Commensal bacteria protect against food allergen sensitization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 36, 2014, Pages 13145-13150

  Stefka, Andrew T ^a   Feehley, Taylor ^a   Tripathi, Prabhanshu ^a   Qiu, Ju ^b   McCoy, Kathy ^c   Mazmanian, Sarkis K ^d   Tjota, Melissa Y ^e   Seo, Goo Young ^a   Cao, Severine ^a   Theriault, Betty R ^f   Antonopoulos, Dionysios A ^e,g   Zhou, Liang ^b   Chang, Eugene B ^e   Fu, Yang Xin ^a   Nagler, Cathryn R ^a,e  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

Barrier; IL 22; Microbiome

Indexed keywords

ALLERGEN; ANTIINFECTIVE AGENT; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22;

ANIMAL; BACTERIAL COUNT; BACTERIUM; C57BL MOUSE; CLOSTRIDIUM; DRUG EFFECTS; EPITHELIUM CELL; FOOD HYPERSENSITIVITY; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNIZATION; IMMUNOLOGY; INNATE IMMUNITY; INTESTINE; METABOLISM; MICROBIOLOGY; MICROFLORA; NEWBORN; PATHOLOGY;

ALLERGENS; ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; BACTERIA; CLOSTRIDIUM; COLONY COUNT, MICROBIAL; EPITHELIAL CELLS; FOOD HYPERSENSITIVITY; IMMUNITY, INNATE; IMMUNIZATION; INTERLEUKINS; INTESTINES; MICE, INBRED C57BL; MICROBIOTA;

EID: 84907000772     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412008111     Document Type: Article

References (39)

1. Berin MC, Sampson HA (2013) Food allergy: An enigmatic epidemic. Trends Immunol 34(8):390-397.
2. Feehley T, Stefka AT, Cao S, Nagler CR (2012) Microbial regulation of allergic responses to food. Semin Immunopathol 34(5):671-688.
3. Cao S, Feehley TJ, Nagler CR (2014) The role of commensal bacteria in the regulation of sensitization to food allergens. FEBS Lett, 10.1016/j.febslet.2014.04.026.
4. Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299(6710):1259-1260.
5. Wills-Karp M, Santeliz J, Karp CL (2001) The germless theory of allergic disease: Revisiting the hygiene hypothesis. Nat Rev Immunol 1(1):69-75.
6. Prioult G, Nagler-Anderson C (2005) Mucosal immunity and allergic responses: Lack of regulation and/or lack of microbial stimulation? Immunol Rev 206:204-218.
7. Cho I, Blaser MJ (2012) The human microbiome: At the interface of health and disease. Nat Rev Genet 13(4):260-270.
8. Blaser M (2011) Antibiotic overuse: Stop the killing of beneficial bacteria. Nature 476(7361):393-394.
9. Nagler-Anderson C (2001) Man the barrier! Strategic defences in the intestinal mucosa. Nat Rev Immunol 1(1):59-67.
10. Maynard CL, Elson CO, Hatton RD, Weaver CT (2012) Reciprocal interactions of the intestinal microbiota and immune system. Nature 489(7415):231-241.
11. Tait Wojno ED, Artis D (2012) Innate lymphoid cells: Balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe 12(4):445-457.
12. Bashir ME, Louie S, Shi HN, Nagler-Anderson C (2004) Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol 172(11):6978-6987.
13. Russell SL, et al. (2012) Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep 13(5):440-447.
14. Nagano Y, Itoh K, Honda K (2012) The induction of Treg cells by gut-indigenous Clostridium. Curr Opin Immunol 24(4):392-397.
15. Geuking MB, et al. (2011) Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34(5):794-806.
16. Atarashi K, et al. (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331(6015):337-341.
17. Atarashi K, et al. (2013) Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500(7461):232-236.
18. Gallo RL, Hooper LV (2012) Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol 12(7):503-516.
19. Sabat R, Ouyang W, Wolk K (2014) Therapeutic opportunities of the IL-22-IL-22R1 system. Nat Rev Drug Discov 13(1):21-38.
20. Kulis M, et al. (2012) The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice. Clin Exp Allergy 42(2):326-336.
21. Ota N, et al. (2011) IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol 12(10):941-948.
22. Zheng Y, et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445(7128):648-651.
23. Lycke N, Karlsson U, Sjölander A, Magnusson KE (1991) The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens. Scand J Immunol 33(6):691-698.
24. Sonnenberg GF, et al. (2012) Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336(6086):1321-1325.
25. Qiu J, et al. (2013) Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39(2):386-399.
26. +regulatory T cells in the lamina propria. Immunity 34(2):237-246.
27. Smith PM, et al. (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341(6145):569-573.
28. Furusawa Y, et al. (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504(7480):446-450.
29. Arpaia N, et al. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504(7480):451-455.
30. Savage JH, Matsui EC, Wood RA, Keet CA (2012) Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. J Allergy Clin Immunol 130(2):453-460.
31. Metsälä J, et al. (2013) Mother's and offspring's use of antibiotics and infant allergy to cow's milk. Epidemiology 24(2):303-309.
32. Henson M, Burks AW (2012) The future of food allergy therapeutics. Semin Immunopathol 34(5):703-714.
33. Matharu KS, et al. (2009) Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology 137(4):1380-1390.
34. van Wijk F, et al. (2005) CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. J Immunol 174(1):174-179.
35. Upadhyay V, et al. (2012) Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol 13(10):947-953.
36. Sa SM, et al. (2007) The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol 178(4):2229-2240.
37. Zheng Y, et al. (2008) Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14(3):282-289.
38. Kirchberger S, et al. (2013) Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med 210(5):917-931.
39. Mielke LA, et al. (2013) Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med 210(6):1117-1124.