Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2

Journal of Immunology

Volumn 199, Issue 8, 2017, Pages 2976-2984

  Zheng, Leon ^a,b   Kelly, Caleb J ^a,b   Battista, Kayla D ^a,b   Schaefer, Rachel ^a,b   Lanis, Jordi M ^a,b   Alexeev, Erica E ^a,b   Wang, Ruth X ^a,b   Onyiah, Joseph C ^a,b   Kominsky, Douglas J ^c   Colgan, Sean P ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CLAUDIN 2; HISTONE DEACETYLASE; INTERLEUKIN 10 RECEPTOR; MESSENGER RNA; STAT3 PROTEIN; BUTYRIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIAL BARRIER; GENE; HUMAN; HUMAN CELL; IL 10RA GENE; IMMUNE RESPONSE; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN REPRESSION; PROTEIN SYNTHESIS REGULATION; TIGHT JUNCTION; TRANSACTIVATION; ANAEROBIC BACTERIUM; CELL CULTURE; CELL LINE; COLON; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INTESTINE FLORA; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; SYMBIOSIS; TRANSCRIPTION INITIATION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UPREGULATION;

BACTERIA, ANAEROBIC; BUTYRATES; CELL LINE; CELLS, CULTURED; CLAUDIN-2; COLON; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; INTESTINAL MUCOSA; RECEPTORS, INTERLEUKIN-10; STAT3 TRANSCRIPTION FACTOR; SYMBIOSIS; TIGHT JUNCTIONS; TRANSCRIPTIONAL ACTIVATION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UP-REGULATION;

EID: 85031497192     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1700105     Document Type: Article

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