Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

Immunity

Volumn 49, Issue 5, 2018, Pages 929-942.e5

  Iatsenko, Igor ^a   Boquete, Jean Philippe ^a   Lemaitre, Bruno ^a  

^a EPFL   (Switzerland)

Author keywords

aging; Drosophila; dysbiosis; dysplasia; Lactobacillus; microbiota; Nox; peptidoglycan recognition protein; ROS

Indexed keywords

DNA; LACTATE DEHYDROGENASE; LACTIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RNA 16S; CARRIER PROTEIN; NOX PROTEIN, DROSOPHILA; PEPTIDOGLYCAN RECOGNITION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; GASTROINTESTINAL DYSPLASIA; GENE MUTATION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INTESTINAL STEM CELL; INTESTINE FUNCTION; INTESTINE INJURY; LACTOBACILLUS PLANTARUM; LIFESPAN; MOUTH INFECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; DYSBIOSIS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; LONGEVITY; METABOLISM; MICROBIOLOGY; MICROFLORA; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYMBIOSIS;

ANIMALS; CARRIER PROTEINS; DROSOPHILA; DYSBIOSIS; GENE EXPRESSION; INTESTINAL MUCOSA; L-LACTATE DEHYDROGENASE; LACTIC ACID; LONGEVITY; MICROBIOTA; MUTATION; NADPH OXIDASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYMBIOSIS;

EID: 85056956630     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.09.017     Document Type: Article

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