Case 25-2014: A 37-year-old man with ulcerative colitis and bloody diarrhea

New England Journal of Medicine

Volumn 371, Issue 7, 2014, Pages 668-675

  Hohmann, Elizabeth L ^a   Ananthakrishnan, Ashwin N ^a   Deshpande, Vikram ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN; ENEMA; HYDROCORTISONE; MERCAPTOPURINE; MESALAZINE; METHYLPREDNISOLONE; PREDNISONE; PROBIOTIC AGENT;

ABDOMINAL CRAMP; ACNE; ADULT; ARTHRALGIA; ARTICLE; BIOLOGICAL THERAPY; BLOODY DIARRHEA; CASE REPORT; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE INFECTION; COLON BIOPSY; COLONOSCOPY; CYTOMEGALOVIRUS COLITIS; CYTOMEGALOVIRUS INFECTION; DEFECATION URGENCY; DIET THERAPY; DIFFERENTIAL DIAGNOSIS; DISEASE DURATION; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FECAL MICROBIOTA TRANSPLANTATION; FECES ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOCOMPROMISED PATIENT; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASE; LIVER FUNCTION TEST; MALE; MEDICAL HISTORY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RECTUM HEMORRHAGE; SIDE EFFECT; SYMPTOM; TREATMENT REFUSAL; ULCERATIVE COLITIS; CLINICAL OBSERVATION; CLINICAL STUDY; COLON; DIAGNOSIS; DIARRHEA; GASTROINTESTINAL HEMORRHAGE; MUSCLE SPASM; PATHOLOGY;

ADULT; COLITIS, ULCERATIVE; COLON; CYTOMEGALOVIRUS INFECTIONS; DIAGNOSIS, DIFFERENTIAL; DIARRHEA; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; SPASM;

EID: 84906095918     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcpc1400842     Document Type: Article

References (22)

1. Högenauer C, Langner C, Beubler E, et al. Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitis. N Engl J Med 2006;355:2418-26. (Pubitemid 44903746)
2. Case Records of the Massachusetts General Hospital (Case 8-2012). N Engl J Med 2012;366:1039-45. [Erratum, N Engl J Med 2012;366:2040.]
3. van Nood E, Dijkgraaf MG, Keller JJ. Duodenal infusion of feces for recurrent Clostridium difficile. N Engl J Med 2013;368:2145.
4. Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 2012;107:761-7.
5. Schwartz M, Gluck M, Koon S. Norovirus gastroenteritis after fecal microbiota transplantation for treatment of Clostridium difficile infection despite asymptomatic donors and lack of sick contacts. Am J Gastroenterol 2013;108:1367.
6. Dowd JB, Aiello AE, Alley DE. Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III. Epidemiol Infect 2009;137:58-65.
7. Ananthakrishnan AN, Issa M, Binion DG. Clostridium difficile and inflammatory bowel disease. Gastroenterol Clin North Am 2009;38:711-28.
8. Rousseau C, Poilane I, De Pontual L, Maherault AC, Le Monnier A, Collignon A. Clostridium difficile carriage in healthy infants in the community: a potential reservoir for pathogenic strains. Clin Infect Dis 2012;55:1209-15.
9. Cottone M, Pietrosi G, Martorana G, et al. Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitis. Am J Gastroenterol 2001;96:773-5. (Pubitemid 32240729)
10. Domènech E, Vega R, Ojanguren I, et al. Cytomegalovirus infection in ulcerative colitis: a prospective, comparative study on prevalence and diagnostic strategy. Inflamm Bowel Dis 2008;14:1373-9.
11. Kandiel A, Lashner B. Cytomegalovirus colitis complicating inflammatory bowel disease. Am J Gastroenterol 2006;101:2857-65. (Pubitemid 44902661)
12. Kim YS, Kim YH, Kim JS, et al. The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection: a prospective multicenter study. J Clin Gastroenterol 2012;46:51-6.
13. Lawlor G, Moss AC. Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander? Inflamm Bowel Dis 2010;16:1620-7.
14. Papadakis KA, Tung JK, Binder SW, et al. Outcome of cytomegalovirus infections in patients with inflammatory bowel disease. Am J Gastroenterol 2001;96:2137-42. (Pubitemid 32660910)
15. Pillet S, Pozzetto B, Jarlot C, Paul S, Roblin X. Management of cytomegalovirus infection in inflammatory bowel diseases. Dig Liver Dis 2012;44:541-8.
16. Kambham N, Vij R, Cartwright CA, Longacre T. Cytomegalovirus infection in steroid-refractory ulcerative colitis: a case-control study. Am J Surg Pathol 2004;28:365-73. (Pubitemid 38269570)
17. Yoshino T, Nakase H, Ueno S, et al. Usefulness of quantitative real-time PCR assay for early detection of cytomegalovirus infection in patients with ulcerative colitis refractory to immunosuppressive therapies. Inflamm Bowel Dis 2007;13:1516-21.
18. McCoy MH, Post K, Sen JD, et al. qPCR increases sensitivity to detect cytomegalovirus in formalin-fixed, paraffinembedded tissue of gastrointestinal biopsies. Hum Pathol 2014;45:48-53.
19. Knights D, Lassen KG, Xavier RJ. Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 2013;62:1505-10.
20. Robinson A, Hankins M, Wiseman G, Jones M. Maintaining stable symptom control in inflammatory bowel disease: a retrospective analysis of adherence, medication switches and the risk of relapse. Aliment Pharmacol Ther 2013;38:531-8.
21. Kahn SA, Vachon A, Rodriquez D, et al. Patient perceptions of fecal microbiota transplantation for ulcerative colitis. Inflamm Bowel Dis 2013;19:1506-13.
22. Anderson JL, Edney RJ, Whelan K. Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease. Aliment Pharmacol Ther 2012;36:503-16.