacteria-mucosal immune crosstalk
    • Ma, N. et al. Nutrients mediate intestinal bacteria-mucosal immune crosstalk. Front. Immunol. 9, 5 (2018).
    • (2018) Front. Immunol. , vol.9 , Issue.5
    • Ma, N.1
  • 289
    • 85044735956 scopus 로고    scopus 로고
    • CCL28-deficient mice have reduced iga antibody-secreting cells and an altered microbiota in the colon
    • Matsuo, K. et al. CCL28-deficient mice have reduced iga antibody-secreting cells and an altered microbiota in the colon. J. Immunol. 200, 800–809 (2018).
    • (2018) J. Immunol. , vol.200 , pp. 800-809
    • Matsuo, K.1
  • 290
    • 85062394869 scopus 로고    scopus 로고
    • Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science (New York
    • Grootjans, J. et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science (New York, NY) 363, 993–998 (2019).
    • (2019) NY) , vol.363 , pp. 993-998
    • Grootjans, J.1
  • 291
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • Hapfelmeier, S. et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science (New York, NY) 328, 1705–1709 (2010).
    • (2010) Science (New York, NY) , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1
  • 293
    • 85052289010 scopus 로고    scopus 로고
    • Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
    • Cho, H. et al. Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity. Mucosal Immunol. 12, 85–96 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 85-96
    • Cho, H.1
  • 294
    • 85044290881 scopus 로고    scopus 로고
    • The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial
    • Kawashima, T. et al. The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial. Sci. Rep. 8, 5065 (2018).
    • (2018) Sci. Rep. , vol.8
    • Kawashima, T.1
  • 295
    • 85043299252 scopus 로고    scopus 로고
    • Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis
    • Wilmore, J. R. et al. Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis. Cell Host Microbe 23, 302–311.e303 (2018).
    • (2018) Cell Host Microbe 23 , vol.e303 , pp. 302-311
    • Wilmore, J.R.1
  • 296
    • 85060111956 scopus 로고    scopus 로고
    • Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10
    • Rojas, O. L. et al. Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10. Cell 176, 610–624.e618 (2019).
    • (2019) Cell 176 , vol.e618 , pp. 610-624
    • Rojas, O.L.1
  • 297
    • 85051249056 scopus 로고    scopus 로고
    • The microbiome and autoimmunity: A paradigm from the gut–liver axis
    • Li, B., Selmi, C., Tang, R., Gershwin, M. E. & Ma, X. The microbiome and autoimmunity: a paradigm from the gut–liver axis. Cell Mol. Immunol. 15, 595–609 (2018).
    • (2018) Cell Mol. Immunol. , vol.15 , pp. 595-609
    • Li, B.1    Selmi, C.2    Tang, R.3    Gershwin, M.E.4    Ma, X.5
  • 298
    • 85017350184 scopus 로고    scopus 로고
    • High-avidity IgA protects the intestine by enchaining growing bacteria
    • Moor, K. et al. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature 544, 498–502 (2017).
    • (2017) Nature , vol.544 , pp. 498-502
    • Moor, K.1
  • 299
    • 85042758014 scopus 로고    scopus 로고
    • FcalphaRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming
    • Hansen, I. S. et al. FcalphaRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nat. Commun. 9, 863 (2018).
    • (2018) Nat. Commun , vol.9 , pp. 863
    • Hansen, I.S.1
  • 300
    • 85060185009 scopus 로고    scopus 로고
    • ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
    • Proietti, M. et al. ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens. Nat. Commun. 10, 250 (2019).
    • (2019) Nat. Commun , vol.10 , pp. 250
    • Proietti, M.1
  • 301
    • 85069971615 scopus 로고    scopus 로고
    • Nutrient sensing in CD11c cells alters the gut microbiota to regulate food intake and body mass
    • Chagwedera, D. N. et al. Nutrient sensing in CD11c cells alters the gut microbiota to regulate food intake and body mass. Cell Metab. https://doi.org/10.1016/j.cmet.2019.05.002 (2019).
    • (2019) Cell Metab
    • Chagwedera, D.N.1
  • 302
    • 85053769565 scopus 로고    scopus 로고
    • IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria
    • Nakajima, A. et al. IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria. J. Exp. Med. 215, 2019–2034 (2018).
    • (2018) J. Exp. Med , vol.215 , pp. 2019-2034
    • Nakajima, A.1
  • 303
    • 85046424492 scopus 로고    scopus 로고
    • Microbial ecology perturbation in human IgA deficiency
    • Fadlallah, J. et al. Microbial ecology perturbation in human IgA deficiency. Sci. Transl. Med. 10, eaan1167 (2018).
    • (2018) Sci. Transl. Med , vol.10
    • Fadlallah, J.1
  • 304
    • 85053523772 scopus 로고    scopus 로고
    • Gut microbiota: IgA protects the pioneers
    • Schofield, W. B. & Palm, N. W. Gut microbiota: IgA protects the pioneers. Curr. Biol. 28, R1117–R1119 (2018).
    • (2018) Curr. Biol. , vol.28 , pp. R1117-R1119
    • Schofield, W.B.1    Palm, N.W.2
  • 306
    • 85068727387 scopus 로고    scopus 로고
    • Characterization of transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells
    • Pokrovskii, M. et al. Characterization of transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells. Immunity https://doi.org/10.1016/j.immuni.2019.06.001 (2019).
    • (2019) Immunity
    • Pokrovskii, M.1
  • 307
    • 84983780960 scopus 로고    scopus 로고
    • The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome
    • Gury-BenAri, M. et al. The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome. Cell 166, 1231–1246. e1213 (2016).
    • (2016) Cell 166 , vol.e1213 , pp. 1231-1246
    • Gury-Benari, M.1
  • 308
    • 85044843984 scopus 로고    scopus 로고
    • Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation
    • Emgard, J. et al. Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation. Immunity 48, 120–132.e128 (2018).
    • (2018) Immunity , vol.48 , pp. 120-132
    • Emgard, J.1
  • 309
    • 84878737123 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
    • Hepworth, M. R. et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature 498, 113–117 (2013).
    • (2013) Nature , vol.498 , pp. 113-117
    • Hepworth, M.R.1
  • 310
    • 84889247024 scopus 로고    scopus 로고
    • Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis
    • Kruglov, A. A. et al. Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis. Science (New York, NY) 342, 1243–1246 (2013).
    • (2013) Science (New York, NY) , vol.342 , pp. 1243-1246
    • Kruglov, A.A.1
  • 311
    • 85061584145 scopus 로고    scopus 로고
    • ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice
    • Deng, T. et al. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol. Immunol. https://doi.org/10.1038/s41423-019-0200-x (2019).
    • (2019) Cell Mol. Immunol.
    • Deng, T.1
  • 312
    • 84930663466 scopus 로고    scopus 로고
    • Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science (New York
    • Hepworth, M. R. et al. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science (New York, NY) 348, 1031–1035 (2015).
    • (2015) NY) , vol.348 , pp. 1031-1035
    • Hepworth, M.R.1
  • 313
    • 84897053496 scopus 로고    scopus 로고
    • Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
    • Mortha, A. et al. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science (New York, NY) 343, 1249288 (2014).
    • (2014) Science (New York, NY) , vol.343
    • Mortha, A.1
  • 314
    • 84896924438 scopus 로고    scopus 로고
    • Immunology axis tolerance
    • Aychek, T. & Jung, S. Immunology axis tolerance. Science (New York, NY) 343, 1439–1440 (2014).
    • (2014) Science (New York, NY) , vol.343 , pp. 1439-1440
    • Aychek, T.1    Jung, S.2
  • 315
    • 85063971809 scopus 로고    scopus 로고
    • Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
    • Zhou, L. et al. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature 568, 405–409 (2019).
    • (2019) Nature , vol.568 , pp. 405-409
    • Zhou, L.1
  • 316
    • 85061393496 scopus 로고    scopus 로고
    • Microbiota sensing by Mincle-Syk axis in dendritic cells regulates interleukin-17 and-22 production and promotes intestinal barrier integrity
    • Martinez-Lopez, M. et al. Microbiota sensing by Mincle-Syk axis in dendritic cells regulates interleukin-17 and-22 production and promotes intestinal barrier integrity. Immunity 50, 446–461.e449 (2019).
    • (2019) Immunity , vol.50 , pp. 446-461
    • Martinez-Lopez, M.1
  • 317
    • 84978128198 scopus 로고    scopus 로고
    • Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
    • Ibiza, S. et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature 535, 440–443 (2016).
    • (2016) Nature , vol.535 , pp. 440-443
    • Ibiza, S.1
  • 318
    • 85002527273 scopus 로고    scopus 로고
    • ILC3s and the Willow tree of voices
    • Bogunovic, M. ILC3s and the Willow tree of voices. Immunity 45, 238–239 (2016).
    • (2016) Immunity , vol.45 , pp. 238-239
    • Bogunovic, M.1
  • 319
    • 84907208430 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate intestinal epithelial cell glycosy-lation
    • Goto, Y. et al. Innate lymphoid cells regulate intestinal epithelial cell glycosy-lation. Science (New York, NY) 345, 1254009 (2014).
    • (2014) Science (New York, NY) , vol.345
    • Goto, Y.1
  • 320
    • 85020701318 scopus 로고    scopus 로고
    • IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance
    • Tsai, P. Y. et al. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host Microbe 21, 671–681.e674 (2017).
    • (2017) Cell Host Microbe 21 , vol.e674 , pp. 671-681
    • Tsai, P.Y.1
  • 321
    • 85056320549 scopus 로고    scopus 로고
    • An interleukin-23–interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis
    • Fatkhullina, A. R. et al. An interleukin-23–interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis. Immunity 49, 943–957.e949 (2018).
    • (2018) Immunity 49 , vol.e949 , pp. 943-957
    • Fatkhullina, A.R.1
  • 322
    • 85050632181 scopus 로고    scopus 로고
    • LIGHT-HVEM signaling in innate lymphoid cell subsets protects against enteric bacterial infection
    • Seo, G. Y. et al. LIGHT-HVEM signaling in innate lymphoid cell subsets protects against enteric bacterial infection. Cell Host Microbe 24, 249–260.e244 (2018).
