메뉴 건너뛰기




Volumn 9, Issue 1, 2018, Pages

FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; FC ALPHA RECEPTOR I PROTEIN; IMMUNOGLOBULIN A; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 23; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE SYK; TBK1 IKKE PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ALPHA E INTEGRINS; ALPHA INTEGRIN; FC RECEPTOR; FC(ALPHA) RECEPTOR; LEUKOCYTE ANTIGEN;

EID: 85042758014     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-03318-5     Document Type: Article
Times cited : (39)

References (68)
  • 1
    • 84902588402 scopus 로고    scopus 로고
    • Intestinal dendritic cells in the regulation of mucosal immunity
    • Bekiaris, V., Persson, E. K. & Agace, W. W. Intestinal dendritic cells in the regulation of mucosal immunity. Immunol. Rev. 260, 86-101 (2014).
    • (2014) Immunol. Rev. , vol.260 , pp. 86-101
    • Bekiaris, V.1    Persson, E.K.2    Agace, W.W.3
  • 2
    • 84875225901 scopus 로고    scopus 로고
    • Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense
    • Farache, J., Zigmond, E., Shakhar, G. & Jung, S. Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense. Immunol. Cell. Biol. 91, 232-239 (2013).
    • (2013) Immunol. Cell. Biol. , vol.91 , pp. 232-239
    • Farache, J.1    Zigmond, E.2    Shakhar, G.3    Jung, S.4
  • 3
    • 80051925503 scopus 로고    scopus 로고
    • Intestinal CD103+ dendritic cells: Master regulators of tolerance?
    • Scott, C. L., Aumeunier, A. M. & Mowat, A. M. Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol. 32, 412-419 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 412-419
    • Scott, C.L.1    Aumeunier, A.M.2    Mowat, A.M.3
  • 4
    • 26844538936 scopus 로고    scopus 로고
    • Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    • Johansson-Lindbom, B. et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J. Exp. Med. 202, 1063-1073 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1063-1073
    • Johansson-Lindbom, B.1
  • 5
    • 73949107838 scopus 로고    scopus 로고
    • Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    • Schulz, O. et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 206, 3101-3114 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 3101-3114
    • Schulz, O.1
  • 6
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes, J. L. et al. A functionally specialized population of mucosal CD103+DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 7
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun, C. M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204, 1775-1785 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1
  • 9
    • 84937707458 scopus 로고    scopus 로고
    • Interleukin-12 and-23 control plasticity of CD127(+) Group 1 and Group 3 innate lymphoid cells in the intestinal lamina propria
    • Bernink, J. H. et al. Interleukin-12 and-23 control plasticity of CD127(+) Group 1 and Group 3 innate lymphoid cells in the intestinal lamina propria. Immunity 43, 146-160 (2015).
    • (2015) Immunity , vol.43 , pp. 146-160
    • Bernink, J.H.1
  • 10
    • 84890987173 scopus 로고    scopus 로고
    • Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
    • Watchmaker, P. B. et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat. Immunol. 15, 98-108 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 98-108
    • Watchmaker, P.B.1
  • 11
    • 85020920341 scopus 로고    scopus 로고
    • Diversity and functions of intestinal mononuclear phagocytes
    • Joeris, T., Muller-Luda, K., Agace, W. W. & Mowat, A. M. Diversity and functions of intestinal mononuclear phagocytes. Mucosal Immunol. 10, 845-864 (2017).
    • (2017) Mucosal Immunol. , vol.10 , pp. 845-864
    • Joeris, T.1    Muller-Luda, K.2    Agace, W.W.3    Mowat, A.M.4
  • 12
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 13
    • 79956303498 scopus 로고    scopus 로고
    • Regulation of the antimicrobial response by NLR proteins
    • Elinav, E., Strowig, T., Henao-Mejia, J. & Flavell, R. A. Regulation of the antimicrobial response by NLR proteins. Immunity 34, 665-679 (2011).
