A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Cell

Volumn 167, Issue 5, 2016, Pages 1339-1353.e21

  Desai, Mahesh S ^a,b,c   Seekatz, Anna M ^b   Koropatkin, Nicole M ^b   Kamada, Nobuhiko ^b   Hickey, Christina A ^d   Wolter, Mathis ^c   Pudlo, Nicholas A ^b   Kitamoto, Sho ^b   Terrapon, Nicolas ^e   Muller, Arnaud ^c   Young, Vincent B ^b   Henrissat, Bernard ^e   Wilmes, Paul ^a   Stappenbeck, Thaddeus S ^d   Núñez, Gabriel ^b   Martens, Eric C ^b  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Akkermansia; bacteroides; Citrobacter rodentium; dietary fiber; gylcans; microbiome; microbiota; mucin; mucus layer; polysaccharides

Indexed keywords

MUCIN; MUC2 PROTEIN, MOUSE; MUCIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITROBACTER RODENTIUM; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DIETARY FIBER; DISEASE PREDISPOSITION; FEMALE; IMMUNE RESPONSE; INTESTINE FLORA; MALE; MICROBIAL COMMUNITY; MOUSE; MUCUS; NONHUMAN; PRIORITY JOURNAL; ADMINISTRATION AND DOSAGE; ANIMAL; COLON; ENTEROBACTERIACEAE INFECTION; ESCHERICHIA COLI; GENETICS; GERMFREE ANIMAL; HUMAN; INTESTINE MUCOSA; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; CITROBACTER RODENTIUM; COLITIS; COLON; DIETARY FIBER; DISEASE SUSCEPTIBILITY; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; FEMALE; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; HUMANS; INTESTINAL MUCOSA; MALE; MICE; MUCIN-2;

EID: 84995739780     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.043     Document Type: Article

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