    • (2018) Cell Host Microbe 24 , vol.e244 , pp. 249-260
    • Seo, G.Y.1
  • 323
    • 84931569282 scopus 로고    scopus 로고
    • Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection
    • Hernandez, P. P. et al. Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nat. Immunol. 16, 698–707 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 698-707
    • Hernandez, P.P.1
  • 324
    • 84951283991 scopus 로고    scopus 로고
    • Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
    • Lindemans, C. A. et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 528, 560–564 (2015).
    • (2015) Nature , vol.528 , pp. 560-564
    • Lindemans, C.A.1
  • 325
    • 85042195471 scopus 로고    scopus 로고
    • Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22
    • Hou, Q. et al. Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22. Cell Death Differ. 25, 1657–1670 (2018).
    • (2018) Cell Death Differ , vol.25 , pp. 1657-1670
    • Hou, Q.1
  • 326
    • 85061504994 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells against genotoxic stress
    • Gronke, K. et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature 566, 249–253 (2019).
    • (2019) Nature , vol.566 , pp. 249-253
    • Gronke, K.1
  • 327
    • 84961801657 scopus 로고    scopus 로고
    • Prostaglandin E(2) constrains systemic inflammation through an innate lymphoid cell–IL-22 axis
    • Duffin, R. et al. Prostaglandin E(2) constrains systemic inflammation through an innate lymphoid cell–IL-22 axis. Science (New York, NY) 351, 1333–1338 (2016).
    • (2016) Science (New York, NY) , vol.351 , pp. 1333-1338
    • Duffin, R.1
  • 328
    • 85060334381 scopus 로고    scopus 로고
    • Macrophage beta2-integrins regulate IL-22 by ILC3s and protect from lethal Citrobacter rodentium-induced colitis. Cell Rep
    • Wang, B. et al. Macrophage beta2-integrins regulate IL-22 by ILC3s and protect from lethal Citrobacter rodentium-induced colitis. Cell Rep. 26, 1614–1626.e1615 (2019).
    • (2019) 26 , vol.e1615 , pp. 1614-1626
    • Wang, B.1
  • 329
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371–1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 330
    • 85068153449 scopus 로고    scopus 로고
    • IL-23-producing IL-10Ralpha-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response
    • Bernshtein, B. et al. IL-23-producing IL-10Ralpha-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response. Sci. Immunol. 4, https://doi.org/10.1126/sciimmunol.aau6571 (2019).
    • (2019) Sci. Immunol , pp. 4
    • Bernshtein, B.1
  • 331
    • 85057741316 scopus 로고    scopus 로고
    • Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis
    • Grizotte-Lake, M. et al. Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis. Immunity 49, 1103–1115.e1106 (2018).
    • (2018) Immunity 49 , vol.e1106 , pp. 1103-1115
    • Grizotte-Lake, M.1
  • 332
    • 85061726025 scopus 로고    scopus 로고
    • Induction of autophagy in Cx3cr1(+) mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis
    • Mathur, R. et al. Induction of autophagy in Cx3cr1(+) mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. Mucosal Immunol. 12, 612–623 (2019).
    • (2019) Mucosal Immunol , vol.12 , pp. 612-623
    • Mathur, R.1
  • 333
    • 85058883245 scopus 로고    scopus 로고
    • Microbiota-induced TNF-like ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis
    • Castellanos, J. G. et al. Microbiota-induced TNF-like ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis. Immunity 49, 1077–1089.e1075 (2018).
    • (2018) Immunity 49 , vol.e1075 , pp. 1077-1089
    • Castellanos, J.G.1
  • 334
    • 85064328185 scopus 로고    scopus 로고
    • Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis
    • Lv, Y. P. et al. Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis. Sci. Adv. 5, eaau6547 (2019).
    • (2019) Sci. Adv. , vol.5
    • Lv, Y.P.1
  • 335
    • 85051681747 scopus 로고    scopus 로고
    • LAG3(+) regulatory T cells restrain interleukin-23-producing CX3CR1(+) gut-resident macrophages during group 3 innate lymphoid cell-driven colitis
    • Bauche, D. et al. LAG3(+) regulatory T cells restrain interleukin-23-producing CX3CR1(+) gut-resident macrophages during group 3 innate lymphoid cell-driven colitis. Immunity 49, 342–352.e345 (2018).
    • (2018) Immunity 49 , vol.e345 , pp. 342-352
    • Bauche, D.1
  • 336
    • 85065412085 scopus 로고    scopus 로고
    • Group 3 ILCs: Peacekeepers or troublemakers? What's your gut telling you?!
    • Pantazi, E. & Powell, N. Group 3 ILCs: peacekeepers or troublemakers? What's your gut telling you?! Front. Immunol. 10, 676 (2019).
    • (2019) Front. Immunol. , vol.10 , Issue.676
    • Pantazi, E.1    Powell, N.2
  • 337
    • 85053395052 scopus 로고    scopus 로고
    • Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
    • Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).
    • (2018) CA Cancer J. Clin. , vol.68 , pp. 394-424
    • Bray, F.1
  • 338
    • 85068403112 scopus 로고    scopus 로고
    • LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer
    • Yang, R. et al. LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer. J. Exp. Clin. Cancer Res. 38, 280 (2019).
    • (2019) J. Exp. Clin. Cancer Res. , vol.38
    • Yang, R.1
  • 339
    • 85062715602 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor activated by benzo (A) pyrene promotes SMARCA6 expression in NSCLC
    • Mao, C. et al. Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC. Am. J. Cancer Res. 8, 1214–1227 (2018).
    • (2018) Am. J. Cancer Res , vol.8 , pp. 1214-1227
    • Mao, C.1
  • 340
    • 84949624399 scopus 로고    scopus 로고
    • Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8
    • Jiang, Y. et al. Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8. Oncogene 34, 6079–6091 (2015).
    • (2015) Oncogene , vol.34 , pp. 6079-6091
    • Jiang, Y.1
  • 341
    • 84989928165 scopus 로고    scopus 로고
    • Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase
    • He, X. et al. Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase. Cancer Res. 76, 5743–5755 (2016).
    • (2016) Cancer Res , vol.76 , pp. 5743-5755
    • He, X.1
  • 342
    • 85070806914 scopus 로고    scopus 로고
    • GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH
    • Yang, R. et al. GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH. Oncogene https://doi.org/10.1038/s41388-019-0909-0 (2019).
    • (2019) Oncogene
    • Yang, R.1
  • 343
    • 85063970833 scopus 로고    scopus 로고
    • Chromatin remodeling factor lymphoid-specific helicase links with Epstein–Barr virus associated the follicular germinal center B cell lymphomas
    • Ouyang, C. et al. Chromatin remodeling factor lymphoid-specific helicase links with Epstein–Barr virus associated the follicular germinal center B cell lymphomas. J. Cancer Res. Ther. 15, 350–357 (2019).
    • (2019) J. Cancer Res. Ther , vol.15 , pp. 350-357
    • Ouyang, C.1
  • 344
    • 85054976871 scopus 로고    scopus 로고
    • Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models
    • Thomas, R. M. et al. Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models. Carcinogenesis 39, 1068–1078 (2018).
    • (2018) Carcinogenesis , vol.39 , pp. 1068-1078
    • Thomas, R.M.1
  • 345
    • 85066501255 scopus 로고    scopus 로고
    • Epidemiology of pancreatic cancer: Global trends, etiology and risk factors
    • Rawla, P., Sunkara, T. & Gaduputi, V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J. Oncol. 10, 10–27 (2019).
    • (2019) World J. Oncol. , vol.10 , pp. 10-27
    • Rawla, P.1    Sunkara, T.2    Gaduputi, V.3
  • 346
    • 85044326821 scopus 로고    scopus 로고
    • Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis
    • Ciocan, D. et al. Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis. Sci. Rep. 8, 4822 (2018).
    • (2018) Sci. Rep. , vol.8
    • Ciocan, D.1
  • 347
    • 85027421119 scopus 로고    scopus 로고
    • Microbiota dysbiosis in select human cancers: Evidence of association and causality
    • Chen, J., Domingue, J. C. & Sears, C. L. Microbiota dysbiosis in select human cancers: evidence of association and causality. Semin. Immunol. 32, 25–34 (2017).
    • (2017) Semin. Immunol. , vol.32 , pp. 25-34
    • Chen, J.1    Domingue, J.C.2    Sears, C.L.3
  • 348
    • 85014346635 scopus 로고    scopus 로고
    • Wu, J. Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis
    • Guo, Y., Liu, W. & Wu, J. Helicobacter pylori infection and pancreatic cancer risk: a meta-analysis. J. Cancer Res. Ther. 12, C229–c232 (2016).
    • (2016) J. Cancer Res. Ther , vol.12 , pp. C229-c232
    • Guo, Y.1    Liu, W.2
  • 349
    • 85013381974 scopus 로고    scopus 로고
    • Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case–control study
    • Huang, J. et al. Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case–control study. Int. J. Cancer 140, 1727–1735 (2017).
    • (2017) Int. J. Cancer , vol.140 , pp. 1727-1735
    • Huang, J.1
  • 350
    • 85066435991 scopus 로고    scopus 로고
    • The microbiota and microbiome in pancreatic cancer: More influential than expected
    • Wei, M. Y. et al. The microbiota and microbiome in pancreatic cancer: more influential than expected. Mol. Cancer 18, 97 (2019).
    • (2019) Mol. Cancer , vol.18
    • Wei, M.Y.1
  • 351
    • 85029481879 scopus 로고    scopus 로고
    • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
    • Geller, L. T. et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science (New York, NY) 357, 1156–1160 (2017).
    • (2017) Science (New York, NY) , vol.357 , pp. 1156-1160
    • Geller, L.T.1
  • 352
    • 85047056415 scopus 로고    scopus 로고
    • The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression
    • Pushalkar, S. et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8, 403–416 (2018).
    • (2018) Cancer Discov , vol.8 , pp. 403-416
    • Pushalkar, S.1
  • 353
    • 85069951512 scopus 로고    scopus 로고
    • Tumor microbiome diversity and composition influence pancreatic cancer outcomes
    • Riquelme, E. et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell 178, 795–806.e712 (2019).