    • (2011) Immunity , vol.34 , pp. 665-679
    • Elinav, E.1    Strowig, T.2    Henao-Mejia, J.3    Flavell, R.A.4
  • 14
    • 79956292569 scopus 로고    scopus 로고
    • Myeloid C-type lectin receptors in pathogen recognition and host defense
    • Osorio, F. & Sousa, Re Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34, 651-664 (2011).
    • (2011) Immunity , vol.34 , pp. 651-664
    • Osorio, F.1    Sousa, Re.2
  • 15
    • 84875489998 scopus 로고    scopus 로고
    • Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation
    • Farache, J. et al. Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity 38, 581-595 (2013).
    • (2013) Immunity , vol.38 , pp. 581-595
    • Farache, J.1
  • 16
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole, J. R. et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483, 345-349 (2012).
    • (2012) Nature , vol.483 , pp. 345-349
    • McDole, J.R.1
  • 17
    • 84894107663 scopus 로고    scopus 로고
    • Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1(+) macrophages to CD103(+) dendritic cells
    • Mazzini, E., Massimiliano, L., Penna, G. & Rescigno, M. Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1(+) macrophages to CD103(+) dendritic cells. Immunity 40, 248-261 (2014).
    • (2014) Immunity , vol.40 , pp. 248-261
    • Mazzini, E.1    Massimiliano, L.2    Penna, G.3    Rescigno, M.4
  • 18
    • 84871150034 scopus 로고    scopus 로고
    • Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node
    • Flores-Langarica, A. et al. Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node. J. Immunol. 189, 5745-5754 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 5745-5754
    • Flores-Langarica, A.1
  • 20
    • 77954131234 scopus 로고    scopus 로고
    • Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells
    • Laffont, S., Siddiqui, K. R. & Powrie, F. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur. J. Immunol. 40, 1877-1883 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1877-1883
    • Laffont, S.1    Siddiqui, K.R.2    Powrie, F.3
  • 21
    • 84870252354 scopus 로고    scopus 로고
    • New concepts in the generation and functions of IgA
    • Pabst, O. New concepts in the generation and functions of IgA. Nat. Rev. Immunol. 12, 821-832 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 821-832
    • Pabst, O.1
  • 22
    • 77955657786 scopus 로고    scopus 로고
    • The role of secretory antibodies in infection immunity
    • Strugnell, R. A. & Wijburg, O. L. The role of secretory antibodies in infection immunity. Nat. Rev. Microbiol. 8, 656-667 (2010).
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 656-667
    • Strugnell, R.A.1    Wijburg, O.L.2
  • 23
    • 77954051526 scopus 로고    scopus 로고
    • Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses
    • Hapfelmeier, S. et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 328, 1705-1709 (2010).
    • (2010) Science , vol.328 , pp. 1705-1709
    • Hapfelmeier, S.1
  • 24
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • Palm, N. W. et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158, 1000-1010 (2014).
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1
  • 25
    • 84863597911 scopus 로고    scopus 로고
    • IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcgammaRIIa in human dendritic cells
    • den Dunnen, J. et al. IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcgammaRIIa in human dendritic cells. Blood 120, 112-121 (2012).
    • (2012) Blood , vol.120 , pp. 112-121
    • Den Dunnen, J.1
  • 26
    • 84922739874 scopus 로고    scopus 로고
    • Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
    • Bakdash, G., Vogelpoel, L. T., van Capel, T. M., Kapsenberg, M. L. & de Jong, E. C. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. Mucosal Immunol. 8, 265-278 (2015).
