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Volumn 18, Issue 3, 2019, Pages 197-218

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; AZACITIDINE; CANCER VACCINE; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FLUOROURACIL; IMMUNE CHECKPOINT INHIBITOR; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; INTERLEUKIN 15; INTERLEUKIN 7; IPILIMUMAB; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; MONOCLONAL ANTIBODY; ONCOLYTIC VIRUS; OXALIPLATIN; PEMBROLIZUMAB; PLATINUM COMPLEX; PROGRAMMED DEATH 1 LIGAND 1 ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR BLOCKING AGENT; SIPULEUCEL T; STING AGONIST; TALIMOGENE LAHERPAREPVEC; TAXANE DERIVATIVE; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR 9 AGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 85059563404     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/s41573-018-0007-y     Document Type: Review
Times cited : (2255)

References (288)
  • 1
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • COI: 1:CAS:528:DC%2BD3MXjsVCrtr4%3D, PID: 11323675
    • Shankaran, V. et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107–1111 (2001).
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1
  • 2
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion
    • COI: 1:CAS:528:DC%2BC3MXjs1Cgtbs%3D, PID: 21436444
    • Schreiber, R. D., Old, L. J. & Smyth, M. J. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331, 1565–1570 (2011).
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 3
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • COI: 1:CAS:528:DC%2BD28XhtVSnsrnK, PID: 17008531, This article is the first demonstration of the dependence of tumour progression and invasion on the intratumoural adaptive immunity. T cell infiltrates and IFNγ signatures have predictive value superior to TNM with respect to the natural history of primary cancers
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960–1964 (2006). This article is the first demonstration of the dependence of tumour progression and invasion on the intratumoural adaptive immunity. T cell infiltrates and IFNγ signatures have predictive value superior to TNM with respect to the natural history of primary cancers.
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711–723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 5
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 3544539
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443–2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 6
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • COI: 1:CAS:528:DC%2BC2cXitFanu7jL, PID: 4246418, This article shows that the baseline density and location at the invasive margin of T cells metastatic melanomas predicts the treatment outcome of patients receiving PD-1-targeting therapies
    • Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568–571 (2014). This article shows that the baseline density and location at the invasive margin of T cells in metastatic melanomas predicts the treatment outcome of patients receiving PD-1-targeting therapies.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 7
    • 84943516465 scopus 로고    scopus 로고
    • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
    • PID: 26359337, This article is the first to show that patients with metastatic melanoma with high mutational burden, neoantigen load and expression of cytolytic markers their tumours are more likely to respond to anti-CTLA4 immunotherapy
    • Van Allen, E. M. et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350, 207–211 (2015). This article is the first to show that patients with metastatic melanoma with high mutational burden, neoantigen load and expression of cytolytic markers in their tumours are more likely to respond to anti-CTLA4 immunotherapy.
    • (2015) Science , vol.350 , pp. 207-211
    • Van Allen, E.M.1
  • 8
    • 85017451727 scopus 로고    scopus 로고
    • T cell invigoration to tumour burden ratio associated with anti-PD-1 response
    • COI: 1:CAS:528:DC%2BC2sXlvVKhsL4%3D, PID: 28397821
    • Huang, A. C. et al. T cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545, 60–65 (2017).
    • (2017) Nature , vol.545 , pp. 60-65
    • Huang, A.C.1
  • 9
    • 79952093380 scopus 로고    scopus 로고
    • Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
    • PID: 21245428
    • Mlecnik, B. et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J. Clin. Oncol. 29, 610–618 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 610-618
    • Mlecnik, B.1
  • 10
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    • COI: 1:CAS:528:DC%2BC3sXhtFOhsbfL, PID: 23890060
    • Galon, J., Angell, H. K., Bedognetti, D. & Marincola, F. M. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 39, 11–26 (2013).
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4
  • 11
    • 84877076923 scopus 로고    scopus 로고
    • From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer
    • COI: 1:CAS:528:DC%2BC3sXls1SntL8%3D, PID: 23579076
    • Angell, H. & Galon, J. From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer. Curr. Opin. Immunol. 25, 261–267 (2013).
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 261-267
    • Angell, H.1    Galon, J.2
  • 12
    • 84878002092 scopus 로고    scopus 로고
    • Trial watch: dendritic cell-based interventions for cancer therapy
    • PID: 23170259
    • Galluzzi, L. et al. Trial watch: dendritic cell-based interventions for cancer therapy. Oncoimmunology 1, 1111–1134 (2012).
    • (2012) Oncoimmunology , vol.1 , pp. 1111-1134
    • Galluzzi, L.1
  • 13
    • 33947216118 scopus 로고    scopus 로고
    • The adaptive immunologic microenvironment in colorectal cancer: a novel perspective
    • COI: 1:CAS:528:DC%2BD2sXit12qtbo%3D, PID: 17332313
    • Galon, J., Fridman, W. H. & Pages, F. The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res. 67, 1883–1886 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 1883-1886
    • Galon, J.1    Fridman, W.H.2    Pages, F.3
  • 14
    • 73349142719 scopus 로고    scopus 로고
    • In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
    • COI: 1:CAS:528:DC%2BC3cXhtVWisL8%3D, PID: 19858404
    • Pages, F. et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J. Clin. Oncol. 27, 5944–5951 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5944-5951
    • Pages, F.1
  • 15
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
    • COI: 1:CAS:528:DC%2BC3sXhvFaktrjE, PID: 24122236
    • Galon, J. et al. Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours. J. Pathol. 232, 199–209 (2014).
    • (2014) J. Pathol. , vol.232 , pp. 199-209
    • Galon, J.1
  • 16
    • 85046846915 scopus 로고    scopus 로고
    • International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
    • PID: 29754777, This article validates Immucore as a consensus and standardized cytotoxic T cell assay that defines immune hot, altered and cold tumours and has a greater progtic value CRC than T-stage, N-stage, lymphovascular invasion, tumour differentiation and MSI status
    • Pages, F. et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet 391, 2128–2139 (2018). This article validates Immunoscore as a consensus and standardized cytotoxic T cell assay that defines immune hot, altered and cold tumours and has a greater prognostic value in CRC than T stage, N stage, lymphovascular invasion, tumour differentiation and MSI status.
    • (2018) Lancet , vol.391 , pp. 2128-2139
    • Pages, F.1
  • 17
    • 65549133014 scopus 로고    scopus 로고
    • Coordination of intratumoral immune reaction and human colorectal cancer recurrence
    • COI: 1:CAS:528:DC%2BD1MXjtF2jsrY%3D, PID: 19258510, This paper presents the first description of the immune hot (optimal), altered-excluded, altered-immuuppressed and cold (absent) tumours
    • Camus, M. et al. Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res. 69, 2685–2693 (2009). This paper presents the first description of the immune hot (optimal), altered-excluded, altered-immunosuppressed and cold (absent) tumours.
    • (2009) Cancer Res. , vol.69 , pp. 2685-2693
    • Camus, M.1
  • 18
    • 84899050715 scopus 로고    scopus 로고
    • Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients
    • PID: 24648340
    • Mlecnik, B. et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci. Transl Med. 6, 228ra37 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 228ra37
    • Mlecnik, B.1
  • 19
    • 84960466507 scopus 로고    scopus 로고
    • Integrative analyses of colorectal cancer show Immunoscore is a stronger predictor of patient survival than microsatellite instability
    • COI: 1:CAS:528:DC%2BC28Xktlahs7g%3D, PID: 26982367
    • Mlecnik, B. et al. Integrative analyses of colorectal cancer show Immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity 44, 698–711 (2016).
    • (2016) Immunity , vol.44 , pp. 698-711
    • Mlecnik, B.1
  • 20
    • 77449130761 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • COI: 1:CAS:528:DC%2BC3cXms1yitbw%3D, PID: 20420947
    • Boland, C. R. & Goel, A. Microsatellite instability in colorectal cancer. Gastroenterology 138, 2073–2087 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 2073-2087
    • Boland, C.R.1    Goel, A.2
  • 21
    • 85039458286 scopus 로고    scopus 로고
    • Cancer immunotherapy targets based on understanding the T cell-inflamed versus non-T cell-inflamed tumor microenvironment
    • COI: 1:CAS:528:DC%2BC1cXitFClsb%2FN, PID: 29275462
    • Gajewski, T. F. et al. Cancer immunotherapy targets based on understanding the T cell-inflamed versus non-T cell-inflamed tumor microenvironment. Adv. Exp. Med. Biol. 1036, 19–31 (2017).
    • (2017) Adv. Exp. Med. Biol. , vol.1036 , pp. 19-31
    • Gajewski, T.F.1
  • 22
    • 84967321420 scopus 로고    scopus 로고
    • The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition
    • COI: 1:CAS:528:DC%2BC28XmsFeqs70%3D, PID: 27084740
    • Hegde, P. S., Karanikas, V. & Evers, S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin. Cancer Res. 22, 1865–1874 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1865-1874
    • Hegde, P.S.1    Karanikas, V.2    Evers, S.3
  • 23
    • 85055072341 scopus 로고    scopus 로고
    • Evolution of metastases in space and time under immune selection
    • Angelova, M. et al. Evolution of metastases in space and time under immune selection. Cell 175, 601 (2018).
    • (2018) Cell , vol.175 , pp. 601
    • Angelova, M.1
  • 24
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • FH cells have a major impact on survival
    • FH cells have a major impact on survival.
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1
  • 25
    • 85030146830 scopus 로고    scopus 로고
    • CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
    • PID: 28570278
    • Gu-Trantien, C. et al. CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer. JCI Insight 2, 91487 (2017).
    • (2017) JCI Insight , vol.2 , pp. 91487
    • Gu-Trantien, C.1
  • 26
    • 84857050018 scopus 로고    scopus 로고
    • Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC38Xlt1Srs78%3D, PID: 21930732
    • Chew, V. et al. Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. Gut 61, 427–438 (2012).
    • (2012) Gut , vol.61 , pp. 427-438
    • Chew, V.1
  • 27
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3sXhsVKgu7vL, PID: 24048123
    • Gajewski, T. F., Schreiber, H. & Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014–1022 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 28
    • 84893851804 scopus 로고    scopus 로고
    • Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+T cells
    • COI: 1:CAS:528:DC%2BC2cXhvVSmsrc%3D, PID: 24366885
    • Goc, J. et al. Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+T cells. Cancer Res. 74, 705–715 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 705-715
    • Goc, J.1
  • 29
    • 84919914302 scopus 로고    scopus 로고
    • T-helper 1 immunoreaction influences survival in muscle-invasive bladder cancer: proof of concept
    • PID: 25525464
    • Ingels, A. et al. T-helper 1 immunoreaction influences survival in muscle-invasive bladder cancer: proof of concept. Ecancermedicalscience 8, 486 (2014).
    • (2014) Ecancermedicalscience , vol.8 , pp. 486
    • Ingels, A.1
  • 30
    • 84962022210 scopus 로고    scopus 로고
    • Validation of intratumoral T-bet+lymphoid cells as predictors of disease-free survival in breast cancer
    • COI: 1:CAS:528:DC%2BC28XjvFagug%3D%3D, PID: 26546451
    • Mulligan, A. M., Pinnaduwage, D., Tchatchou, S., Bull, S. B. & Andrulis, I. L. Validation of intratumoral T-bet+lymphoid cells as predictors of disease-free survival in breast cancer. Cancer Immunol. Res. 4, 41–48 (2016).
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 41-48
    • Mulligan, A.M.1    Pinnaduwage, D.2    Tchatchou, S.3    Bull, S.B.4    Andrulis, I.L.5
  • 31
    • 84872562952 scopus 로고    scopus 로고
    • Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry
    • COI: 1:CAS:528:DC%2BC3sXht1CgtLo%3D, PID: 23213058
    • Mulligan, A. M. et al. Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. Clin. Cancer Res. 19, 336–346 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 336-346
    • Mulligan, A.M.1
  • 32
    • 85054777584 scopus 로고    scopus 로고
    • Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy
    • PID: 30309915
    • Cristescu, R. et al. Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy. Science 362, eaar3593 (2018).
    • (2018) Science , vol.362
    • Cristescu, R.1
  • 33
    • 84899755904 scopus 로고    scopus 로고
    • Interferons and their stimulated genes in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC2cXns1Cltbc%3D, PID: 24787290
    • Cheon, H., Borden, E. C. & Stark, G. R. Interferons and their stimulated genes in the tumor microenvironment. Semin. Oncol. 41, 156–173 (2014).
    • (2014) Semin. Oncol. , vol.41 , pp. 156-173
    • Cheon, H.1    Borden, E.C.2    Stark, G.R.3
  • 34
    • 85011000628 scopus 로고    scopus 로고
    • Escape from IFN-gamma-dependent immunosurveillance in tumorigenesis
    • PID: 28143527
    • Lin, C. F. et al. Escape from IFN-gamma-dependent immunosurveillance in tumorigenesis. J. Biomed. Sci. 24, 10 (2017).
    • (2017) J. Biomed. Sci. , vol.24 , pp. 10
    • Lin, C.F.1
  • 35
    • 80053469514 scopus 로고    scopus 로고
    • The two faces of interferon-gamma in cancer
    • COI: 1:CAS:528:DC%2BC3MXht1Ggs7jO, PID: 21705455
    • Zaidi, M. R. & Merlino, G. The two faces of interferon-gamma in cancer. Clin. Cancer Res. 17, 6118–6124 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6118-6124
    • Zaidi, M.R.1    Merlino, G.2
  • 36
    • 84968919518 scopus 로고    scopus 로고
    • Dual faces of IFNgamma in cancer progression: a role of PD-L1 induction in the determination of pro- and antitumor immunity
    • COI: 1:CAS:528:DC%2BC28XnslGisLg%3D, PID: 27016309
    • Mandai, M. et al. Dual faces of IFNgamma in cancer progression: a role of PD-L1 induction in the determination of pro- and antitumor immunity. Clin. Cancer Res. 22, 2329–2334 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 2329-2334
    • Mandai, M.1
  • 37
    • 85019977333 scopus 로고    scopus 로고
    • Type I interferon in chronic virus infection and cancer
    • COI: 1:CAS:528:DC%2BC2sXotVOru74%3D, PID: 28579323
    • Snell, L. M., McGaha, T. L. & Brooks, D. G. Type I interferon in chronic virus infection and cancer. Trends Immunol. 38, 542–557 (2017).
