A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Nature Genetics

Volumn 50, Issue 7, 2018, Pages 968-978

  Wu, Lang ^a   Shi, Wei ^b   Long, Jirong ^a   Guo, Xingyi ^a   Michailidou, Kyriaki ^c,d   Beesley, Jonathan ^b   Bolla, Manjeet K ^c   Shu, Xiao Ou ^a   Lu, Yingchang ^a   Cai, Qiuyin ^a   Al Ejeh, Fares ^b   Rozali, Esdy ^b   Wang, Qin ^c   Dennis, Joe ^c   Li, Bingshan ^e   Zeng, Chenjie ^a   Feng, Helian ^f   Gusev, Alexander ^g,h,i   Barfield, Richard T ^f   Andrulis, Irene L ^j,k   Anton Culver, Hoda ^l   Arndt, Volker ^m   Aronson, Kristan J ⁿ   Auer, Paul L ^o,p   Barrdahl, Myrto ^m   Baynes, Caroline ^q   Beckmann, Matthias W ^r   Benitez, Javier ^s,t   Bermisheva, Marina ^u,v   Blomqvist, Carl ^w,x   Bogdanova, Natalia V ^v,y   Bojesen, Stig E ^z,aa   Brauch, Hiltrud ^m,ab,ac   Brenner, Hermann ^m   Brinton, Louise ^ad   Broberg, Per ^ae   Brucker, Sara Y ^af   Burwinkel, Barbara ^m,ag   Caldés, Trinidad ^ah   Canzian, Federico ^m   Carter, Brian D ^ai   Castelao, J Esteban ^aj   Chang Claude, Jenny ^m,ak   Chen, Xiaoqing ^b   Cheng, Ting Yuan David ^al   Christiansen, Hans ^v   Clarke, Christine L ^am   Collée, Margriet ^an   Cornelissen, Sten ^ao   Couch, Fergus J ^ap   Cox, David ^aq,ar   Cox, Angela ^as   Cross, Simon S ^at   Cunningham, Julie M ^ap   Czene, Kamila ^au   Daly, Mary B ^av   Devilee, Peter ^aw   Doheny, Kimberly F ^ax   Dörk, Thilo ^v   Dos Santos Silva, Isabel ^ay   Dumont, Martine ^az   Dwek, Miriam ^ba   Eccles, Diana M ^bb   Eilber, Ursula ^m   Eliassen, A Heather ^f,i   Engel, Christoph ^bc   Eriksson, Mikael ^au   Fachal, Laura ^q   Fasching, Peter A ^r,bd   Figueroa, Jonine ^ad,be   Flesch Janys, Dieter ^ak   Fletcher, Olivia ^bf   Flyger, Henrik ^z   Fritschi, Lin ^bg   Gabrielson, Marike ^au   Gago Dominguez, Manuela ^bh,bi   Gapstur, Susan M ^ai   García Closas, Montserrat ^ad   Gaudet, Mia M ^ai   Ghoussaini, Maya ^q   Giles, Graham G ^bj,bk   Goldberg, Mark S ^bl,bm   Goldgar, David E ^bn   González Neira, Anna ^s   Guénel, Pascal ^bo   Hahnen, Eric ^bp,bq   Haiman, Christopher A ^br   Håkansson, Niclas ^au   Hall, Per ^au,bs   Hallberg, Emily ^ap   Hamann, Ute ^m   Harrington, Patricia ^q   Hein, Alexander ^r   Hicks, Belynda ^bt   Hillemanns, Peter ^v   Hollestelle, Antoinette ^bu   Hoover, Robert N ^ad   Hopper, John L ^bk   Huang, Guanmengqian ^m   Humphreys, Keith ^au   Hunter, David J ^f,bv   Jakubowska, Anna ^bw   Janni, Wolfgang ^bx   John, Esther M ^by,bz,ca   Johnson, Nichola ^bf   Jones, Kristine ^bt   Jones, Michael E ^bf   Jung, Audrey ^m   Kaaks, Rudolf ^m   Kerin, Michael J ^cb   Khusnutdinova, Elza ^ca,cc   Kosma, Veli Matti ^cd,ce   Kristensen, Vessela N ^cf,cg,ch   Lambrechts, Diether ^ci,cj   Le Marchand, Loic ^ck   Li, Jingmei ^cl   Lindström, Sara ^o,cm   Lissowska, Jolanta ^cn   Lo, Wing Yee ^ab,ac   Loibl, Sibylle ^co   Lubinski, Jan ^bu   Luccarini, Craig ^q   Lux, Michael P ^r   MacInnis, Robert J ^bj,bk   Maishman, Tom ^cp   Kostovska, Ivana Maleva ^v,cq   Mannermaa, Arto ^cd,ce   Manson, JoAnn E ^f,i   Margolin, Sara ^au   Mavroudis, Dimitrios ^cr   Meijers Heijboer, Hanne ^cs   Meindl, Alfons ^ct   Menon, Usha ^cu   Meyer, Jeffery ^ap   Mulligan, Anna Marie ^cv,cw   Neuhausen, Susan L ^cx   Nevanlinna, Heli ^w   Neven, Patrick ^cy   Nielsen, Sune F ^z   Nordestgaard, Børge G ^z,aa   Olopade, Olufunmilayo I ^cz   Olson, Janet E ^ap   Olsson, Håkan ^ae   Peterlongo, Paolo ^da   Peto, Julian ^ay   Plaseska Karanfilska, Dijana ^cq   Prentice, Ross ^o   Presneau, Nadege ^ba   Pylkäs, Katri ^db,dc   Rack, Brigitte ^bx   Radice, Paolo ^dd   Rahman, Nazneen ^bf   Rennert, Gad ^de   Rennert, Hedy S ^de   Rhenius, Valerie ^q   Romero, Atocha ^ah,df   Romm, Jane ^ax   Rudolph, Anja ^m   Saloustros, Emmanouil ^cr   Sandler, Dale P ^dg   Sawyer, Elinor J ^dh   Schmidt, Marjanka K ^ao   Schmutzler, Rita K ^bp,bq   Schneeweiss, Andreas ^ag   Scott, Rodney J ^di,dj   Scott, Christopher G ^ap   Seal, Sheila ^bf   Shah, Mitul ^q   Shrubsole, Martha J ^a   Smeets, Ann ^cy   Southey, Melissa C ^dk   Spinelli, John J ^dl,dm   Stone, Jennifer ^bg,dn   Surowy, Harald ^m,ag   Swerdlow, Anthony J ^bf   Tamimi, Rulla M ^f,i   Tapper, William ^bb   Taylor, Jack A ^dg   Terry, Mary Beth ^do   Tessier, Daniel C ^bl   Thomas, Abigail ^ap   Thöne, Kathrin ^ak   Tollenaar, Rob A E M ^aw   Torres, Diana ^m,dp   Truong, Thérèse ^bo   Untch, Michael ^dq   Vachon, Celine ^ap   Van Den Berg, David ^br   Vincent, Daniel ^bl   Waisfisz, Quinten ^dc   Weinberg, Clarice R ^dg   Wendt, Camilla ^au   Whittemore, Alice S ^bz,ca   Wildiers, Hans ^cy   Willett, Walter C ^f,i   Winqvist, Robert ^db,dc   Wolk, Alicja ^au   Xia, Lucy ^br   Yang, Xiaohong R ^ad   Ziogas, Argyrios ^l   Ziv, Elad ^dr   Dunning, Alison M ^q   Pharoah, Paul D P ^c,q   Simard, Jacques ^az   Milne, Roger L ^bj,bk   Edwards, Stacey L ^b   Kraft, Peter ^f   Easton, Douglas F ^c,q   Chenevix Trench, Georgia ^b   Zheng, Wei ^a   more..