    • (2019) Cell 178 , vol.e712 , pp. 795-806
    • Riquelme, E.1
  • 354
    • 84927138939 scopus 로고    scopus 로고
    • Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
    • Mitsuhashi, K. et al. Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. Oncotarget 6, 7209–7220 (2015).
    • (2015) Oncotarget , vol.6 , pp. 7209-7220
    • Mitsuhashi, K.1
  • 355
    • 85055902585 scopus 로고    scopus 로고
    • Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer
    • Maekawa, T. et al. Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer. Biochem. Biophys. Res. Commun. 506, 962–969 (2018).
    • (2018) Biochem. Biophys. Res. Commun , vol.506 , pp. 962-969
    • Maekawa, T.1
  • 356
    • 85051101269 scopus 로고    scopus 로고
    • Bactibilia in women affected with diseases of the biliary tract and pancreas. A STROBE guidelines-adherent cross-sectional study in Southern Italy
    • Serra, N. et al. Bactibilia in women affected with diseases of the biliary tract and pancreas. A STROBE guidelines-adherent cross-sectional study in Southern Italy. J. Med. Microbiol. 67, 1090–1095 (2018).
    • (2018) J. Med. Microbiol. , vol.67 , pp. 1090-1095
    • Serra, N.1
  • 357
    • 85063003976 scopus 로고    scopus 로고
    • Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer
    • Gaiser, R. A. et al. Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer. Gut https://doi.org/10.1136/gutjnl-2018-317458 (2019).
    • (2019) Gut
    • Gaiser, R.A.1
  • 358
    • 84992055617 scopus 로고    scopus 로고
    • Human oral microbiome and prospective risk for pancreatic cancer: A population-based nested case-control study
    • Fan, X. et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut 67, 120–127 (2018).
    • (2018) Gut , vol.67 , pp. 120-127
    • Fan, X.1
  • 359
    • 84866372497 scopus 로고    scopus 로고
    • MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
    • Ochi, A. et al. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J. Exp. Med. 209, 1671–1687 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1671-1687
    • Ochi, A.1
  • 361
    • 85049300895 scopus 로고    scopus 로고
    • Gut microbiota promotes tumor growth in mice by modulating immune response
    • Sethi, V. et al. Gut microbiota promotes tumor growth in mice by modulating immune response. Gastroenterology 155, 33–37.e36 (2018).
    • (2018) Gastroenterology , vol.155 , pp. 33-37
    • Sethi, V.1
  • 362
    • 85054346991 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Vogel, A. et al. Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 29, iv238–iv255 (2018).
    • (2018) Ann. Oncol. , vol.29 , pp. iv238-iv255
    • Vogel, A.1
  • 364
    • 85050639122 scopus 로고    scopus 로고
    • Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
    • Ren, Z. et al. Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma. Gut 68, 1014–1023 (2019).
    • (2019) Gut , vol.68 , pp. 1014-1023
    • Ren, Z.1
  • 365
    • 85020168296 scopus 로고    scopus 로고
    • Disparities in liver cancer occurrence in the United States by race/ ethnicity and state
    • Islami, F. et al. Disparities in liver cancer occurrence in the United States by race/ ethnicity and state. CA Cancer J. Clin. 67, 273–289 (2017).
    • (2017) CA Cancer J. Clin. , vol.67 , pp. 273-289
    • Islami, F.1
  • 366
    • 85042603956 scopus 로고    scopus 로고
    • Gut roundtable meeting paper: Selected recent advances in hepatocellular carcinoma
    • Gerbes, A. et al. Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma. Gut 67, 380–388 (2018).
    • (2018) Gut , vol.67 , pp. 380-388
    • Gerbes, A.1
  • 367
    • 85063324322 scopus 로고    scopus 로고
    • Scaling up prevention and treatment towards the elimination of hepatitis C: A global mathematical model
    • Heffernan, A., Cooke, G. S., Nayagam, S., Thursz, M. & Hallett, T. B. Scaling up prevention and treatment towards the elimination of hepatitis C: a global mathematical model. Lancet 393, 1319–1329 (2019).
    • (2019) Lancet , vol.393 , pp. 1319-1329
    • Heffernan, A.1    Cooke, G.S.2    Nayagam, S.3    Thursz, M.4    Hallett, T.B.5
  • 370
    • 85062538332 scopus 로고    scopus 로고
    • Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis
    • Munoz, L. et al. Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis. Hepatology https://doi.org/10.1002/hep.30349 (2018).
    • (2018) Hepatology
    • Munoz, L.1
  • 371
    • 85065673449 scopus 로고    scopus 로고
    • Overuse of antianaerobic drug is associated with poor post-chemotherapy prognosis of patients with hepatocellular carcinoma
    • Iida, N. et al. Overuse of antianaerobic drug is associated with poor post-chemotherapy prognosis of patients with hepatocellular carcinoma. Int. J. Cancer https://doi.org/10.1002/ijc.32339 (2019).
    • (2019) Int. J. Cancer
    • Iida, N.1
  • 372
    • 84991271558 scopus 로고    scopus 로고
    • Profile of gut microbiota associated with the presence of hepatocellular cancer in patients with liver cirrhosis
    • Grat, M. et al. Profile of gut microbiota associated with the presence of hepatocellular cancer in patients with liver cirrhosis. Transpl. Proc. 48, 1687–1691 (2016).
    • (2016) Transpl. Proc. , vol.48 , pp. 1687-1691
    • Grat, M.1
  • 373
    • 85049524387 scopus 로고    scopus 로고
    • Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease
    • Ponziani, F. R. et al. Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease. Hepatology 69, 107–120 (2019).
    • (2019) Hepatology , vol.69 , pp. 107-120
    • Ponziani, F.R.1
  • 374
    • 85069232946 scopus 로고    scopus 로고
    • Analysis of the relationship between the degree of dysbiosis in gut microbiota and prognosis at different stages of primary hepatocellular carcinoma
    • Ni, J. et al. Analysis of the relationship between the degree of dysbiosis in gut microbiota and prognosis at different stages of primary hepatocellular carcinoma. Front. Microbiol. 10, 1458 (2019).
    • (2019) Front. Microbiol. , vol.10 , Issue.1458
    • Ni, J.1
  • 375
    • 85066919194 scopus 로고    scopus 로고
    • A different gut microbiome linked to inflammation found in cirrhotic patients with and without hepatocellular carcinoma
    • Pinero, F. et al. A different gut microbiome linked to inflammation found in cirrhotic patients with and without hepatocellular carcinoma. Ann. Hepatol. 18, 480–487 (2019).
    • (2019) Ann. Hepatol. , vol.18 , pp. 480-487
    • Pinero, F.1
  • 376
    • 85060397557 scopus 로고    scopus 로고
    • Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma
    • Liu, Q. et al. Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma. Gut Pathog. 11, 1 (2019).
    • (2019) Gut Pathog , vol.11 , pp. 1
    • Liu, Q.1
  • 377
    • 10044289669 scopus 로고    scopus 로고
    • Identification of Helicobacter species in human liver samples from patients with primary hepatocellular carcinoma
    • Huang, Y. et al. Identification of Helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J. Clin. Pathol. 57, 1273–1277 (2004).
    • (2004) J. Clin. Pathol. , vol.57 , pp. 1273-1277
    • Huang, Y.1
  • 378
    • 14544280606 scopus 로고    scopus 로고
    • Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma
    • Rocha, M. et al. Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Gut 54, 396–401 (2005).
    • (2005) Gut , vol.54 , pp. 396-401
    • Rocha, M.1
  • 379
    • 84930476752 scopus 로고    scopus 로고
    • Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma
    • Kruttgen, A. et al. Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma. Gut Microbes 3, 228–233 (2012).
    • (2012) Gut Microbes , vol.3 , pp. 228-233
    • Kruttgen, A.1
  • 380
    • 84883160673 scopus 로고    scopus 로고
    • Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue
    • Yang, J., Ji, S., Zhang, Y. & Wang, J. Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue. Singap. Med. J. 54, 451–457 (2013).
    • (2013) Singap. Med. J. , vol.54 , pp. 451-457
    • Yang, J.1    Ji, S.2    Zhang, Y.3    Wang, J.4
  • 381
    • 84974605228 scopus 로고    scopus 로고
    • The cytolethal distending toxin subunit CdtB of Helicobacter induces a Th17-related and antimicrobial signature in intestinal and hepatic cells in vitro
    • Pere-Vedrenne, C. et al. The cytolethal distending toxin subunit CdtB of Helicobacter induces a Th17-related and antimicrobial signature in intestinal and hepatic cells in vitro. J. Infect. Dis. 213, 1979–1989 (2016).
    • (2016) J. Infect. Dis. , vol.213 , pp. 1979-1989
    • Pere-Vedrenne, C.1
  • 382
    • 85027490834 scopus 로고    scopus 로고
    • The cytolethal distending toxin subunit CdtB of Helicobacter hepaticus promotes senescence and endoreplication in xenograft mouse models of hepatic and intestinal cell lines
    • Pere-Vedrenne, C. et al. The cytolethal distending toxin subunit CdtB of Helicobacter hepaticus promotes senescence and endoreplication in xenograft mouse models of hepatic and intestinal cell lines. Front. Cell Infect. Microbiol. 7, 268 (2017).
    • (2017) Front. Cell Infect. Microbiol. , vol.7 , pp. 268
    • Pere-Vedrenne, C.1
  • 383
    • 73449143207 scopus 로고    scopus 로고
    • Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens
    • Fox, J. G. et al. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 59, 88–97 (2010).
    • (2010) Gut , vol.59 , pp. 88-97
    • Fox, J.G.1
  • 384
    • 84866383592 scopus 로고    scopus 로고
    • Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats
    • Zhang, H. L. et al. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J. Hepatol. 57, 803–812 (2012).
    • (2012) J. Hepatol , vol.57 , pp. 803-812
    • Zhang, H.L.1
  • 385
    • 85047516392 scopus 로고    scopus 로고
    • On the potential role of intestinal microbial community in hepatocarcinogenesis in chronic hepatitis B
    • Mohamadkhani, A. On the potential role of intestinal microbial community in hepatocarcinogenesis in chronic hepatitis B. Cancer Med. https://doi.org/10.1002/cam4.1550 (2018).