    • (2017) Trends Immunol. , vol.38 , pp. 542-557
    • Snell, L.M.1    McGaha, T.L.2    Brooks, D.G.3
  • 38
    • 84962840922 scopus 로고    scopus 로고
    • Combination cancer therapies with immune checkpoint blockade: convergence on interferon signaling
    • COI: 1:CAS:528:DC%2BC28XlslersLo%3D, PID: 27058661
    • Minn, A. J. & Wherry, E. J. Combination cancer therapies with immune checkpoint blockade: convergence on interferon signaling. Cell 165, 272–275 (2016).
    • (2016) Cell , vol.165 , pp. 272-275
    • Minn, A.J.1    Wherry, E.J.2
  • 39
    • 85001996779 scopus 로고    scopus 로고
    • Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
    • COI: 1:CAS:528:DC%2BC28XitVSms7bF, PID: 27912061
    • Benci, J. L. et al. Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell 167, 1540–1554 (2016).
    • (2016) Cell , vol.167 , pp. 1540-1554
    • Benci, J.L.1
  • 40
    • 84911094375 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by interferon-gamma by suppression of tumor-associated macrophage differentiation
    • COI: 1:CAS:528:DC%2BC2cXht1ansb7K, PID: 24854099
    • Sun, T. et al. Inhibition of tumor angiogenesis by interferon-gamma by suppression of tumor-associated macrophage differentiation. Oncol. Res. 21, 227–235 (2014).
    • (2014) Oncol. Res. , vol.21 , pp. 227-235
    • Sun, T.1
  • 41
    • 84924348637 scopus 로고    scopus 로고
    • CD4 T cell subsets and tumor immunity: the helpful and the not-so-helpful
    • COI: 1:CAS:528:DC%2BC2cXmtFSjtbg%3D, PID: 24778273
    • Kim, H. J. & Cantor, H. CD4 T cell subsets and tumor immunity: the helpful and the not-so-helpful. Cancer Immunol. Res. 2, 91–98 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 91-98
    • Kim, H.J.1    Cantor, H.2
  • 42
    • 65449158768 scopus 로고    scopus 로고
    • Genetic and epigenetic networks controlling T helper 1 cell differentiation
    • COI: 1:CAS:528:DC%2BD1MXmsFSqu7s%3D, PID: 19476511
    • Placek, K., Coffre, M., Maiella, S., Bianchi, E. & Rogge, L. Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology 127, 155–162 (2009).
    • (2009) Immunology , vol.127 , pp. 155-162
    • Placek, K.1    Coffre, M.2    Maiella, S.3    Bianchi, E.4    Rogge, L.5
  • 43
    • 85019566250 scopus 로고    scopus 로고
    • Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies
    • PID: 28539557
    • Kato, D. et al. Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies. Nihon Rinsho Meneki Gakkai Kaishi 40, 68–77 (2017).
    • (2017) Nihon Rinsho Meneki Gakkai Kaishi , vol.40 , pp. 68-77
    • Kato, D.1
  • 44
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • COI: 1:CAS:528:DC%2BC2MXhtFaitrrL, PID: 25970248, This article shows that a melanoma cell-intrinsic oncogenic pathway (active β-catenin signalling) contributes to a lack of T cell infiltration tumour sites and resistance to anti-PD-L1 and/or anti-CTLA4 mAb therapy
    • Spranger, S., Bao, R. & Gajewski, T. F. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 523, 231–235 (2015). This article shows that a melanoma cell-intrinsic oncogenic pathway (active β-catenin signalling) contributes to a lack of T cell infiltration in tumour sites and resistance to anti-PD-L1 and/or anti-CTLA4 mAb therapy.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 45
    • 84865428430 scopus 로고    scopus 로고
    • Immune suppression and resistance mediated by constitutive activation of Wnt/beta-catenin signaling in human melanoma cells
    • COI: 1:CAS:528:DC%2BC38Xht1alu7jM, PID: 22815287
    • Yaguchi, T. et al. Immune suppression and resistance mediated by constitutive activation of Wnt/beta-catenin signaling in human melanoma cells. J. Immunol. 189, 2110–2117 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 2110-2117
    • Yaguchi, T.1
  • 46
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
    • COI: 1:CAS:528:DC%2BD28XntVCgsrg%3D, PID: 16801397
    • Sumimoto, H., Imabayashi, F., Iwata, T. & Kawakami, Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203, 1651–1656 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 47
    • 4444240325 scopus 로고    scopus 로고
    • Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
    • COI: 1:CAS:528:DC%2BD2cXmsVKltLw%3D, PID: 15208655
    • Sumimoto, H. et al. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 23, 6031–6039 (2004).
    • (2004) Oncogene , vol.23 , pp. 6031-6039
    • Sumimoto, H.1
  • 48
    • 79960409792 scopus 로고    scopus 로고
    • Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors
    • COI: 1:CAS:528:DC%2BC3MXnvVals7k%3D, PID: 21632716
    • Iwata-Kajihara, T. et al. Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol. 187, 27–36 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 27-36
    • Iwata-Kajihara, T.1
  • 49
    • 84902551922 scopus 로고    scopus 로고
    • Immunosuppression through constitutively activated NF-kappaB signalling in human ovarian cancer and its reversal by an NF-kappaB inhibitor
    • COI: 1:CAS:528:DC%2BC2cXos1ehs7c%3D, PID: 24867687
    • Nishio, H. et al. Immunosuppression through constitutively activated NF-kappaB signalling in human ovarian cancer and its reversal by an NF-kappaB inhibitor. Br. J. Cancer 110, 2965–2974 (2014).
    • (2014) Br. J. Cancer , vol.110 , pp. 2965-2974
    • Nishio, H.1
  • 50
    • 85030417315 scopus 로고    scopus 로고
    • Comprehensive intrametastatic immune quantification and major impact of immunoscore on survival
    • Mlecnik, B. et al. Comprehensive intrametastatic immune quantification and major impact of immunoscore on survival. J. Natl Cancer Inst. 110, 97–108 (2018).
    • (2018) J. Natl Cancer Inst. , vol.110 , pp. 97-108
    • Mlecnik, B.1
  • 51
    • 85046665554 scopus 로고    scopus 로고
    • Interfaces of malignant and immunologic clonal dynamics in ovarian cancer
    • COI: 1:CAS:528:DC%2BC1cXptlyrsL8%3D, PID: 29754820
    • Zhang, A. W. et al. Interfaces of malignant and immunologic clonal dynamics in ovarian cancer. Cell 173, 1755–1769 (2018).
    • (2018) Cell , vol.173 , pp. 1755-1769
    • Zhang, A.W.1
  • 52
    • 84982095840 scopus 로고    scopus 로고
    • Modification of the tumor microenvironment in KRAS or c-MYC-induced ovarian cancer-associated peritonitis
    • PID: 27483433
    • Yoshida, M. et al. Modification of the tumor microenvironment in KRAS or c-MYC-induced ovarian cancer-associated peritonitis. PLOS ONE 11, e0160330 (2016).
    • (2016) PLOS ONE , vol.11
    • Yoshida, M.1
  • 53
    • 85031765447 scopus 로고    scopus 로고
    • The damaging effect of passenger mutations on cancer progression
    • COI: 1:CAS:528:DC%2BC2sXhsV2lsrfP, PID: 28536279
    • McFarland, C. D. et al. The damaging effect of passenger mutations on cancer progression. Cancer Res. 77, 4763–4772 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 4763-4772
    • McFarland, C.D.1
  • 54
    • 85042540245 scopus 로고    scopus 로고
    • TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis
    • COI: 1:CAS:528:DC%2BC1cXisl2ls7g%3D, PID: 29443964
    • Tauriello, D. V. F. et al. TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis. Nature 554, 538–543 (2018).
    • (2018) Nature , vol.554 , pp. 538-543
    • Tauriello, D.V.F.1
  • 55
    • 84877896663 scopus 로고    scopus 로고
    • Targeting PD-1/PD-L1 interactions for cancer immunotherapy
    • PID: 23243584
    • Zitvogel, L. & Kroemer, G. Targeting PD-1/PD-L1 interactions for cancer immunotherapy. Oncoimmunology 1, 1223–1225 (2012).
    • (2012) Oncoimmunology , vol.1 , pp. 1223-1225
    • Zitvogel, L.1    Kroemer, G.2
  • 56
    • 77949780426 scopus 로고    scopus 로고
    • Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer
    • COI: 1:CAS:528:DC%2BC3cXlt1Sis7s%3D, PID: 19909745
    • Mlecnik, B. et al. Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer. Gastroenterology 138, 1429–1440 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1429-1440
    • Mlecnik, B.1
  • 58
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • COI: 1:CAS:528:DC%2BD1MXhtVyiur3K, PID: 19423728
    • Ahmadzadeh, M. et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114, 1537–1544 (2009).
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1
  • 59
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors
    • COI: 1:CAS:528:DC%2BC2cXotVSntrY%3D, PID: 24667641
    • Gros, A. et al. PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors. J. Clin. Invest. 124, 2246–2259 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2246-2259
    • Gros, A.1
  • 60
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • COI: 1:CAS:528:DC%2BC38XptVGnu7w%3D, PID: 22146893
    • Ji, R. R. et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol. Immunother. 61, 1019–1031 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1019-1031
    • Ji, R.R.1
  • 61
    • 85040827832 scopus 로고    scopus 로고
    • High response rate to PD-1 blockade in desmoplastic melanomas
    • COI: 1:CAS:528:DC%2BC1cXntVGhsQ%3D%3D, PID: 29320474
    • Eroglu, Z. et al. High response rate to PD-1 blockade in desmoplastic melanomas. Nature 553, 347–350 (2018).
    • (2018) Nature , vol.553 , pp. 347-350
    • Eroglu, Z.1
  • 62
    • 84966309581 scopus 로고    scopus 로고
    • The “cancer immunogram
    • COI: 1:CAS:528:DC%2BC28Xns1ags7s%3D, PID: 27151852
    • Blank, C. U., Haanen, J. B., Ribas, A. & Schumacher, T. N. The “cancer immunogram”. Science 352, 658–660 (2016).
    • (2016) Science , vol.352 , pp. 658-660
    • Blank, C.U.1    Haanen, J.B.2    Ribas, A.3    Schumacher, T.N.4
  • 63
    • 85053277083 scopus 로고    scopus 로고
    • T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient
    • COI: 1:CAS:528:DC%2BC1cXhs1eks7jL, PID: 30167863
    • Wieland, A. et al. T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient. Cancer Immunol. Immunother. 67, 1767–1776 (2018).
    • (2018) Cancer Immunol. Immunother. , vol.67 , pp. 1767-1776
    • Wieland, A.1
  • 64
    • 85038413048 scopus 로고    scopus 로고
    • Emergence of high-avidity Melan-A-specific clonotypes as a reflection of anti-PD-1 clinical efficacy
    • COI: 1:CAS:528:DC%2BC2sXhvFOgur7F, PID: 29212853
    • Simon, S. et al. Emergence of high-avidity Melan-A-specific clonotypes as a reflection of anti-PD-1 clinical efficacy. Cancer Res. 77, 7083–7093 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 7083-7093
    • Simon, S.1
  • 65
    • 85031295254 scopus 로고    scopus 로고
    • Tumor and microenvironment evolution during immunotherapy with nivolumab
    • COI: 1:CAS:528:DC%2BC2sXhs1GjsrjL, PID: 29033130
    • Riaz, N. et al. Tumor and microenvironment evolution during immunotherapy with nivolumab. Cell 171, 934–949 (2017).
    • (2017) Cell , vol.171 , pp. 934-949
    • Riaz, N.1
  • 66
    • 33751552197 scopus 로고    scopus 로고
    • Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
    • COI: 1:CAS:528:DC%2BD28Xht12htb7N, PID: 17116737
    • Fife, B. T. et al. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway. J. Exp. Med. 203, 2737–2747 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2737-2747
    • Fife, B.T.1
  • 67
    • 84967179683 scopus 로고    scopus 로고
    • Emerging opportunities and challenges in cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC28XmsFeqsrY%3D, PID: 27084738
    • Whiteside, T. L., Demaria, S., Rodriguez-Ruiz, M. E., Zarour, H. M. & Melero, I. Emerging opportunities and challenges in cancer immunotherapy. Clin. Cancer Res. 22, 1845–1855 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1845-1855
    • Whiteside, T.L.1    Demaria, S.2    Rodriguez-Ruiz, M.E.3    Zarour, H.M.4    Melero, I.5
  • 68
    • 84858797295 scopus 로고    scopus 로고
    • The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation
    • COI: 1:CAS:528:DC%2BC38XktVars78%3D, PID: 22421787
    • Weng, N. P., Araki, Y. & Subedi, K. The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation. Nat. Rev. Immunol. 12, 306–315 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 306-315
    • Weng, N.P.1    Araki, Y.2    Subedi, K.3
  • 69
    • 85040984776 scopus 로고    scopus 로고
    • Recent advances in targeting CD8 T-Cell immunity for more effective cancer immunotherapy
    • PID: 29403496
    • Durgeau, A., Virk, Y., Corgnac, S. & Mami-Chouaib, F. Recent advances in targeting CD8 T-Cell immunity for more effective cancer immunotherapy. Front. Immunol. 9, 14 (2018).
    • (2018) Front. Immunol. , vol.9 , pp. 14
    • Durgeau, A.1    Virk, Y.2    Corgnac, S.3    Mami-Chouaib, F.4
  • 70
    • 84959422566 scopus 로고    scopus 로고
    • The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis
    • PID: 26912905
    • Mlecnik, B. et al. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci. Transl Med. 8, 327ra26 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 327ra26
    • Mlecnik, B.1
  • 71
    • 29144514645 scopus 로고    scopus 로고
    • Effector memory T cells, early metastasis, and survival in colorectal cancer
    • COI: 1:CAS:528:DC%2BD2MXhtlarsrrE, PID: 16371631
    • Pages, F. et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med. 353, 2654–2666 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2654-2666
    • Pages, F.1
  • 72
    • 84944685270 scopus 로고    scopus 로고
    • Tumor microenvironment and immunotherapy: the whole picture is better than a glimpse
    • COI: 1:CAS:528:DC%2BC2MXhs12ju77J, PID: 26488814
    • Church, S. E. & Galon, J. Tumor microenvironment and immunotherapy: the whole picture is better than a glimpse. Immunity 43, 631–633 (2015).
