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Volumn 51, Issue 4, 2019, Pages 600-605

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; PROPIONIC ACID; SHORT CHAIN FATTY ACID; VOLATILE FATTY ACID;

EID: 85061738433     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-019-0350-x     Document Type: Letter
Times cited : (1012)

References (55)
  • 1
    • 84968901892 scopus 로고    scopus 로고
    • Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
    • COI: 1:CAS:528:DC%2BC28Xms1KisL8%3D
    • Zhernakova, A. et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science 352, 565–569 (2016).
    • (2016) Science , vol.352 , pp. 565-569
    • Zhernakova, A.1
  • 2
    • 84989832355 scopus 로고    scopus 로고
    • The effect of host genetics on the gut microbiome
    • COI: 1:CAS:528:DC%2BC28Xhs1SltL3I
    • Bonder, M. J. et al. The effect of host genetics on the gut microbiome. Nat. Genet. 48, 1407–1412 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1407-1412
    • Bonder, M.J.1
  • 3
    • 84940648792 scopus 로고    scopus 로고
    • Mendelian randomization: new applications in the coming age of hypothesis-free causality
    • COI: 1:CAS:528:DC%2BC2MXhsFShs7jN
    • Evans, D. M. & Davey Smith, G. Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu. Rev. Genomics Hum. Genet. 16, 327–350 (2015).
    • (2015) Annu. Rev. Genomics Hum. Genet. , vol.16 , pp. 327-350
    • Evans, D.M.1    Davey Smith, G.2
  • 4
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen, N. et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5, e9085 (2010).
    • (2010) PLoS One , vol.5
    • Larsen, N.1
  • 5
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • COI: 1:CAS:528:DC%2BC3sXotlGls7k%3D
    • Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99–103 (2013).
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1
  • 6
    • 23344442120 scopus 로고    scopus 로고
    • Obesity alters gut microbial ecology
    • COI: 1:CAS:528:DC%2BD2MXnvVWju7g%3D
    • Ley, R. E. et al. Obesity alters gut microbial ecology. Proc. Natl Acad. Sci. USA 102, 11070–11075 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11070-11075
    • Ley, R.E.1
  • 7
    • 85013156411 scopus 로고    scopus 로고
    • Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes
    • COI: 1:CAS:528:DC%2BC2sXislOlsLk%3D
    • Kreznar, J. H. et al. Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes. Cell Rep. 18, 1739–1750 (2017).
    • (2017) Cell Rep. , vol.18 , pp. 1739-1750
    • Kreznar, J.H.1
  • 8
    • 85018831116 scopus 로고    scopus 로고
    • The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities
    • COI: 1:CAS:528:DC%2BC2sXmsVaks78%3D
    • Brunkwall, L. & Orho-Melander, M. The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities. Diabetologia 60, 943–951 (2017).
    • (2017) Diabetologia , vol.60 , pp. 943-951
    • Brunkwall, L.1    Orho-Melander, M.2
  • 9
    • 85032366326 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition
    • COI: 1:CAS:528:DC%2BC2sXhs1Siur7J
    • Kootte, R. S. et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metab. 26, 611–619.e6 (2017).
    • (2017) Cell Metab. , vol.26 , pp. 611-619
    • Kootte, R.S.1
  • 10
    • 84883181684 scopus 로고    scopus 로고
    • Human gut microbiota changes reveal the progression of glucose intolerance
    • COI: 1:CAS:528:DC%2BC3sXhsVWhsbfP
    • Zhang, X. et al. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One 8, e71108 (2013).
    • (2013) PLoS One , vol.8
    • Zhang, X.1
  • 11
    • 84962195820 scopus 로고    scopus 로고
    • Intestinal short chain fatty acids and their link with diet and human health
    • Ríos-Covián, D. et al. Intestinal short chain fatty acids and their link with diet and human health. Front. Microbiol. 7, 185 (2016).
