Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Science

Volumn 359, Issue 6371, 2018, Pages 97-103

  Gopalakrishnan, V ^a,b   Spencer, C N ^a,b   Nezi, L ^a   Reuben, A ^a   Andrews, M C ^a   Karpinets, T V ^a   Prieto, P A ^a,g   Vicente, D ^a   Hoffman, K ^a   Wei, S C ^a   Cogdill, A P ^a   Zhao, L ^a   Hudgens, C W ^a   Hutchinson, D S ^c   Manzo, T ^a   Petaccia De Macedo, M ^a,h   Cotechini, T ^d   Kumar, T ^a   Chen, W S ^a,i   Reddy, S M ^a   Szczepaniak Sloane, R ^a   Galloway Pena, J ^a   Jiang, H ^a   Chen, P L ^a   Shpall, E J ^a   Rezvani, K ^a   Alousi, A M ^a   Chemaly, R F ^a   Shelburne, S ^a   Vence, L M ^a   Okhuysen, P C ^a   Jensen, V B ^a   Swennes, A G ^c   McAllister, F ^a   Marcelo Riquelme Sanchez, E ^a   Zhang, Y ^a   Le Chatelier, E ^e   Zitvogel, L ^f   Pons, N ^e   Austin Breneman, J L ^a,j   Haydu, L E ^a   Burton, E M ^a   Gardner, J M ^a   Sirmans, E ^a   Hu, J ^a   Lazar, A J ^a   Tsujikawa, T ^d   Diab, A ^a   Tawbi, H ^a   Glitza, I C ^a   Hwu, W J ^a   Patel, S P ^a   Woodman, S E ^a   Amaria, R N ^a   Davies, M A ^a   Gershenwald, J E ^a   Hwu, P ^a   Lee, J E ^a   Zhang, J ^a   Coussens, L M ^d   Cooper, Z A ^a,k   Futreal, P A ^a   Daniel, C R ^a,b   Ajami, N J ^c   Petrosino, J F ^c   Tetzlaff, M T ^a   Sharma, P ^a   Allison, J P ^a   Jenq, R R ^a   Wargo, J A ^a   more..

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e CEMAGREF   (France)

^f INSTITUT GUSTAVE ROUSSY   (France)

^g UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^h A C CAMARGO CANCER CENTER   (Brazil)

ⁱ H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^j HARVARD UNIVERSITY   (United States)

^k MEDIMMUNE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROGRAMMED DEATH 1 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

APOPTOSIS; BACTERIUM; CANCER; GENETIC ANALYSIS; GENOMICS; IMMUNITY; PROTEIN; RELATIVE ABUNDANCE; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL IMMUNITY; CANCER PATIENT; CLOSTRIDIALES; CONTROLLED STUDY; DYSBIOSIS; FAECALIBACTERIUM; FECAL MICROBIOTA TRANSPLANTATION; FECES ANALYSIS; GERMFREE MOUSE; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; INTESTINE FLORA; MAJOR CLINICAL STUDY; MELANOMA; METAGENOMICS; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; POPULATION ABUNDANCE; PRIORITY JOURNAL; RUMINOCOCCACEAE; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; IMMUNOLOGY; METAGENOME; SKIN TUMOR;

MUS;

ANIMALS; FECAL MICROBIOTA TRANSPLANTATION; GASTROINTESTINAL MICROBIOME; HUMANS; IMMUNOTHERAPY; MELANOMA; METAGENOME; MICE; PROGRAMMED CELL DEATH 1 RECEPTOR; SKIN NEOPLASMS;

EID: 85033587326     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan4236     Document Type: Article

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