    • (2015) Immunity , vol.43 , pp. 631-633
    • Church, S.E.1    Galon, J.2
  • 73
    • 84974803082 scopus 로고    scopus 로고
    • Radiotherapy: changing the game in immunotherapy
    • PID: 27774519
    • Demaria, S., Coleman, C. N. & Formenti, S. C. Radiotherapy: changing the game in immunotherapy. Trends Cancer 2, 286–294 (2016).
    • (2016) Trends Cancer , vol.2 , pp. 286-294
    • Demaria, S.1    Coleman, C.N.2    Formenti, S.C.3
  • 74
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • COI: 1:CAS:528:DC%2BC2MXls1Wmurg%3D
    • Sharma, P. & Allison, J. P. The future of immune checkpoint therapy. Science 348, 56–61 (2015).
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 75
    • 84958555198 scopus 로고    scopus 로고
    • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
    • COI: 1:CAS:528:DC%2BC28XislOqtbw%3D, PID: 26883990
    • Koyama, S. et al. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat. Commun. 7, 10501 (2016).
    • (2016) Nat. Commun. , vol.7
    • Koyama, S.1
  • 76
    • 85009205136 scopus 로고    scopus 로고
    • Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer
    • PID: 28197389
    • Shayan, G. et al. Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Oncoimmunology 6, e1261779 (2017).
    • (2017) Oncoimmunology , vol.6
    • Shayan, G.1
  • 77
    • 85015817432 scopus 로고    scopus 로고
    • Tim-3 expression on tumor-infiltrating PD-1(+)CD8(+) T cells correlates with poor clinical outcome in renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC2sXjsVOksr4%3D, PID: 27872087
    • Granier, C. et al. Tim-3 expression on tumor-infiltrating PD-1(+)CD8(+) T cells correlates with poor clinical outcome in renal cell carcinoma. Cancer Res. 77, 1075–1082 (2017).
    • (2017) Cancer Res. , vol.77 , pp. 1075-1082
    • Granier, C.1
  • 78
    • 84954285734 scopus 로고    scopus 로고
    • Combinatorial cancer immunotherapies
    • PID: 26923003
    • Hellmann, M. D., Friedman, C. F. & Wolchok, J. D. Combinatorial cancer immunotherapies. Adv. Immunol. 130, 251–277 (2016).
    • (2016) Adv. Immunol. , vol.130 , pp. 251-277
    • Hellmann, M.D.1    Friedman, C.F.2    Wolchok, J.D.3
  • 79
    • 85046890226 scopus 로고    scopus 로고
    • Adjuvant pembrolizumab versus placebo in resected stage III melanoma
    • COI: 1:CAS:528:DC%2BC1cXpsFyqsbc%3D, PID: 29658430
    • Eggermont, A. M. M. et al. Adjuvant pembrolizumab versus placebo in resected stage III melanoma. N. Engl. J. Med. 378, 1789–1801 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 1789-1801
    • Eggermont, A.M.M.1
  • 80
    • 84957839638 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition
    • COI: 1:CAS:528:DC%2BC28XhsVGru7s%3D, PID: 26558876
    • Buchbinder, E. I. & Desai, A. CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am. J. Clin. Oncol. 39, 98–106 (2016).
    • (2016) Am. J. Clin. Oncol. , vol.39 , pp. 98-106
    • Buchbinder, E.I.1    Desai, A.2
  • 81
    • 84938631461 scopus 로고    scopus 로고
    • Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade
    • PID: 25914862
    • Taube, J. M. Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade. Oncoimmunology 3, e963413 (2014).
    • (2014) Oncoimmunology , vol.3
    • Taube, J.M.1
  • 82
    • 85041813538 scopus 로고    scopus 로고
    • Implications of the tumor immune microenvironment for staging and therapeutics
    • COI: 1:CAS:528:DC%2BC2sXhvFKiurjP, PID: 29192647
    • Taube, J. M. et al. Implications of the tumor immune microenvironment for staging and therapeutics. Mod. Pathol. 31, 214–234 (2018).
    • (2018) Mod. Pathol. , vol.31 , pp. 214-234
    • Taube, J.M.1
  • 83
    • 85030460514 scopus 로고    scopus 로고
    • Overall survival with combined nivolumab and ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC2sXhs1Git73I, PID: 28889792
    • Wolchok, J. D. et al. Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 377, 1345–1356 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 1345-1356
    • Wolchok, J.D.1
  • 84
    • 85045136401 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC1cXntlGhsrY%3D, PID: 29562145
    • Motzer, R. J. et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N. Engl. J. Med. 378, 1277–1290 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 1277-1290
    • Motzer, R.J.1
  • 85
    • 85047309884 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden
    • COI: 1:CAS:528:DC%2BC1cXhtV2rtrnL, PID: 29658845
    • Hellmann, M. D. et al. Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N. Engl. J. Med. 378, 2093–2104 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 2093-2104
    • Hellmann, M.D.1
  • 86
    • 85015730293 scopus 로고    scopus 로고
    • TIM-3 as a target for cancer immunotherapy and mechanisms of action
    • PID: 28300768
    • Du, W. et al. TIM-3 as a target for cancer immunotherapy and mechanisms of action. Int. J. Mol. Sci. 18, E645 (2017).
    • (2017) Int. J. Mol. Sci. , vol.18 , pp. E645
    • Du, W.1
  • 87
    • 85002765709 scopus 로고    scopus 로고
    • TIGIT: a key inhibitor of the cancer immunity cycle
    • COI: 1:CAS:528:DC%2BC28Xhs1yiur%2FI, PID: 27793572
    • Manieri, N. A., Chiang, E. Y. & Grogan, J. L. TIGIT: a key inhibitor of the cancer immunity cycle. Trends Immunol. 38, 20–28 (2017).
    • (2017) Trends Immunol. , vol.38 , pp. 20-28
    • Manieri, N.A.1    Chiang, E.Y.2    Grogan, J.L.3
  • 88
    • 19944433635 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
    • COI: 1:CAS:528:DC%2BD2cXhtFSjtrzK, PID: 15568026
    • Sedy, J. R. et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6, 90–98 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 90-98
    • Sedy, J.R.1
  • 89
    • 85016090030 scopus 로고    scopus 로고
    • VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
    • COI: 1:CAS:528:DC%2BC2sXkvFahsbY%3D, PID: 28346412
    • Gao, J. et al. VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer. Nat. Med. 23, 551–555 (2017).
    • (2017) Nat. Med. , vol.23 , pp. 551-555
    • Gao, J.1
  • 90
    • 85054764324 scopus 로고    scopus 로고
    • Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
    • Stanczak, M. A. et al. Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. J. Clin. Invest. 10.1172/JCI120612 (2018).
    • (2018) J. Clin. Invest.
    • Stanczak, M.A.1
  • 91
    • 85040085793 scopus 로고    scopus 로고
    • The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC1cXhs1Cru7jI, PID: 29118006
    • Buchan, S. L., Rogel, A. & Al-Shamkhani, A. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood 131, 39–48 (2018).
    • (2018) Blood , vol.131 , pp. 39-48
    • Buchan, S.L.1    Rogel, A.2    Al-Shamkhani, A.3
  • 92
    • 84967205692 scopus 로고    scopus 로고
    • CD28 costimulation: from mechanism to therapy
    • COI: 1:CAS:528:DC%2BC28XotFars7g%3D, PID: 27192564
    • Esensten, J. H., Helou, Y. A., Chopra, G., Weiss, A. & Bluestone, J. A. CD28 costimulation: from mechanism to therapy. Immunity 44, 973–988 (2016).
    • (2016) Immunity , vol.44 , pp. 973-988
    • Esensten, J.H.1    Helou, Y.A.2    Chopra, G.3    Weiss, A.4    Bluestone, J.A.5
  • 93
    • 85015665428 scopus 로고    scopus 로고
    • T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
    • COI: 1:CAS:528:DC%2BC2sXlsVWhu7g%3D, PID: 6286077
    • Hui, E. et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science 355, 1428–1433 (2017).
    • (2017) Science , vol.355 , pp. 1428-1433
    • Hui, E.1
  • 94
    • 85015679329 scopus 로고    scopus 로고
    • Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent
    • COI: 1:CAS:528:DC%2BC2sXlsVWhu70%3D, PID: 28280249
    • Kamphorst, A. O. et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science 355, 1423–1427 (2017).
    • (2017) Science , vol.355 , pp. 1423-1427
    • Kamphorst, A.O.1
  • 95
    • 84940378016 scopus 로고    scopus 로고
    • Agonists of co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS
    • COI: 1:CAS:528:DC%2BC2MXhsV2mur3L, PID: 26320067
    • Sanmamed, M. F. et al. Agonists of co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin. Oncol. 42, 640–655 (2015).
    • (2015) Semin. Oncol. , vol.42 , pp. 640-655
    • Sanmamed, M.F.1
  • 96
    • 84860257860 scopus 로고    scopus 로고
    • The storm has cleared: lessons from the CD28 superagonist TGN1412 trial
    • PID: 22487653
    • Hunig, T. The storm has cleared: lessons from the CD28 superagonist TGN1412 trial. Nat. Rev. Immunol. 12, 317–318 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 317-318
    • Hunig, T.1
  • 97
    • 85062377375 scopus 로고    scopus 로고
    • Efficacy of anti-ICOS agonist monoclonal antibodies in preclinical tumor models provides a rationale for clinical development as cancer immunotherapeutics
    • Elpek, K. et al. Efficacy of anti-ICOS agonist monoclonal antibodies in preclinical tumor models provides a rationale for clinical development as cancer immunotherapeutics. Cancer Immunol. Res. 4, A059 (2016).
    • (2016) Cancer Immunol. Res. , vol.4 , pp. A059
    • Elpek, K.1
  • 98
    • 85016921823 scopus 로고    scopus 로고
    • Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting
    • PID: 27509527
    • Chaudhary, B. & Elkord, E. Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting. Vaccines 4, E28 (2016).
    • (2016) Vaccines , vol.4 , pp. E28
    • Chaudhary, B.1    Elkord, E.2
  • 99
    • 85033576428 scopus 로고    scopus 로고
    • Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
    • PID: 29097494
    • Routy, B. et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359, 91–97 (2017).
    • (2017) Science , vol.359 , pp. 91-97
    • Routy, B.1
  • 100
    • 84948677086 scopus 로고    scopus 로고
    • Could microbial therapy boost cancer immunotherapy?
    • COI: 1:CAS:528:DC%2BC2MXitVahu7bO, PID: 26612936
    • Snyder, A., Pamer, E. & Wolchok, J. Could microbial therapy boost cancer immunotherapy? Science 350, 1031–1032 (2015).
    • (2015) Science , vol.350 , pp. 1031-1032
    • Snyder, A.1    Pamer, E.2    Wolchok, J.3
  • 101
    • 85033587326 scopus 로고    scopus 로고
    • Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
    • PID: 29097493
    • Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359, 97–103 (2017).
    • (2017) Science , vol.359 , pp. 97-103
    • Gopalakrishnan, V.1
  • 102
    • 85040119520 scopus 로고    scopus 로고
    • The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
    • COI: 1:CAS:528:DC%2BC1cXjslOksg%3D%3D
    • Matson, V. et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 359, 104–108 (2018).
    • (2018) Science , vol.359 , pp. 104-108
    • Matson, V.1
  • 103
    • 84930660527 scopus 로고    scopus 로고
    • Molecular mechanisms of CD8(+) T cell trafficking and localization
    • COI: 1:CAS:528:DC%2BC2MXmtlagsQ%3D%3D, PID: 25577280
    • Nolz, J. C. Molecular mechanisms of CD8(+) T cell trafficking and localization. Cell. Mol. Life Sci. 72, 2461–2473 (2015).
    • (2015) Cell. Mol. Life Sci. , vol.72 , pp. 2461-2473
    • Nolz, J.C.1
  • 104
    • 85028431759 scopus 로고    scopus 로고
    • Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC2sXovVSjtr8%3D, PID: 28555670
    • Nagarsheth, N., Wicha, M. S. & Zou, W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat. Rev. Immunol. 17, 559–572 (2017).
    • (2017) Nat. Rev. Immunol. , vol.17 , pp. 559-572
    • Nagarsheth, N.1    Wicha, M.S.2    Zou, W.3
  • 105
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
    • COI: 1:CAS:528:DC%2BC2MXhslOrtLjI, PID: 26503055
    • Peng, D. et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 527, 249–253 (2015).
    • (2015) Nature , vol.527 , pp. 249-253
    • Peng, D.1
  • 106
    • 84958981871 scopus 로고    scopus 로고
    • PRC2 epigenetically silences Th1-type chemokines to suppress effector T-cell trafficking in colon cancer
    • COI: 1:CAS:528:DC%2BC28Xos1SqtA%3D%3D, PID: 26567139
    • Nagarsheth, N. et al. PRC2 epigenetically silences Th1-type chemokines to suppress effector T-cell trafficking in colon cancer. Cancer Res. 76, 275–282 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 275-282
    • Nagarsheth, N.1
  • 107
    • 84938218119 scopus 로고    scopus 로고
    • CD4+and CD8+T cells have opposing roles in breast cancer progression and outcome
    • PID: 25968569
    • Huang, Y. et al. CD4+and CD8+T cells have opposing roles in breast cancer progression and outcome. Oncotarget 6, 17462–17478 (2015).
    • (2015) Oncotarget , vol.6 , pp. 17462-17478
    • Huang, Y.1
  • 108
    • 84979763259 scopus 로고    scopus 로고
    • Molecular drivers of the non-T cell-inflamed tumor microenvironment in urothelial bladder cancer
    • COI: 1:CAS:528:DC%2BC28XhtVyitLnK, PID: 27197067
    • Sweis, R. F. et al. Molecular drivers of the non-T cell-inflamed tumor microenvironment in urothelial bladder cancer. Cancer Immunol. Res. 4, 563–568 (2016).
