Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet

Epilepsy Research

Volumn 145, Issue , 2018, Pages 163-168

  Zhang, Yunjian ^a   Zhou, Shuizhen ^a   Zhou, Yuanfeng ^a   Yu, Lifei ^a   Zhang, Linmei ^a   Wang, Yi ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Children; Gut microbiota; Ketogenic diet; Refractory epilepsy

Indexed keywords

CLONAZEPAM; DNA 16S; LAMOTRIGINE; LEVETIRACETAM; OXCARBAZEPINE; TOPIRAMATE; VALPROIC ACID; RNA 16S;

ALISTIPES; ALPHA RHYTHM; ARTICLE; BACTEROIDETES; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLOSTRIDIALES; CONTROLLED STUDY; DISEASE CONTROL; DNA SEQUENCE; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; FECES ANALYSIS; FEMALE; FIRMICUTES; HUMAN; INTESTINE FLORA; INTRACTABLE EPILEPSY; KETOGENIC DIET; LABORATORY TEST; LACHNOSPIRACEAE; MALE; MICROBIAL DIVERSITY; NONHUMAN; OUTCOME ASSESSMENT; POPULATION ABUNDANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RIKENELLACEAE; RUMINOCOCCACEAE; SCHOOL CHILD; SPECIES COMPOSITION; SPECIES RICHNESS; THERAPY EFFECT; DIET THERAPY; DRUG EFFECT; GENETICS; INFANT; METABOLISM; PROCEDURES; RETROSPECTIVE STUDY;

CHILD; CHILD, PRESCHOOL; DIET, KETOGENIC; DRUG RESISTANT EPILEPSY; ELECTROENCEPHALOGRAPHY; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; INFANT; MALE; RETROSPECTIVE STUDIES; RNA, RIBOSOMAL, 16S;

EID: 85049652751     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2018.06.015     Document Type: Article

References (31)

1. Backhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., Khan, M.T., Zhang, J., Li, J., Xiao, L., Al-Aama, J., Zhang, D., Lee, Y.S., Kotowska, D., Colding, C., Tremaroli, V., Yin, Y., Bergman, S., Xu, X., Madsen, L., Kristiansen, K., Dahlgren, J., Wang, J., Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17 (2015), 690–703.
2. Bercsenyi, K., Giribaldi, F., Schiavo, G., The elusive compass of clostridial neurotoxins: deciding when and where to go?. Curr. Top Microbiol. Immunol. 364 (2013), 91–113.
3. Brandscheid, C., Schuck, F., Reinhardt, S., Schafer, K.H., Pietrzik, C.U., Grimm, M., Hartmann, T., Schwiertz, A., Endres, K., Altered gut microbiome composition and tryptic activity of the 5xFAD Alzheimer's mouse model. J. Alzheimers Dis. 56 (2017), 775–788.
4. Chen, J., Chia, N., Kalari, K.R., Yao, J.Z., Novotna, M., Soldan, M.M., Luckey, D.H., Marietta, E.V., Jeraldo, P.R., Chen, X., Weinshenker, B.G., Rodriguez, M., Kantarci, O.H., Nelson, H., Murray, J.A., Mangalam, A.K., Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci. Rep., 6, 2016, 28484.
5. Clemente, J.C., Ursell, L.K., Parfrey, L.W., Knight, R., The impact of the gut microbiota on human health: an integrative view. Cell 148 (2012), 1258–1270.
6. David, L.A., Maurice, C.F., Carmody, R.N., Gootenberg, D.B., Button, J.E., Wolfe, B.E., Ling, A.V., Devlin, A.S., Varma, Y., Fischbach, M.A., Biddinger, S.B., Dutton, R.J., Turnbaugh, P.J., Diet rapidly and reproducibly alters the human gut microbiome. Nature 23:7484 (2014), 559–563 505.
7. Ding, H.T., Taur, Y., Walkup, J.T., Gut microbiota and autism: key concepts and findings. J. Autism. Dev. Disord., 2016.
8. Edgar, R.C., UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat. Methods 10 (2013), 996–998.
9. Erny, D., Hrabe, D.A.A., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., Schwierzeck, V., Utermohlen, O., Chun, E., Garrett, W.S., McCoy, K.D., Diefenbach, A., Staeheli, P., Stecher, B., Amit, I., Prinz, M., Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18 (2015), 965–977.
10. Finnie, J.W., Manavis, J., Chidlow, G., Loss of endothelial barrier antigen immunoreactivity as a marker of clostridium perfringens type D epsilon toxin-induced microvascular damage in rat brain. J. Comp. Pathol. 151 (2014), 153–156.
11. Hedin, C.R., van der Gast, C.J., Stagg, A.J., Lindsay, J.O., Whelan, K., The gut microbiota of siblings offers insights into microbial pathogenesis of inflammatory bowel disease. Gut Microbes 8 (2017), 359–365.
12. Kelly, J.R., Borre, Y, O’ B.C., Patterson, E., El, A.S., Deane, J., Kennedy, P.J., Beers, S., Scott, K., Moloney, G., Hoban, A.E., Scott, L., Fitzgerald, P., Ross, P., Stanton, C., Clarke, G., Cryan, J.F., Dinan, T.G., 2016. Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res 82:109–118.
13. Maukonen, J., Kolho, K.L., Paasela, M., Honkanen, J., Klemetti, P., Vaarala, O., Saarela, M., Altered fecal microbiota in paediatric inflammatory bowel disease. J. Crohns Colitis 9 (2015), 1088–1095.
14. Meehan, C.J., Beiko, R.G., A phylogenomic view of ecological specialization in the lachnospiraceae, a family of digestive tract-associated bacteria. Genome Biol. Evol. 6 (2014), 703–713.
15. Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linlokken, A., Wilson, R., Rudi, K., Correlation between the human fecal microbiota and depression. Neurogastroenterol. Motil. 26 (2014), 1155–1162.
16. Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., Whitney, A., Cross, J.H., The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 7 (2008), 500–506.
17. Newell, C., Bomhof, M.R., Reimer, R.A., Hittel, D.S., Rho, J.M., Shearer, J., Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder. Mol. Autism, 7, 2016, 37.
18. Pal, C., Bengtsson-Palme, J., Kristiansson, E., Larsson, D.G., The structure and diversity of human, animal and environmental resistomes. Microbiome, 4, 2016, 54.
19. Sankar, S.A., Lagier, J.C., Pontarotti, P., Raoult, D., Fournier, P.E., The human gut microbiome, a taxonomic conundrum. Syst. Appl. Microbiol. 38 (2015), 276–286.
20. Schmidt, C., Mental health: thinking from the gut. Nature 518 (2015), S12–S15.
21. Sharon, G., Sampson, T.R., Geschwind, D.H., Mazmanian, S.K., The central nervous system and the gut microbiome. Cell 167 (2016), 915–932.
22. Singh, A., Trevick, S., The epidemiology of global epilepsy. Neurol. Clin. 34 (2016), 837–847.
23. Smith, P.A., The tantalizing links between gut microbes and the brain. Nature 526 (2015), 312–314.
24. Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Pindo, M., Renzi, D., Rizzetto, L., Stefanini, I., Calabro, A., De Filippo, C., Altered gut microbiota in Rett syndrome. Microbiome, 4, 2016, 41.
25. Tagliabue, A., Ferraris, C., Uggeri, F., Trentani, C., Bertoli, S., de Giorgis, V., Veggiotti, P., Elli, M., Short-term impact of a classical ketogenic diet on gut microbiota in GLUT1 deficiency syndrome: a 3-month prospective observational study. Clin. Nutr. ESPEN 17 (2017), 33–37.
26. Unger, M.M., Spiegel, J., Dillmann, K.U., Grundmann, D., Philippeit, H., Burmann, J., Fassbender, K., Schwiertz, A., Schafer, K.H., Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism Relat. Disord. 32 (2016), 66–72.
27. Wang, L., Zeng, B., Liu, Z., Liao, Z., Zhong, Q., Gu, L., Wei, H., Fang, X., Green tea polyphenols modulate colonic microbiota diversity and lipid metabolism in high-fat diet treated HFA mice. J. Food Sci. 83:3 (2018), 864–873.
28. Winesett, S.P., Bessone, S.K., Kossoff, E.H., The ketogenic diet in pharmacoresistant childhood epilepsy. Expert Rev. Neurother. 15 (2015), 621–628.
29. Xie, G., Zhou, Q., Qiu, C.Z., Dai, W.K., Wang, H.P., Li, Y.H., Liao, J.X., Lu, X.G., Lin, S.F., Ye, J.H., Ma, Z.Y., Wang, W.J., Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J. Gastroenterol. 23 (2017), 6164–6171.
30. Zhang, Y., Wang, Y., Zhou, Y., Zhang, L., Yu, L., Zhou, S., Therapeutic effects of the ketogenic diet in children with Lennox-Gastaut syndrome. Epilepsy Res. 128 (2016), 176–180.
31. Zhou, S., Xu, R., He, F., Zhou, J., Wang, Y., Zhou, J., Wang, M., Zhou, W., Diversity of gut microbiota metabolic pathways in 10 pairs of Chinese infant twins. PLoS One, 11, 2016, e161627.