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Volumn 174, Issue 2, 2019, Pages 443-452

Neutrophil-to-lymphocyte ratio as a predictor of survival in patients with triple-negative breast cancer

Author keywords

Neutrophil to lymphocyte ratio (NLR); Overall survival (OS); Triple negative breast cancer (TNBC)

Indexed keywords

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NEOADJUVANT CHEMOTHERAPY; NEUTROPHIL LYMPHOCYTE RATIO; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TRIPLE NEGATIVE BREAST CANCER; BLOOD; CHEMORADIOTHERAPY; CYTOLOGY; DRUG EFFECT; KAPLAN MEIER METHOD; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MIDDLE AGED; MORTALITY; NEOADJUVANT THERAPY; NEUTROPHIL; RADIATION RESPONSE; TREATMENT OUTCOME;

EID: 85059645118     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-018-05106-7     Document Type: Article
Times cited : (55)

References (42)
  • 3
    • 56049103793 scopus 로고    scopus 로고
    • Understanding and treating triple-negative breast cancer
    • Anders C, Carey LA (2008) Understanding and treating triple-negative breast cancer. Oncology (Williston Park) 22(11):1233–1243
    • (2008) Oncology (Williston Park) , vol.22 , Issue.11 , pp. 1233-1243
    • Anders, C.1    Carey, L.A.2
  • 5
    • 84994112876 scopus 로고    scopus 로고
    • Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
    • Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L (2016) Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol 13(11):674–690
    • (2016) Nat Rev Clin Oncol , vol.13 , Issue.11 , pp. 674-690
    • Bianchini, G.1    Balko, J.M.2    Mayer, I.A.3    Sanders, M.E.4    Gianni, L.5
  • 6
    • 84875048243 scopus 로고    scopus 로고
    • Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer
    • Campian JL, Ye X, Brock M, Grossman SA (2013) Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Cancer Invest 31(3):183–188
    • (2013) Cancer Invest , vol.31 , Issue.3 , pp. 183-188
    • Campian, J.L.1    Ye, X.2    Brock, M.3    Grossman, S.A.4
  • 7
    • 84944747759 scopus 로고    scopus 로고
    • Survival in patients with severe lymphopenia following treatment with radiation and chemotherapy for newly diagnosed solid tumors
    • Grossman SA et al (2015) Survival in patients with severe lymphopenia following treatment with radiation and chemotherapy for newly diagnosed solid tumors. J Natl Compr Canc Netw 13(10):1225–1231
    • (2015) J Natl Compr Canc Netw , vol.13 , Issue.10 , pp. 1225-1231
    • Grossman, S.A.1
  • 8
    • 67650481213 scopus 로고    scopus 로고
    • Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas
    • Ray-Coquard I et al (2009) Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 69(13):5383–5391
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5383-5391
    • Ray-Coquard, I.1
  • 9
    • 85063168349 scopus 로고    scopus 로고
    • Neutrophil lymphocyte ratio (NLR) change after systemic treatment as a predictive factor of cancer specific survival in stage IV breast cancer
    • Shin H, Kim J, Kim HJ (2015) Neutrophil lymphocyte ratio (NLR) change after systemic treatment as a predictive factor of cancer specific survival in stage IV breast cancer. J Clin Oncol 33(28_suppl):29–29
    • (2015) J Clin Oncol , vol.33 , pp. 29
    • Shin, H.1    Kim, J.2    Kim, H.J.3
  • 10
    • 85008319004 scopus 로고    scopus 로고
    • Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis
    • Ethier J-L, Desautels D, Templeton A, Shah PS, Amir E (2017) Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis. Breast Cancer Res 19:2
    • (2017) Breast Cancer Res , vol.19 , pp. 2
    • Ethier, J.-L.1    Desautels, D.2    Templeton, A.3    Shah, P.S.4    Amir, E.5
  • 11
    • 84905164478 scopus 로고    scopus 로고
    • Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis
    • Templeton AJ et al. (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 10.1093/jnci/dju124
    • (2014) J Natl Cancer Inst
    • Templeton, A.J.1
  • 12
    • 84929158217 scopus 로고    scopus 로고
    • Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients
    • Pistelli M et al (2015) Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients. BMC Cancer 15(1):195
    • (2015) BMC Cancer , vol.15 , Issue.1 , pp. 195
    • Pistelli, M.1
  • 13
    • 84944909050 scopus 로고    scopus 로고
    • Elevated preoperative neutrophil-to-lymphocyte ratio predicts poor disease-free survival in Chinese women with breast cancer
    • Hong J et al (2016) Elevated preoperative neutrophil-to-lymphocyte ratio predicts poor disease-free survival in Chinese women with breast cancer. Tumor Biol 37(3):4135–4142
    • (2016) Tumor Biol , vol.37 , Issue.3 , pp. 4135-4142
    • Hong, J.1
  • 14
    • 84964553537 scopus 로고    scopus 로고
    • The pretreatment neutrophil/lymphocyte ratio is associated with all-cause mortality in black and white patients with non-metastatic breast cancer
    • Rimando J, Campbell J, Kim JH, Tang S-C, Kim S (2016) The pretreatment neutrophil/lymphocyte ratio is associated with all-cause mortality in black and white patients with non-metastatic breast cancer. Front Oncol 6:81
    • (2016) Front Oncol , vol.6 , pp. 81
    • Rimando, J.1    Campbell, J.2    Kim, J.H.3    Tang, S.-C.4    Kim, S.5
  • 15
    • 84893636593 scopus 로고    scopus 로고
    • Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer?
    • Dirican A et al (2015) Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer? Int J Clin Oncol 20(1):70–81
    • (2015) Int J Clin Oncol , vol.20 , Issue.1 , pp. 70-81
    • Dirican, A.1
  • 16
    • 84871690791 scopus 로고    scopus 로고
    • Pretreatment neutrophil/lymphocyte ratio is superior to platelet/lymphocyte ratio as a predictor of long-term mortality in breast cancer patients
    • Azab B et al (2013) Pretreatment neutrophil/lymphocyte ratio is superior to platelet/lymphocyte ratio as a predictor of long-term mortality in breast cancer patients. Med Oncol 30(1):432
    • (2013) Med Oncol , vol.30 , Issue.1 , pp. 432
    • Azab, B.1
  • 17
    • 84934441600 scopus 로고    scopus 로고
    • Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer
    • Koh C-H et al (2015) Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer 113(1):150–158
    • (2015) Br J Cancer , vol.113 , Issue.1 , pp. 150-158
    • Koh, C.-H.1
  • 18
    • 84908221387 scopus 로고    scopus 로고
    • Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer
    • Fu P et al. (2014) Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer. Onco Targets Ther 7:1743
    • (2014) Onco Targets Ther , vol.7 , pp. 1743
    • Fu, P.1
  • 19
    • 84945544960 scopus 로고    scopus 로고
    • Predictive value of neutrophil/lymphocyte ratio for efficacy of preoperative chemotherapy in triple-negative breast cancer
    • Asano Y et al (2016) Predictive value of neutrophil/lymphocyte ratio for efficacy of preoperative chemotherapy in triple-negative breast cancer. Ann Surg Oncol 23(4):1104–1110
    • (2016) Ann Surg Oncol , vol.23 , Issue.4 , pp. 1104-1110
    • Asano, Y.1
  • 20
    • 84905039525 scopus 로고    scopus 로고
    • Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery
    • Forget P, Bentin C, Machiels J-P, Berliere M, Coulie PG, De Kock M (2014) Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery. Br J Anaesth 113:i82–i87
    • (2014) Br J Anaesth , vol.113 , pp. i82-i87
    • Forget, P.1    Bentin, C.2    Machiels, J.-P.3    Berliere, M.4    Coulie, P.G.5    De Kock, M.6
  • 21
    • 84906324633 scopus 로고    scopus 로고
    • Prognostic significance of pre-treatment neutrophil: lymphocyte ratio in Japanese patients with breast cancer
    • Nakano K, Hosoda M, Yamamoto M, Yamashita H (2014) Prognostic significance of pre-treatment neutrophil: lymphocyte ratio in Japanese patients with breast cancer. Anticancer Res 34(7):3819–3824
    • (2014) Anticancer Res , vol.34 , Issue.7 , pp. 3819-3824
    • Nakano, K.1    Hosoda, M.2    Yamamoto, M.3    Yamashita, H.4
  • 22
    • 84922391558 scopus 로고    scopus 로고