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 563-568
    • Sweis, R.F.1
  • 109
    • 84962921798 scopus 로고    scopus 로고
    • Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
    • COI: 1:CAS:528:DC%2BC28XksVWit7Y%3D, PID: 26977880
    • Tang, H. et al. Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade. Cancer Cell 29, 285–296 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 285-296
    • Tang, H.1
  • 110
    • 84947077516 scopus 로고    scopus 로고
    • Targeting ECM disrupts cancer progression
    • PID: 26539408
    • Venning, F. A., Wullkopf, L. & Erler, J. T. Targeting ECM disrupts cancer progression. Front. Oncol. 5, 224 (2015).
    • (2015) Front. Oncol. , vol.5 , pp. 224
    • Venning, F.A.1    Wullkopf, L.2    Erler, J.T.3
  • 111
    • 84877870613 scopus 로고    scopus 로고
    • Vascular normalization as an emerging strategy to enhance cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXnsFejs7s%3D, PID: 23440426
    • Huang, Y., Goel, S., Duda, D. G., Fukumura, D. & Jain, R. K. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res. 73, 2943–2948 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 2943-2948
    • Huang, Y.1    Goel, S.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 112
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • COI: 1:CAS:528:DC%2BC3MXmvVegurs%3D, PID: 21629292
    • Carmeliet, P. & Jain, R. K. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat. Rev. Drug Discov. 10, 417–427 (2011).
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 113
    • 84922369778 scopus 로고    scopus 로고
    • Targeting the tumor vasculature to enhance T cell activity
    • COI: 1:CAS:528:DC%2BC2MXhs1Smtrc%3D, PID: 25665467
    • Lanitis, E., Irving, M. & Coukos, G. Targeting the tumor vasculature to enhance T cell activity. Curr. Opin. Immunol. 33, 55–63 (2015).
    • (2015) Curr. Opin. Immunol. , vol.33 , pp. 55-63
    • Lanitis, E.1    Irving, M.2    Coukos, G.3
  • 114
    • 85028529620 scopus 로고    scopus 로고
    • Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?
    • Tan, L. Y. et al. Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy? Clin. Transl Immunol. 6, e134 (2017).
    • (2017) Clin. Transl Immunol , vol.6
    • Tan, L.Y.1
  • 115
    • 84971645609 scopus 로고    scopus 로고
    • Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
    • COI: 1:CAS:528:DC%2BC28XntlShsL4%3D, PID: 27139518
    • Wigerup, C., Pahlman, S. & Bexell, D. Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacol. Ther. 164, 152–169 (2016).
    • (2016) Pharmacol. Ther. , vol.164 , pp. 152-169
    • Wigerup, C.1    Pahlman, S.2    Bexell, D.3
  • 116
    • 85029597119 scopus 로고    scopus 로고
    • Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment
    • COI: 1:CAS:528:DC%2BC1cXntFCntr0%3D, PID: 29296695
    • Serra, S. et al. Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment. Blood Adv. 1, 47–61 (2016).
    • (2016) Blood Adv. , vol.1 , pp. 47-61
    • Serra, S.1
  • 117
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • COI: 1:CAS:528:DC%2BC3cXpt1GjtbY%3D, PID: 20661219
    • Stagg, J. & Smyth, M. J. Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29, 5346–5358 (2010).
    • (2010) Oncogene , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 118
    • 84888385324 scopus 로고    scopus 로고
    • Immunity, inflammation and cancer: a leading role for adenosine
    • COI: 1:CAS:528:DC%2BC3sXhslKmtrnL, PID: 24226193
    • Antonioli, L., Blandizzi, C., Pacher, P. & Hasko, G. Immunity, inflammation and cancer: a leading role for adenosine. Nat. Rev. Cancer 13, 842–857 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 842-857
    • Antonioli, L.1    Blandizzi, C.2    Pacher, P.3    Hasko, G.4
  • 119
    • 79954576658 scopus 로고    scopus 로고
    • CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis
    • COI: 1:CAS:528:DC%2BC3MXkslWjs78%3D, PID: 21292811
    • Stagg, J. et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 71, 2892–2900 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 2892-2900
    • Stagg, J.1
  • 120
    • 84959262007 scopus 로고    scopus 로고
    • Anti-CD73 in cancer immunotherapy: awakening new opportunities
    • PID: 27014745
    • Antonioli, L., Yegutkin, G. G., Pacher, P., Blandizzi, C. & Hasko, G. Anti-CD73 in cancer immunotherapy: awakening new opportunities. Trends Cancer 2, 95–109 (2016).
    • (2016) Trends Cancer , vol.2 , pp. 95-109
    • Antonioli, L.1    Yegutkin, G.G.2    Pacher, P.3    Blandizzi, C.4    Hasko, G.5
  • 121
    • 84939555315 scopus 로고    scopus 로고
    • CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma
    • COI: 1:CAS:528:DC%2BC28XhsFGksL%2FN, PID: 26279761
    • Hayes, G. M. et al. CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma. Am. J. Transl Res. 7, 1181–1188 (2015).
    • (2015) Am. J. Transl Res. , vol.7 , pp. 1181-1188
    • Hayes, G.M.1
  • 122
    • 84872132330 scopus 로고    scopus 로고
    • Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice
    • COI: 1:CAS:528:DC%2BC3sXms12hug%3D%3D, PID: 22859060
    • Sun, X. et al. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology 57, 205–216 (2013).
    • (2013) Hepatology , vol.57 , pp. 205-216
    • Sun, X.1
  • 123
    • 85053035082 scopus 로고    scopus 로고
    • Targeting adenosine for cancer immunotherapy
    • PID: 29914571
    • Leone, R. D. & Emens, L. A. Targeting adenosine for cancer immunotherapy. J. Immunother. Cancer 6, 57 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 57
    • Leone, R.D.1    Emens, L.A.2
  • 124
    • 85016196801 scopus 로고    scopus 로고
    • Development of inhibitors targeting hypoxia-inducible factor 1 and 2 for cancer therapy
    • COI: 1:CAS:528:DC%2BC1cXitlGjtL3I, PID: 28332352
    • Yu, T., Tang, B. & Sun, X. Development of inhibitors targeting hypoxia-inducible factor 1 and 2 for cancer therapy. Yonsei Med. J. 58, 489–496 (2017).
    • (2017) Yonsei Med. J. , vol.58 , pp. 489-496
    • Yu, T.1    Tang, B.2    Sun, X.3
  • 125
    • 84941796489 scopus 로고    scopus 로고
    • A2aR antagonists: next generation checkpoint blockade for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC28XhtFOlsb7E, PID: 25941561
    • Leone, R. D., Lo, Y. C. & Powell, J. D. A2aR antagonists: next generation checkpoint blockade for cancer immunotherapy. Comput. Struct. Biotechnol. J. 13, 265–272 (2015).
    • (2015) Comput. Struct. Biotechnol. J. , vol.13 , pp. 265-272
    • Leone, R.D.1    Lo, Y.C.2    Powell, J.D.3
  • 126
    • 33644851219 scopus 로고    scopus 로고
    • VEGF inhibitors in cancer therapy
    • COI: 1:CAS:528:DC%2BD28XitlCqtA%3D%3D, PID: 16454752
    • Cardones, A. R. & Banez, L. L. VEGF inhibitors in cancer therapy. Curr. Pharm. Des. 12, 387–394 (2006).
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 387-394
    • Cardones, A.R.1    Banez, L.L.2
  • 127
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • COI: 1:CAS:528:DC%2BC38Xjslersb4%3D, PID: 22419253
    • Fridman, W. H., Pages, F., Sautes-Fridman, C. & Galon, J. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12, 298–306 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 128
    • 85031305807 scopus 로고    scopus 로고
    • The role of angiogenesis in cancer treatment
    • Rajabi, M. & Mousa, S. A. The role of angiogenesis in cancer treatment. Biomedicines 5, 34 (2017).
    • (2017) Biomedicines , vol.5 , pp. 34
    • Rajabi, M.1    Mousa, S.A.2
  • 129
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • COI: 1:CAS:528:DC%2BD1MXltFSmtbc%3D, PID: 19249681
    • Ebos, J. M. et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232–239 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1
  • 130
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • COI: 1:CAS:528:DC%2BD1MXltFSmtbY%3D, PID: 19249680
    • Paez-Ribes, M. et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220–231 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1
  • 131
    • 84886675563 scopus 로고    scopus 로고
    • Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease
    • PID: 22393532
    • Goel, S., Wong, A. H. & Jain, R. K. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harb. Perspect. Med. 2, a006486 (2012).
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2 , pp. a006486
    • Goel, S.1    Wong, A.H.2    Jain, R.K.3
  • 132
    • 85027944490 scopus 로고    scopus 로고
    • Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
    • COI: 1:CAS:528:DC%2BC2sXlsV2gs74%3D, PID: 28371798
    • Tian, L. et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature 544, 250–254 (2017).
    • (2017) Nature , vol.544 , pp. 250-254
    • Tian, L.1
  • 133
    • 78649720282 scopus 로고    scopus 로고
    • Biology of interleukin-10
    • COI: 1:CAS:528:DC%2BC3cXhsFamt7zJ, PID: 21115385
    • Sabat, R. et al. Biology of interleukin-10. Cytokine Growth Factor Rev. 21, 331–344 (2010).
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 331-344
    • Sabat, R.1
  • 134
    • 77953507082 scopus 로고    scopus 로고
    • a potent regulator of tumor microenvironment and host immune response, implication for therapy
    • COI: 1:CAS:528:DC%2BC3cXmsVamsb8%3D, PID: 20455854
    • Yang, L. TGFbeta a potent regulator of tumor microenvironment and host immune response, implication for therapy. Curr. Mol. Med. 10, 374–380 (2010).
    • (2010) Curr. Mol. Med. , vol.10 , pp. 374-380
    • Yang, L.T.G.F.1
  • 135
    • 84990046448 scopus 로고    scopus 로고
    • Interleukin-10: an immune-activating cytokine in cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC28XitFWksrjO, PID: 27573656
    • Zhang, H., Wang, Y., Hwang, E. S. & He, Y. W. Interleukin-10: an immune-activating cytokine in cancer immunotherapy. J. Clin. Oncol. 34, 3576–3578 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 3576-3578
    • Zhang, H.1    Wang, Y.2    Hwang, E.S.3    He, Y.W.4
  • 136
    • 84922668738 scopus 로고    scopus 로고
    • Targeting the TGFbeta pathway for cancer therapy
    • COI: 1:CAS:528:DC%2BC2cXhvFSmtLvF, PID: 25444759
    • Neuzillet, C. et al. Targeting the TGFbeta pathway for cancer therapy. Pharmacol. Ther. 147, 22–31 (2015).
    • (2015) Pharmacol. Ther. , vol.147 , pp. 22-31
    • Neuzillet, C.1
  • 137
    • 85040863373 scopus 로고    scopus 로고
    • Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-beta
    • PID: 29343622
    • Lan, Y. et al. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-beta. Sci. Transl Med. 10, eaan5488 (2018).
    • (2018) Sci. Transl Med. , vol.10
    • Lan, Y.1
  • 138
    • 84861010803 scopus 로고    scopus 로고
    • The immunosuppressive factors IL-10, TGF-beta, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
    • COI: 1:CAS:528:DC%2BC38Xhslyit77N, PID: 22592077
    • Shimabukuro-Vornhagen, A. et al. The immunosuppressive factors IL-10, TGF-beta, and VEGF do not affect the antigen-presenting function of CD40-activated B cells. J. Exp. Clin. Cancer Res. 31, 47 (2012).
    • (2012) J. Exp. Clin. Cancer Res. , vol.31 , pp. 47
    • Shimabukuro-Vornhagen, A.1
  • 139
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • COI: 1:CAS:528:DC%2BD2cXhtVarsb7P, PID: 15573129
    • Gabrilovich, D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 4, 941–952 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 140
    • 84989172165 scopus 로고    scopus 로고
    • Ionic immune suppression within the tumour microenvironment limits T cell effector function
    • COI: 1:CAS:528:DC%2BC28XhsFWiurbI, PID: 27626381
    • Eil, R. et al. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537, 539–543 (2016).
    • (2016) Nature , vol.537 , pp. 539-543
    • Eil, R.1
  • 141
    • 80054093406 scopus 로고    scopus 로고
    • The prognostic value of histological tumor necrosis in solid organ malignant disease: a systematic review
    • COI: 1:CAS:528:DC%2BC3MXhtlWjt7jL, PID: 21992733
    • Richards, C. H., Mohammed, Z., Qayyum, T., Horgan, P. G. & McMillan, D. C. The prognostic value of histological tumor necrosis in solid organ malignant disease: a systematic review. Future Oncol. 7, 1223–1235 (2011).
    • (2011) Future Oncol. , vol.7 , pp. 1223-1235
    • Richards, C.H.1    Mohammed, Z.2    Qayyum, T.3    Horgan, P.G.4    McMillan, D.C.5
  • 142
    • 84944045501 scopus 로고    scopus 로고
    • Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner
    • COI: 1:CAS:528:DC%2BC2MXhsFKqsbvL, PID: 26411680
    • Holmgaard, R. B. et al. Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner. Cell Rep. 13, 412–424 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 412-424
    • Holmgaard, R.B.1
  • 143
    • 85007210906 scopus 로고    scopus 로고
    • Modulation of cancer-specific immune responses by amino acid degrading enzymes
    • COI: 1:CAS:528:DC%2BC28XitFamsrvO, PID: 28000524
    • Timosenko, E., Hadjinicolaou, A. V. & Cerundolo, V. Modulation of cancer-specific immune responses by amino acid degrading enzymes. Immunotherapy 9, 83–97 (2017).
    • (2017) Immunotherapy , vol.9 , pp. 83-97
    • Timosenko, E.1    Hadjinicolaou, A.V.2    Cerundolo, V.3
  • 144
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloid-derived suppressor cells in the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC28XhsFKltbc%3D, PID: 26858199
    • Kumar, V., Patel, S., Tcyganov, E. & Gabrilovich, D. I. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. 37, 208–220 (2016).
    • (2016) Trends Immunol. , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 145
    • 84897992390 scopus 로고    scopus 로고
    • Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways
    • COI: 1:CAS:528:DC%2BC3sXhvVKgsbbO, PID: 24259296
    • Raber, P. L. et al. Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways. Int. J. Cancer 134, 2853–2864 (2014).
