Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

Science Translational Medicine

Volumn 10, Issue 464, 2018, Pages

  Scott, Nicholas A ^a,b   Andrusaite, Anna ^c   Andersen, Peter ^d   Lawson, Melissa ^e   Alcon Giner, Cristina ^e   Leclaire, Charlotte ^e   Caim, Shabhonam ^e   Le Gall, Gwenaelle ^e   Shaw, Tovah ^a,b   Connolly, James P R ^c   Roe, Andrew J ^c   Wessel, Hannah ^c   Bravo Blas, Alberto ^c   Thomson, Carolyn A ^c   Kästele, Verena ^c   Wang, Ping ^a   Peterson, Daniel A ^d,f   Bancroft, Allison ^a,g   Li, Xuhang ^d   Grencis, Richard ^a,g   McI Mowat, Allan ^h   Hall, Lindsay J ^e   Travis, Mark A ^a,b,g   Milling, Simon W F ^c   Mann, Elizabeth R ^a,b,c   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NORWICH RESEARCH PARK   (United Kingdom)

^f ELI LILLY AND COMPANY   (United States)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ANTIBIOTIC AGENT; BUTYRIC ACID; CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 10; PROPIONIC ACID; SHORT CHAIN FATTY ACID; TUMOR NECROSIS FACTOR; ANTIINFECTIVE AGENT; BUTYRIC ACID DERIVATIVE; CYTOKINE; FATTY ACID; LIPOPOLYSACCHARIDE;

ADAPTIVE IMMUNITY; ADULT; ANIMAL EXPERIMENT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CLEARANCE; CELL INFILTRATION; COLON; CONTROLLED STUDY; CYTOKINE RESPONSE; DYSBIOSIS; HOMEOSTASIS; IMMUNE RESPONSE; INFECTION SENSITIVITY; INFLAMMATION; INTESTINAL IMMUNE HOMEOSTASIS; INTESTINAL MACROPHAGE; INTESTINAL MONOCYTE; INTESTINE FLORA; LYMPHOCYTE FUNCTION; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; METABOLIC REPROGRAMMING; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SUPPLEMENTATION; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; INNATE IMMUNITY; INTESTINE; METABOLISM; PATHOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; BUTYRATES; CYTOKINES; FATTY ACIDS; GASTROINTESTINAL MICROBIOME; HOMEOSTASIS; IMMUNITY, INNATE; INFLAMMATION; INTESTINES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE, INBRED C57BL; RECEPTORS, CCR2; T-LYMPHOCYTES; TH1 CELLS;

EID: 85055538084     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aao4755     Document Type: Article

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