메뉴 건너뛰기




Volumn 50, Issue 2, 2019, Pages 432-445.e7

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BUTYRIC ACID; CD11C PROTEIN; GENTAMICIN; HISTONE DEACETYLASE 3; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN; SHORT CHAIN FATTY ACID; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; BUTYRIC ACID DERIVATIVE; CYTOKINE;

EID: 85060327779     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.12.018     Document Type: Article
Times cited : (670)

References (60)
  • 3
    • 84961769001 scopus 로고    scopus 로고
    • CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23
    • Arnold, I.C., Mathisen, S., Schulthess, J., Danne, C., Hegazy, A.N., Powrie, F., CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23. Mucosal Immunol. 9 (2016), 352–363.
    • (2016) Mucosal Immunol. , vol.9 , pp. 352-363
    • Arnold, I.C.1    Mathisen, S.2    Schulthess, J.3    Danne, C.4    Hegazy, A.N.5    Powrie, F.6
  • 7
    • 84939787854 scopus 로고    scopus 로고
    • Role of Autophagy in the Maintenance of Intestinal Homeostasis
    • Baxt, L.A., Xavier, R.J., Role of Autophagy in the Maintenance of Intestinal Homeostasis. Gastroenterology 149 (2015), 553–562.
    • (2015) Gastroenterology , vol.149 , pp. 553-562
    • Baxt, L.A.1    Xavier, R.J.2
  • 8
    • 84864541097 scopus 로고    scopus 로고
    • G protein-coupled receptors for energy metabolites as new therapeutic targets
    • Blad, C.C., Tang, C., Offermanns, S., G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 11 (2012), 603–619.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 603-619
    • Blad, C.C.1    Tang, C.2    Offermanns, S.3
  • 10
    • 85046298440 scopus 로고    scopus 로고
    • Integrated analysis of single cell transcriptomic data across conditions, technologies, and species
    • Butler, A., Satija, R., Integrated analysis of single cell transcriptomic data across conditions, technologies, and species. Nat. Biotechnol. 36 (2018), 411–420.
    • (2018) Nat. Biotechnol. , vol.36 , pp. 411-420
    • Butler, A.1    Satija, R.2
  • 11
    • 84989843371 scopus 로고    scopus 로고
    • Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
    • Cadwell, K., Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat. Rev. Immunol. 16 (2016), 661–675.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 661-675
    • Cadwell, K.1
  • 12
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang, P.V., Hao, L., Offermanns, S., Medzhitov, R., The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl. Acad. Sci. USA 111 (2014), 2247–2252.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 15
    • 84989285235 scopus 로고    scopus 로고
    • Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation
    • Cushing, K., Alvarado, D.M., Ciorba, M.A., Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation. Clin Transl Gastroen, 6, 2015.
    • (2015) Clin Transl Gastroen , vol.6
    • Cushing, K.1    Alvarado, D.M.2    Ciorba, M.A.3
  • 16
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie, J.R., Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133:7, Suppl (2003), 2485S–2493S.
    • (2003) J. Nutr. , vol.133 , Issue.7 , pp. 2485S-2493S
    • Davie, J.R.1
  • 17
    • 84951574149 scopus 로고    scopus 로고
    • MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
    • Finak, G., McDavid, A., Yajima, M., Deng, J., Gersuk, V., Shalek, A.K., Slichter, C.K., Miller, H.W., McElrath, M.J., Prlic, M., et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol., 16, 2015, 278.
    • (2015) Genome Biol. , vol.16 , pp. 278
    • Finak, G.1    McDavid, A.2    Yajima, M.3    Deng, J.4    Gersuk, V.5    Shalek, A.K.6    Slichter, C.K.7    Miller, H.W.8    McElrath, M.J.9    Prlic, M.10
  • 18
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank, D.N., St Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., Pace, N.R., Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci. USA 104 (2007), 13780–13785.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3    Boedeker, E.C.4    Harpaz, N.5    Pace, N.R.6
  • 19
    • 85041133375 scopus 로고    scopus 로고
    • Targeted and Untargeted Metabolic Profiling of Wild Grassland Plants identifies Antibiotic and Anthelmintic Compounds Targeting Pathogen Physiology, Metabolism and Reproduction
    • French, K.E., Harvey, J., McCullagh, J.S.O., Targeted and Untargeted Metabolic Profiling of Wild Grassland Plants identifies Antibiotic and Anthelmintic Compounds Targeting Pathogen Physiology, Metabolism and Reproduction. Sci. Rep., 8, 2018, 1695.