    • (2015) Mucosal Immunol. , vol.8 , pp. 265-278
    • Bakdash, G.1    Vogelpoel, L.T.2    Van Capel, T.M.3    Kapsenberg, M.L.4    De Jong, E.C.5
  • 28
    • 85038589566 scopus 로고    scopus 로고
    • Serum IgA immune complexes promote proinflammatory cytokine production by human macrophages, monocytes, and Kupffer cells through FcalphaRI-TLR cross-talk
    • Hansen, I. S., Hoepel, W., Zaat, S. A. J., Baeten, D. L. P. & den Dunnen, J. Serum IgA immune complexes promote proinflammatory cytokine production by human macrophages, monocytes, and Kupffer cells through FcalphaRI-TLR cross-talk. J. Immunol. 199, 4124-4131 (2017).
    • (2017) J. Immunol. , vol.199 , pp. 4124-4131
    • Hansen, I.S.1    Hoepel, W.2    Zaat, S.A.J.3    Baeten, D.L.P.4    Den Dunnen, J.5
  • 29
    • 84899498861 scopus 로고    scopus 로고
    • IgA subclass switch recombination in human mucosal and systemic immune compartments
    • Lin, M., Du, L., Brandtzaeg, P. & Pan-Hammarstrom, Q. IgA subclass switch recombination in human mucosal and systemic immune compartments. Mucosal Immunol. 7, 511-520 (2014).
    • (2014) Mucosal Immunol. , vol.7 , pp. 511-520
    • Lin, M.1    Du, L.2    Brandtzaeg, P.3    Pan-Hammarstrom, Q.4
  • 30
    • 84878167904 scopus 로고    scopus 로고
    • IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation
    • Persson, E. K. et al. IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38, 958-969 (2013).
    • (2013) Immunity , vol.38 , pp. 958-969
    • Persson, E.K.1
  • 31
    • 84885447087 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
    • Welty, N. E. et al. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J. Exp. Med. 210, 2011-2024 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 2011-2024
    • Welty, N.E.1
  • 32
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. & Sallusto, F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8, 942-949 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 33
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9, 641-649 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 34
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe, E. et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat. Immunol. 9, 650-657 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 650-657
    • Volpe, E.1
  • 35
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson, N. J. et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8, 950-957 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 950-957
    • Wilson, N.J.1
  • 36
    • 84874234535 scopus 로고    scopus 로고
    • Human inflammatory dendritic cells induce Th17 cell differentiation
    • Segura, E. et al. Human inflammatory dendritic cells induce Th17 cell differentiation. Immunity 38, 336-348 (2013).
    • (2013) Immunity , vol.38 , pp. 336-348
    • Segura, E.1
  • 37
    • 84867636023 scopus 로고    scopus 로고
    • Innate lymphoid cells: Balancing immunity, inflammation, and tissue repair in the intestine
    • Tait Wojno, E. D. & Artis, D. Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe 12, 445-457 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 445-457
    • Tait Wojno, E.D.1    Artis, D.2
  • 38
    • 0026507126 scopus 로고
    • A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
    • Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356, 768-774 (1992).
    • (1992) Nature , vol.356 , pp. 768-774
    • Thornberry, N.A.1
  • 40
    • 84896654124 scopus 로고    scopus 로고
    • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKepsilon supports the anabolic demands of dendritic cell activation
    • Everts, B. et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKepsilon supports the anabolic demands of dendritic cell activation. Nat. Immunol. 15, 323-332 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 323-332
    • Everts, B.1
  • 41
    • 0000904661 scopus 로고
    • Localization of the primary metabolic block produced by 2-deoxyglucose
    • Wick, A. N., Drury, D. R., Nakada, H. I. & Wolfe, J. B. Localization of the primary metabolic block produced by 2-deoxyglucose. J. Biol. Chem. 224, 963-969 (1957).
    • (1957) J. Biol. Chem. , vol.224 , pp. 963-969
    • Wick, A.N.1    Drury, D.R.2    Nakada, H.I.3    Wolfe, J.B.4
  • 43
    • 84877015897 scopus 로고    scopus 로고
    • Anti-inflammatory role of the IgA Fc receptor (CD89): From autoimmunity to therapeutic perspectives
    • Ben Mkaddem, S., Rossato, E., Heming, N. & Monteiro, R. C. Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives. Autoimmun. Rev. 12, 666-669 (2013).