    • (2018) Cancer Med.
    • Mohamadkhani, A.1
  • 386
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504–516 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 504-516
    • Dapito, D.H.1
  • 387
    • 77957948007 scopus 로고    scopus 로고
    • Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents
    • Yu, L. X. et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 52, 1322–1333 (2010).
    • (2010) Hepatology , vol.52 , pp. 1322-1333
    • Yu, L.X.1
  • 388
    • 85028471063 scopus 로고    scopus 로고
    • The gut microbiome and liver cancer: Mechanisms and clinical translation
    • Yu, L. X. & Schwabe, R. F. The gut microbiome and liver cancer: mechanisms and clinical translation. Nat. Rev. Gastroenterol. Hepatol. 14, 527–539 (2017).
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.14 , pp. 527-539
    • Yu, L.X.1    Schwabe, R.F.2
  • 389
    • 85067470086 scopus 로고    scopus 로고
    • Molecular targets in hepatocarcinogenesis and implications for therapy
    • Wu, M. Y., Yiang, G. T., Cheng, P. W., Chu, P. Y. & Li, C. J. Molecular targets in hepatocarcinogenesis and implications for therapy. J. Clin. Med. 7, 213–239 (2018).
    • (2018) J. Clin. Med. , vol.7 , pp. 213-239
    • Wu, M.Y.1    Yiang, G.T.2    Cheng, P.W.3    Chu, P.Y.4    Li, C.J.5
  • 390
    • 85050885305 scopus 로고    scopus 로고
    • IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma
    • Yin, Z. et al. IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. J. Cell. Biochem. 119, 9419–9432 (2018).
    • (2018) J. Cell. Biochem. , vol.119 , pp. 9419-9432
    • Yin, Z.1
  • 391
    • 85053786452 scopus 로고    scopus 로고
    • Anti-Inflammatory activity of dehydroandrographolide by TLR4/ NF-kappaB signaling pathway inhibition in bile duct-ligated mice
    • Weng, Z. et al. Anti-Inflammatory activity of dehydroandrographolide by TLR4/ NF-kappaB signaling pathway inhibition in bile duct-ligated mice. Cell Physiol. Biochem. 49, 1083–1096 (2018).
    • (2018) Cell Physiol. Biochem. , vol.49 , pp. 1083-1096
    • Weng, Z.1
  • 392
    • 85017373900 scopus 로고    scopus 로고
    • Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
    • Loo, T. M. et al. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Disco. 7, 522–538 (2017).
    • (2017) Cancer Disco , vol.7 , pp. 522-538
    • Loo, T.M.1
  • 393
    • 85041701746 scopus 로고    scopus 로고
    • Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice
    • Yamada, S. et al. Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice. Oncotarget 9, 9925–9939 (2018).
    • (2018) Oncotarget , vol.9 , Issue.9925-9939
    • Yamada, S.1
  • 394
    • 85052900643 scopus 로고    scopus 로고
    • Bile acids, the microbiome, immunity, and liver tumors
    • Schramm, C. Bile acids, the microbiome, immunity, and liver tumors. N. Engl. J. Med. 379, 888–890 (2018).
    • (2018) N. Engl. J. Med. , vol.379 , pp. 888-890
    • Schramm, C.1
  • 395
    • 85062708151 scopus 로고    scopus 로고
    • Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer
    • Li, R. et al. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death Differ. https://doi.org/10.1038/s41418-019-0312-y (2019).
    • (2019) Cell Death Differ
    • Li, R.1
  • 396
    • 85069498153 scopus 로고    scopus 로고
    • Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment
    • Li, Q. et al. Intestinal dysbacteriosis-induced IL-25 promotes development of HCC via alternative activation of macrophages in tumor microenvironment. J. Exp. Clin. Cancer Res. 38, 303 (2019).
    • (2019) J. Exp. Clin. Cancer Res , vol.38 , pp. 303
    • Li, Q.1
  • 397
    • 85067341804 scopus 로고    scopus 로고
    • Cancer treatment and survivorship statistics, 2019
    • Miller, K. D. et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J. Clin. https://doi.org/10.3322/caac.21565 (2019).
    • (2019) CA Cancer J. Clin
    • Miller, K.D.1
  • 398
    • 85056782350 scopus 로고    scopus 로고
    • A blueprint for cancer screening and early detection: Advancing screening's contribution to cancer control
    • Wender, R. C., Brawley, O. W., Fedewa, S. A., Gansler, T. & Smith, R. A. A blueprint for cancer screening and early detection: advancing screening's contribution to cancer control. CA Cancer J. Clin. 69, 50–79 (2019).
    • (2019) CA Cancer J. Clin. , vol.69 , pp. 50-79
    • Wender, R.C.1    Brawley, O.W.2    Fedewa, S.A.3    Gansler, T.4    Smith, R.A.5
  • 399
    • 85043507272 scopus 로고    scopus 로고
    • Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
    • Allemani, C. et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet 391, 1023–1075 (2018).
    • (2018) Lancet , vol.391 , pp. 1023-1075
    • Allemani, C.1
  • 400
    • 85048695897 scopus 로고    scopus 로고
    • A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
    • Wu, L. et al. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nat. Genet. 50, 968–978 (2018).
    • (2018) Nat. Genet , vol.50 , pp. 968-978
    • Wu, L.1
  • 401
    • 85019678437 scopus 로고    scopus 로고
    • Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study
    • Knight, J. A. et al. Alcohol consumption and cigarette smoking in combination: a predictor of contralateral breast cancer risk in the WECARE study. Int. J. Cancer 141, 916–924 (2017).
    • (2017) Int. J. Cancer , vol.141 , pp. 916-924
    • Knight, J.A.1
  • 402
    • 85058423281 scopus 로고    scopus 로고
    • Global patterns in excess body weight and the associated cancer burden. CA Cancer
    • Sung, H. et al. Global patterns in excess body weight and the associated cancer burden. CA Cancer J. Clin. 69, 88–112 (2019).
    • (2019) J. Clin , vol.69 , pp. 88-112
    • Sung, H.1
  • 403
    • 85042362092 scopus 로고    scopus 로고
    • Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota
    • Goedert, J. J. et al. Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota. Br. J. Cancer 118, 471–479 (2018).
    • (2018) Br. J. Cancer , vol.118 , pp. 471-479
    • Goedert, J.J.1
  • 404
    • 84939434779 scopus 로고    scopus 로고
    • Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: A population-based case–control pilot study
    • Goedert, J. J. et al. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case–control pilot study. J. Natl. Cancer Inst. 107, https://doi.org/10.1093/jnci/djv147 (2015).
    • (2015) J. Natl. Cancer Inst , pp. 107
    • Goedert, J.J.1
  • 405
    • 85054931590 scopus 로고    scopus 로고
    • Breast cancer in postmenopausal women is associated with an altered gut metagenome
    • Zhu, J. et al. Breast cancer in postmenopausal women is associated with an altered gut metagenome. Microbiome 6, 136 (2018).
    • (2018) Microbiome , vol.6 , pp. 136
    • Zhu, J.1
  • 406
    • 85009739653 scopus 로고    scopus 로고
    • Intestinal proportion of Blautia sp. Is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer
    • Luu, T. H. et al. Intestinal proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer. Nutr. Cancer 69, 267–275 (2017).
    • (2017) Nutr. Cancer , vol.69 , pp. 267-275
    • Luu, T.H.1
  • 407
    • 1442309705 scopus 로고    scopus 로고
    • Antibiotic use in relation to the risk of breast cancer
    • Velicer, C. M. et al. Antibiotic use in relation to the risk of breast cancer. JAMA 291, 827–835 (2004).
    • (2004) JAMA , vol.291 , pp. 827-835
    • Velicer, C.M.1
  • 409
    • 79953013708 scopus 로고    scopus 로고
    • A pilot study of male breast cancer in the Veterans Affairs healthcare system
    • Satram-Hoang, S. et al. A pilot study of male breast cancer in the Veterans Affairs healthcare system. J. Environ. Pathol. Toxicol. Oncol. 29, 235–244 (2010).
    • (2010) J. Environ. Pathol. Toxicol. Oncol. , vol.29 , pp. 235-244
    • Satram-Hoang, S.1
  • 410
    • 32944461994 scopus 로고    scopus 로고
    • Association between antibiotic use prior to breast cancer diagnosis and breast tumour characteristics (United States)
    • Velicer, C. M., Heckbert, S. R., Rutter, C., Lampe, J. W. & Malone, K. Association between antibiotic use prior to breast cancer diagnosis and breast tumour characteristics (United States). Cancer Causes Control 17, 307–313 (2006).
    • (2006) Cancer Causes Control , vol.17 , pp. 307-313
    • Velicer, C.M.1    Heckbert, S.R.2    Rutter, C.3    Lampe, J.W.4    Malone, K.5
  • 411
    • 33845308613 scopus 로고    scopus 로고
    • Antibiotics and risk of breast cancer: Up to 9 years of follow-up of 2.1 million women
    • Friedman, G. D. et al. Antibiotics and risk of breast cancer: up to 9 years of follow-up of 2.1 million women. Cancer Epidemiol. Biomark. Prev. 15, 2102–2106 (2006).
    • (2006) Cancer Epidemiol. Biomark. Prev. , vol.15 , pp. 2102-2106
    • Friedman, G.D.1
  • 413
    • 85068978931 scopus 로고    scopus 로고
    • Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer
    • Buchta Rosean, C. et al. Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer. Cancer Res. 79, 3662–3675 (2019).
    • (2019) Cancer Res , vol.79 , pp. 3662-3675
    • Buchta Rosean, C.1
  • 414
    • 84928714899 scopus 로고    scopus 로고
    • Gut bacteria require neutrophils to promote mammary tumorigenesis
    • Lakritz, J. R. et al. Gut bacteria require neutrophils to promote mammary tumorigenesis. Oncotarget 6, 9387–9396 (2015).
    • (2015) Oncotarget , vol.6 , Issue.9387-9396
    • Lakritz, J.R.1
  • 415
    • 33747481384 scopus 로고    scopus 로고
    • Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    • Rao, V. P. et al. Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 66, 7395–7400 (2006).