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g DANA FARBER CANCER INSTITUTE   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j MOUNT SINAI HOSPITAL   (Canada)

^k UNIVERSITY OF TORONTO   (Canada)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

ⁿ QUEEN S UNIVERSITY   (Canada)

^o USA   (United States)

^p UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^q UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^r UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^s Structural Biology and Biocomputing Programme   (Spain)

^t CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^u INSTITUTE OF BIOCHEMISTRY AND GENETICS   (Russian Federation)

^v HANNOVER MEDICAL SCHOOL   (Germany)

^w HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^x ÖREBRO UNIVERSITY   (Sweden)

^y Research Institute of Oncology and Medical Radiology of the Ministry of Health of the Byelorussian SSR   (Belarus)

^z GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^aa UNIVERSITY OF COPENHAGEN   (Denmark)

^ab DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^ac UNIVERSITY OF TÜBINGEN   (Germany)

^ad NATIONAL CANCER INSTITUTE   (United States)

^ae LUND UNIVERSITY   (Sweden)

^af UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^ag UNIVERSITY OF HEIDELBERG   (Germany)

^ah HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^ai AMERICAN CANCER SOCIETY   (United States)

^aj Research Group on Rare Diseases and Pediatric Medicine   (Spain)

^ak UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^al UNIVERSITY OF FLORIDA   (United States)

^am UNIVERSITY OF SYDNEY   (Australia)

