Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

Immunity

Volumn 49, Issue 1, 2018, Pages 33-41.e7

  Nadjsombati, Marija S ^a   McGinty, John W ^a   Lyons Cohen, Miranda R ^a   Jaffe, James B ^a   DiPeso, Lucian ^a   Schneider, Christoph ^c,d   Miller, Corey N ^c,d   Pollack, Joshua L ^c,e   Nagana Gowda, G A ^b   Fontana, Mary F ^a   Erle, David J ^c   Anderson, Mark S ^c,d   Locksley, Richard M ^c,d   Raftery, Daniel ^b   von Moltke, Jakob ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Pionyr Immunotherapeutics   (United States)

Author keywords

chemosensing; helminth; ILC2; nippostrongylus brasiliensis; protist; small intestine; succinate; tritrichomonas; tuft cell; type 2 immunity

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 4 RECEPTOR ALPHA; MESSENGER RNA; SUCCINATE RECEPTOR 1; SUCCINIC ACID; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GPR91 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL METABOLISM; BRUSH BORDER; CELL COUNT; CELL HYPERPLASIA; COLON; EPITHELIUM CELL; FEEDBACK SYSTEM; FLUID INTAKE; GALLBLADDER; GENE ONTOLOGY; HAPLOINSUFFICIENCY; HELMINTHIASIS; IMMUNE RESPONSE; IN VIVO STUDY; INNATE IMMUNITY; INTESTINE CELL; LAMINA PROPRIA; LYMPHOCYTE; MESENTERY LYMPH NODE; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RNA SEQUENCE; SMALL INTESTINE; SMALL INTESTINE TUFT CELL; THYMUS; TISSUE SPECIFICITY; TRACHEA; TRITRICHOMONAS; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECT; FEMALE; IMMUNOLOGY; INTESTINE MUCOSA; KNOCKOUT MOUSE; MALE; METABOLISM; MUCOSAL IMMUNITY; NIPPOSTRONGYLUS; PROTOZOAL INFECTION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STRONGYLE INFECTION; TH2 CELL;

ANIMALS; CELL LINE; FEMALE; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NIPPOSTRONGYLUS; ORGAN SPECIFICITY; PROTOZOAN INFECTIONS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; STRONGYLIDA INFECTIONS; SUCCINIC ACID; TH2 CELLS; TRITRICHOMONAS; TRPM CATION CHANNELS;

EID: 85049510740     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.06.016     Document Type: Article

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