    • (2016) Front. Microbiol. , vol.7 , pp. 185
    • Ríos-Covián, D.1
  • 12
    • 85006021688 scopus 로고    scopus 로고
    • The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro
    • COI: 1:CAS:528:DC%2BC2sXhs1SrtLY%3D
    • Pingitore, A. et al. The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes Obes. Metab. 19, 257–265 (2017).
    • (2017) Diabetes Obes. Metab. , vol.19 , pp. 257-265
    • Pingitore, A.1
  • 13
    • 84945202481 scopus 로고    scopus 로고
    • Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
    • COI: 1:CAS:528:DC%2BC28XhtVKrsbbE
    • Chambers, E. S. et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 64, 1744–1754 (2015).
    • (2015) Gut , vol.64 , pp. 1744-1754
    • Chambers, E.S.1
  • 14
    • 85043228831 scopus 로고    scopus 로고
    • Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
    • COI: 1:CAS:528:DC%2BC1cXjvFGrs7Y%3D
    • Zhao, L. et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science 359, 1151–1156 (2018).
    • (2018) Science , vol.359 , pp. 1151-1156
    • Zhao, L.1
  • 15
    • 33846974390 scopus 로고    scopus 로고
    • Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier
    • COI: 1:CAS:528:DC%2BD28XhtlagsLzE
    • Peng, L., He, Z., Chen, W., Holzman, I. R. & Lin, J. Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier. Pediatr. Res. 61, 37–41 (2007).
    • (2007) Pediatr. Res. , vol.61 , pp. 37-41
    • Peng, L.1    He, Z.2    Chen, W.3    Holzman, I.R.4    Lin, J.5
  • 16
    • 73949137604 scopus 로고    scopus 로고
    • Microbiota and SCFA in lean and overweight healthy subjects
    • Schwiertz, A. et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 18, 190–195 (2010).
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 190-195
    • Schwiertz, A.1
  • 17
    • 84989943149 scopus 로고    scopus 로고
    • Association of host genome with intestinal microbial composition in a large healthy cohort
    • COI: 1:CAS:528:DC%2BC28Xhs1SltL3L
    • Turpin, W. et al. Association of host genome with intestinal microbial composition in a large healthy cohort. Nat. Genet. 48, 1413–1417 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1413-1417
    • Turpin, W.1
  • 18
    • 84969492201 scopus 로고    scopus 로고
    • Genetic determinants of the gut microbiome in UK Twins
    • COI: 1:CAS:528:DC%2BC28XntlShtbo%3D
    • Goodrich, J. K. et al. Genetic determinants of the gut microbiome in UK Twins. Cell Host Microbe 19, 731–743 (2016).
    • (2016) Cell Host Microbe , vol.19 , pp. 731-743
    • Goodrich, J.K.1
  • 19
    • 85043351358 scopus 로고    scopus 로고
    • Environment dominates over host genetics in shaping human gut microbiota
    • COI: 1:CAS:528:DC%2BC1cXjsFaitLg%3D
    • Rothschild, D. et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 555, 210–215 (2018).
    • (2018) Nature , vol.555 , pp. 210-215
    • Rothschild, D.1
  • 20
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • COI: 1:CAS:528:DC%2BC2MXislehtL8%3D
    • Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197–206 (2015).
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1
  • 21
    • 84923169934 scopus 로고    scopus 로고
    • New genetic loci link adipose and insulin biology to body fat distribution
    • COI: 1:CAS:528:DC%2BC2MXisleht7w%3D
    • Shungin, D. et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187–196 (2015).
    • (2015) Nature , vol.518 , pp. 187-196
    • Shungin, D.1
  • 22
    • 84861614905 scopus 로고    scopus 로고
    • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    • COI: 1:CAS:528:DC%2BC38XmvFCjtbw%3D
    • Manning, A. K. et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat. Genet. 44, 659–669 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 659-669
    • Manning, A.K.1
  • 23
    • 80053405321 scopus 로고    scopus 로고
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXhtl2is73K
    • Strawbridge, R. J. et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 60, 2624–2634 (2011).