    • (2006) Cancer Res , vol.66 , pp. 7395-7400
    • Rao, V.P.1
  • 416
    • 84922202505 scopus 로고    scopus 로고
    • Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
    • Rutkowski, M. R. et al. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell 27, 27–40 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 27-40
    • Rutkowski, M.R.1
  • 417
    • 85059645118 scopus 로고    scopus 로고
    • Neutrophil-to-lymphocyte ratio as a predictor of survival in patients with triple-negative breast cancer
    • Patel, D. A. et al. Neutrophil-to-lymphocyte ratio as a predictor of survival in patients with triple-negative breast cancer. Breast Cancer Res. Treat. 174, 443–452 (2019).
    • (2019) Breast Cancer Res. Treat. , vol.174 , pp. 443-452
    • Patel, D.A.1
  • 418
    • 85068844982 scopus 로고    scopus 로고
    • Prediction of late recurrence in patients with breast cancer: Elevated neutrophil to lymphocyte ratio (NLR) at 5 years after diagnosis and late recurrence
    • Moon, G., Noh, H., Cho, I. J., Lee, J. I. & Han, A. Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5 years after diagnosis and late recurrence. Breast Cancer (Tokyo, Japan) https://doi.org/10.1007/s12282-019-00994-z (2019).
    • (2019) Breast Cancer (Tokyo, Japan)
    • Moon, G.1    Noh, H.2    Cho, I.J.3    Lee, J.I.4    Han, A.5
  • 420
    • 84901014117 scopus 로고    scopus 로고
    • Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice
    • Lakritz, J. R. et al. Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int. J. Cancer 135, 529–540 (2014).
    • (2014) Int. J. Cancer , vol.135 , pp. 529-540
    • Lakritz, J.R.1
  • 421
    • 85061046595 scopus 로고    scopus 로고
    • Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors
    • Kovacs, T. et al. Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors. Sci. Rep. 9, 1300 (2019).
    • (2019) Sci. Rep. , vol.9
    • Kovacs, T.1
  • 422
    • 85046624546 scopus 로고    scopus 로고
    • Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness
    • Miko, E. et al. Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness. Biochim. Biophys. Acta Bioenerg. 1859, 958–974 (2018).
    • (2018) Biochim. Biophys. Acta Bioenerg. , vol.1859 , pp. 958-974
    • Miko, E.1
  • 423
    • 84906823214 scopus 로고    scopus 로고
    • A joint analysis of metabolomics and genetics of breast cancer
    • Tang, X. et al. A joint analysis of metabolomics and genetics of breast cancer. Breast Cancer Res. 16, 415 (2014).
    • (2014) Breast Cancer Res , vol.16
    • Tang, X.1
  • 424
    • 33750535007 scopus 로고    scopus 로고
    • The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression
    • Swales, K. E. et al. The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression. Cancer Res. 66, 10120–10126 (2006).
    • (2006) Cancer Res , vol.66 , pp. 10120-10126
    • Swales, K.E.1
  • 425
    • 85128288050 scopus 로고    scopus 로고
    • Microbiome–microbial metabolome–cancer cell interactions in breast cancer-familiar, but unexplored
    • Miko, E. et al. Microbiome–microbial metabolome–cancer cell interactions in breast cancer-familiar, but unexplored. Cells 8, https://doi.org/10.3390/cells8040293 (2019).
    • (2019) Cells , vol.8
    • Miko, E.1
  • 426
    • 85032730219 scopus 로고    scopus 로고
    • Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
    • Salimi, V. et al. Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment. Lipids Health Dis. 16, 208 (2017).
    • (2017) Lipids Health Dis , vol.16
    • Salimi, V.1
  • 427
    • 85031714679 scopus 로고    scopus 로고
    • Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells
    • Thirunavukkarasan, M. et al. Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. PLoS ONE 12, e0186334 (2017).
    • (2017) Plos ONE , vol.12
    • Thirunavukkarasan, M.1
  • 429
    • 85080840688 scopus 로고    scopus 로고
    • Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action
    • Tao, J. et al. Targeting gut microbiota with dietary components on cancer: effects and potential mechanisms of action. Crit. Rev. Food Sci. Nutr. https://doi. org/10.1080/10408398.2018.1555789, 1–13 (2019).
    • (2019) Crit. Rev. Food Sci. Nutr. , pp. 1-13
    • Tao, J.1
  • 430
    • 85066023825 scopus 로고    scopus 로고
    • Effects of phytoestrogens on the activity and growth of primary breast cancer cells ex vivo
    • Chen, F. P. & Chien, M. H. Effects of phytoestrogens on the activity and growth of primary breast cancer cells ex vivo. J. Obstet. Gynaecol. Res. 45, 1352–1362 (2019).
    • (2019) J. Obstet. Gynaecol. Res. , vol.45 , pp. 1352-1362
    • Chen, F.P.1    Chien, M.H.2
  • 431
    • 85053005776 scopus 로고    scopus 로고
    • Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives
    • Basu, P. & Maier, C. Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. Biomed. Pharmacother. 107, 1648–1666 (2018).
    • (2018) Biomed. Pharmacother. , vol.107 , pp. 1648-1666
    • Basu, P.1    Maier, C.2
  • 433
    • 85062701853 scopus 로고    scopus 로고
    • Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives
    • Mali, A. V., Padhye, S. B., Anant, S., Hegde, M. V. & Kadam, S. S. Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives. Eur. J. Pharm. 852, 107–124 (2019).
    • (2019) Eur. J. Pharm. , vol.852 , pp. 107-124
    • Mali, A.V.1    Padhye, S.B.2    Anant, S.3    Hegde, M.V.4    Kadam, S.S.5
  • 434
    • 85055701548 scopus 로고    scopus 로고
    • The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFkappaB signaling, and inhibits mammary tumor growth
    • Bowers, L. W. et al. The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFkappaB signaling, and inhibits mammary tumor growth. Breast Cancer Res. Treat. 173, 545–557 (2019).
    • (2019) Breast Cancer Res. Treat. , vol.173 , pp. 545-557
    • Bowers, L.W.1
  • 435
    • 85049221661 scopus 로고    scopus 로고
    • Enterolactone modulates the ERK/NF-kappaB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-beta-induced epithelial–mesenchymal transition
    • Mali, A. V., Joshi, A. A., Hegde, M. V. & Kadam, S. S. Enterolactone modulates the ERK/NF-kappaB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-beta-induced epithelial–mesenchymal transition. Cancer Biol. Med. 15, 137–156 (2018).
    • (2018) Cancer Biol. Med. , vol.15 , pp. 137-156
    • Mali, A.V.1    Joshi, A.A.2    Hegde, M.V.3    Kadam, S.S.4
  • 436
    • 85041130674 scopus 로고    scopus 로고
    • Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3
    • Di, Y., De Silva, F., Krol, E. S. & Alcorn, J. Flaxseed lignans enhance the cytotoxicity of chemotherapeutic agents against breast cancer cell lines MDA-MB-231 and SKBR3. Nutr. Cancer 70, 306–315 (2018).
    • (2018) Nutr. Cancer , vol.70 , pp. 306-315
    • Di, Y.1    de Silva, F.2    Krol, E.S.3    Alcorn, J.4
  • 437
    • 85049734157 scopus 로고    scopus 로고
    • Metabolic biosynthesis pathways identified from fecal microbiome associated with prostate cancer
    • Liss, M. A. et al. Metabolic biosynthesis pathways identified from fecal microbiome associated with prostate cancer. Eur. Urol. 74, 575–582 (2018).
    • (2018) Eur. Urol. , vol.74 , pp. 575-582
    • Liss, M.A.1
  • 438
    • 85049620968 scopus 로고    scopus 로고
    • Compositional differences in gastrointestinal microbiota in prostate cancer patients treated with androgen axis-targeted therapies
    • Sfanos, K. S. et al. Compositional differences in gastrointestinal microbiota in prostate cancer patients treated with androgen axis-targeted therapies. Prostate Cancer Prostatic Dis. 21, 539–548 (2018).
    • (2018) Prostate Cancer Prostatic Dis , vol.21 , pp. 539-548
    • Sfanos, K.S.1
  • 439
    • 85031691970 scopus 로고    scopus 로고
    • The role of gut microbiome in the pathogenesis of prostate cancer: A prospective, pilot study
    • Golombos, D. M. et al. The role of gut microbiome in the pathogenesis of prostate cancer: a prospective, pilot study. Urology 111, 122–128 (2018).
    • (2018) Urology , vol.111 , pp. 122-128
    • Golombos, D.M.1
  • 440
    • 85052602374 scopus 로고    scopus 로고
    • Unearthing roles for the gut microbiome
    • Fenner, A. Unearthing roles for the gut microbiome. Nat. Rev. Urol. 15, 589 (2018).
    • (2018) Nat. Rev. Urol. , vol.15 , pp. 589
    • Fenner, A.1
  • 441
    • 85056165391 scopus 로고    scopus 로고
    • Alterations of fecal bacterial communities in patients with lung cancer
    • Zhang, W. Q. et al. Alterations of fecal bacterial communities in patients with lung cancer. Am. J. Transl. Res. 10, 3171–3185 (2018).
    • (2018) Am. J. Transl. Res , vol.10 , pp. 3171-3185
    • Zhang, W.Q.1
  • 442
    • 85067086371 scopus 로고    scopus 로고
    • Lung tissue microbial profile in lung cancer is distinct from emphysema
    • Liu, Y. et al. Lung tissue microbial profile in lung cancer is distinct from emphysema. Am. J. Cancer Res. 8, 1775–1787 (2018).
    • (2018) Am. J. Cancer Res , vol.8 , pp. 1775-1787
    • Liu, Y.1
  • 443
    • 84994741661 scopus 로고    scopus 로고
    • Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions
    • Lee, S. H. et al. Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions. Lung Cancer 102, 89–95 (2016).
    • (2016) Lung Cancer , vol.102 , pp. 89-95
    • Lee, S.H.1
  • 444
    • 85061787031 scopus 로고    scopus 로고
    • Commensal microbiota promote lung cancer development via gammadelta T cells
    • Jin, C. et al. Commensal microbiota promote lung cancer development via gammadelta T cells. Cell 176, 998–1013.e1016 (2019).
