Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Science

Volumn 350, Issue 6264, 2015, Pages 1079-1084

  Vétizou, Marie ^a,b,c   Pitt, Jonathan M ^a,b,c   Daillère, Romain ^a,b,c   Lepage, Patricia ^d   Waldschmitt, Nadine ^e   Flament, Caroline ^a,b,f   Rusakiewicz, Sylvie ^a,b,f   Routy, Bertrand ^a,b,c,f   Roberti, Maria P ^a,b,f   Duong, Connie P M ^a,b,f   Poirier Colame, Vichnou ^a,b,f   Roux, Antoine ^a,b,g   Becharef, Sonia ^a,b,f   Formenti, Silvia ^h   Golden, Encouse ^h   Cording, Sascha ⁱ   Eberl, Gerard ⁱ   Schlitzer, Andreas ^j   Ginhoux, Florent ^j   Mani, Sridhar ^k   Yamazaki, Takahiro ^a,b,f   Jacquelot, Nicolas ^a,b,c   Enot, David P ^a,g,l   Bérard, Marion ⁱ   Nigou, Jérôme ^m,n   Opolon, Paule ^a   Eggermont, Alexander ^a,b   Woerther, Paul Louis ^l   Chachaty, Elisabeth ^l   Chaput, Nathalie ^a,o   Robert, Caroline ^a,p   Mateus, Christina ^a   Kroemer, Guido ^g,l,q,r,s   Raoult, Didier ^t   Boneca, Ivo Gomperts ^i,u   Carbonnel, Franck ^c,v   Chamaillard, Mathias ^e   Zitvogel, Laurence ^a,b,c,f   more..

^a INSTITUT GUSTAVE ROUSSY   (France)

^b University Paris XI   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UMR1319 MICALIS   (France)

^e UNIV LILLE   (France)

^f Center of Clinical Investigations in Biotherapies of Cancer (CICBT)   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h NEW YORK UNIVERSITY   (United States)

ⁱ INSTITUT PASTEUR   (France)

^j AGENCY FOR SCIENCE   (Singapore)

^k ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^l GRCC   (France)

^m INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

ⁿ UNIVERSITÉ PAUL SABATIER   (France)

^o CNRS UMS3655   (France)

^p Universite Paris Sud   (France)

^q Institut Gustave Roussy   (France)

^r CENTRE DE RECHERCHE DES CORDELIERS   (France)

^s HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^t AIX MARSEILLE UNIVERSITY   (France)

^u INSERM   (France)

^v BICÊTRE HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTINEOPLASTIC AGENT; BACTERIAL POLYSACCHARIDE; COLISTIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IMIPENEM; STREPTOMYCIN; ANTIINFECTIVE AGENT; IPILIMUMAB; MONOCLONAL ANTIBODY;

ANTIBODY; BACTERIUM; BIOTECHNOLOGY; CANCER; CELLS AND CELL COMPONENTS; DIGESTIVE SYSTEM; IMMUNE SYSTEM; IMMUNIZATION; TUMOR;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL OVERGROWTH; BACTEROIDES FRAGILIS; BACTEROIDES THETAIOTAOMICRON; CANCER GROWTH; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; EXPERIMENTAL SARCOMA; FEEDING; HUMAN; IMMUNIZATION; IMMUNOSTIMULATION; INTESTINE FLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION; TUMOR ASSOCIATED LEUKOCYTE; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BACTEROIDES; C57BL MOUSE; DRUG EFFECTS; DYSBIOSIS; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GERMFREE ANIMAL; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOTHERAPY; INTESTINE; MALE; MELANOMA; MICROBIOLOGY; MIDDLE AGED; SKIN NEOPLASMS; VERY ELDERLY;

BACTEROIDALES; BACTEROIDES; BACTEROIDES FRAGILIS; BACTEROIDES THETAIOTAOMICRON; MUS;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, MONOCLONAL; BACTEROIDES; CTLA-4 ANTIGEN; DYSBIOSIS; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOTHERAPY; INTESTINES; MALE; MELANOMA; MICE; MICE, INBRED C57BL; MIDDLE AGED; SKIN NEOPLASMS; T-LYMPHOCYTES;

EID: 84948461699     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad1329     Document Type: Article

References (18)

1. K. S. Peggs, S. A. Quezada, A. J. Korman, J. P. Allison, Curr. Opin. Immunol. 18, 206-213 (2006).
2. F. S. Hodi et al., N. Engl. J. Med. 363, 711-723 (2010).
3. K. E. Beck et al., J. Clin. Oncol. 24, 2283-2289 (2006).
4. D. Berman et al., Cancer Immun. 10, 11 (2010).
5. S. Viaud et al., Science 342, 971-976 (2013).
6. A. Rogoz, B. S. Reis, R. A. Karssemeijer, D. Mucida, J. Immunol. Methods 421, 89-95 (2015).
7. S. Dasgupta, D. Erturk-Hasdemir, J. Ochoa-Reparaz, H. C. Reinecker, D. L. Kasper, Cell Host Microbe 15, 413-423 (2014).
8. S. K. Mazmanian, C. H. Liu, A. O. Tzianabos, D. L. Kasper, Cell 122, 107-118 (2005).
9. F. Stingele et al., J. Immunol. 172, 1483-1490 (2004).
10. A. O. Tzianabos et al., J. Biol. Chem. 267, 18230-18235 (1992).
11. J. Y. Huang, S. M. Lee, S. K. Mazmanian, Anaerobe 17, 137-141 (2011).
12. M. Arumugam et al., Nature 473, 174-180 (2011).
13. J. Qin et al., Nature 464, 59-65 (2010).
14. A. Cebula et al., Nature 497, 258-262 (2013).
15. J. L. Sonnenburg, C. T. Chen, J. I. Gordon, PLOS Biol. 4, e413 (2006).
16. W. Lam et al., Sci. Transl. Med. 2, 45ra59 (2010).
17. H. Xu et al., Nature 513, 237-241 (2014).
18. M. Mimee, A. C. Tucker, C. A. Voigt, T. K. Lu, Cell Systems 1, 62-71 (2015).