    • (2014) Int. J. Cancer , vol.134 , pp. 2853-2864
    • Raber, P.L.1
  • 146
    • 85052113638 scopus 로고    scopus 로고
    • Epacadostat (E) plus pembrolizumab (P) versus pembrolizumab alone in patients (pts) with unresectable or metastatic melanoma: results of the phase 3 ECHO-301/KEYNOTE-252 study
    • Long, G. V. et al. Epacadostat (E) plus pembrolizumab (P) versus pembrolizumab alone in patients (pts) with unresectable or metastatic melanoma: results of the phase 3 ECHO-301/KEYNOTE-252 study. J. Clin. Oncol. 36, 108 (2018).
    • (2018) J. Clin. Oncol. , vol.36 , pp. 108
    • Long, G.V.1
  • 147
    • 84995948061 scopus 로고    scopus 로고
    • Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells
    • PID: 27828943
    • De Henau, O. et al. Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells. Nature 539, 443–447 (2016).
    • (2016) Nature , vol.539 , pp. 443-447
    • De Henau, O.1
  • 148
    • 85024385914 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
    • PID: 5514481
    • Cannarile, M. A. et al. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J. Immunother. Cancer 5, 53 (2017).
    • (2017) J. Immunother. Cancer , vol.5 , pp. 53
    • Cannarile, M.A.1
  • 149
    • 85016106531 scopus 로고    scopus 로고
    • Established T cell-inflamed tumors rejected after adaptive resistance was reversed by combination STING activation and PD-1 pathway blockade
    • COI: 1:CAS:528:DC%2BC28XitVegt7%2FM, PID: 27821498
    • Moore, E. et al. Established T cell-inflamed tumors rejected after adaptive resistance was reversed by combination STING activation and PD-1 pathway blockade. Cancer Immunol. Res. 4, 1061–1071 (2016).
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 1061-1071
    • Moore, E.1
  • 150
    • 85029038267 scopus 로고    scopus 로고
    • Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells
    • PID: 28915554
    • Clavijo, P. E. et al. Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells. Oncotarget 8, 55804–55820 (2017).
    • (2017) Oncotarget , vol.8 , pp. 55804-55820
    • Clavijo, P.E.1
  • 151
    • 66149156276 scopus 로고    scopus 로고
    • Chemokine expression in melanoma metastases associated with CD8+T cell recruitment
    • COI: 1:CAS:528:DC%2BD1MXjvVWitr8%3D, PID: 19293190
    • Harlin, H. et al. Chemokine expression in melanoma metastases associated with CD8+T cell recruitment. Cancer Res. 69, 3077–3085 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3077-3085
    • Harlin, H.1
  • 152
    • 84880720167 scopus 로고    scopus 로고
    • Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXht1GhtLrP, PID: 23715562
    • Ulloa-Montoya, F. et al. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31, 2388–2395 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 2388-2395
    • Ulloa-Montoya, F.1
  • 153
    • 84913586780 scopus 로고    scopus 로고
    • Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
    • COI: 1:CAS:528:DC%2BC2cXhvVSqsbbM, PID: 25344738
    • Sistigu, A. et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat. Med. 20, 1301–1309 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1301-1309
    • Sistigu, A.1
  • 154
    • 84899131835 scopus 로고    scopus 로고
    • The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
    • COI: 1:CAS:528:DC%2BC2cXntFGht74%3D, PID: 24766893
    • Cai, X., Chiu, Y. H. & Chen, Z. J. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol. Cell 54, 289–296 (2014).
    • (2014) Mol. Cell , vol.54 , pp. 289-296
    • Cai, X.1    Chiu, Y.H.2    Chen, Z.J.3
  • 155
    • 84978419964 scopus 로고    scopus 로고
    • The host STING pathway at the interface of cancer and immunity
    • PID: 27367184
    • Corrales, L., McWhirter, S. M., Dubensky, T. W. Jr & Gajewski, T. F. The host STING pathway at the interface of cancer and immunity. J. Clin. Invest. 126, 2404–2411 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 2404-2411
    • Corrales, L.1    McWhirter, S.M.2    Dubensky, T.W.3    Gajewski, T.F.4
  • 156
    • 85039552232 scopus 로고    scopus 로고
    • Antigen cross-presentation and T cell cross-priming in cancer immunology and immunotherapy
    • COI: 1:STN:280:DC%2BC1M%2FitV2mtQ%3D%3D, PID: 28945841
    • Sanchez-Paulete, A. R. et al. Antigen cross-presentation and T cell cross-priming in cancer immunology and immunotherapy. Ann. Oncol. 28, xii44–xii55 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. xii44-xii55
    • Sanchez-Paulete, A.R.1
  • 157
  • 158
    • 84929705879 scopus 로고    scopus 로고
    • Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
    • COI: 1:CAS:528:DC%2BC2MXotVCmtbc%3D, PID: 25959818
    • Corrales, L. et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11, 1018–1030 (2015).
    • (2015) Cell Rep. , vol.11 , pp. 1018-1030
    • Corrales, L.1
  • 159
    • 85042304571 scopus 로고    scopus 로고
    • Small molecules drive big improvements in immuno-oncology therapies
    • COI: 1:CAS:528:DC%2BC1cXjtlWqsbo%3D
    • Huck, B. R., Kotzner, L. & Urbahns, K. Small molecules drive big improvements in immuno-oncology therapies. Angew. Chem. Int. Ed. 57, 4412–4428 (2018).
    • (2018) Angew. Chem. Int. Ed. , vol.57 , pp. 4412-4428
    • Huck, B.R.1    Kotzner, L.2    Urbahns, K.3
  • 160
    • 85020641723 scopus 로고    scopus 로고
    • A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice
    • COI: 1:CAS:528:DC%2BC2sXpt1Sgs7s%3D, PID: 28483787
    • Foote, J. B. et al. A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice. Cancer Immunol. Res. 5, 468–479 (2017).
    • (2017) Cancer Immunol. Res. , vol.5 , pp. 468-479
    • Foote, J.B.1
  • 161
    • 85029333573 scopus 로고    scopus 로고
    • Pattern recognition receptors: immune targets to enhance cancer immunotherapy
    • COI: 1:STN:280:DC%2BC1crht1OksA%3D%3D, PID: 28444111
    • Shekarian, T. et al. Pattern recognition receptors: immune targets to enhance cancer immunotherapy. Ann. Oncol. 28, 1756–1766 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. 1756-1766
    • Shekarian, T.1
  • 162
    • 85048932545 scopus 로고    scopus 로고
    • Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment
    • PID: 29989043
    • Elion, D. L. & Cook, R. S. Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment. Oncotarget 9, 29007–29017 (2018).
    • (2018) Oncotarget , vol.9 , pp. 29007-29017
    • Elion, D.L.1    Cook, R.S.2
  • 163
    • 84881401720 scopus 로고    scopus 로고
    • Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment
    • PID: 23722543
    • Le Mercier, I. et al. Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment. Cancer Res. 73, 4629–4640 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 4629-4640
    • Le Mercier, I.1
  • 164
    • 84862907845 scopus 로고    scopus 로고
    • In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
    • PID: 22045986
    • Kim, Y. H. et al. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study. Blood 119, 355–363 (2012).
    • (2012) Blood , vol.119 , pp. 355-363
    • Kim, Y.H.1
  • 165
    • 34848856815 scopus 로고    scopus 로고
    • Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself
    • COI: 1:CAS:528:DC%2BD2sXosVyqsb4%3D, PID: 17675511
    • Li, J. et al. Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. J. Immunol. 179, 2493–2500 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 2493-2500
    • Li, J.1
  • 166
    • 84995640008 scopus 로고    scopus 로고
    • Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+T cells
    • COI: 1:CAS:528:DC%2BC28XhslKnu73N, PID: 27799536
    • + T cells. Proc. Natl Acad. Sci. USA 113, E7240–E7249 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E7240-E7249
    • Wang, S.1
  • 167
    • 85036635837 scopus 로고    scopus 로고
    • Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
    • PID: 28931759
    • Sato-Kaneko, F. et al. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight 2, 93397 (2017).
    • (2017) JCI Insight , vol.2 , pp. 93397
    • Sato-Kaneko, F.1
  • 168
    • 85041668143 scopus 로고    scopus 로고
    • Eradication of spontaneous malignancy by local immunotherapy
    • PID: 29386357
    • Sagiv-Barfi, I. et al. Eradication of spontaneous malignancy by local immunotherapy. Sci. Transl Med. 10, eaan4488 (2018).
    • (2018) Sci. Transl Med. , vol.10
    • Sagiv-Barfi, I.1
  • 170
    • 85047865218 scopus 로고    scopus 로고
    • Further advances in cancer immunotherapy: going beyond checkpoint blockade
    • PID: 29910800
    • Wilkinson, R. W. & Leishman, A. J. Further advances in cancer immunotherapy: going beyond checkpoint blockade. Front. Immunol. 9, 1082 (2018).
    • (2018) Front. Immunol. , vol.9 , pp. 1082
    • Wilkinson, R.W.1    Leishman, A.J.2
  • 171
    • 85054354559 scopus 로고    scopus 로고
    • In situ vaccination with a TLR 9 agonist and local low dose radiation induces systemic responses in untreated indolent lymphoma
    • Frank, M. J. et al. In situ vaccination with a TLR 9 agonist and local low dose radiation induces systemic responses in untreated indolent lymphoma. Cancer Discov. 10.1158/2159-8290.CD-18-0743 (2018).
    • (2018) Cancer Discov.
    • Frank, M.J.1
  • 172
    • 85020471606 scopus 로고    scopus 로고
    • Phase Ib trial of the toll-like receptor 8 agonist, motolimod (VTX-2337), combined with cetuximab in patients with recurrent or metastatic SCCHN
    • COI: 1:CAS:528:DC%2BC2sXnslyrs7Y%3D, PID: 27810904
    • Chow, L. Q. M. et al. Phase Ib trial of the toll-like receptor 8 agonist, motolimod (VTX-2337), combined with cetuximab in patients with recurrent or metastatic SCCHN. Clin. Cancer Res. 23, 2442–2450 (2017).
    • (2017) Clin. Cancer Res. , vol.23 , pp. 2442-2450
    • Chow, L.Q.M.1
  • 173
    • 84898733422 scopus 로고    scopus 로고
    • Intratumoral immunization: a new paradigm for cancer therapy
    • COI: 1:CAS:528:DC%2BC2cXls1eiurc%3D, PID: 24691639
    • Marabelle, A., Kohrt, H., Caux, C. & Levy, R. Intratumoral immunization: a new paradigm for cancer therapy. Clin. Cancer Res. 20, 1747–1756 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1747-1756
    • Marabelle, A.1    Kohrt, H.2    Caux, C.3    Levy, R.4
  • 174
    • 84875189381 scopus 로고    scopus 로고
    • Molecular pathways: toll-like receptors in the tumor microenvironment—poor prognosis or new therapeutic opportunity
    • COI: 1:CAS:528:DC%2BC3sXktFKksL4%3D, PID: 23271799
    • Ridnour, L. A. et al. Molecular pathways: toll-like receptors in the tumor microenvironment—poor prognosis or new therapeutic opportunity. Clin. Cancer Res. 19, 1340–1346 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1340-1346
    • Ridnour, L.A.1
  • 175
    • 85050994830 scopus 로고    scopus 로고
    • TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC1cXhsVWqsbbF, PID: 29553135
    • Huang, L., Xu, H. & Peng, G. TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy. Cell. Mol. Immunol. 15, 428–437 (2018).
    • (2018) Cell. Mol. Immunol. , vol.15 , pp. 428-437
    • Huang, L.1    Xu, H.2    Peng, G.3
  • 176
    • 85029668940 scopus 로고    scopus 로고
    • TLR agonists as adjuvants for cancer vaccines
    • COI: 1:CAS:528:DC%2BC1cXitFCntbrM, PID: 28921471
    • Li, J. K., Balic, J. J., Yu, L. & Jenkins, B. TLR agonists as adjuvants for cancer vaccines. Adv. Exp. Med. Biol. 1024, 195–212 (2017).
    • (2017) Adv. Exp. Med. Biol. , vol.1024 , pp. 195-212
    • Li, J.K.1    Balic, J.J.2    Yu, L.3    Jenkins, B.4
  • 177
    • 84961671432 scopus 로고    scopus 로고
    • Trial watch: immunostimulation with toll-like receptor agonists in cancer therapy
    • PID: 27141345
    • Iribarren, K. et al. Trial watch: immunostimulation with toll-like receptor agonists in cancer therapy. Oncoimmunology 5, e1088631 (2016).
    • (2016) Oncoimmunology , vol.5
    • Iribarren, K.1
  • 178
    • 84874845333 scopus 로고    scopus 로고
    • Agonistic CD40 antibodies and cancer therapy
    • COI: 1:CAS:528:DC%2BC3sXjsFektrg%3D, PID: 23460534
    • Vonderheide, R. H. & Glennie, M. J. Agonistic CD40 antibodies and cancer therapy. Clin. Cancer Res. 19, 1035–1043 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1035-1043
    • Vonderheide, R.H.1    Glennie, M.J.2
  • 179
    • 0037087379 scopus 로고    scopus 로고
    • T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody
    • COI: 1:CAS:528:DC%2BD38XitFSktrY%3D, PID: 11884438
    • Tutt, A. L. et al. T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody. J. Immunol. 168, 2720–2728 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 2720-2728
    • Tutt, A.L.1
  • 180
    • 84928811075 scopus 로고    scopus 로고
    • The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T cell-dependent tumor immunity
    • COI: 1:CAS:528:DC%2BC2MXjsF2itbo%3D, PID: 25316820
    • Mangsbo, S. M. et al. The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T cell-dependent tumor immunity. Clin. Cancer Res. 21, 1115–1126 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1115-1126
    • Mangsbo, S.M.1
  • 181
    • 85010917048 scopus 로고    scopus 로고
    • Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists
    • COI: 1:CAS:528:DC%2BC28XitVyru7jF, PID: 27927088
    • Beatty, G. L., Li, Y. & Long, K. B. Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists. Expert Rev. Anticancer Ther. 17, 175–186 (2017).
    • (2017) Expert Rev. Anticancer Ther. , vol.17 , pp. 175-186
    • Beatty, G.L.1    Li, Y.2    Long, K.B.3
  • 182
    • 84961726923 scopus 로고    scopus 로고
    • Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis
    • COI: 1:CAS:528:DC%2BC28XkvVCiu74%3D, PID: 27005831
    • Ohta, T. et al. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci. Rep. 6, 23505 (2016).
