Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

Cell

Volumn 176, Issue 5, 2019, Pages 998-1013.e16

  Jin, Chengcheng ^a   Lagoudas, Georgia K ^b   Zhao, Chen ^c   Bullman, Susan ^d,e   Bhutkar, Arjun ^a   Hu, Bo ^e   Ameh, Samuel ^a   Sandel, Demi ^a   Liang, Xu Sue ^a   Mazzilli, Sarah ^f   Whary, Mark T ^a   Meyerson, Matthew ^d,e   Germain, Ronald ^c   Blainey, Paul C ^a,b,d   Fox, James G ^a,b   Jacks, Tyler ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IL 17; inflammation; lung adenocarcinoma; lung cancer; microbiota; neutrophils; tumor microenvironment; T cells

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; LYMPHOCYTE ANTIGEN RECEPTOR; MYD88 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BONE MARROW CELL; CANCER THERAPY; CELLULAR IMMUNITY; COHORT ANALYSIS; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DYSBIOSIS; EFFECTOR CELL; EVIDENCE BASED PRACTICE; FEMALE; GAMMA DELTA T LYMPHOCYTE; GENE LOSS; GENE MUTATION; GERMFREE MOUSE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MICROBIAL INTERACTION; MICROFLORA; MOLECULAR INTERACTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; ONCOGENE K RAS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES COMPOSITION; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; IMMUNOLOGY; INTRAEPITHELIAL LYMPHOCYTE; LUNG; LUNG TUMOR; METABOLISM; NEUTROPHIL; PHYSIOLOGY; SYMBIOSIS; T LYMPHOCYTE;

ANIMALS; CELL PROLIFERATION; FEMALE; HOST MICROBIAL INTERACTIONS; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-23; INTRAEPITHELIAL LYMPHOCYTES; LUNG; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICROBIOTA; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SYMBIOSIS; T-LYMPHOCYTES;

EID: 85061787031     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.12.040     Document Type: Article

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