Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Nature Immunology

Volumn 17, Issue 5, 2016, Pages 505-513

  Mathewson, Nathan D ^a   Jenq, Robert ^b   Mathew, Anna V ^a   Koenigsknecht, Mark ^a   Hanash, Alan ^b   Toubai, Tomomi ^a   Oravecz Wilson, Katherine ^a   Wu, Shin Rong ^a   Sun, Yaping ^a   Rossi, Corinne ^a   Fujiwara, Hideaki ^a   Byun, Jaeman ^a   Shono, Yusuke ^b   Lindemans, Caroline ^b   Calafiore, Marco ^b   Schmidt, Thomas C ^a   Honda, Kenya ^c   Young, Vincent B ^a   Pennathur, Subramaniam ^a   Van Den Brink, Marcel ^b   Reddy, Pavan ^a   more..

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; EPITHELIAL CELL ADHESION MOLECULE; HISTONE; SHORT CHAIN FATTY ACID; BUTYRIC ACID DERIVATIVE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; VOLATILE FATTY ACID;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL DAMAGE; CLOSTRIDIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GRAFT VERSUS HOST REACTION; HISTONE ACETYLATION; INTESTINAL TISSUE; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET ORGAN; ACETYLATION; ADVERSE EFFECTS; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; GRAFT VS HOST DISEASE; IMMUNOBLOTTING; IMMUNOLOGY; INTESTINE; MASS FRAGMENTOGRAPHY; METABOLISM; METABOLOME; MICROBIOLOGY; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ACETYLATION; ANIMALS; BONE MARROW TRANSPLANTATION; BUTYRATES; CELLS, CULTURED; EPITHELIAL CELLS; FATTY ACIDS, VOLATILE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION; GRAFT VS HOST DISEASE; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; IMMUNOBLOTTING; INTESTINES; METABOLOME; MICE, INBRED BALB C; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84961392222     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3400     Document Type: Article

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