    • (2016) Sci. Rep. , vol.6
    • Ohta, T.1
  • 183
    • 84959464101 scopus 로고    scopus 로고
    • T cell migration, search strategies and mechanisms
    • COI: 1:CAS:528:DC%2BC28Xit1Wktrc%3D, PID: 26852928
    • Krummel, M. F., Bartumeus, F. & Gerard, A. T cell migration, search strategies and mechanisms. Nat. Rev. Immunol. 16, 193–201 (2016).
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 193-201
    • Krummel, M.F.1    Bartumeus, F.2    Gerard, A.3
  • 184
    • 85041637908 scopus 로고    scopus 로고
    • NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control
    • COI: 1:CAS:528:DC%2BC1cXis1ansr0%3D, PID: 29429633
    • Bottcher, J. P. et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172, 1022–1037 (2018).
    • (2018) Cell , vol.172 , pp. 1022-1037
    • Bottcher, J.P.1
  • 185
    • 77953498509 scopus 로고    scopus 로고
    • Found in translation: the human equivalent of mouse CD8+dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXns1Sntb8%3D, PID: 20513744
    • Villadangos, J. A. & Shortman, K. Found in translation: the human equivalent of mouse CD8+dendritic cells. J. Exp. Med. 207, 1131–1134 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1131-1134
    • Villadangos, J.A.1    Shortman, K.2
  • 186
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • + T cell priming against tumours depends on STING
    • + T cell priming against tumours depends on STING.
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.R.1
  • 187
    • 84912128872 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
    • COI: 1:CAS:528:DC%2BC2cXhvFOitrbM, PID: 25517616
    • Deng, L. et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41, 843–852 (2014).
    • (2014) Immunity , vol.41 , pp. 843-852
    • Deng, L.1
  • 188
    • 85028304716 scopus 로고    scopus 로고
    • Mitotic progression following DNA damage enables pattern recognition within micronuclei
    • COI: 1:CAS:528:DC%2BC2sXht1GgtrvP, PID: 28759889
    • Harding, S. M. et al. Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature 548, 466–470 (2017).
    • (2017) Nature , vol.548 , pp. 466-470
    • Harding, S.M.1
  • 189
    • 84978665423 scopus 로고    scopus 로고
    • Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance
    • PID: 27343548
    • Zheng, W. et al. Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance. Oncotarget 7, 43039–43051 (2016).
    • (2016) Oncotarget , vol.7 , pp. 43039-43051
    • Zheng, W.1
  • 190
    • 85012872289 scopus 로고    scopus 로고
    • First-in-human study testing a new radioenhancer using nanoparticles (NBTXR3) activated by radiation therapy in patients with locally advanced soft tissue sarcomas
    • COI: 1:CAS:528:DC%2BC2sXisFyks78%3D, PID: 27998887
    • Bonvalot, S. et al. First-in-human study testing a new radioenhancer using nanoparticles (NBTXR3) activated by radiation therapy in patients with locally advanced soft tissue sarcomas. Clin. Cancer Res. 23, 908–917 (2017).
    • (2017) Clin. Cancer Res. , vol.23 , pp. 908-917
    • Bonvalot, S.1
  • 191
    • 84923197176 scopus 로고    scopus 로고
    • Immune escape mechanisms as a guide for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC2MXislGhtb4%3D, PID: 25501578
    • Beatty, G. L. & Gladney, W. L. Immune escape mechanisms as a guide for cancer immunotherapy. Clin. Cancer Res. 21, 687–692 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 687-692
    • Beatty, G.L.1    Gladney, W.L.2
  • 192
    • 77950366886 scopus 로고    scopus 로고
    • Decoding cell death signals in inflammation and immunity
    • COI: 1:CAS:528:DC%2BC3cXlsVSgurc%3D, PID: 20303871
    • Zitvogel, L., Kepp, O. & Kroemer, G. Decoding cell death signals in inflammation and immunity. Cell 140, 798–804 (2010).
    • (2010) Cell , vol.140 , pp. 798-804
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 193
    • 84962301577 scopus 로고    scopus 로고
    • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
    • COI: 1:CAS:528:DC%2BC28XksFCht70%3D, PID: 26940869, This article demonstrates that a relationship exists between clonal neoantigen burden and overall survival primary lung adenocarcinomas. Sensitivity to PD-1 and CTLA4 blockade patients with advanced NSCLC and melanoma was enhanced tumours enriched for clonal neoantigens
    • McGranahan, N. et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351, 1463–1469 (2016). This article demonstrates that a relationship exists between clonal neoantigen burden and overall survival in primary lung adenocarcinomas. Sensitivity to PD-1 and CTLA4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumours enriched for clonal neoantigens.
    • (2016) Science , vol.351 , pp. 1463-1469
    • McGranahan, N.1
  • 194
    • 84870239310 scopus 로고    scopus 로고
    • Immunogenic cell death and DAMPs in cancer therapy
    • COI: 1:CAS:528:DC%2BC38Xhs1KltrzF, PID: 23151605
    • Krysko, D. V. et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860–875 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 860-875
    • Krysko, D.V.1
  • 195
    • 84875552922 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer therapy
    • COI: 1:CAS:528:DC%2BC3sXnsFClsL8%3D, PID: 23157435
    • Kroemer, G., Galluzzi, L., Kepp, O. & Zitvogel, L. Immunogenic cell death in cancer therapy. Annu. Rev. Immunol. 31, 51–72 (2013).
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 51-72
    • Kroemer, G.1    Galluzzi, L.2    Kepp, O.3    Zitvogel, L.4
  • 196
    • 84991619059 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer and infectious disease
    • COI: 1:CAS:528:DC%2BC28Xhs1ygtrjJ, PID: 27748397
    • Galluzzi, L., Buque, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol. 17, 97–111 (2017).
    • (2017) Nat. Rev. Immunol. , vol.17 , pp. 97-111
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 197
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • COI: 1:CAS:528:DC%2BD2sXhvFWisw%3D%3D, PID: 17187072
    • Obeid, M. et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13, 54–61 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 54-61
    • Obeid, M.1
  • 198
    • 84947763610 scopus 로고    scopus 로고
    • Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
    • COI: 1:CAS:528:DC%2BC2MXhvVeqsr3P, PID: 26516201
    • Vacchelli, E. et al. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972–978 (2015).
    • (2015) Science , vol.350 , pp. 972-978
    • Vacchelli, E.1
  • 199
    • 84857391089 scopus 로고    scopus 로고
    • Leukocyte composition of human breast cancer
    • COI: 1:CAS:528:DC%2BC38Xjs1WmsLY%3D, PID: 21825174
    • Ruffell, B. et al. Leukocyte composition of human breast cancer. Proc. Natl Acad. Sci. USA 109, 2796–2801 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2796-2801
    • Ruffell, B.1
  • 200
    • 84978416083 scopus 로고    scopus 로고
    • Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy
    • COI: 1:CAS:528:DC%2BC2sXnvVWmsLk%3D, PID: 27278091
    • Park, J. H. et al. Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Int. J. Oncol. 49, 471–478 (2016).
    • (2016) Int. J. Oncol. , vol.49 , pp. 471-478
    • Park, J.H.1
  • 201
    • 84949639567 scopus 로고    scopus 로고
    • Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer
    • COI: 1:CAS:528:DC%2BC2MXhvFWrurvL, PID: 26506894
    • Ladoire, S. et al. Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer. Autophagy 11, 1878–1890 (2015).
    • (2015) Autophagy , vol.11 , pp. 1878-1890
    • Ladoire, S.1
  • 202
    • 84971517378 scopus 로고    scopus 로고
    • The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer
    • COI: 1:CAS:528:DC%2BC28Xmt1eis7o%3D, PID: 26979828
    • Ladoire, S. et al. The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer. Autophagy 12, 864–875 (2016).
    • (2016) Autophagy , vol.12 , pp. 864-875
    • Ladoire, S.1
  • 203
    • 84964317484 scopus 로고    scopus 로고
    • Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis
    • COI: 1:CAS:528:DC%2BC28XltlSkt70%3D, PID: 26842877
    • Fucikova, J. et al. Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis. Cancer Res. 76, 1746–1756 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 1746-1756
    • Fucikova, J.1
  • 204
    • 84976353299 scopus 로고    scopus 로고
    • Calreticulin expression: interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer
    • PID: 27622029
    • Stoll, G. et al. Calreticulin expression: interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer. Oncoimmunology 5, e1177692 (2016).
    • (2016) Oncoimmunology , vol.5
    • Stoll, G.1
  • 205
    • 79952397249 scopus 로고    scopus 로고
    • Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia
    • COI: 1:STN:280:DC%2BC3M3jsVWntw%3D%3D, PID: 21368877
    • Wemeau, M. et al. Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia. Cell Death Dis. 1, e104 (2010).
    • (2010) Cell Death Dis. , vol.1
    • Wemeau, M.1
  • 206
    • 85015063326 scopus 로고    scopus 로고
    • Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients
    • COI: 1:CAS:528:DC%2BC2sXosVChs70%3D, PID: 27802968
    • Fucikova, J. et al. Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients. Blood 128, 3113–3124 (2016).
    • (2016) Blood , vol.128 , pp. 3113-3124
    • Fucikova, J.1
  • 207
    • 84956607773 scopus 로고    scopus 로고
    • Immunological effects of conventional chemotherapy and targeted anticancer agents
    • COI: 1:CAS:528:DC%2BC2MXitVansbvK, PID: 26678337
    • Galluzzi, L., Buque, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunological effects of conventional chemotherapy and targeted anticancer agents. Cancer Cell 28, 690–714 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 690-714
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 208
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
    • COI: 1:CAS:528:DC%2BC3cXkslShsLk%3D, PID: 20388795
    • Vincent, J. et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 70, 3052–3061 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3052-3061
    • Vincent, J.1
  • 209
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • COI: 1:CAS:528:DC%2BD2sXisVaqtbY%3D, PID: 16960692
    • + regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol. Immunother. 56, 641–648 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 641-648
    • Ghiringhelli, F.1
  • 210
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • COI: 1:CAS:528:DC%2BC3sXhsl2htL3P, PID: 4048947
    • Viaud, S. et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971–976 (2013).
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 211
    • 84964637801 scopus 로고    scopus 로고
    • Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer
    • COI: 1:CAS:528:DC%2BC28XntVOksbs%3D, PID: 27133165
    • Wang, W. et al. Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer. Cell 165, 1092–1105 (2016).
    • (2016) Cell , vol.165 , pp. 1092-1105
    • Wang, W.1
  • 212
    • 84898714462 scopus 로고    scopus 로고
    • Prognostic and predictive values of the immunoscore in patients with rectal cancer
    • PID: 24691640
    • Anitei, M. G. et al. Prognostic and predictive values of the immunoscore in patients with rectal cancer. Clin. Cancer Res. 20, 1891–1899 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1891-1899
    • Anitei, M.G.1
  • 213
    • 85047328215 scopus 로고    scopus 로고
    • Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC1cXhtV2rtrjL, PID: 29658856
    • Gandhi, L. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378, 2078–2092 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 2078-2092
    • Gandhi, L.1
  • 214
    • 85016108628 scopus 로고    scopus 로고
    • Kinase regulation of human MHC class I molecule expression on cancer cells
    • COI: 1:CAS:528:DC%2BC1MXntVCqsg%3D%3D, PID: 27680026
    • Brea, E. J. et al. Kinase regulation of human MHC class I molecule expression on cancer cells. Cancer Immunol. Res. 4, 936–947 (2016).
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 936-947
    • Brea, E.J.1
  • 215
    • 84901835457 scopus 로고    scopus 로고
    • 5-Azacytidine treatment sensitizes tumor cells to T cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies
    • COI: 1:STN:280:DC%2BC2crovVemug%3D%3D, PID: 24681961
    • Gang, A. O. et al. 5-Azacytidine treatment sensitizes tumor cells to T cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies. Blood Cancer J. 4, e197 (2014).
    • (2014) Blood Cancer J. , vol.4
    • Gang, A.O.1
  • 216
    • 84991711222 scopus 로고    scopus 로고
    • Turning tumour cells into antigen presenting cells: the next step to improve cancer immunotherapy?
    • PID: 27755997
    • de Charette, M., Marabelle, A. & Houot, R. Turning tumour cells into antigen presenting cells: the next step to improve cancer immunotherapy? Eur. J. Cancer 68, 134–147 (2016).
    • (2016) Eur. J. Cancer , vol.68 , pp. 134-147
    • de Charette, M.1    Marabelle, A.2    Houot, R.3
  • 217
    • 84940381273 scopus 로고    scopus 로고
    • Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
    • COI: 1:CAS:528:DC%2BC2MXhsVensLnJ, PID: 26317466
    • Chiappinelli, K. B. et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell 162, 974–986 (2015).
    • (2015) Cell , vol.162 , pp. 974-986
    • Chiappinelli, K.B.1
  • 218
    • 77950633126 scopus 로고    scopus 로고
    • Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation
    • COI: 1:CAS:528:DC%2BC3cXjtFKhsL4%3D, PID: 20095041
    • Stengel, S., Fiebig, U., Kurth, R. & Denner, J. Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation. Genes Chromosomes Cancer 49, 401–411 (2010).
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 401-411
    • Stengel, S.1    Fiebig, U.2    Kurth, R.3    Denner, J.4
  • 219
    • 84872762500 scopus 로고    scopus 로고
    • Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: emergence of new molecular targets
    • PID: 23085571
    • Strissel, P. L. et al. Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: emergence of new molecular targets. Oncotarget 3, 1204–1219 (2012).
    • (2012) Oncotarget , vol.3 , pp. 1204-1219
    • Strissel, P.L.1
  • 220
    • 84994671515 scopus 로고    scopus 로고
    • Impact of inhibitor of apoptosis proteins on immune modulation and inflammation
    • COI: 1:CAS:528:DC%2BC28XhvVGjs7rE, PID: 27713393
    • Sharma, S., Kaufmann, T. & Biswas, S. Impact of inhibitor of apoptosis proteins on immune modulation and inflammation. Immunol. Cell Biol. 95, 236–243 (2017).
