Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

Cell Chemical Biology

Volumn 26, Issue 1, 2019, Pages 27-34.e4

  Kang, Jason D ^a,e   Myers, Christopher J ^a   Harris, Spencer C ^a   Kakiyama, Genta ^d,e   Lee, In Kyoung ^b   Yun, Bong Sik ^b   Matsuzaki, Keiichi ^c   Furukawa, Megumi ^c   Min, Hae Ki ^d   Bajaj, Jasmohan S ^d,e   Zhou, Huiping ^a,e   Hylemon, Phillip B ^a,e  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Chonbuk National University   (South Korea)

^c NIHON UNIVERSITY   (Japan)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

1 acetyl carboline; Clostridium difficile; Clostridium scindens; Clostridium sordellii; cyclic dipeptides; dysbiosis; gut microbiome; turbomycin A

Indexed keywords

1 ACETYL BETA CARBOLINE; ANTIBIOTIC AGENT; CHOLIC ACID; DEOXYCHOLIC ACID; DIPEPTIDE; LITHOCHOLIC ACID; PROLINE; TURBOMYCIN A; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BAIE PROTEIN, CLOSTRIDIUM SCINDENS; BILE ACID; HYDROLYASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BILE ACID 7ALPHA DEHYDROXYLATING BACTERIUM; CELL DIVISION; CONTROLLED STUDY; DRUG POTENTIATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; MITOSIS INHIBITION; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; SYNTHESIS; CHEMISTRY; CLOSTRIDIUM; DRUG EFFECT; GENETICS; HYDROXYLATION; METABOLISM;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BILE ACIDS AND SALTS; CLOSTRIDIUM; HYDRO-LYASES; HYDROXYLATION;

EID: 85059667892     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2018.10.003     Document Type: Article

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