Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

Cell Death and Differentiation

Volumn 26, Issue 11, 2019, Pages 2447-2463

  Li, Rui ^a   Zhou, Rui ^a   Wang, Hui ^b   Li, Weidong ^b   Pan, Mingxin ^c   Yao, Xueqing ^d   Zhan, Wanqi ^a   Yang, Shibin ^e   Xu, Lijun ^a   Ding, Yanqing ^a   Zhao, Liang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^e THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; ODANACATIB; TOLL LIKE RECEPTOR 4; TUMOR MARKER; CTSK PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BALB/C NUDE MOUSE; C57BL 6 MOUSE; CANCER GROWTH; CANCER PROGNOSIS; CARCINOGENESIS; CELL MIGRATION; CELL MOTILITY; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME ANALYSIS; ENZYME RELEASE; ESCHERICHIA COLI; FEASIBILITY STUDY; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GUT MICROBIOTA IMBALANCE; HCT 116 CELL LINE; HT-29 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; LIVER METASTASIS; LOVO CELL LINE; LS174T CELL LINE; MACROPHAGE; MC-38 CELL LINE; METASTASIS; MICROBIOLOGICAL PHENOMENA AND FUNCTIONS; MOUSE; NCM460 CELL LINE; NONHUMAN; PHENOTYPE; POLARIZATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SW480 CELL LINE; SW620 CELL LINE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CANCER TRANSPLANTATION; COLORECTAL TUMOR; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CATHEPSIN K; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; ESCHERICHIA COLI; FEMALE; GASTROINTESTINAL MICROBIOME; HCT116 CELLS; HETEROGRAFTS; HT29 CELLS; HUMANS; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PROGNOSIS; TOLL-LIKE RECEPTOR 4; TUMOR MICROENVIRONMENT;

EID: 85062708151     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/s41418-019-0312-y     Document Type: Article

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