    • (2017) Immunol. Cell Biol. , vol.95 , pp. 236-243
    • Sharma, S.1    Kaufmann, T.2    Biswas, S.3
  • 221
    • 84993984528 scopus 로고    scopus 로고
    • The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
    • PID: 27760111
    • Kotschy, A. et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature 538, 477–482 (2016).
    • (2016) Nature , vol.538 , pp. 477-482
    • Kotschy, A.1
  • 222
    • 84875663689 scopus 로고    scopus 로고
    • Achieving cancer cell death with PI3K/mTOR-targeted therapies
    • COI: 1:CAS:528:DC%2BC3sXmslWgt7s%3D, PID: 23551096
    • Yea, S. S. & Fruman, D. A. Achieving cancer cell death with PI3K/mTOR-targeted therapies. Ann. NY Acad. Sci. 1280, 15–18 (2013).
    • (2013) Ann. NY Acad. Sci. , vol.1280 , pp. 15-18
    • Yea, S.S.1    Fruman, D.A.2
  • 223
    • 84984676988 scopus 로고    scopus 로고
    • Role of interleukin-6 in cancer progression and therapeutic resistance
    • COI: 1:CAS:528:DC%2BC28XpsVymt7c%3D, PID: 27260630
    • Kumari, N., Dwarakanath, B. S., Das, A. & Bhatt, A. N. Role of interleukin-6 in cancer progression and therapeutic resistance. Tumour Biol. 37, 11553–11572 (2016).
    • (2016) Tumour Biol. , vol.37 , pp. 11553-11572
    • Kumari, N.1    Dwarakanath, B.S.2    Das, A.3    Bhatt, A.N.4
  • 224
    • 84992027493 scopus 로고    scopus 로고
    • A large fraction of HLA class I ligands are proteasome-generated spliced peptides
    • COI: 1:CAS:528:DC%2BC28Xhs1yltLbF, PID: 27846572
    • Liepe, J. et al. A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science 354, 354–358 (2016).
    • (2016) Science , vol.354 , pp. 354-358
    • Liepe, J.1
  • 225
    • 85035025088 scopus 로고    scopus 로고
    • Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
    • PID: 29170503
    • Lauss, M. et al. Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma. Nat. Commun. 8, 1738 (2017).
    • (2017) Nat. Commun. , vol.8
    • Lauss, M.1
  • 226
    • 85037841016 scopus 로고    scopus 로고
    • Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
    • COI: 1:CAS:528:DC%2BC2sXhvVynsLbM, PID: 29186113, This article shows that inactivation of DNA MMR mechanisms increased mutational load, promoted continuous renewal of neoantigens human CRCs and triggered immune surveillance mouse models
    • Germano, G. et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature 552, 116–120 (2017). This article shows that inactivation of DNA MMR mechanisms increased mutational load, promoted continuous renewal of neoantigens in human CRCs and triggered immune surveillance in mouse models.
    • (2017) Nature , vol.552 , pp. 116-120
    • Germano, G.1
  • 227
  • 228
    • 84899678913 scopus 로고    scopus 로고
    • From breaking bad to worse: exploiting homologous DNA repair deficiency in cancer
    • COI: 1:CAS:528:DC%2BC2cXns1Cms74%3D, PID: 24795010
    • Hemann, M. T. From breaking bad to worse: exploiting homologous DNA repair deficiency in cancer. Cancer Discov. 4, 516–518 (2014).
    • (2014) Cancer Discov. , vol.4 , pp. 516-518
    • Hemann, M.T.1
  • 229
    • 84941655113 scopus 로고    scopus 로고
    • Cancer immunotherapy: harnessing the immune system to battle cancer
    • PID: 26325031
    • Yang, Y. Cancer immunotherapy: harnessing the immune system to battle cancer. J. Clin. Invest. 125, 3335–3337 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 3335-3337
    • Yang, Y.1
  • 230
    • 85030457550 scopus 로고    scopus 로고
    • Tragedy, perseverance, and chance — the story of CAR-T therapy
    • PID: 28902570
    • Rosenbaum, L. Tragedy, perseverance, and chance — the story of CAR-T therapy. N. Engl. J. Med. 377, 1313–1315 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 1313-1315
    • Rosenbaum, L.1
  • 231
    • 84921487573 scopus 로고    scopus 로고
    • Designing chimeric antigen receptors to effectively and safely target tumors
    • COI: 1:CAS:528:DC%2BC2MXhtVGiu7Y%3D, PID: 25621840
    • Jensen, M. C. & Riddell, S. R. Designing chimeric antigen receptors to effectively and safely target tumors. Curr. Opin. Immunol. 33, 9–15 (2015).
    • (2015) Curr. Opin. Immunol. , vol.33 , pp. 9-15
    • Jensen, M.C.1    Riddell, S.R.2
  • 232
    • 85032747309 scopus 로고    scopus 로고
    • Cancer immunotherapy using CAR-T cells: from the research bench to the assembly line
    • Gomes-Silva, D. & Ramos, C. A. Cancer immunotherapy using CAR-T cells: from the research bench to the assembly line. Biotechnol. J. 13, 1700097 (2018).
    • (2018) Biotechnol. J. , vol.13 , pp. 1700097
    • Gomes-Silva, D.1    Ramos, C.A.2
  • 233
    • 85006208770 scopus 로고    scopus 로고
    • Clinical manufacturing of CAR T cells: foundation of a promising therapy
    • COI: 1:CAS:528:DC%2BC28XhtVWktrfP
    • Wang, X. & Riviere, I. Clinical manufacturing of CAR T cells: foundation of a promising therapy. Mol. Ther. Oncolyt. 3, 16015 (2016).
    • (2016) Mol. Ther. Oncolyt. , vol.3 , pp. 16015
    • Wang, X.1    Riviere, I.2
  • 235
    • 84954214717 scopus 로고    scopus 로고
    • Biology and applications of CRISPR systems: harnessing nature’s toolbox for genome engineering
    • COI: 1:CAS:528:DC%2BC28XhtFShsbw%3D, PID: 26771484
    • Wright, A. V., Nunez, J. K. & Doudna, J. A. Biology and applications of CRISPR systems: harnessing nature’s toolbox for genome engineering. Cell 164, 29–44 (2016).
    • (2016) Cell , vol.164 , pp. 29-44
    • Wright, A.V.1    Nunez, J.K.2    Doudna, J.A.3
  • 236
    • 85014564234 scopus 로고    scopus 로고
    • Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
    • COI: 1:CAS:528:DC%2BC2sXjsVSgtrY%3D, PID: 28225754
    • Eyquem, J. et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature 543, 113–117 (2017).
    • (2017) Nature , vol.543 , pp. 113-117
    • Eyquem, J.1
  • 237
    • 84866541815 scopus 로고    scopus 로고
    • CD8 T cell priming in the presence of IFN-alpha renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy
    • COI: 1:CAS:528:DC%2BC38XhtlOmurjI, PID: 22925929
    • Hervas-Stubbs, S. et al. CD8 T cell priming in the presence of IFN-alpha renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy. J. Immunol. 189, 3299–3310 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 3299-3310
    • Hervas-Stubbs, S.1
  • 238
    • 85027695492 scopus 로고    scopus 로고
    • Post-translational peptide splicing and T cell responses
    • COI: 1:CAS:528:DC%2BC2sXht1yltLfM, PID: 28830734
    • Mishto, M. & Liepe, J. Post-translational peptide splicing and T cell responses. Trends Immunol. 38, 904–915 (2017).
    • (2017) Trends Immunol. , vol.38 , pp. 904-915
    • Mishto, M.1    Liepe, J.2
  • 239
    • 84976406873 scopus 로고    scopus 로고
    • Neoantigen landscape dynamics during human melanoma-T cell interactions
    • COI: 1:CAS:528:DC%2BC28Xht12jurvO, PID: 27350335
    • Verdegaal, E. M. et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature 536, 91–95 (2016).
    • (2016) Nature , vol.536 , pp. 91-95
    • Verdegaal, E.M.1
  • 240
    • 85019144614 scopus 로고    scopus 로고
    • Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy
    • COI: 1:CAS:528:DC%2BC2sXnsVanurY%3D, PID: 28486109
    • Spranger, S., Dai, D., Horton, B. & Gajewski, T. F. Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy. Cancer Cell 31, 711–723 (2017).
    • (2017) Cancer Cell , vol.31 , pp. 711-723
    • Spranger, S.1    Dai, D.2    Horton, B.3    Gajewski, T.F.4
  • 241
    • 85030757752 scopus 로고    scopus 로고
    • Characterization of anti-CD19 chimeric antigen receptor (CAR) T cell-mediated tumor microenvironment immune gene profile in a multicenter trial (ZUMA-1) with axicabtagene ciloleucel (axi-cel, KTE-C19)
    • Galon, J. et al. Characterization of anti-CD19 chimeric antigen receptor (CAR) T cell-mediated tumor microenvironment immune gene profile in a multicenter trial (ZUMA-1) with axicabtagene ciloleucel (axi-cel, KTE-C19). J. Clin. Oncol. 35, 3025 (2017).
    • (2017) J. Clin. Oncol. , vol.35 , pp. 3025
    • Galon, J.1
  • 242
    • 84940824279 scopus 로고    scopus 로고
    • Oncolytic viruses: a new class of immunotherapy drugs
    • COI: 1:CAS:528:DC%2BC2MXhsVagsb3O, PID: 26323545
    • Kaufman, H. L., Kohlhapp, F. J. & Zloza, A. Oncolytic viruses: a new class of immunotherapy drugs. Nat. Rev. Drug Discov. 14, 642–662 (2015).
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 642-662
    • Kaufman, H.L.1    Kohlhapp, F.J.2    Zloza, A.3
  • 243
    • 77955067224 scopus 로고    scopus 로고
    • Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity
    • COI: 1:CAS:528:DC%2BD1MXotV2qtrs%3D, PID: 19106640
    • Pataer, A., Swisher, S. G., Roth, J. A., Logothetis, C. J. & Corn, P. G. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol. Ther. 8, 245–252 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 245-252
    • Pataer, A.1    Swisher, S.G.2    Roth, J.A.3    Logothetis, C.J.4    Corn, P.G.5
  • 244
    • 85045068631 scopus 로고    scopus 로고
    • Randomized, open-label phase II study evaluating the efficacy and safety of talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone in patients with advanced, unresectable melanoma
    • COI: 1:CAS:528:DC%2BC1MXhvV2iur4%3D, PID: 28981385, This paper presents the first randomized trial evaluating the combination of an oncolytic virus to a checkpoint inhibitor and showing a significantly higher objective response rate of T-VEC plus ipilimumab versus ipilimumab alone
    • Chesney, J. et al. Randomized, open-label phase II study evaluating the efficacy and safety of talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone in patients with advanced, unresectable melanoma. J. Clin. Oncol. 36, 1658–1667 (2018). This paper presents the first randomized trial evaluating the combination of an oncolytic virus with a checkpoint inhibitor and showing a significantly higher objective response rate for T-VEC plus ipilimumab versus ipilimumab alone.
    • (2018) J. Clin. Oncol. , vol.36 , pp. 1658-1667
    • Chesney, J.1
  • 245
    • 85028829596 scopus 로고    scopus 로고
    • Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy
    • COI: 1:CAS:528:DC%2BC2sXhsVOhu7rJ, PID: 28886381, This article shows that oncolytic virotherapy with T-VEC patients with advanced melanoma increased the cytotoxic T cell infiltration and therapeutic efficacy of an anti-PD-1 antibody
    • Ribas, A. et al. Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy. Cell 170, 1109–1119 (2017). This article shows that oncolytic virotherapy with T-VEC in patients with advanced melanoma increased the cytotoxic T cell infiltration and therapeutic efficacy of an anti-PD-1 antibody.
    • (2017) Cell , vol.170 , pp. 1109-1119
    • Ribas, A.1
  • 246
    • 85028888585 scopus 로고    scopus 로고
    • Converting cold into hot tumors by combining immunotherapies
    • COI: 1:CAS:528:DC%2BC2sXhsVOhu7rF, PID: 28886376
    • Haanen, J. Converting cold into hot tumors by combining immunotherapies. Cell 170, 1055–1056 (2017).
    • (2017) Cell , vol.170 , pp. 1055-1056
    • Haanen, J.1
  • 247
    • 85027837205 scopus 로고    scopus 로고
    • Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
    • PID: 28920000
    • Nestvold, J. et al. Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology 6, e1338236 (2017).
    • (2017) Oncoimmunology , vol.6
    • Nestvold, J.1
  • 248
    • 85018939221 scopus 로고    scopus 로고
    • Next generation approaches for tumor vaccination
    • PID: 28482672
    • Patel, A., Kaufman, H. L. & Disis, M. L. Next generation approaches for tumor vaccination. Chin. Clin. Oncol. 6, 19 (2017).
    • (2017) Chin. Clin. Oncol. , vol.6 , pp. 19
    • Patel, A.1    Kaufman, H.L.2    Disis, M.L.3
  • 249
    • 85003475383 scopus 로고    scopus 로고
    • Predictive biomarkers for checkpoint inhibitor-based immunotherapy
    • COI: 1:CAS:528:DC%2BC28XhvF2gsL7M, PID: 27924752
    • Gibney, G. T., Weiner, L. M. & Atkins, M. B. Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Lancet Oncol. 17, e542–e551 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. e542-e551
    • Gibney, G.T.1    Weiner, L.M.2    Atkins, M.B.3
  • 250
    • 84934344058 scopus 로고    scopus 로고
    • Human tumor antigens and cancer immunotherapy
    • PID: 26161423
    • Vigneron, N. Human tumor antigens and cancer immunotherapy. Biomed. Res. Int. 2015, 948501 (2015).
    • (2015) Biomed. Res. Int. , vol.2015 , pp. 948501
    • Vigneron, N.1
  • 251
    • 84925045090 scopus 로고    scopus 로고
    • Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
    • COI: 1:CAS:528:DC%2BC2MXks1yqsLc%3D, PID: 25762141
    • Mitchell, D. A. et al. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature 519, 366–369 (2015).