    • (2019) Cell , vol.176 , pp. 998-1013
    • Jin, C.1
  • 445
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancer-immune set point
    • Chen, D. S. & Mellman, I. Elements of cancer immunity and the cancer-immune set point. Nature 541, 321–330 (2017).
    • (2017) Nature , vol.541 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 446
    • 85045378539 scopus 로고    scopus 로고
    • Cancer immunotherapy using checkpoint blockade
    • Ribas, A. & Wolchok, J. D. Cancer immunotherapy using checkpoint blockade. Science (New York, NY) 359, 1350–1355 (2018).
    • (2018) Science (New York, NY) , vol.359 , pp. 1350-1355
    • Ribas, A.1    Wolchok, J.D.2
  • 447
    • 85051485029 scopus 로고    scopus 로고
    • Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
    • Chen, G. et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560, 382–386 (2018).
    • (2018) Nature , vol.560 , pp. 382-386
    • Chen, G.1
  • 448
    • 85058360616 scopus 로고    scopus 로고
    • Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-gamma and IL-12
    • Garris, C. S. et al. Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-gamma and IL-12. Immunity 49, 1148–1161.e1147 (2018).
    • (2018) Immunity 49 , vol.e1147 , pp. 1148-1161
    • Garris, C.S.1
  • 449
    • 85059413620 scopus 로고    scopus 로고
    • Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity
    • Pai, C. S. et al. Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity. J. Clin. Investig. 129, 349–363 (2019).
    • (2019) J. Clin. Investig. , vol.129 , pp. 349-363
    • Pai, C.S.1
  • 450
    • 85042373437 scopus 로고    scopus 로고
    • A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy
    • Du, X. et al. A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Cell Res. 28, 416–432 (2018).
    • (2018) Cell Res , vol.28 , pp. 416-432
    • Du, X.1
  • 451
    • 85042225434 scopus 로고    scopus 로고
    • Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice
    • Du, X. et al. Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice. Cell Res. 28, 433–447 (2018).
    • (2018) Cell Res , vol.28 , pp. 433-447
    • Du, X.1
  • 452
    • 85061618202 scopus 로고    scopus 로고
    • Anti-CTLA-4 immunotherapy does not deplete FOXP3(+) regulatory T cells (Tregs) in human cancers
    • Sharma, A. et al. Anti-CTLA-4 immunotherapy does not deplete FOXP3(+) regulatory T cells (Tregs) in human cancers. Clin. Cancer Res. 25, 1233–1238 (2019).
    • (2019) Clin. Cancer Res , vol.25 , pp. 1233-1238
    • Sharma, A.1
  • 453
    • 85019333926 scopus 로고    scopus 로고
    • Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
    • Menzies, A. M. et al. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann. Oncol. 28, 368–376 (2017).
    • (2017) Ann. Oncol , vol.28 , pp. 368-376
    • Menzies, A.M.1
  • 454
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Zaretsky, J. M. et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N. Engl. J. Med. 375, 819–829 (2016).
    • (2016) N. Engl. J. Med , vol.375 , pp. 819-829
    • Zaretsky, J.M.1
  • 455
    • 85059563404 scopus 로고    scopus 로고
    • Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
    • Galon, J. & Bruni, D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat. Rev. Drug Discov. 18, 197–218 (2019).
    • (2019) Nat. Rev. Drug Discov. , vol.18 , pp. 197-218
    • Galon, J.1    Bruni, D.2
  • 456
    • 85069795167 scopus 로고    scopus 로고
    • Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma
    • Zheng, Y. et al. Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma. J. Immunother. Cancer 7, 193 (2019).
    • (2019) J. Immunother. Cancer , vol.7 , pp. 193
    • Zheng, Y.1
  • 457
    • 85033576428 scopus 로고    scopus 로고
    • Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
    • Routy, B. et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science (New York, NY) 359, 91–97 (2018).
    • (2018) Science (New York, NY) , vol.359 , pp. 91-97
    • Routy, B.1
  • 458
    • 85033587326 scopus 로고    scopus 로고
    • Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
    • Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science (New York, NY) 359, 97–103 (2018).
    • (2018) Science (New York, NY) , vol.359 , pp. 97-103
    • Gopalakrishnan, V.1
  • 459
    • 85067195053 scopus 로고    scopus 로고
    • The diversity of gut microbiome is associated with favorable responses to anti-programmed death 1 immunotherapy in chinese patients with NSCLC
    • Jin, Y. et al. The diversity of gut microbiome is associated with favorable responses to anti-programmed death 1 immunotherapy in chinese patients with NSCLC. J. Thorac. Oncol. https://doi.org/10.1016/j.jtho.2019.04.007 (2019).
    • (2019) J. Thorac. Oncol
    • Jin, Y.1
  • 460
    • 85040119520 scopus 로고    scopus 로고
    • The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
    • Matson, V. et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science (New York, NY) 359, 104–108 (2018).
    • (2018) Science (New York, NY) , vol.359 , pp. 104-108
    • Matson, V.1
  • 461
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (New York, NY) 350, 1084–1089 (2015).
    • (2015) Science (New York, NY) , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 462
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science (New York, NY) 350, 1079–1084 (2015).
    • (2015) Science (New York, NY) , vol.350 , pp. 1079-1084
    • Vetizou, M.1
  • 463
    • 85059290786 scopus 로고    scopus 로고
    • Impact of antibiotic use on survival in patients with advanced cancers treated on immune checkpoint inhibitor phase I clinical trials
    • Sen, S., Carmagnani Pestana, R., Hess, K., Viola, G. M. & Subbiah, V. Impact of antibiotic use on survival in patients with advanced cancers treated on immune checkpoint inhibitor phase I clinical trials. Ann. Oncol. 29, 2396–2398 (2018).
    • (2018) Ann. Oncol. , vol.29 , pp. 2396-2398
    • Sen, S.1    Carmagnani Pestana, R.2    Hess, K.3    Viola, G.M.4    Subbiah, V.5
  • 464
    • 85031736103 scopus 로고    scopus 로고
    • Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune checkpoint therapy efficacy in melanoma patients
    • Frankel, A. E. et al. Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune checkpoint therapy efficacy in melanoma patients. Neoplasia 19, 848–855 (2017).
    • (2017) Neoplasia , vol.19 , pp. 848-855
    • Frankel, A.E.1
  • 465
    • 85016945039 scopus 로고    scopus 로고
    • Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment
    • Botticelli, A. et al. Cross-talk between microbiota and immune fitness to steer and control response to anti PD-1/PDL-1 treatment. Oncotarget 8, 8890–8899 (2017).
    • (2017) Oncotarget , vol.8 , Issue.8890-8899
    • Botticelli, A.1
  • 467
    • 85043351358 scopus 로고    scopus 로고
    • Environment dominates over host genetics in shaping human gut microbiota
    • Rothschild, D. et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 555, 210–215 (2018).
    • (2018) Nature , vol.555 , pp. 210-215
    • Rothschild, D.1
  • 468
    • 85055249203 scopus 로고    scopus 로고
    • US immigration westernizes the human gut microbiome
    • Vangay, P. et al. US immigration westernizes the human gut microbiome. Cell 175, 962–972.e910 (2018).
    • (2018) Cell 175 , vol.e910 , pp. 962-972
    • Vangay, P.1
  • 469
    • 85053046009 scopus 로고    scopus 로고
    • Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography
    • Deschasaux, M. et al. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nat. Med. 24, 1526–1531 (2018).
    • (2018) Nat. Med. , vol.24 , pp. 1526-1531
    • Deschasaux, M.1
  • 470
    • 85029483308 scopus 로고    scopus 로고
    • The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
    • Wang, Y. et al. The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science (New York, NY) 357, 912–916 (2017).
    • (2017) Science (New York, NY) , vol.357 , pp. 912-916
    • Wang, Y.1
  • 471
    • 85029896595 scopus 로고    scopus 로고
    • Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice
    • Allen, J. M. et al. Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice. Gut Microbes 9, 115–130 (2018).
    • (2018) Gut Microbes , vol.9 , pp. 115-130
    • Allen, J.M.1
  • 472
    • 85044022455 scopus 로고    scopus 로고
    • Exercise alters gut microbiota composition and function in lean and obese humans
    • Allen, J. M. et al. Exercise alters gut microbiota composition and function in lean and obese humans. Med. Sci. Sports Exerc. 50, 747–757 (2018).
    • (2018) Med. Sci. Sports Exerc. , vol.50 , pp. 747-757
    • Allen, J.M.1
  • 473
    • 85055166681 scopus 로고    scopus 로고
    • Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women
    • Munukka, E. et al. Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women. Front. Microbiol. 9, 2323 (2018).
    • (2018) Front. Microbiol. , vol.9 , Issue.2323
    • Munukka, E.1
  • 474
    • 85044539533 scopus 로고    scopus 로고
    • Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
    • Gao, X. et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc. Natl. Acad. Sci. USA 115, E2960–e2969 (2018).
    • (2018) Proc. Natl. Acad. Sci. USA , vol.115 , pp. E2960-e2969
    • Gao, X.1
  • 475
    • 85043332830 scopus 로고    scopus 로고
    • Extensive impact of non-antibiotic drugs on human gut bacteria
    • Maier, L. et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 555, 623–628 (2018).
    • (2018) Nature , vol.555 , pp. 623-628
    • Maier, L.1
  • 476
    • 85048051773 scopus 로고    scopus 로고
    • Proton pump inhibitor initiation and withdrawal affects gut microbiota and readmission risk in cirrhosis
    • Bajaj, J. S. et al. Proton pump inhibitor initiation and withdrawal affects gut microbiota and readmission risk in cirrhosis. Am. J. Gastroenterol. 113, 1177–1186 (2018).
    • (2018) Am. J. Gastroenterol , vol.113 , pp. 1177-1186
    • Bajaj, J.S.1
  • 477
    • 85055962163 scopus 로고    scopus 로고
    • Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
    • Sun, L. et al. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nat. Med. 24, 1919–1929 (2018).
    • (2018) Nat. Med , vol.24 , pp. 1919-1929
    • Sun, L.1
  • 478
    • 85045334125 scopus 로고    scopus 로고
    • Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice
    • Gong, S. et al. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J. Hepatol. 69, 51–59 (2018).
