Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

Gut

Volumn 68, Issue 8, 2019, Pages 1430-1438

  Chambers, Edward S ^a   Byrne, Claire S ^a   Morrison, Douglas J ^b   Murphy, Kevin G ^a   Preston, Tom ^b   Tedford, Catriona ^c   Garcia Perez, Isabel ^a   Fountana, Sofia ^a   Serrano Contreras, Jose Ivan ^a   Holmes, Elaine ^a   Reynolds, Catherine J ^a   Roberts, Jordie F ^a   Boyton, Rosemary J ^a   Altmann, Daniel M ^a   Mcdonald, Julie A K ^a   Marchesi, Julian R ^a,d   Akbar, Arne N ^e   Riddell, Natalie E ^f   Wallis, Gareth A ^g   Frost, Gary S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b SCOTTISH UNIVERSITIES ENVIRONMENTAL RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF SURREY   (United Kingdom)

^g UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

colonic microflora; glucose metabolism; inflammation; short chain fatty acids

Indexed keywords

C REACTIVE PROTEIN; CELLULOSE; ESTER DERIVATIVE; GLUCOSE; GLYCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 8; INULIN; INULIN PROPIONATE ESTER; TUMOR NECROSIS FACTOR; TYROSINE; UNCLASSIFIED DRUG; INSULIN; PROPIONIC ACID DERIVATIVE;

ACTINOBACTERIA; ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLOSTRIDIA; CLOSTRIDIALES; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE HOMEOSTASIS; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTESTINE FLORA; MALE; METABOLISM; METABOLOMICS; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SPECIES COMPOSITION; SYSTEMIC INFLAMMATION; THERAPY EFFECT; TREATMENT DURATION; BODY MASS; DIET THERAPY; DIETARY SUPPLEMENT; FECES; METABOLOME; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; TREATMENT OUTCOME;

ADULT; BODY MASS INDEX; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; INULIN; MALE; METABOLOME; MIDDLE AGED; OBESITY; OVERWEIGHT; PROPIONATES; TREATMENT OUTCOME;

EID: 85064196539     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2019-318424     Document Type: Article

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