    • (2011) Diabetes , vol.60 , pp. 2624-2634
    • Strawbridge, R.J.1
  • 24
    • 78649461131 scopus 로고    scopus 로고
    • 1 (C) levels via glycemic and nonglycemic pathways
    • COI: 1:CAS:528:DC%2BC3MXlsVaktA%3D%3D
    • 1 (C) levels via glycemic and nonglycemic pathways. Diabetes 59, 3229–3239 (2010).
    • (2010) Diabetes , vol.59 , pp. 3229-3239
    • Soranzo, N.1
  • 25
    • 84901378366 scopus 로고    scopus 로고
    • A central role for GRB10 in regulation of islet function in man
    • Prokopenko, I. et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet. 10, e1004235 (2014).
    • (2014) PLoS Genet. , vol.10
    • Prokopenko, I.1
  • 26
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • COI: 1:CAS:528:DC%2BC3cXntVCksw%3D%3D
    • Saxena, R. et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 42, 142–148 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 142-148
    • Saxena, R.1
  • 27
    • 85030182446 scopus 로고    scopus 로고
    • An expanded genome-wide association study of type 2 diabetes in Europeans
    • COI: 1:CAS:528:DC%2BC1cXosVynsb4%3D
    • Scott, R. A. et al. An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes 66, 2888–2902 (2017).
    • (2017) Diabetes , vol.66 , pp. 2888-2902
    • Scott, R.A.1
  • 28
    • 84995678287 scopus 로고    scopus 로고
    • A functional genomics approach to understand variation in cytokine production in humans
    • COI: 1:CAS:528:DC%2BC28XhvVWitrbE
    • Li, Y. et al. A functional genomics approach to understand variation in cytokine production in humans. Cell 167, 1099–1110.e14 (2016).
    • (2016) Cell , vol.167 , pp. 1099-1110
    • Li, Y.1
  • 29
    • 84885840876 scopus 로고    scopus 로고
    • Mendelian randomization analysis with multiple genetic variants using summarized data
    • Burgess, S., Butterworth, A. & Thompson, S. G. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37, 658–665 (2013).
    • (2013) Genet. Epidemiol. , vol.37 , pp. 658-665
    • Burgess, S.1    Butterworth, A.2    Thompson, S.G.3
  • 30
    • 85045854182 scopus 로고    scopus 로고
    • Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
    • COI: 1:CAS:528:DC%2BC1cXotF2kt7g%3D
    • Verbanck, M., Chen, C. Y., Neale, B. & Do, R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet. 50, 693–698 (2018).
    • (2018) Nat. Genet. , vol.50 , pp. 693-698
    • Verbanck, M.1    Chen, C.Y.2    Neale, B.3    Do, R.4
  • 31
    • 84963670568 scopus 로고    scopus 로고
    • Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator
    • Bowden, J., Davey Smith, G., Haycock, P. C. & Burgess, S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet. Epidemiol. 40, 304–314 (2016).
    • (2016) Genet. Epidemiol. , vol.40 , pp. 304-314
    • Bowden, J.1    Davey Smith, G.2    Haycock, P.C.3    Burgess, S.4
  • 32
    • 84936755918 scopus 로고    scopus 로고
    • Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
    • Bowden, J., Davey Smith, G. & Burgess, S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44, 512–525 (2015).
    • (2015) Int. J. Epidemiol. , vol.44 , pp. 512-525
    • Bowden, J.1    Davey Smith, G.2    Burgess, S.3
  • 34
    • 78650636780 scopus 로고    scopus 로고
    • Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis
    • Rücker, G., Schwarzer, G., Carpenter, J. R., Binder, H. & Schumacher, M. Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis. Biostatistics 12, 122–142 (2011).
    • (2011) Biostatistics , vol.12 , pp. 122-142
    • Rücker, G.1    Schwarzer, G.2    Carpenter, J.R.3    Binder, H.4    Schumacher, M.5
  • 35
    • 85054630384 scopus 로고    scopus 로고
    • TheUK Biobank resource with deep phenotyping and genomic data
    • COI: 1:CAS:528:DC%2BC1cXhvV2qsbvI
    • Bycroft, C. et al. TheUK Biobank resource with deep phenotyping and genomic data. Nature 562, 203–209 (2018).