    • (2018) J. Hepatol , vol.69 , pp. 51-59
    • Gong, S.1
  • 479
    • 85052760428 scopus 로고    scopus 로고
    • Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features
    • Zmora, N. et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 174, 1388–1405.e1321 (2018).
    • (2018) Cell 174 , vol.e1321 , pp. 1388-1405
    • Zmora, N.1
  • 480
    • 85000363137 scopus 로고    scopus 로고
    • Microbiota diurnal rhythmicity programs host transcriptome oscillations
    • Thaiss, C. A. et al. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell 167, 1495–1510.e1412 (2016).
    • (2016) Cell 167 , vol.e1412 , pp. 1495-1510
    • Thaiss, C.A.1
  • 481
    • 85058263820 scopus 로고    scopus 로고
    • Microbiota and cancer immunotherapy: In search of microbial signals
    • Gharaibeh, R. Z. & Jobin, C. Microbiota and cancer immunotherapy: in search of microbial signals. Gut https://doi.org/10.1136/gutjnl-2018-317220 (2018).
    • (2018) Gut
    • Gharaibeh, R.Z.1    Jobin, C.2
  • 482
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • van Nood, E. et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. Med. 368, 407–415 (2013).
    • (2013) N. Engl. J. Med , vol.368 , pp. 407-415
    • van Nood, E.1
  • 483
    • 85059255050 scopus 로고    scopus 로고
    • Fecal microbiota transplantation in cancer management: Current status and perspectives
    • Chen, D., Wu, J., Jin, D., Wang, B. & Cao, H. Fecal microbiota transplantation in cancer management: current status and perspectives. Int. J. Cancer https://doi. org/10.1002/ijc.32003 (2018).
    • (2018) Int. J. Cancer
    • Chen, D.1    Wu, J.2    Jin, D.3    Wang, B.4    Cao, H.5
  • 484
    • 85067358355 scopus 로고    scopus 로고
    • Initial experience of fecal microbiota transplantation in gastrointestinal disease: A case series
    • Wang, J. W. et al. Initial experience of fecal microbiota transplantation in gastrointestinal disease: a case series. Kaohsiung J. Med. Sci. https://doi.org/10.1002/kjm2.12094 (2019).
    • (2019) Kaohsiung J. Med. Sci
    • Wang, J.W.1
  • 485
    • 85012869662 scopus 로고    scopus 로고
    • Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: A randomised placebo-controlled trial
    • Paramsothy, S. et al. Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet 389, 1218–1228 (2017).
    • (2017) Lancet , vol.389 , pp. 1218-1228
    • Paramsothy, S.1
  • 486
    • 85059955924 scopus 로고    scopus 로고
    • Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: A randomized clinical trial
    • Costello, S. P. et al. Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial. JAMA 321, 156–164 (2019).
    • (2019) JAMA , vol.321 , pp. 156-164
    • Costello, S.P.1
  • 487
    • 85069431710 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: Efficacy of faecal microbiota transplantation for the treatment of ndrome
    • Ianiro, G. et al. Systematic review with meta-analysis: efficacy of faecal microbiota transplantation for the treatment of ndrome. Aliment Pharmacol. Ther. https://doi.org/10.1111/apt.15330 (2019).
    • (2019) Aliment Pharmacol. Ther
    • Ianiro, G.1
  • 488
    • 85067505516 scopus 로고    scopus 로고
    • Fecal microbial transplant capsules are safe in hepatic ence-phalopathy: A phase 1, randomized, placebo-controlled trial
    • Bajaj, J. S. et al. Fecal microbial transplant capsules are safe in hepatic ence-phalopathy: a phase 1, randomized, placebo-controlled trial. Hepatology https://doi.org/10.1002/hep.30690 (2019).
    • (2019) Hepatology
    • Bajaj, J.S.1
  • 489
    • 85016009015 scopus 로고    scopus 로고
    • Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: An open-label study
    • Kang, D. W. et al. Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome 5, 10 (2017).
    • (2017) Microbiome , vol.5
    • Kang, D.W.1
  • 490
    • 85060874585 scopus 로고    scopus 로고
    • Modulating the microbiome to improve therapeutic response in cancer
    • McQuade, J. L., Daniel, C. R., Helmink, B. A. & Wargo, J. A. Modulating the microbiome to improve therapeutic response in cancer. Lancet Oncol. 20, e77–e91 (2019).
    • (2019) Lancet Oncol , vol.20 , pp. e77-e91
    • McQuade, J.L.1    Daniel, C.R.2    Helmink, B.A.3    Wargo, J.A.4
  • 492
    • 84963613854 scopus 로고    scopus 로고
    • The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation
    • Langdon, A., Crook, N. & Dantas, G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med 8, 39 (2016).
    • (2016) Genome Med , vol.8
    • Langdon, A.1    Crook, N.2    Dantas, G.3
  • 494
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • Youngster, I. et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312, 1772–1778 (2014).
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1
  • 495
    • 84900297692 scopus 로고    scopus 로고
    • Fecal transplant for recurrent Clostridium difficile infection in children with and without inflammatory bowel disease
    • Russell, G. H. et al. Fecal transplant for recurrent Clostridium difficile infection in children with and without inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 58, 588–592 (2014).
    • (2014) J. Pediatr. Gastroenterol. Nutr. , vol.58 , pp. 588-592
    • Russell, G.H.1
  • 496
    • 84978328160 scopus 로고    scopus 로고
    • Weight gain after fecal microbiota transplantation
    • Alang, N. & Kelly, C. R. Weight gain after fecal microbiota transplantation. Open Forum Infect. Dis. 2, ofv004 (2015).
    • (2015) Open Forum Infect. Dis. , vol.2
    • Alang, N.1    Kelly, C.R.2
  • 497
    • 84906095918 scopus 로고    scopus 로고
    • Case Records of the Massachusetts General Hospital. Case 25-2014. A 37-year-old man with ulcerative colitis and bloody diarrhea
    • Hohmann, E. L., Ananthakrishnan, A. N. & Deshpande, V. Case Records of the Massachusetts General Hospital. Case 25-2014. A 37-year-old man with ulcerative colitis and bloody diarrhea. N. Engl. J. Med. 371, 668–675 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 668-675
    • Hohmann, E.L.1    Ananthakrishnan, A.N.2    Deshpande, V.3
  • 498
    • 84881148330 scopus 로고    scopus 로고
    • Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts
    • Schwartz, M., Gluck, M. & Koon, S. Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts. Am. J. Gastroenterol. 108, 1367 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1367
    • Schwartz, M.1    Gluck, M.2    Koon, S.3
  • 499
    • 85035071123 scopus 로고    scopus 로고
    • Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice
    • Wong, S. H. et al. Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice. Gastroenterology 153, 1621–1633.e1626 (2017).
    • (2017) Gastroenterology 153 , vol.e1626 , pp. 1621-1633
    • Wong, S.H.1
  • 500
    • 85065551646 scopus 로고    scopus 로고
    • The dirty aspects of fecal microbiota transplantation: A review of its adverse effects and complications
    • Dailey, F. E., Turse, E. P., Daglilar, E. & Tahan, V. The dirty aspects of fecal microbiota transplantation: a review of its adverse effects and complications. Curr. Opin. Pharm. 49, 29–33 (2019).
    • (2019) Curr. Opin. Pharm. , vol.49 , pp. 29-33
    • Dailey, F.E.1    Turse, E.P.2    Daglilar, E.3    Tahan, V.4
  • 502
    • 85066834571 scopus 로고    scopus 로고
    • Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time
    • de Groot, P. et al. Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time. Gut https://doi.org/10.1136/gutjnl-2019-318320 (2019).
    • (2019) Gut
    • de Groot, P.1
  • 503
    • 85060250951 scopus 로고    scopus 로고
    • Antibiotics-induced monodominance of a novel gut bacterial order
    • Hildebrand, F. et al. Antibiotics-induced monodominance of a novel gut bacterial order. Gut https://doi.org/10.1136/gutjnl-2018-317715 (2019).
    • (2019) Gut
    • Hildebrand, F.1
  • 504
    • 85013456475 scopus 로고    scopus 로고
    • Randomised clinical trial: Faecal microbiota transplantation for recurrent Clostridum difficile infection—fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy
    • Jiang, Z. D. et al. Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection—fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy. Aliment Pharm. Ther. 45, 899–908 (2017).
    • (2017) Aliment Pharm. Ther. , vol.45 , pp. 899-908
    • Jiang, Z.D.1
  • 505
    • 85061630243 scopus 로고    scopus 로고
    • Bacterial viability in faecal transplants: Which bacteria survive?
    • Papanicolas, L. E. et al. Bacterial viability in faecal transplants: Which bacteria survive? EBioMedicine 41, 509–516 (2019).
    • (2019) Ebiomedicine , vol.41 , pp. 509-516
    • Papanicolas, L.E.1
  • 506
    • 85066397004 scopus 로고    scopus 로고
    • Efficacy of fecal microbiota transplantation in irritable bowel syndrome: A systematic review and meta-analysis
    • Xu, D. et al. Efficacy of fecal microbiota transplantation in irritable bowel syndrome: a systematic review and meta-analysis. Am. J. Gastroenterol. 114, 1043–1050 (2019).
    • (2019) Am. J. Gastroenterol. , vol.114 , pp. 1043-1050
    • Xu, D.1
  • 507
    • 85037042631 scopus 로고    scopus 로고
    • Effect of oral capsule-vs colonoscopy-delivered fecal microbiota transplantation on recurrent Clostridium difficile infection: A randomized clinical trial
    • Kao, D. et al. Effect of oral capsule-vs colonoscopy-delivered fecal microbiota transplantation on recurrent Clostridium difficile infection: a randomized clinical trial. JAMA 318, 1985–1993 (2017).
    • (2017) JAMA , vol.318 , pp. 1985-1993
    • Kao, D.1
  • 508
    • 85048672675 scopus 로고    scopus 로고
    • Role of the gut microbiota in nutrition and health
    • Valdes, A. M., Walter, J., Segal, E. & Spector, T. D. Role of the gut microbiota in nutrition and health. BMJ 361, k2179 (2018).