    • (2013) Autoimmun. Rev. , vol.12 , pp. 666-669
    • Ben Mkaddem, S.1    Rossato, E.2    Heming, N.3    Monteiro, R.C.4
  • 44
    • 79955746123 scopus 로고    scopus 로고
    • The control of adaptive immune responses by the innate immune system
    • Schenten, D. & Medzhitov, R. The control of adaptive immune responses by the innate immune system. Adv. Immunol. 109, 87-124 (2011).
    • (2011) Adv. Immunol. , vol.109 , pp. 87-124
    • Schenten, D.1    Medzhitov, R.2
  • 45
    • 77958469091 scopus 로고    scopus 로고
    • Update on mucosal immunoglobulin A in gastrointestinal disease
    • Brandtzaeg, P. Update on mucosal immunoglobulin A in gastrointestinal disease. Curr. Opin. Gastroenterol. 26, 554-563 (2010).
    • (2010) Curr. Opin. Gastroenterol. , vol.26 , pp. 554-563
    • Brandtzaeg, P.1
  • 46
    • 80054954035 scopus 로고    scopus 로고
    • The human immunoglobulin A Fc receptor FcalphaRI: A multifaceted regulator of mucosal immunity
    • Bakema, J. E. & van Egmond, M. The human immunoglobulin A Fc receptor FcalphaRI: a multifaceted regulator of mucosal immunity. Mucosal Immunol. 4, 612-624 (2011).
    • (2011) Mucosal Immunol. , vol.4 , pp. 612-624
    • Bakema, J.E.1    Van Egmond, M.2
  • 47
    • 0035451799 scopus 로고    scopus 로고
    • Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities
    • Smith, P. D. et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities. J. Immunol. 167, 2651-2656 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 2651-2656
    • Smith, P.D.1
  • 48
    • 0038717098 scopus 로고    scopus 로고
    • Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue
    • Hamre, R., Farstad, I. N., Brandtzaeg, P. & Morton, H. C. Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue. Scand. J. Immunol. 57, 506-516 (2003).
    • (2003) Scand. J. Immunol. , vol.57 , pp. 506-516
    • Hamre, R.1    Farstad, I.N.2    Brandtzaeg, P.3    Morton, H.C.4
  • 49
    • 84864861276 scopus 로고    scopus 로고
    • The role of neutrophils during intestinal inflammation
    • Fournier, B. M. & Parkos, C. A. The role of neutrophils during intestinal inflammation. Mucosal Immunol. 5, 354-366 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 354-366
    • Fournier, B.M.1    Parkos, C.A.2
  • 50
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi, C. & Pamer, E. G. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11, 762-774 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 51
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Neurath, M. F. Cytokines in inflammatory bowel disease. Nat. Rev. Immunol. 14, 329-342 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 329-342
    • Neurath, M.F.1
  • 53
    • 84976536797 scopus 로고    scopus 로고
    • Advances in the development of new biologics in inflammatory bowel disease
    • Ungar, B. & Kopylov, U. Advances in the development of new biologics in inflammatory bowel disease. Ann. Gastroenterol. 29, 243-248 (2016).
    • (2016) Ann. Gastroenterol. , vol.29 , pp. 243-248
    • Ungar, B.1    Kopylov, U.2
  • 54
    • 84947569140 scopus 로고    scopus 로고
    • Pathogen resistance mediated by IL-22 signaling at the epithelial-microbiota interface
    • Schreiber, F., Arasteh, J. M. & Lawley, T. D. Pathogen resistance mediated by IL-22 signaling at the epithelial-microbiota interface. J. Mol. Biol. 427, 3676-3682 (2015).