    • (2018) Nature , vol.562 , pp. 203-209
    • Bycroft, C.1
  • 36
    • 0036739483 scopus 로고    scopus 로고
    • Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces
    • COI: 1:CAS:528:DC%2BD38XnvFyiu7w%3D, PID: 12361264
    • Duncan, S. H., Hold, G. L., Barcenilla, A., Stewart, C. S. & Flint, H. J. Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces. Int. J. Syst. Evol. Microbiol. 52, 1615–1620 (2002).
    • (2002) Int. J. Syst. Evol. Microbiol. , vol.52 , pp. 1615-1620
    • Duncan, S.H.1    Hold, G.L.2    Barcenilla, A.3    Stewart, C.S.4    Flint, H.J.5
  • 37
    • 0037126667 scopus 로고    scopus 로고
    • The microbiology of butyrate formation in the human colon
    • COI: 1:CAS:528:DC%2BD38XptlCqs7g%3D
    • Pryde, S. E., Duncan, S. H., Hold, G. L., Stewart, C. S. & Flint, H. J. The microbiology of butyrate formation in the human colon. FEMS Microbiol. Lett. 217, 133–139 (2002).
    • (2002) FEMS Microbiol. Lett. , vol.217 , pp. 133-139
    • Pryde, S.E.1    Duncan, S.H.2    Hold, G.L.3    Stewart, C.S.4    Flint, H.J.5
  • 38
    • 84878452354 scopus 로고    scopus 로고
    • Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders
    • COI: 1:CAS:528:DC%2BC3sXotlekur0%3D
    • Jakobsdottir, G., Bjerregaard, J. H., Skovbjerg, H. & Nyman, M. Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. Scand. J. Gastroenterol. 48, 696–701 (2013).
    • (2013) Scand. J. Gastroenterol. , vol.48 , pp. 696-701
    • Jakobsdottir, G.1    Bjerregaard, J.H.2    Skovbjerg, H.3    Nyman, M.4
  • 39
    • 85029647310 scopus 로고    scopus 로고
    • Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population
    • Liu, F. et al. Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population. Sci. Rep. 7, 11789 (2017).
    • (2017) Sci. Rep. , vol.7
    • Liu, F.1
  • 40
    • 85006379794 scopus 로고    scopus 로고
    • Formation of propionate and butyrate by the human colonic microbiota
    • COI: 1:CAS:528:DC%2BC2sXhsFagu78%3D
    • Louis, P. & Flint, H. J. Formation of propionate and butyrate by the human colonic microbiota. Environ. Microbiol. 19, 29–41 (2017).
    • (2017) Environ. Microbiol. , vol.19 , pp. 29-41
    • Louis, P.1    Flint, H.J.2
  • 41
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • den Besten, G. et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 54, 2325–2340 (2013).
    • (2013) J. Lipid Res. , vol.54 , pp. 2325-2340
    • den Besten, G.1
  • 42
    • 85021322151 scopus 로고    scopus 로고
    • Host genetics and gut microbiome: challenges and perspectives
    • COI: 1:CAS:528:DC%2BC2sXhtVGmsr%2FE
    • Kurilshikov, A., Wijmenga, C., Fu, J. & Zhernakova, A. Host genetics and gut microbiome: challenges and perspectives. Trends Immunol. 38, 633–647 (2017).
    • (2017) Trends Immunol. , vol.38 , pp. 633-647
    • Kurilshikov, A.1    Wijmenga, C.2    Fu, J.3    Zhernakova, A.4
  • 43
    • 84896722557 scopus 로고    scopus 로고
    • Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates
    • Taylor, A. E. et al. Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. Econ. Hum. Biol. 13, 99–106 (2014).
    • (2014) Econ. Hum. Biol. , vol.13 , pp. 99-106
    • Taylor, A.E.1
  • 44
    • 85048287255 scopus 로고    scopus 로고
    • Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative
    • Wang, J. et al. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Microbiome 6, 101 (2018).