    • (2018) Sci. Rep. , vol.8 , pp. 1695
    • French, K.E.1    Harvey, J.2    McCullagh, J.S.O.3
  • 22
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    • Haberland, M., Montgomery, R.L., Olson, E.N., The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat. Rev. Genet. 10 (2009), 32–42.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 23
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13 (2012), 251–262.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 24
    • 84863899006 scopus 로고    scopus 로고
    • Nutritional immunity: transition metals at the pathogen-host interface
    • Hood, M.I., Skaar, E.P., Nutritional immunity: transition metals at the pathogen-host interface. Nat. Rev. Microbiol. 10 (2012), 525–537.
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 525-537
    • Hood, M.I.1    Skaar, E.P.2
  • 26
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T., Guan, K.L., TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003), 577–590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 28
    • 84977492441 scopus 로고    scopus 로고
    • The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice
    • Jia, H., Wang, Y., Morris, C.D., Jacques, V., Gottesfeld, J.M., Rusche, J.R., Thomas, E.A., The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. PLoS ONE, 11, 2016, e0152498.
    • (2016) PLoS ONE , vol.11 , pp. e0152498
    • Jia, H.1    Wang, Y.2    Morris, C.D.3    Jacques, V.4    Gottesfeld, J.M.5    Rusche, J.R.6    Thomas, E.A.7
  • 30
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: kyoto encyclopedia of genes and genomes
    • Kanehisa, M., Goto, S., KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28 (2000), 27–30.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 31
    • 80051898476 scopus 로고    scopus 로고
    • Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
    • Kehl-Fie, T.E., Chitayat, S., Hood, M.I., Damo, S., Restrepo, N., Garcia, C., Munro, K.A., Chazin, W.J., Skaar, E.P., Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe 10 (2011), 158–164.
    • (2011) Cell Host Microbe , vol.10 , pp. 158-164
    • Kehl-Fie, T.E.1    Chitayat, S.2    Hood, M.I.3    Damo, S.4    Restrepo, N.5    Garcia, C.6    Munro, K.A.7    Chazin, W.J.8    Skaar, E.P.9
  • 32
    • 84942982260 scopus 로고    scopus 로고
    • Metabolic reprogramming in macrophages and dendritic cells in innate immunity
    • Kelly, B., O'Neill, L.A.J., Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 25 (2015), 771–784.
    • (2015) Cell Res. , vol.25 , pp. 771-784
    • Kelly, B.1    O'Neill, L.A.J.2
  • 33
    • 14644404879 scopus 로고    scopus 로고
    • The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2
    • Kerkhoff, C., Nacken, W., Benedyk, M., Dagher, M.C., Sopalla, C., Doussiere, J., The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. FASEB J. 19 (2005), 467–469.
    • (2005) FASEB J. , vol.19 , pp. 467-469
    • Kerkhoff, C.1    Nacken, W.2    Benedyk, M.3    Dagher, M.C.4    Sopalla, C.5    Doussiere, J.6
  • 34
    • 84920504512 scopus 로고    scopus 로고
    • mTOR: a pharmacologic target for autophagy regulation
    • Kim, Y.C., Guan, K.L., mTOR: a pharmacologic target for autophagy regulation. J. Clin. Invest. 125 (2015), 25–32.
    • (2015) J. Clin. Invest. , vol.125 , pp. 25-32
    • Kim, Y.C.1    Guan, K.L.2
  • 37
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love, M.I., Huber, W., Anders, S., Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol., 15, 2014, 550.
    • (2014) Genome Biol. , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 42
    • 84971201113 scopus 로고    scopus 로고
    • Gut microbiota, metabolites and host immunity
    • Rooks, M.G., Garrett, W.S., Gut microbiota, metabolites and host immunity. Nat. Rev. Immunol. 16 (2016), 341–352.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 341-352
    • Rooks, M.G.1    Garrett, W.S.2
  • 44
    • 84953357060 scopus 로고    scopus 로고
    • Multiple amino acid sensing inputs to mTORC1
    • Shimobayashi, M., Hall, M.N., Multiple amino acid sensing inputs to mTORC1. Cell Res. 26 (2016), 7–20.