    • (2015) J. Mol. Biol. , vol.427 , pp. 3676-3682
    • Schreiber, F.1    Arasteh, J.M.2    Lawley, T.D.3
  • 55
    • 84903441668 scopus 로고    scopus 로고
    • Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation
    • Schott, J. et al. Translational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation. PLoS Genet. 10, e1004368 (2014).
    • (2014) PLoS. Genet. , vol.10 , pp. e1004368
    • Schott, J.1
  • 56
    • 84898712109 scopus 로고    scopus 로고
    • Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements
    • Vlasova-St Louis, L. & Bohjanen, P. R. Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements. J. Interferon Cytokine Res. 34, 233-241 (2014).
    • (2014) J. Interferon Cytokine Res. , vol.34 , pp. 233-241
    • Vlasova-St Louis, L.1    Bohjanen, P.R.2
  • 57
    • 77954716659 scopus 로고    scopus 로고
    • TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2
    • Gais, P. et al. TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J. Immunol. 184, 5842-5848 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 5842-5848
    • Gais, P.1
  • 58
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi, L., Eigenbrod, T., Munoz-Planillo, R. & Nunez, G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 10, 241-247 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 59
    • 85002736887 scopus 로고    scopus 로고
    • FcgammaR mediates TLR2-and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes
    • Duffy, E. B., Periasamy, S., Hunt, D., Drake, J. R. & Harton, J. A. FcgammaR mediates TLR2-and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. J. Leukoc. Biol. 100, 1335-1347 (2016).
    • (2016) J. Leukoc. Biol. , vol.100 , pp. 1335-1347
    • Duffy, E.B.1    Periasamy, S.2    Hunt, D.3    Drake, J.R.4    Harton, J.A.5
  • 60
    • 84937513657 scopus 로고    scopus 로고
    • MTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
    • Moon, J. S. et al. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep. 12, 102-115 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 102-115
    • Moon, J.S.1
  • 61
    • 84961290384 scopus 로고    scopus 로고
    • UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
    • Moon, J. S. et al. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J. Clin. Invest. 125, 665-680 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 665-680
    • Moon, J.S.1
  • 62
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • Lawrence, T., Bebien, M., Liu, G. Y., Nizet, V. & Karin, M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434, 1138-1143 (2005).
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 63
    • 34548863106 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
    • Tas, S. W. et al. Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood 110, 1540-1549 (2007).
    • (2007) Blood , vol.110 , pp. 1540-1549
    • Tas, S.W.1
  • 64
    • 28544438330 scopus 로고    scopus 로고
    • Role of ITAM-containing adapter proteins and their receptors in the immune system and bone
    • Humphrey, M. B., Lanier, L. L. & Nakamura, M. C. Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol. Rev. 208, 50-65 (2005).
    • (2005) Immunol. Rev. , vol.208 , pp. 50-65
    • Humphrey, M.B.1    Lanier, L.L.2    Nakamura, M.C.3
  • 65
    • 0022494444 scopus 로고
    • Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa
    • Bjerke, K., Brandtzaeg, P. & Rognum, T. O. Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa. Gut 27, 667-674 (1986).
    • (1986) Gut , vol.27 , pp. 667-674
    • Bjerke, K.1    Brandtzaeg, P.2    Rognum, T.O.3
  • 66
    • 84857040883 scopus 로고    scopus 로고
    • Role of ITAM signaling module in signal integration
    • Bezbradica, J. S. & Medzhitov, R. Role of ITAM signaling module in signal integration. Curr. Opin. Immunol. 24, 58-66 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 58-66
    • Bezbradica, J.S.1    Medzhitov, R.2
  • 67
    • 84952875076 scopus 로고    scopus 로고
    • Celiac disease: Autoimmunity in response to food antigen
    • Stamnaes, J. & Sollid, L. M. Celiac disease: Autoimmunity in response to food antigen. Semin. Immunol. 27, 343-352 (2015).
    • (2015) Semin. Immunol. , vol.27 , pp. 343-352
    • Stamnaes, J.1    Sollid, L.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.