Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Science

Volumn 359, Issue 6371, 2018, Pages 91-97

  Routy, Bertrand ^a,b   Le Chatelier, Emmanuelle ^c   Derosa, Lisa ^a,b   Duong, Connie P M ^a,b,d   Alou, Maryam Tidjani ^a,b   Daillère, Romain ^a,b   Fluckiger, Aurélie ^a,b,d   Messaoudene, Meriem ^a,b   Rauber, Conrad ^a,b   Roberti, Maria P ^a,b,d   Fidelle, Marine ^a,d   Flament, Caroline ^a,b,d   Poirier Colame, Vichnou ^a,b,d   Opolon, Paule ^a   Klein, Christophe ^e   Iribarren, Kristina ^e,f,g,h   Mondragón, Laura ^e,f,g,h   Jacquelot, Nicolas ^a,b   Qu, Bo ^a,b   Ferrere, Gladys ^a,b   Clémenson, Céline ^a   Mezquita, Laura ^a   Masip, Jordi Remon ^a   Naltet, Charles ⁱ   Brosseau, Solenn ⁱ   Kaderbhai, Coureche ^j   Richard, Corentin ^j   Rizvi, Hira ^k   Levenez, Florence ^c   Galleron, Nathalie ^c   Quinquis, Benoit ^c   Pons, Nicolas ^c   Ryffel, Bernhard ^l   Minard Colin, Véronique ^a,f   Gonin, Patrick ^a,f   Soria, Jean Charles ^a   Deutsch, Eric ^a   Loriot, Yohann ^a   Ghiringhelli, François ^j   Zalcman, Gérard ⁱ   Goldwasser, François ^g,m,n   Escudier, Bernard ^a,o   Hellmann, Matthew D ^k,p   Eggermont, Alexander ^a,b   Raoult, Didier ^q   Albiges, Laurence ^a   Kroemer, Guido ^e,f,g,h,r,s   Zitvogel, Laurence ^a,b,d   more..

^a INSTITUT GUSTAVE ROUSSY   (France)

^b University Paris XI   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d Center of Clinical Investigations in Biotherapies of Cancer (CICBT)   (France)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

^f GRCC   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h SORBONNE UNIVERSITÉ   (France)

ⁱ BICHAT HOSPITAL   (France)

^j Centre Anti Cancer GF Leclerc   (France)

^k MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^l UNIVERSITÉ D'ORLÉANS   (France)

^m Université Paris Diderot ^*  (France)

ⁿ Immunomodulatory Therapies Multidisciplinary Study Group (CERTIM)   (France)

^o Universite Paris Sud   (France)

^p WEILL CORNELL MEDICAL COLLEGE   (United States)

^q AIX MARSEILLE UNIVERSITÉ   (France)

^r HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^s KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR3; INTERLEUKIN 12; PROGRAMMED DEATH 1 RECEPTOR; ANTIINFECTIVE AGENT; CC CHEMOKINE RECEPTOR 9; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR; MONOCLONAL ANTIBODY;

CANCER; DIGESTIVE SYSTEM; FECES; GENOMICS; INHIBITOR; MICROORGANISM; PROTEIN; RELATIVE ABUNDANCE; TUMOR;

ADVANCED CANCER; AKKERMANSIA MUCINIPHILA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; EPITHELIUM TUMOR; FECAL MICROBIOTA TRANSPLANTATION; FECES ANALYSIS; INTESTINE FLORA; METAGENOMICS; MICROBIAL COMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPLEMENTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; FECES; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; METAGENOME; MICROBIOLOGY; NEOPLASM; PROCEDURES; T LYMPHOCYTE; VERRUCOMICROBIA;

AKKERMANSIA MUCINIPHILA; MUS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, MONOCLONAL; CD4 ANTIGENS; FECAL MICROBIOTA TRANSPLANTATION; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-12; METAGENOME; MICE; NEOPLASMS; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, CCR; RECEPTORS, CXCR3; T-LYMPHOCYTES; VERRUCOMICROBIA;

EID: 85033576428     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan3706     Document Type: Article

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