The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

Immunity

Volumn 49, Issue 6, 2018, Pages 1116-1131.e7

  Tyagi, Abdul Malik ^a   Yu, Mingcan ^a   Darby, Trevor M ^a   Vaccaro, Chiara ^a   Li, Jau Yi ^a   Owens, Joshua A ^a   Hsu, Emory ^a   Adams, Jonathan ^a   Weitzmann, M Neale ^a,b   Jones, Rheinallt M ^a   Pacifici, Roberto ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

bone formation; butyrate; Lactobacillus rhamnosus GG; microbiota; NFAT; probiotics; regulatory T cells; short chain fatty acids; T cells; Wnt10b

Indexed keywords

BONE SIALOPROTEIN; BUTYRIC ACID; COLLAGEN TYPE 1; INTERLEUKIN 10; OSTEOCALCIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; WNT10B PROTEIN; BUTYRIC ACID DERIVATIVE; PROBIOTIC AGENT; WNT PROTEIN; WNT10B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MASS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL SELECTION; CONTROLLED STUDY; IN VITRO STUDY; LACTOBACILLUS RHAMNOSUS; MICROBIAL METABOLISM; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SUPPLEMENTATION; T LYMPHOCYTE; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; CELL COMMUNICATION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; BUTYRATES; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL PROLIFERATION; FEMALE; LACTOBACILLUS RHAMNOSUS; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOGENESIS; PROBIOTICS; T-LYMPHOCYTES, REGULATORY; WNT PROTEINS;

EID: 85058361062     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.10.013     Document Type: Article

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