    • Prognostic significance of the ratio of absolute neutrophil to lymphocyte counts for breast cancer patients with ER/PR-positivity and HER2-negativity in neoadjuvant setting
    • Koh YW, Lee HJ, Ahn J-H, Lee JW, Gong G (2014) Prognostic significance of the ratio of absolute neutrophil to lymphocyte counts for breast cancer patients with ER/PR-positivity and HER2-negativity in neoadjuvant setting. Tumor Biol 35(10):9823–9830
    • (2014) Tumor Biol , vol.35 , Issue.10 , pp. 9823-9830
    • Koh, Y.W.1    Lee, H.J.2    Ahn, J.-H.3    Lee, J.W.4    Gong, G.5
  • 23
    • 84856679198 scopus 로고    scopus 로고
    • Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients
    • Azab B et al (2012) Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 19(1):217–224
    • (2012) Ann Surg Oncol , vol.19 , Issue.1 , pp. 217-224
    • Azab, B.1
  • 24
    • 0026510591 scopus 로고
    • Lymphocyte infiltrates as a prognostic variable in female breast cancer
    • Aaltomaa S et al (1992) Lymphocyte infiltrates as a prognostic variable in female breast cancer. Eur J Cancer 28A(4–5):859–864
    • (1992) Eur J Cancer , vol.28A , pp. 4-5859
    • Aaltomaa, S.1
  • 25
    • 51349088017 scopus 로고    scopus 로고
    • Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
    • Desmedt C et al (2008) Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin Cancer Res 14(16):5158–5165
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5158-5165
    • Desmedt, C.1
  • 26
    • 44849101184 scopus 로고    scopus 로고
    • The humoral immune system has a key prognostic impact in node-negative breast cancer
    • Schmidt M et al (2008) The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res 68(13):5405–5413
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5405-5413
    • Schmidt, M.1
  • 27
    • 84879661529 scopus 로고    scopus 로고
    • CD4 + follicular helper T cell infiltration predicts breast cancer survival
    • Gu-Trantien C et al (2013) CD4 + follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest 123(7):2873–2892
    • (2013) J Clin Invest , vol.123 , Issue.7 , pp. 2873-2892
    • Gu-Trantien, C.1
  • 28
    • 84958913704 scopus 로고    scopus 로고
    • Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer
    • Verma R et al (2016) Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Res 18(1):10
    • (2016) Breast Cancer Res , vol.18 , Issue.1 , pp. 10
    • Verma, R.1
  • 29
    • 85042279032 scopus 로고    scopus 로고
    • Neutrophil to lymphocyte ratio (NLR) for prediction of distant metastasis-free survival (DMFS) in early breast cancer: a propensity score-matched analysis
    • Orditura M et al (2016) Neutrophil to lymphocyte ratio (NLR) for prediction of distant metastasis-free survival (DMFS) in early breast cancer: a propensity score-matched analysis. ESMO Open 1(2):e000038
    • (2016) ESMO Open , vol.1 , Issue.2
    • Orditura, M.1
  • 30
    • 85059608694 scopus 로고    scopus 로고
    • 283PNeutrophil-lymphocyte ratio (NLR) as a prognostic factor in metastatic breast cancer
    • Ayala F, de la Peña et al (2017) 283PNeutrophil-lymphocyte ratio (NLR) as a prognostic factor in metastatic breast cancer. Ann Oncol. 10.1093/annonc/mdx365.046
    • (2017) Ann Oncol
    • Ayala, F.1    de la Peña2
  • 31
    • 84992103934 scopus 로고    scopus 로고
    • Pretreatment neutrophil to lymphocyte ratio (NLR) in patients with triple negative breast cancer (TNBC) treated with neoadjuvant chemotherapy
    • Walker PR, Hildebrand JR (2016) Pretreatment neutrophil to lymphocyte ratio (NLR) in patients with triple negative breast cancer (TNBC) treated with neoadjuvant chemotherapy. J Clin Oncol 34(15_suppl):e12570–e12570
    • (2016) J Clin Oncol , vol.34 , pp. e12570
    • Walker, P.R.1    Hildebrand, J.R.2
  • 32
    • 85059635392 scopus 로고    scopus 로고
    • Abstract P3-08-12: prognostic relevance of neutrophil-to-lymphocyte ratio (NLR) in young women with breast cancer (BC)
    • Jerzak K, Zhu S, Nofech-Mozes S, Pond G, Warner E (2018) Abstract P3-08-12: prognostic relevance of neutrophil-to-lymphocyte ratio (NLR) in young women with breast cancer (BC). Cancer Res 78(4 Supplement):P3-08–P3-12