    • (2016) Cell Res. , vol.26 , pp. 7-20
    • Shimobayashi, M.1    Hall, M.N.2
  • 49
    • 79952749503 scopus 로고    scopus 로고
    • Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    • Sun, Q., Chen, X., Ma, J., Peng, H., Wang, F., Zha, X., Wang, Y., Jing, Y., Yang, H., Chen, R., et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc. Natl. Acad. Sci. USA 108 (2011), 4129–4134.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 4129-4134
    • Sun, Q.1    Chen, X.2    Ma, J.3    Peng, H.4    Wang, F.5    Zha, X.6    Wang, Y.7    Jing, Y.8    Yang, H.9    Chen, R.10
  • 50
    • 85045886211 scopus 로고    scopus 로고
    • Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease
    • Uhlig, H.H., Powrie, F., Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease. Annu. Rev. Immunol. 36 (2018), 755–781.
    • (2018) Annu. Rev. Immunol. , vol.36 , pp. 755-781
    • Uhlig, H.H.1    Powrie, F.2
  • 51
    • 42949171444 scopus 로고    scopus 로고
    • Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells
    • Usami, M., Kishimoto, K., Ohata, A., Miyoshi, M., Aoyama, M., Fueda, Y., Kotani, J., Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. Nutr. Res. 28 (2008), 321–328.
    • (2008) Nutr. Res. , vol.28 , pp. 321-328
    • Usami, M.1    Kishimoto, K.2    Ohata, A.3    Miyoshi, M.4    Aoyama, M.5    Fueda, Y.6    Kotani, J.7
  • 52
    • 84941066042 scopus 로고    scopus 로고
    • Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans
    • van der Beek, C.M., Bloemen, J.G., van den Broek, M.A., Lenaerts, K., Venema, K., Buurman, W.A., Dejong, C.H., Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans. J. Nutr. 145 (2015), 2019–2024.
    • (2015) J. Nutr. , vol.145 , pp. 2019-2024
    • van der Beek, C.M.1    Bloemen, J.G.2    van den Broek, M.A.3    Lenaerts, K.4    Venema, K.5    Buurman, W.A.6    Dejong, C.H.7
  • 56
    • 80051471073 scopus 로고    scopus 로고
    • Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils
    • Vinolo, M.A.R., Rodrigues, H.G., Hatanaka, E., Sato, F.T., Sampaio, S.C., Curi, R., Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. J. Nutr. Biochem. 22 (2011), 849–855.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 849-855
    • Vinolo, M.A.R.1    Rodrigues, H.G.2    Hatanaka, E.3    Sato, F.T.4    Sampaio, S.C.5    Curi, R.6
  • 57
    • 80054980812 scopus 로고    scopus 로고
    • Regulation of inflammation by short chain fatty acids
    • Vinolo, M.A.R., Rodrigues, H.G., Nachbar, R.T., Curi, R., Regulation of inflammation by short chain fatty acids. Nutrients 3 (2011), 858–876.
    • (2011) Nutrients , vol.3 , pp. 858-876
    • Vinolo, M.A.R.1    Rodrigues, H.G.2    Nachbar, R.T.3    Curi, R.4
  • 58
    • 84855923925 scopus 로고    scopus 로고
    • Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
    • Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., Zhao, L., Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 6 (2012), 320–329.
    • (2012) ISME J. , vol.6 , pp. 320-329
    • Wang, T.1    Cai, G.2    Qiu, Y.3    Fei, N.4    Zhang, M.5    Pang, X.6    Jia, W.7    Cai, S.8    Zhao, L.9
  • 60
    • 58049163436 scopus 로고    scopus 로고
    • Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes
    • Zaia, A.A., Sappington, K.J., Nisapakultorn, K., Chazin, W.J., Dietrich, E.A., Ross, K.F., Herzberg, M.C., Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes. Mucosal Immunol. 2 (2009), 43–53.
    • (2009) Mucosal Immunol. , vol.2 , pp. 43-53
    • Zaia, A.A.1    Sappington, K.J.2    Nisapakultorn, K.3    Chazin, W.J.4    Dietrich, E.A.5    Ross, K.F.6    Herzberg, M.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.