^an ERASMUS MEDICAL CENTER   (Netherlands)

^ao ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^ap MAYO CLINIC   (United States)

^aq IMPERIAL COLLEGE LONDON   (United Kingdom)

^ar CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^as UNIVERSITY OF SHEFFIELD   (United Kingdom)

^at UNIVERSITY OF SHEFFIELD   (United Kingdom)

^au KAROLINSKA INSTITUTE   (Sweden)

^av FOX CHASE CANCER CENTER   (United States)

^aw LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^ax JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ay LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^az LAVAL UNIVERSITY   (Canada)

^ba UNIVERSITY OF WESTMINSTER   (United Kingdom)

^bb UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^bc UNIVERSITY OF LEIPZIG   (Germany)

^bd UNIVERSITY OF CALIFORNIA   (United States)

^be UNIVERSITY OF EDINBURGH   (United Kingdom)

^bf INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^bg CURTIN UNIVERSITY   (Australia)

^bh Santiago University Clinical Hospital   (Spain)

^bi UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^bj CANCER EPIDEMIOLOGY CENTRE   (Australia)

^bk UNIVERSITY OF MELBOURNE   (Australia)

^bl MCGILL UNIVERSITY   (Canada)

^bm ROYAL VICTORIA HOSPITAL   (Canada)

^bn UNIVERSITY OF UTAH   (United States)

^bo CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^bp UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^bq UNIVERSITY OF COLOGNE   (Germany)

^br UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^bs STOCKHOLM SÖDER HOSPITAL   (Sweden)

^bt FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^bu ERASMUS MC CANCER INSTITUTE   (Netherlands)

^bv UNIVERSITY OF OXFORD   (United Kingdom)

^bw POMERANIAN MEDICAL UNIVERSITY   (Poland)

^bx UNIVERSITY HOSPITAL ULM   (Germany)

^by CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^bz STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ca STANFORD CANCER INSTITUTE   (United States)

^cb NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^cc Science and Education Center of Bashkir People History Ufa University of Science and Technology   (Russian Federation)

^cd UNIVERSITY OF EASTERN FINLAND   (Finland)

^ce KUOPIO UNIVERSITY HOSPITAL   (Finland)

^cf OSLO UNIVERSITY HOSPITAL   (Norway)

^cg UNIVERSITY OF OSLO   (Norway)

^ch OSLO UNIVERSITY HOSPITAL   (Norway)

^ci UNIVERSITY OF LEUVEN   (Belgium)

^cj UNIVERSITY OF LEUVEN   (Belgium)

^ck UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^cl GENOME INSTITUTE OF SINGAPORE   (Singapore)

^cm UNIVERSITY OF WASHINGTON   (United States)

^cn INSTITUTE OF ONCOLOGY   (Poland)

^co German Breast Group GmbH   (Germany)

^cp UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^cq MACEDONIAN ACADEMY OF SCIENCES AND ARTS   (Macedonia)

^cr UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^cs VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^ct TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^cu UNIVERSITY COLLEGE LONDON   (United Kingdom)

^cv UNIVERSITY OF TORONTO   (Canada)

^cw UNIVERSITY HEALTH NETWORK   (Canada)

^cx CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^cy Katholieke Universiteit   (Belgium)

^cz UNIVERSITY OF CHICAGO   (United States)

^da FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^db UNIVERSITY OF OULU   (Finland)

^dc Northern Finland Laboratory Centre   (Finland)

^dd NATIONAL CANCER INSTITUTE   (Italy)

^de CARMEL MEDICAL CENTER   (Israel)

^df HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^dg NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^dh GUY S HOSPITAL   (United Kingdom)

^di JOHN HUNTER HOSPITAL   (Australia)

^dj UNIVERSITY OF NEWCASTLE   (Australia)

^dk UNIVERSITY OF MELBOURNE   (Australia)

^dl BRITISH COLUMBIA CANCER AGENCY   (Canada)

^dm UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^dn ROYAL WOMEN'S HOSPITAL   (Australia)

^do Department of Medicine   (United States)

^dp PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^dq HELIOS Clinic Berlin Buch   (Germany)

^dr UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LONG UNTRANSLATED RNA; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ADULT; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONTROLLED STUDY; EUROPEAN; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; GENE EXPRESSION REGULATION; GENETIC SUSCEPTIBILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOME-WIDE ASSOCIATION STUDY; BREAST TUMOR; GENE EXPRESSION; GENETIC PREDISPOSITION; GENETICS; PROCEDURES; RISK;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; TRANSCRIPTOME;

EID: 85048695897     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0132-x     Document Type: Article

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