    • (2015) Nature , vol.519 , pp. 366-369
    • Mitchell, D.A.1
  • 252
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • COI: 1:CAS:528:DC%2BD2MXit1Wksbk%3D, PID: 15758009
    • Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987–996 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1
  • 253
    • 85047787988 scopus 로고    scopus 로고
    • First results on survival from a large phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
    • PID: 29843811
    • Liau, L. M. et al. First results on survival from a large phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma. J. Transl Med. 16, 142 (2018).
    • (2018) J. Transl Med. , vol.16
    • Liau, L.M.1
  • 254
    • 85034865728 scopus 로고    scopus 로고
    • A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
    • COI: 1:CAS:528:DC%2BC2sXhslygtLvI, PID: 29132144
    • Luksza, M. et al. A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy. Nature 551, 517–520 (2017).
    • (2017) Nature , vol.551 , pp. 517-520
    • Luksza, M.1
  • 255
    • 85024396858 scopus 로고    scopus 로고
    • Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
    • COI: 1:CAS:528:DC%2BC2sXhtFaqt73L, PID: 28678784, This paper presents the development and successful application of a personalized vaccine-based immunotherapy exploiting the concept of an individualized mutanome and computational prediction of neo-epitopes
    • Sahin, U. et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature 547, 222–226 (2017). This paper presents the development and successful application of a personalized vaccine-based immunotherapy exploiting the concept of an individualized mutanome and computational prediction of neo-epitopes.
    • (2017) Nature , vol.547 , pp. 222-226
    • Sahin, U.1
  • 256
    • 85024377220 scopus 로고    scopus 로고
    • An immunogenic personal neoantigen vaccine for patients with melanoma
    • COI: 1:CAS:528:DC%2BC2sXhtFaqt7rO, PID: 28678778, This article provides a strong rationale for further development of neo-epitope vaccines, alone and combination with checkpoint blockade or other immunotherapies
    • Ott, P. A. et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 547, 217–221 (2017). This article provides a strong rationale for further development of neo-epitope vaccines, alone and in combination with checkpoint blockade or other immunotherapies.
    • (2017) Nature , vol.547 , pp. 217-221
    • Ott, P.A.1
  • 257
    • 85046862171 scopus 로고    scopus 로고
    • Trial watch: immunostimulation with recombinant cytokines for cancer therapy
    • PID: 29872569
    • Garcia-Martinez, E. et al. Trial watch: immunostimulation with recombinant cytokines for cancer therapy. Oncoimmunology 7, e1433982 (2018).
    • (2018) Oncoimmunology , vol.7
    • Garcia-Martinez, E.1
  • 258
    • 84973098657 scopus 로고    scopus 로고
    • Role of IL-2 in cancer immunotherapy
    • PID: 27471638
    • Jiang, T., Zhou, C. & Ren, S. Role of IL-2 in cancer immunotherapy. Oncoimmunology 5, e1163462 (2016).
    • (2016) Oncoimmunology , vol.5
    • Jiang, T.1    Zhou, C.2    Ren, S.3
  • 259
    • 85042829852 scopus 로고    scopus 로고
    • Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
    • COI: 1:CAS:528:DC%2BC1cXjtlGqtbo%3D, PID: 29496879
    • Sockolosky, J. T. et al. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science 359, 1037–1042 (2018).
    • (2018) Science , vol.359 , pp. 1037-1042
    • Sockolosky, J.T.1
  • 260
    • 84873134031 scopus 로고    scopus 로고
    • Interleukin-15 in gene therapy of cancer
    • COI: 1:CAS:528:DC%2BC3sXktFersrg%3D, PID: 23157547
    • Ochoa, M. C. et al. Interleukin-15 in gene therapy of cancer. Curr. Gene Ther. 13, 15–30 (2013).
    • (2013) Curr. Gene Ther. , vol.13 , pp. 15-30
    • Ochoa, M.C.1
  • 261
    • 85048273123 scopus 로고    scopus 로고
    • First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
    • COI: 1:CAS:528:DC%2BC1cXhvFOiurrL, PID: 29463563
    • Romee, R. et al. First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood 131, 2515–2527 (2018).
    • (2018) Blood , vol.131 , pp. 2515-2527
    • Romee, R.1
  • 262
    • 33846632842 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression: intelligent design
    • COI: 1:CAS:528:DC%2BD2sXpvVCitA%3D%3D, PID: 17259970
    • Mazzucchelli, R. & Durum, S. K. Interleukin-7 receptor expression: intelligent design. Nat. Rev. Immunol. 7, 144–154 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 144-154
    • Mazzucchelli, R.1    Durum, S.K.2
  • 263
    • 84979649721 scopus 로고    scopus 로고
    • Interleukin-7 modulates anti-tumor CD8+T cell responses via its action on host cells
    • PID: 27447484
    • Deiser, K., Stoycheva, D., Bank, U., Blankenstein, T. & Schuler, T. Interleukin-7 modulates anti-tumor CD8+T cell responses via its action on host cells. PLOS ONE 11, e0159690 (2016).
    • (2016) PLOS ONE , vol.11
    • Deiser, K.1    Stoycheva, D.2    Bank, U.3    Blankenstein, T.4    Schuler, T.5
  • 264
    • 85040192359 scopus 로고    scopus 로고
    • Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC1cXmt1Krsw%3D%3D, PID: 29224228
    • Xu, X., Sun, Q., Mei, Y., Liu, Y. & Zhao, L. Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy. Cancer Sci. 109, 279–288 (2018).
    • (2018) Cancer Sci. , vol.109 , pp. 279-288
    • Xu, X.1    Sun, Q.2    Mei, Y.3    Liu, Y.4    Zhao, L.5
  • 265
    • 84952039532 scopus 로고    scopus 로고
    • Therapeutic utility of the newly discovered properties of interleukin-21
    • COI: 1:CAS:528:DC%2BC28XhtlKqsA%3D%3D, PID: 26748727
    • Al-Chami, E., Tormo, A., Khodayarian, F. & Rafei, M. Therapeutic utility of the newly discovered properties of interleukin-21. Cytokine 82, 33–37 (2016).
    • (2016) Cytokine , vol.82 , pp. 33-37
    • Al-Chami, E.1    Tormo, A.2    Khodayarian, F.3    Rafei, M.4
  • 266
    • 85013898901 scopus 로고    scopus 로고
    • Interleukin 21 inhibits cancer-mediated FOXP3 induction in naive human CD4 T cells
    • COI: 1:CAS:528:DC%2BC2sXjsVGnsLk%3D, PID: 28239749
    • Kannappan, V. et al. Interleukin 21 inhibits cancer-mediated FOXP3 induction in naive human CD4 T cells. Cancer Immunol. Immunother. 66, 637–645 (2017).
    • (2017) Cancer Immunol. Immunother. , vol.66 , pp. 637-645
    • Kannappan, V.1
  • 267
    • 77949895721 scopus 로고    scopus 로고
    • IL-21 and T follicular helper cells
    • COI: 1:CAS:528:DC%2BD1MXhsFygu77P, PID: 19933709
    • Spolski, R. & Leonard, W. J. IL-21 and T follicular helper cells. Int. Immunol. 22, 7–12 (2010).
    • (2010) Int. Immunol. , vol.22 , pp. 7-12
    • Spolski, R.1    Leonard, W.J.2
  • 268
    • 85030544570 scopus 로고    scopus 로고
    • Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models
    • PID: 29296539
    • Lewis, K. E. et al. Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models. Oncoimmunology 7, e1377873 (2017).
    • (2017) Oncoimmunology , vol.7
    • Lewis, K.E.1
  • 269
    • 84977626639 scopus 로고    scopus 로고
    • Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient
    • PID: 27242164
    • Chapuis, A. G. et al. Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient. J. Exp. Med. 213, 1133–1139 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 1133-1139
    • Chapuis, A.G.1
  • 270
    • 85040564709 scopus 로고    scopus 로고
    • ‘Liquid biopsy’ for cancer promises early detection
    • COI: 1:CAS:528:DC%2BC1cXhvFygtro%3D, PID: 29348215
    • Kaiser, J. ‘Liquid biopsy’ for cancer promises early detection. Science 359, 259 (2018).
    • (2018) Science , vol.359 , pp. 259
    • Kaiser, J.1
  • 271
    • 84958953141 scopus 로고    scopus 로고
    • An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy
    • COI: 1:CAS:528:DC%2BC28Xis1Glsw%3D%3D, PID: 26573799
    • Tavare, R. et al. An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy. Cancer Res. 76, 73–82 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 73-82
    • Tavare, R.1
  • 272
    • 85007543412 scopus 로고    scopus 로고
    • Patterns of immune infiltration in breast cancer and their clinical implications: a gene-expression-based retrospective study
    • PID: 27959923
    • Ali, H. R., Chlon, L., Pharoah, P. D., Markowetz, F. & Caldas, C. Patterns of immune infiltration in breast cancer and their clinical implications: a gene-expression-based retrospective study. PLOS Med. 13, e1002194 (2016).
    • (2016) PLOS Med. , vol.13
    • Ali, H.R.1    Chlon, L.2    Pharoah, P.D.3    Markowetz, F.4    Caldas, C.5
  • 273
    • 84928927858 scopus 로고    scopus 로고
    • Robust enumeration of cell subsets from tissue expression profiles
    • COI: 1:CAS:528:DC%2BC2MXlsVOgu7Y%3D, PID: 25822800
    • Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods 12, 453–457 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 453-457
    • Newman, A.M.1
  • 274
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • COI: 1:CAS:528:DC%2BC2MXhtF2lsbo%3D, PID: 25594174
    • Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48–61 (2015).
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 275
    • 84938984463 scopus 로고    scopus 로고
    • The prognostic landscape of genes and infiltrating immune cells across human cancers
    • COI: 1:CAS:528:DC%2BC2MXht1WltLnI, PID: 26193342
    • Gentles, A. J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 938–945 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 938-945
    • Gentles, A.J.1
  • 276
    • 85034614124 scopus 로고    scopus 로고
    • xCell: digitally portraying the tissue cellular heterogeneity landscape
    • PID: 29141660
    • Aran, D., Hu, Z. & Butte, A. J. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 18, 220 (2017).
    • (2017) Genome Biol. , vol.18
    • Aran, D.1    Hu, Z.2    Butte, A.J.3
  • 277
    • 85035064069 scopus 로고    scopus 로고
    • TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells
    • COI: 1:CAS:528:DC%2BC2sXhslOltbnE, PID: 29092952
    • Li, T. et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77, e108–e110 (2017).
    • (2017) Cancer Res. , vol.77 , pp. e108-e110
    • Li, T.1
  • 278
    • 85044934017 scopus 로고    scopus 로고
    • The immune landscape of cancer
    • COI: 1:CAS:528:DC%2BC1cXntFSjt7o%3D, PID: 29628290
    • Thorsson, V. et al. The immune landscape of cancer. Immunity 48, 812–830 (2018).
    • (2018) Immunity , vol.48 , pp. 812-830
    • Thorsson, V.1
  • 279
    • 85049372156 scopus 로고    scopus 로고
    • Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database
    • PID: 29939984
    • Zappia, L., Phipson, B. & Oshlack, A. Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database. PLOS Comput. Biol. 14, e1006245 (2018).
    • (2018) PLOS Comput. Biol. , vol.14
    • Zappia, L.1    Phipson, B.2    Oshlack, A.3
  • 280
    • 85042936697 scopus 로고    scopus 로고
    • Efficient in situ barcode sequencing using padlock probe-based BaristaSeq
    • COI: 1:CAS:528:DC%2BC1cXitlGisL3I, PID: 29190363
    • Chen, X., Sun, Y. C., Church, G. M., Lee, J. H. & Zador, A. M. Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Res. 46, e22 (2018).
    • (2018) Nucleic Acids Res. , vol.46
    • Chen, X.1    Sun, Y.C.2    Church, G.M.3    Lee, J.H.4    Zador, A.M.5
  • 281
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • COI: 1:CAS:528:DC%2BC2cXitFanurbM, PID: 4836193
    • Herbst, R. S. et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515, 563–567 (2014).
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 282
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • COI: 1:CAS:528:DC%2BC38XltValu7o%3D, PID: 22236695
    • Topalian, S. L., Drake, C. G. & Pardoll, D. M. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr. Opin. Immunol. 24, 207–212 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 283
    • 85026675148 scopus 로고    scopus 로고
    • IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade
    • PID: 28650338
    • Ayers, M. et al. IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade. J. Clin. Invest. 127, 2930–2940 (2017).
    • (2017) J. Clin. Invest. , vol.127 , pp. 2930-2940
    • Ayers, M.1
  • 284
    • 85010652953 scopus 로고    scopus 로고
    • Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
    • PID: 28104840
    • Davoli, T., Uno, H., Wooten, E. C. & Elledge, S. J. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science 355, eaaf8399 (2017).
    • (2017) Science , vol.355
    • Davoli, T.1    Uno, H.2    Wooten, E.C.3    Elledge, S.J.4
  • 285
    • 85032304187 scopus 로고    scopus 로고
    • Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development
    • PID: 29072369
    • Papaccio, F. et al. Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development. Stem Cells Transl Med. 6, 2115–2125 (2017).
    • (2017) Stem Cells Transl Med. , vol.6 , pp. 2115-2125
    • Papaccio, F.1
  • 286
    • 85021779932 scopus 로고    scopus 로고
    • EMT and MET: necessary or permissive for metastasis?
    • PID: 28548345
    • Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A. & Levine, H. EMT and MET: necessary or permissive for metastasis? Mol. Oncol. 11, 755–769 (2017).
    • (2017) Mol. Oncol. , vol.11 , pp. 755-769
    • Jolly, M.K.1    Ware, K.E.2    Gilja, S.3    Somarelli, J.A.4    Levine, H.5
  • 287
    • 85021823613 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer
    • PID: 28677253
    • Moustakas, A. & de Herreros, A. G. Epithelial-mesenchymal transition in cancer. Mol. Oncol. 11, 715–717 (2017).
    • (2017) Mol. Oncol. , vol.11 , pp. 715-717
    • Moustakas, A.1    de Herreros, A.G.2
  • 288
    • 85021323188 scopus 로고    scopus 로고
    • New insights into the role of EMT in tumor immune escape
    • PID: 28614624
    • Terry, S. et al. New insights into the role of EMT in tumor immune escape. Mol. Oncol. 11, 824–846 (2017).
    • (2017) Mol. Oncol. , vol.11 , pp. 824-846
    • Terry, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.