Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Cell Host and Microbe

Volumn 23, Issue 6, 2018, Pages 775-785.e5

  Bhattarai, Yogesh ^a   Williams, Brianna B ^b   Battaglioli, Eric J ^a   Whitaker, Weston R ^c   Till, Lisa ^d   Grover, Madhusudan ^a,d   Linden, David R ^d   Akiba, Yasutada ^e,f,g   Kandimalla, Karunya K ^h   Zachos, Nicholas C ⁱ   Kaunitz, Jonathan D ^e,f,g,j   Sonnenburg, Justin L ^c   Fischbach, Michael A ^b   Farrugia, Gianrico ^a,d,k   Kashyap, Purna C ^a,d  

^a MAYO CLINIC   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^g Brentwood Biomedical Research Institute Los Angeles   (United States)

^h UNIVERSITY OF MINNESOTA   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k MAYO CLINIC   (United States)

more..

Author keywords

Bacteroides thetaiotaomicron; constipation; genetically engineered; GI transit; IBS; microbiome; motility; phage promoter; secretion; tryptophan

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; G PROTEIN COUPLED RECEPTOR; SEROTONIN 4 RECEPTOR; TRYPTAMINE; TRYPTAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BACTEROIDES THETAIOTAOMICRON; COLON EPITHELIUM; COLON MUCOSA; COLONIC SECRETION; DECARBOXYLATION; ENZYME ACTIVITY; FEMALE; GASTROINTESTINAL TRANSIT; HUMAN; INTESTINE FLORA; MALE; MICROBIAL COLONIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; 129 MOUSE; ANIMAL; COLON; DRUG EFFECT; EPITHELIUM; FECES; GENETICS; GERMFREE ANIMAL; INTESTINAL SECRETIONS; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE; SEX FACTOR;

ANIMALS; BACTEROIDES THETAIOTAOMICRON; COLON; EPITHELIUM; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; INTESTINAL SECRETIONS; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; PRIMARY CELL CULTURE; RECEPTORS, SEROTONIN, 5-HT4; SEX FACTORS; SPECIFIC PATHOGEN-FREE ORGANISMS; TRYPTAMINES;

EID: 85048206165     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2018.05.004     Document Type: Article

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