    • (2018) BMJ , vol.361
    • Valdes, A.M.1    Walter, J.2    Segal, E.3    Spector, T.D.4
  • 509
    • 85028348393 scopus 로고    scopus 로고
    • A randomized synbiotic trial to prevent sepsis among infants in rural India
    • Panigrahi, P. et al. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature 548, 407–412 (2017).
    • (2017) Nature , vol.548 , pp. 407-412
    • Panigrahi, P.1
  • 510
    • 85040032347 scopus 로고    scopus 로고
    • Lactobacillus reuteri to treat infant colic: A meta-analysis
    • Sung, V. et al. Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics 141, https://doi.org/10.1542/peds.2017-1811 (2018).
    • (2018) Pediatrics , pp. 141
    • Sung, V.1
  • 511
    • 84997079362 scopus 로고    scopus 로고
    • Probiotics and the prevention of antibiotic-associated diarrhea in infants and children
    • Johnston, B. C., Goldenberg, J. Z. & Parkin, P. C. Probiotics and the prevention of antibiotic-associated diarrhea in infants and children. JAMA 316,1484–1485 (2016).
    • (2016) JAMA , vol.316 , pp. 1484-1485
    • Johnston, B.C.1    Goldenberg, J.Z.2    Parkin, P.C.3
  • 512
    • 85051979016 scopus 로고    scopus 로고
    • Probiotics to prevent Clostridium difficile infection in patients receiving antibiotics
    • Goldenberg, J. Z., Mertz, D. & Johnston, B. C. Probiotics to prevent Clostridium difficile infection in patients receiving antibiotics. JAMA 320, 499–500 (2018).
    • (2018) JAMA , vol.320 , pp. 499-500
    • Goldenberg, J.Z.1    Mertz, D.2    Johnston, B.C.3
  • 513
    • 85055195582 scopus 로고    scopus 로고
    • Pathogen elimination by probiotic Bacillus via signalling interference
    • Piewngam, P. et al. Pathogen elimination by probiotic Bacillus via signalling interference. Nature 562, 532–537 (2018).
    • (2018) Nature , vol.562 , pp. 532-537
    • Piewngam, P.1
  • 514
    • 85053084082 scopus 로고    scopus 로고
    • Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria
    • Isabella, V. M. et al. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat. Biotechnol. 36, 857–864 (2018).
    • (2018) Nat. Biotechnol. , vol.36 , pp. 857-864
    • Isabella, V.M.1
  • 515
    • 84959314003 scopus 로고    scopus 로고
    • Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice
    • Li, J. et al. Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. Proc. Natl. Acad. Sci. USA 113, E1306–E1315 (2016).
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. E1306-E1315
    • Li, J.1
  • 516
    • 85067098815 scopus 로고    scopus 로고
    • Combination therapy of TGF-beta blockade and commensal-derived probiotics provides enhanced antitumor immune response and tumor suppression
    • Shi, L. et al. Combination therapy of TGF-beta blockade and commensal-derived probiotics provides enhanced antitumor immune response and tumor suppression. Theranostics 9, 4115–4129 (2019).
    • (2019) Theranostics , vol.9 , pp. 4115-4129
    • Shi, L.1
  • 517
    • 84880860692 scopus 로고    scopus 로고
    • Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity
    • Yamamoto, M. L. et al. Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity. Cancer Res. 73, 4222–4232 (2013).
    • (2013) Cancer Res , vol.73 , pp. 4222-4232
    • Yamamoto, M.L.1
  • 518
    • 84948440369 scopus 로고    scopus 로고
    • Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia
    • Bindels, L. B. et al. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia. ISME J. 10, 1456–1470 (2016).
    • (2016) ISME J , vol.10 , pp. 1456-1470
    • Bindels, L.B.1
  • 519
    • 85053806933 scopus 로고    scopus 로고
    • Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: A strategy to promote immunosurveillance against lung metastases
    • Le Noci, V. et al. Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: a strategy to promote immunosurveillance against lung metastases. Cell Rep. 24, 3528–3538 (2018).
    • (2018) Cell Rep , vol.24 , pp. 3528-3538
    • Le Noci, V.1
  • 520
    • 0028900687 scopus 로고
    • Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial
    • Aso, Y. et al. Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group. Eur. Urol. 27, 104–109 (1995).
    • (1995) The BLP Study Group. Eur. Urol. , vol.27 , pp. 104-109
    • Aso, Y.1
  • 521
    • 85056086517 scopus 로고    scopus 로고
    • Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip
    • Shin, W. & Kim, H. J. Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip. Proc. Natl. Acad. Sci. USA 115, E10539–E10547 (2018).
    • (2018) Proc. Natl. Acad. Sci. USA , vol.115 , pp. E10539-E10547
    • Shin, W.1    Kim, H.J.2
  • 522
    • 85052739697 scopus 로고    scopus 로고
    • Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT
    • Suez, J. et al. Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell 174, 1406–1423.e1416 (2018).
    • (2018) Cell 174 , vol.e1416 , pp. 1406-1423
    • Suez, J.1
  • 523
    • 84992363298 scopus 로고    scopus 로고
    • Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome
    • Maldonado-Gomez, M. X. et al. Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20, 515–526 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 515-526
    • Maldonado-Gomez, M.X.1
  • 524
    • 85047558885 scopus 로고    scopus 로고
    • An exclusive metabolic niche enables strain engraftment in the gut microbiota
    • Shepherd, E. S., DeLoache, W. C., Pruss, K. M., Whitaker, W. R. & Sonnenburg, J. L. An exclusive metabolic niche enables strain engraftment in the gut microbiota. Nature 557, 434–438 (2018).
    • (2018) Nature , vol.557 , pp. 434-438
    • Shepherd, E.S.1    Deloache, W.C.2    Pruss, K.M.3    Whitaker, W.R.4    Sonnenburg, J.L.5
  • 525
    • 85060794638 scopus 로고    scopus 로고
    • Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers
    • Baxter, N. T. et al. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers. mBio, 10 https://doi.org/10.1128/mBio.02566-18 (2019).
    • (2019) Mbio , vol.10
    • Baxter, N.T.1
  • 526
    • 85052211052 scopus 로고    scopus 로고
    • Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort
    • Gurry, T. et al. Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort. Sci. Rep. 8, 12699 (2018).
    • (2018) Sci. Rep , vol.8
    • Gurry, T.1
  • 527
    • 85051593870 scopus 로고    scopus 로고
    • Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice. Front
    • Matt, S. M. et al. Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice. Front. Immunol. 9, 1832 (2018).
    • (2018) Immunol , vol.9 , pp. 1832
    • Matt, S.M.1
  • 528
    • 85060169680 scopus 로고    scopus 로고
    • An engineered E. Coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
    • Kurtz, C. B. et al. An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans. Sci. Transl. Med. 11, https://doi.org/10.1126/scitranslmed.aau7975 (2019).
    • (2019) Sci. Transl. Med , vol.11
    • Kurtz, C.B.1
  • 529
    • 85049234817 scopus 로고    scopus 로고
    • Genetically modified bacteria enlisted in fight against disease
    • Reardon, S. Genetically modified bacteria enlisted in fight against disease. Nature 558, 497–498 (2018).
    • (2018) Nature , vol.558 , pp. 497-498
    • Reardon, S.1
  • 531
    • 85049652751 scopus 로고    scopus 로고
    • Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet
    • Zhang, Y. et al. Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet. Epilepsy Res. 145, 163–168 (2018).
    • (2018) Epilepsy Res , vol.145 , pp. 163-168
    • Zhang, Y.1
  • 532
    • 85046857479 scopus 로고    scopus 로고
    • The gut microbiota mediates the anti-seizure effects of the ketogenic diet
    • Olson, C. A. et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet. Cell 173, 1728–1741.e1713 (2018).
    • (2018) Cell 173 , vol.e1713 , pp. 1728-1741
    • Olson, C.A.1
  • 533
    • 85054461194 scopus 로고    scopus 로고
    • Gut microbes may account for the anti-seizure effects of the ketogenic diet
    • Hampton, T. Gut microbes may account for the anti-seizure effects of the ketogenic diet. JAMA 320, 1307 (2018).
    • (2018) JAMA , vol.320 , pp. 1307
    • Hampton, T.1
  • 534
    • 85052574900 scopus 로고    scopus 로고
    • High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production
    • Miranda, P. M. et al. High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production. Microbiome 6, 57 (2018).
    • (2018) Microbiome , vol.6
    • Miranda, P.M.1
  • 535
    • 85062528006 scopus 로고    scopus 로고
    • Dietary patterns and risk of hepatocellular carcinoma among U.S. men and women
    • Ma, Y. et al. Dietary patterns and risk of hepatocellular carcinoma among U.S. men and women. Hepatology https://doi.org/10.1002/hep.30362 (2018).
    • (2018) Hepatology
    • Ma, Y.1
  • 536
    • 85060920431 scopus 로고    scopus 로고
    • Transforming medicine with the microbiome
    • Zmora, N., Soffer, E. & Elinav, E. Transforming medicine with the microbiome. Sci. Transl. Med. 11, https://doi.org/10.1126/scitranslmed.aaw1815 (2019).
    • (2019) Sci. Transl. Med , pp. 11
    • Zmora, N.1    Soffer, E.2    Elinav, E.3
  • 537
    • 85056590725 scopus 로고    scopus 로고
    • The gut microbiota at the intersection of diet and human health
    • Gentile, C. L. & Weir, T. L. The gut microbiota at the intersection of diet and human health. Science (New York, NY) 362, 776–780 (2018).
    • (2018) Science (New York, NY) , vol.362 , pp. 776-780
    • Gentile, C.L.1    Weir, T.L.2
  • 538
    • 85064196539 scopus 로고    scopus 로고
    • Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: A randomised cross-over trial
    • Chambers, E. S. et al. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut 68, 1430–1438 (2019).
    • (2019) Gut , vol.68 , pp. 1430-1438
    • Chambers, E.S.1
  • 539
    • 84867404198 scopus 로고    scopus 로고
    • Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
    • Bindels, L. B. et al. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Br. J. Cancer 107, 1337–1344 (2012).
    • (2012) Br. J. Cancer , vol.107 , pp. 1337-1344
    • Bindels, L.B.1


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