    • (2018) Microbiome , vol.6
    • Wang, J.1
  • 45
    • 84941588145 scopus 로고    scopus 로고
    • Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics
    • Tigchelaar, E. F. et al. Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics. BMJ Open 5, e006772 (2015).
    • (2015) BMJ Open , vol.5
    • Tigchelaar, E.F.1
  • 46
    • 84906673427 scopus 로고    scopus 로고
    • Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels
    • Li, N. et al. Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels. Diabetes 63, 3149–3158 (2014).
    • (2014) Diabetes , vol.63 , pp. 3149-3158
    • Li, N.1
  • 47
    • 84864577726 scopus 로고    scopus 로고
    • Alternative method for gas chromatography-mass spectrometry analysis of short-chain fatty acids in faecal samples
    • García-Villalba, R. et al. Alternative method for gas chromatography-mass spectrometry analysis of short-chain fatty acids in faecal samples. J. Sep. Sci. 35, 1906–1913 (2012).
    • (2012) J. Sep. Sci. , vol.35 , pp. 1906-1913
    • García-Villalba, R.1
  • 48
    • 84994738020 scopus 로고    scopus 로고
    • Linking the human gut microbiome to inflammatory cytokine production capacity
    • COI: 1:CAS:528:DC%2BC28XhvVWitrbJ
    • Schirmer, M. et al. Linking the human gut microbiome to inflammatory cytokine production capacity. Cell 167, 1125–1136.e8 (2016).
    • (2016) Cell , vol.167 , pp. 1125-1136
    • Schirmer, M.1
  • 49
    • 84983479616 scopus 로고    scopus 로고
    • A reference panel of 64,976 haplotypes for genotype imputation
    • COI: 1:CAS:528:DC%2BC28Xhtlykt7zO
    • McCarthy, S. et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet. 48, 1279–1283 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1279-1283
    • McCarthy, S.1
  • 50
    • 85055773262 scopus 로고    scopus 로고
    • Species-level functional profiling of metagenomes and metatranscriptomes
    • COI: 1:CAS:528:DC%2BC1cXitVCks7nF
    • Franzosa, E. A. et al. Species-level functional profiling of metagenomes and metatranscriptomes. Nat. Methods 15, 962–968 (2018).
    • (2018) Nat. Methods , vol.15 , pp. 962-968
    • Franzosa, E.A.1
  • 51
    • 84964682615 scopus 로고    scopus 로고
    • Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans
    • COI: 1:CAS:528:DC%2BC28XntVOksL8%3D
    • Vatanen, T. et al. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. Cell 165, 842–853 (2016).
    • (2016) Cell , vol.165 , pp. 842-853
    • Vatanen, T.1
  • 52
    • 77950301214 scopus 로고    scopus 로고
    • Variance component model to account for sample structure in genome-wide association studies
    • COI: 1:CAS:528:DC%2BC3cXivVCisb8%3D
    • Kang, H. M. et al. Variance component model to account for sample structure in genome-wide association studies. Nat. Genet. 42, 348–354 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 348-354
    • Kang, H.M.1
  • 53
    • 84923946495 scopus 로고    scopus 로고
    • LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
    • COI: 1:CAS:528:DC%2BC2MXhvFCntb8%3D
    • Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291–295 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 291-295
    • Bulik-Sullivan, B.K.1
  • 54
    • 84924060689 scopus 로고    scopus 로고
    • Efficient Bayesian mixed-model analysis increases association power in large cohorts
    • COI: 1:CAS:528:DC%2BC2MXhvFCntb4%3D
    • Loh, P. R. et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet. 47, 284–290 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 284-290
    • Loh, P.R.1
  • 55
    • 84992416977 scopus 로고    scopus 로고
    • Algorithms for the capture and adjudication of prevalent and incident diabetes in UK Biobank
    • Eastwood, S. V. et al. Algorithms for the capture and adjudication of prevalent and incident diabetes in UK Biobank. PLoS One 11, e0162388 (2016).
    • (2016) PLoS One , vol.11
    • Eastwood, S.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.