    • (2018) Cancer Res , vol.78
    • Jerzak, K.1    Zhu, S.2    Nofech-Mozes, S.3    Pond, G.4    Warner, E.5
  • 33
    • 84876095247 scopus 로고    scopus 로고
    • Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients
    • Noh H, Eomm M, Han A (2013) Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients. J Breast Cancer 16(1):55–59
    • (2013) J Breast Cancer , vol.16 , Issue.1 , pp. 55-59
    • Noh, H.1    Eomm, M.2    Han, A.3
  • 34
    • 85065630002 scopus 로고    scopus 로고
    • Prognostic value of pretreatment neutrophil lymphocyte ratio in metastatic breast cancer
    • Mazouz A et al (2015) Prognostic value of pretreatment neutrophil lymphocyte ratio in metastatic breast cancer. J Clin Oncol 33(15_suppl):e11500–e11500
    • (2015) J Clin Oncol , vol.33 , pp. e11500
    • Mazouz, A.1
  • 35
    • 85046261068 scopus 로고    scopus 로고
    • Neutrophil-lymphocyte ratio predicts response to chemotherapy in triple-negative breast cancer
    • Chae S et al (2018) Neutrophil-lymphocyte ratio predicts response to chemotherapy in triple-negative breast cancer. Curr Oncol 25(2):e113–e119
    • (2018) Curr Oncol , vol.25 , Issue.2 , pp. e113-e119
    • Chae, S.1
  • 36
    • 85028324007 scopus 로고    scopus 로고
    • Neutrophil/lymphocyte and platelet/lymphocyte ratios are not different among breast cancer subtypes
    • Yersal Ö et al (2017) Neutrophil/lymphocyte and platelet/lymphocyte ratios are not different among breast cancer subtypes. Asian Pac J Cancer Prev 18(8):2227–2231
    • (2017) Asian Pac J Cancer Prev , vol.18 , Issue.8 , pp. 2227-2231
    • Yersal, Ö.1
  • 37
    • 84992103934 scopus 로고    scopus 로고
    • Prognostic utility of tumour infiltrating lymphocytes (TILs) and neutrophil-to-lymphocyte ratio (NLR) in early-stage triple negative breast cancer (TNBC)
    • Pearson A et al (2016) Prognostic utility of tumour infiltrating lymphocytes (TILs) and neutrophil-to-lymphocyte ratio (NLR) in early-stage triple negative breast cancer (TNBC). J Clin Oncol 34(15_suppl):1075
    • (2016) J Clin Oncol , vol.34 , pp. 1075
    • Pearson, A.1
  • 38
    • 84952639050 scopus 로고    scopus 로고
    • Lymphopenia and its association with survival in patients with locally advanced cervical cancer
    • Wu ES et al (2016) Lymphopenia and its association with survival in patients with locally advanced cervical cancer. Gynecol Oncol 140(1):76–82
    • (2016) Gynecol Oncol , vol.140 , Issue.1 , pp. 76-82
    • Wu, E.S.1
  • 39
    • 85048404475 scopus 로고    scopus 로고
    • Immunotherapy for triple-negative breast cancer: a focus on immune checkpoint inhibitors
    • Dua I, Tan AR (2017) Immunotherapy for triple-negative breast cancer: a focus on immune checkpoint inhibitors. Am J Hematol/Oncol 13(4):20–27
    • (2017) Am J Hematol/Oncol , vol.13 , Issue.4 , pp. 20-27
    • Dua, I.1    Tan, A.R.2
  • 40
    • 85041497790 scopus 로고    scopus 로고
    • Checkpoint inhibitors in triple-negative breast cancer (TNBC): Where to go from here
    • Kwa MJ, Adams S (2018) Checkpoint inhibitors in triple-negative breast cancer (TNBC): Where to go from here. Cancer 124(10):2086–2103
    • (2018) Cancer , vol.124 , Issue.10 , pp. 2086-2103
    • Kwa, M.J.1    Adams, S.2
  • 41
    • 85059620652 scopus 로고    scopus 로고
    • Feasibility of lymphocyte harvesting and reinfusion in patients with newly diagnosed high-grade gliomas
    • Campian JL et al (2014) Feasibility of lymphocyte harvesting and reinfusion in patients with newly diagnosed high-grade gliomas. J Clin Oncol 32(15_suppl):2094
    • (2014) J Clin Oncol , vol.32 , pp. 2094
    • Campian, J.L.1
  • 42
    • 85048273123 scopus 로고    scopus 로고
    • First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
    • Romee R et al (2018) First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood 131:2515
    • (2018) Blood , vol.131 , pp. 2515
    • Romee, R.1


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