Autophagy: Suicide Prevention Hotline for the Gut Epithelium

Cell Host and Microbe

Volumn 23, Issue 2, 2018, Pages 147-148

  Grizotte Lake, Mayara ^a   Vaishnava, Shipra ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CYTOKINE; GAMMA INTERFERON; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

APOPTOSIS; AUTOPHAGY; BACTERIUM; CELL DEATH; CELL PROTECTION; CELL VIABILITY; COLON EPITHELIUM; CYTOKINE RELEASE; DYSBIOSIS; GRAFT VERSUS HOST REACTION; HELICOBACTER HEPATICUS; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM; MICROBIAL COMMUNITY; NONHUMAN; NOROVIRUS; ORGANOID; PANETH CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTOZOON; SALMONELLOSIS; SHORT SURVEY; TOXOPLASMOSIS; VIRUS; HOTLINE; MICROBIOLOGY; SUICIDE;

AUTOPHAGY; HOTLINES; HUMANS; INFLAMMATORY BOWEL DISEASES; SUICIDE;

EID: 85042638378     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2018.01.015     Document Type: Short Survey

References (9)

1. Adolph, T.E., Tomczak, M.F., Niederreiter, L., Ko, H.J., Böck, J., Martinez-Naves, E., Glickman, J.N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503 (2013), 272–276.
2. Benjamin, J.L., Sumpter, R. Jr., Levine, B., Hooper, L.V., Intestinal epithelial autophagy is essential for host defense against invasive bacteria. Cell Host Microbe 13 (2013), 723–734.
3. Burger, E., Araujo, A., López-Yglesias, A., Rajala, M.W., Geng, L., Levine, B., Hooper, L.V., Burstein, E., Yarovinsky, F., Loss of Paneth cell causes acute susceptibility to Toxoplasma gondii-mediated infection. Cell Host Microbe 23 (2018), 177–190 this issue.
4. Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Loh, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456 (2008), 259–263.
5. Conway, K.L., Kuballa, P., Song, J.H., Patel, K.K., Castoreno, A.B., Yilmaz, O.H., Jijon, H.B., Zhang, M., Aldrich, L.N., Villablanca, E.J., et al. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology 145 (2013), 1347–1357.
6. Lassen, K.G., Kuballa, P., Conway, K.L., Patel, K.K., Becker, C.E., Peloquin, J.M., Villablanca, E.J., Norman, J.M., Liu, T.C., Heath, R.J., et al. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc. Natl. Acad. Sci. USA 111 (2014), 7741–7746.
7. Matsuzawa-Ishimoto, Y., Shono, Y., Gomez, L.E., Hubbard-Lucey, V.M., Cammer, M., Neil, J., Dewan, M.Z., Lieberman, S.R., Lazrak, A., Marinis, J.M., et al. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J. Exp. Med. 214 (2017), 3687–3705.
8. Pott, J., Kabat, A.M., Maloy, K.J., Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice. Cell Host Microbe 23 (2018), 191–202 this issue.
9. Stappenbeck, T.S., The role of autophagy in Paneth cell differentiation and secretion. Mucosal Immunol. 3 (2010), 8–10.